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The map label for this gene is argH [H]

Identifier: 154687065

GI number: 154687065

Start: 2764538

End: 2765914

Strand: Reverse

Name: argH [H]

Synonym: RBAM_026370

Alternate gene names: 154687065

Gene position: 2765914-2764538 (Counterclockwise)

Preceding gene: 154687066

Following gene: 154687064

Centisome position: 70.58

GC content: 47.49

Gene sequence:

>1377_bases
ATGAAGAAGCTTTGGGGAGGCCGTTTTCAAAAAACACCGGAAAAGTGGGTCGATGAGTTCGGCGCATCCATCACATTCGA
CCAAAACTTAGTCAAAGAGGATATTACAGGGTCTCTCGCTCATGCGGCAATGCTGAAAAAATGCGGCATTCTGACGGAAG
AAGAAGAAGGCGCCATCCGACAGGGGCTGCAGACCCTCCTGCAAAAAGCAGAGGAAGGAACGCTTGAATTCTCTGTTGAT
TATGAAGATATCCATTTGAATATTGAAAAAATGCTGATCGAAGAAATCGGACCGCTAGGCGGCAAGCTCCATACCGGCAG
AAGCCGGAATGACCAGGTGGCGACCGACATGCATTTGTATTTGAAAGATCATGTCTCACATATCATCGTGCTGATTGAAC
AGTTCCAAAAAGCGCTGATCGAAAAAGCGGAGGCCAATGTCGAGACCATTCTGCCGGGGTACACCCATTTGCAGCGGGCT
CAGCCGATTTCTTTCGCCCACCATCTGCTTGCTTATTTTTGGATGCTTGAACGGGATAAAGAGCGTTTTCGCGATGCTAT
GAAGCGGATTAACATATCGCCGCTCGGATGCGGGGCGCTTGCCGGAACCACTTTTCCGATAGACCGTAACTATTCGGCGG
AGCTGCTCGGTTTTGACTCCATTTATGAGAACAGTCTTGACGGAGTCAGTGACAGAGATTTTATTCTCGAGTTTTTAAGC
GGCAGCAGCATGCTGATGATGCACCTTTCGCGTTTATCAGAAGAAATCATTCTATGGTGCTCGCAGGAATTCAGATTCAT
TGAACTGGATGATACGTATGCGACGGGAAGCAGCATGATGCCGCAGAAGAAAAACCCCGACATGGCGGAGCTGATCCGCG
GTAAAACCGGACGCGTATACGGTGATATGATGGGGCTTTTCACGATTATGAAAGGGCTCCCGCTCGCTTACAACAAAGAC
CTGCAGGAAGATAAAGAAGGCATGTTTGACACGGTGAAAACCGTTGAAGGAAGCCTTCAGATTTTCACGGGCATGATTGA
AACGATGAAAGTAAACAAAGACATCATGAAACAAGCGACAAAACAAGATTTTTCAAACGCGACGGAACTTGCCGATTATT
TAGCTAAAAAAGGCATGCCGTTCAGAGAAGCGCATGAAGTGGTCGGCAAGCTTGTGTACAGCTGCATTGAAAAAGGAATC
TATTTAAGTGATATGGCATTTGAAGAATTCCTTCAAGCCAGCAGTCTCTTTGAAGAAGACATCTATACCGTGCTCGATCC
GCATCATGCGGTTGAAAAAAGAATGAGCGCCGGCGGAACGGGTTTTCAGCAGGTAGAACAGGCGCTCGTAAAAGCAAAAG
CCTGCGCCGGCATTTAA

Upstream 100 bases:

>100_bases
ACGATGCTTTTGACCATCACGCGGCAATCGGTTTCATTGAGCTTTGGGGGCTGCCGACAAAAGTAAACAGCATTGTGAAA
AAGAAGGAGCAGATTGAAGC

Downstream 100 bases:

>100_bases
TTTGCTGAAATTCCCTTCATATTTTCCCGTCATATCAGACACCCTACATCTATAAAGATGGGAGGTAGAAGGAATGCGCA
AAGAACAAGACCGTTACATC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKKLWGGRFQKTPEKWVDEFGASITFDQNLVKEDITGSLAHAAMLKKCGILTEEEEGAIRQGLQTLLQKAEEGTLEFSVD
YEDIHLNIEKMLIEEIGPLGGKLHTGRSRNDQVATDMHLYLKDHVSHIIVLIEQFQKALIEKAEANVETILPGYTHLQRA
QPISFAHHLLAYFWMLERDKERFRDAMKRINISPLGCGALAGTTFPIDRNYSAELLGFDSIYENSLDGVSDRDFILEFLS
GSSMLMMHLSRLSEEIILWCSQEFRFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKD
LQEDKEGMFDTVKTVEGSLQIFTGMIETMKVNKDIMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLVYSCIEKGI
YLSDMAFEEFLQASSLFEEDIYTVLDPHHAVEKRMSAGGTGFQQVEQALVKAKACAGI

Sequences:

>Translated_458_residues
MKKLWGGRFQKTPEKWVDEFGASITFDQNLVKEDITGSLAHAAMLKKCGILTEEEEGAIRQGLQTLLQKAEEGTLEFSVD
YEDIHLNIEKMLIEEIGPLGGKLHTGRSRNDQVATDMHLYLKDHVSHIIVLIEQFQKALIEKAEANVETILPGYTHLQRA
QPISFAHHLLAYFWMLERDKERFRDAMKRINISPLGCGALAGTTFPIDRNYSAELLGFDSIYENSLDGVSDRDFILEFLS
GSSMLMMHLSRLSEEIILWCSQEFRFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKD
LQEDKEGMFDTVKTVEGSLQIFTGMIETMKVNKDIMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLVYSCIEKGI
YLSDMAFEEFLQASSLFEEDIYTVLDPHHAVEKRMSAGGTGFQQVEQALVKAKACAGI
>Mature_458_residues
MKKLWGGRFQKTPEKWVDEFGASITFDQNLVKEDITGSLAHAAMLKKCGILTEEEEGAIRQGLQTLLQKAEEGTLEFSVD
YEDIHLNIEKMLIEEIGPLGGKLHTGRSRNDQVATDMHLYLKDHVSHIIVLIEQFQKALIEKAEANVETILPGYTHLQRA
QPISFAHHLLAYFWMLERDKERFRDAMKRINISPLGCGALAGTTFPIDRNYSAELLGFDSIYENSLDGVSDRDFILEFLS
GSSMLMMHLSRLSEEIILWCSQEFRFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKD
LQEDKEGMFDTVKTVEGSLQIFTGMIETMKVNKDIMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLVYSCIEKGI
YLSDMAFEEFLQASSLFEEDIYTVLDPHHAVEKRMSAGGTGFQQVEQALVKAKACAGI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=452, Percent_Identity=45.1327433628319, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI68303542, Length=452, Percent_Identity=45.1327433628319, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI68303547, Length=452, Percent_Identity=42.4778761061947, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI68303549, Length=452, Percent_Identity=42.4778761061947, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=48.3516483516484, Blast_Score=450, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321806, Length=456, Percent_Identity=42.9824561403509, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=38.5462555066079, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=38.5462555066079, Blast_Score=351, Evalue=6e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51727; Mature: 51727

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLWGGRFQKTPEKWVDEFGASITFDQNLVKEDITGSLAHAAMLKKCGILTEEEEGAIR
CCCCCCCCCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QGLQTLLQKAEEGTLEFSVDYEDIHLNIEKMLIEEIGPLGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LKDHVSHIIVLIEQFQKALIEKAEANVETILPGYTHLQRAQPISFAHHLLAYFWMLERDK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFRDAMKRINISPLGCGALAGTTFPIDRNYSAELLGFDSIYENSLDGVSDRDFILEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHC
GSSMLMMHLSRLSEEIILWCSQEFRFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKTVEGSLQIFTGMIETMKVNKDIMKQAT
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KQDFSNATELADYLAKKGMPFREAHEVVGKLVYSCIEKGIYLSDMAFEEFLQASSLFEED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IYTVLDPHHAVEKRMSAGGTGFQQVEQALVKAKACAGI
HHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLWGGRFQKTPEKWVDEFGASITFDQNLVKEDITGSLAHAAMLKKCGILTEEEEGAIR
CCCCCCCCCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QGLQTLLQKAEEGTLEFSVDYEDIHLNIEKMLIEEIGPLGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LKDHVSHIIVLIEQFQKALIEKAEANVETILPGYTHLQRAQPISFAHHLLAYFWMLERDK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFRDAMKRINISPLGCGALAGTTFPIDRNYSAELLGFDSIYENSLDGVSDRDFILEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHC
GSSMLMMHLSRLSEEIILWCSQEFRFIELDDTYATGSSMMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKTVEGSLQIFTGMIETMKVNKDIMKQAT
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KQDFSNATELADYLAKKGMPFREAHEVVGKLVYSCIEKGIYLSDMAFEEFLQASSLFEED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IYTVLDPHHAVEKRMSAGGTGFQQVEQALVKAKACAGI
HHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]