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The map label for this gene is ahcY [H]

Identifier: 156936835

GI number: 156936835

Start: 38018

End: 39262

Strand: Direct

Name: ahcY [H]

Synonym: Igni_0040

Alternate gene names: 156936835

Gene position: 38018-39262 (Clockwise)

Preceding gene: 156936834

Following gene: 156936836

Centisome position: 2.93

GC content: 52.61

Gene sequence:

>1245_bases
ATGGGCTTCAAAGTCAAGGATATAAGCTTGGCCGACCAAGGGAAGCTGAAGATCGAGTGGGCAGAAAATCACATGCCAGT
GGTAGTGGGCCTCAGGAAGCTCTGCGAGGAGAAGAAGGTGTTCGAAGGTAAGAGGATCTCTGCAGTACTCCACGTTACCA
AGGAGACTGCAGCCCTCGTCCGGTCCCTCAAGTTTTGCGGTGCTGAAGTGTACCTAGCGGGCAGCAACCCTCTGAGCACA
CAAGACGACGTAGCGGCAGCCCTCGCACAAGAAGGCATAAACGTCTATGCGTGGAAGGGCGAGACGGAAGAAGAGTACTG
GTGGGCTATTAAGAAAATCATCGAAGAGGGCGACCCAGACCTTGTAATAGACGACGGCGGCGACCTCCACGCTACCATAC
ACAAGGAGTATCCGAAACTGGCTGAGAAGATCATTGGTGGAACTGAGGAGACTACGACCGGAGTAATAAGGCTAAAGGCT
ATGGAAAAAGAGGGTGTCTTGAAGTACCCAGTGATAGCCGTAAACGACGCGTTTACGAAGTTCCTCTTCGATAACCGCTA
TGGAACCGGTCAGAGCACCATAGACGGTATACTGAGGGCGACTAACATTTTGTTGGCGGGCAAGGTCGCAGTGGTCGCGG
GCTACGGATGGGTAGGGAGAGGAATAGCTATGAGGCTTAGAGGCATGGGGGCGCGCGTAGTGGTTACTGAAGTGAACCCG
TTAAGGGCGCTCGAGGCCGTTCACGACGGGTTTGACGTTATGAGGATGGACGACGCAGCCAAGATAGGCGACCTGTTCGT
CACGGCTACCGGTAATATACACGTAATTAGAAAGGAACACATACTCAAGATGAAGGACGGCGCAATCCTCGCAAACGCGG
GCCACTTCAACGTAGAAATCGACGTGAAGGCGCTTGAGGAGATAGCTATATCTAAGAGGAGGATAAGGCCTTACGTCGAC
GAGTACAAGCTCCCGGACGGTAGGCGGATATACTTGCTCGCTGAAGGACGTCTCGTAAACCTGGTCGCGGCGGAAGGCCA
CCCCAGCGAGGTAATGGACATGAGTTTCGCTAACCAGTTCCTCTCCCTTAAGTACTTATTAGAGAAAGCTGGCGAACTGG
CGCCTAAGGTTTACAAGGTTCCCGCCGAAATCGACGAAGAAGTGGCAAGGCGTAAACTGGAAGCAATGGGCATTAAAATA
GACAGCTTAACGGAAGAACAGGTGAGGTACCTCAACTCATGGTAA

Upstream 100 bases:

>100_bases
CTCCTCCGAAGAAGGAGGCAGCCTAAGGGATCGCCAACGATCCTCGCTCAACATAACCCTTTTTTCACCTTTAAACAAAA
CTTGGCCAGGGTTTCGGTAT

Downstream 100 bases:

>100_bases
GGATCGTTGTAATTGGAAACATTAACATAGATATAATAGCTTTCTTGGACGAGCTCCCCTCAATAGATGAGGGGAGGGAA
GCTAAGGACTGGCGGGTGCT

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MGFKVKDISLADQGKLKIEWAENHMPVVVGLRKLCEEKKVFEGKRISAVLHVTKETAALVRSLKFCGAEVYLAGSNPLST
QDDVAAALAQEGINVYAWKGETEEEYWWAIKKIIEEGDPDLVIDDGGDLHATIHKEYPKLAEKIIGGTEETTTGVIRLKA
MEKEGVLKYPVIAVNDAFTKFLFDNRYGTGQSTIDGILRATNILLAGKVAVVAGYGWVGRGIAMRLRGMGARVVVTEVNP
LRALEAVHDGFDVMRMDDAAKIGDLFVTATGNIHVIRKEHILKMKDGAILANAGHFNVEIDVKALEEIAISKRRIRPYVD
EYKLPDGRRIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLSLKYLLEKAGELAPKVYKVPAEIDEEVARRKLEAMGIKI
DSLTEEQVRYLNSW

Sequences:

>Translated_414_residues
MGFKVKDISLADQGKLKIEWAENHMPVVVGLRKLCEEKKVFEGKRISAVLHVTKETAALVRSLKFCGAEVYLAGSNPLST
QDDVAAALAQEGINVYAWKGETEEEYWWAIKKIIEEGDPDLVIDDGGDLHATIHKEYPKLAEKIIGGTEETTTGVIRLKA
MEKEGVLKYPVIAVNDAFTKFLFDNRYGTGQSTIDGILRATNILLAGKVAVVAGYGWVGRGIAMRLRGMGARVVVTEVNP
LRALEAVHDGFDVMRMDDAAKIGDLFVTATGNIHVIRKEHILKMKDGAILANAGHFNVEIDVKALEEIAISKRRIRPYVD
EYKLPDGRRIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLSLKYLLEKAGELAPKVYKVPAEIDEEVARRKLEAMGIKI
DSLTEEQVRYLNSW
>Mature_413_residues
GFKVKDISLADQGKLKIEWAENHMPVVVGLRKLCEEKKVFEGKRISAVLHVTKETAALVRSLKFCGAEVYLAGSNPLSTQ
DDVAAALAQEGINVYAWKGETEEEYWWAIKKIIEEGDPDLVIDDGGDLHATIHKEYPKLAEKIIGGTEETTTGVIRLKAM
EKEGVLKYPVIAVNDAFTKFLFDNRYGTGQSTIDGILRATNILLAGKVAVVAGYGWVGRGIAMRLRGMGARVVVTEVNPL
RALEAVHDGFDVMRMDDAAKIGDLFVTATGNIHVIRKEHILKMKDGAILANAGHFNVEIDVKALEEIAISKRRIRPYVDE
YKLPDGRRIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLSLKYLLEKAGELAPKVYKVPAEIDEEVARRKLEAMGIKID
SLTEEQVRYLNSW

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=413, Percent_Identity=49.8789346246973, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=50.3856041131105, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI298286489, Length=412, Percent_Identity=41.2621359223301, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI195539349, Length=412, Percent_Identity=41.2621359223301, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI195539337, Length=412, Percent_Identity=41.504854368932, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI24308043, Length=412, Percent_Identity=41.504854368932, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI21361647, Length=413, Percent_Identity=39.9515738498789, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17506425, Length=417, Percent_Identity=47.4820143884892, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320882, Length=427, Percent_Identity=46.3700234192037, Blast_Score=358, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24642172, Length=412, Percent_Identity=48.3009708737864, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24656245, Length=401, Percent_Identity=40.6483790523691, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI45553385, Length=411, Percent_Identity=42.8223844282238, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI45553387, Length=411, Percent_Identity=42.8223844282238, Blast_Score=302, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45935; Mature: 45804

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFKVKDISLADQGKLKIEWAENHMPVVVGLRKLCEEKKVFEGKRISAVLHVTKETAALV
CCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHH
RSLKFCGAEVYLAGSNPLSTQDDVAAALAQEGINVYAWKGETEEEYWWAIKKIIEEGDPD
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
LVIDDGGDLHATIHKEYPKLAEKIIGGTEETTTGVIRLKAMEKEGVLKYPVIAVNDAFTK
EEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEECCEEEECHHHHH
FLFDNRYGTGQSTIDGILRATNILLAGKVAVVAGYGWVGRGIAMRLRGMGARVVVTEVNP
HHHCCCCCCCHHHHHHHHHHHHEEEECCEEEEECCCCHHCCHHHHEECCCCEEEEEECCH
LRALEAVHDGFDVMRMDDAAKIGDLFVTATGNIHVIRKEHILKMKDGAILANAGHFNVEI
HHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCEEEEECCEEEEEE
DVKALEEIAISKRRIRPYVDEYKLPDGRRIYLLAEGRLVNLVAAEGHPSEVMDMSFANQF
EHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHH
LSLKYLLEKAGELAPKVYKVPAEIDEEVARRKLEAMGIKIDSLTEEQVRYLNSW
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCC
>Mature Secondary Structure 
GFKVKDISLADQGKLKIEWAENHMPVVVGLRKLCEEKKVFEGKRISAVLHVTKETAALV
CCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHH
RSLKFCGAEVYLAGSNPLSTQDDVAAALAQEGINVYAWKGETEEEYWWAIKKIIEEGDPD
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
LVIDDGGDLHATIHKEYPKLAEKIIGGTEETTTGVIRLKAMEKEGVLKYPVIAVNDAFTK
EEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEECCEEEECHHHHH
FLFDNRYGTGQSTIDGILRATNILLAGKVAVVAGYGWVGRGIAMRLRGMGARVVVTEVNP
HHHCCCCCCCHHHHHHHHHHHHEEEECCEEEEECCCCHHCCHHHHEECCCCEEEEEECCH
LRALEAVHDGFDVMRMDDAAKIGDLFVTATGNIHVIRKEHILKMKDGAILANAGHFNVEI
HHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCEEEEECCEEEEEE
DVKALEEIAISKRRIRPYVDEYKLPDGRRIYLLAEGRLVNLVAAEGHPSEVMDMSFANQF
EHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHH
LSLKYLLEKAGELAPKVYKVPAEIDEEVARRKLEAMGIKIDSLTEEQVRYLNSW
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]