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The map label for this gene is argG

Identifier: 154687066

GI number: 154687066

Start: 2765911

End: 2767122

Strand: Reverse

Name: argG

Synonym: RBAM_026380

Alternate gene names: 154687066

Gene position: 2767122-2765911 (Counterclockwise)

Preceding gene: 154687067

Following gene: 154687065

Centisome position: 70.62

GC content: 48.84

Gene sequence:

>1212_bases
ATGGCAGAACAAAAAAAGGTTGTATTGGCATACTCAGGAGGTCTTGATACTTCTGTAGCGATAAAATGGCTGCAAGAACA
GGGATACGATGTTGTTGCCTGCTGTTTAGACGTAGGGGAAGGAAAGGATTTGGCATTCGTTCAGCAAAAAGCGCTGGAAG
TAGGCGCCGTAAATTCCTATGTGATTGATGCGAAAGAAGAATTCGCCCGGGAGTACGCGCTCATTTCTATGCAGGCCCAT
ACAATGTATGAAGGCAAGTATCCGCTCGTATCTGCACTATCCCGTCCGTTAATCGCGAAAAAACTCGTTGAAGTCGCGGA
AAAGGAAAACGCGGTGGCCGTAGCGCACGGCTGCACGGGAAAAGGCAACGATCAGGTGCGTTTCGAAGTATCCATTAAAT
CATTAAATCCTGATCTGGAGGTCATTGCTCCGGTCCGTGAGTGGCAATGGTCGCGTGAAGAAGAAATTGAATATGCCGCA
AGCCGCGGCATACCGATTCCGATCAATCTTGACAGCCCGTATTCCATCGACCAGAACCTATGGGGACGCGCCAATGAATG
CGGTATATTAGAAGATCCGTGGGCGGCGCCGCCTGAAGGGGCATATGACCTGACAGCATCTCTTGAAAACACGCCGGACG
TTCCGGAAATCATCGAAATCGCATTTGAAGCCGGTGTTCCGGTTTCAATCGACGGCGTAACCTACCCGCTCGCTGATTTA
ATTCTCAAGCTGAACGAGACTGCCGGAAAACACGGCATCGGCCGGATTGACCATGTGGAAAACCGCCTGGTCGGCATTAA
GTCCCGTGAAGTTTATGAGTGCCCGGGCGCCATGACTTTGATTACGGCTCACAAAGAGCTTGAGGATCTGACTTTAGTGA
AAGAAGTGGCCCATTTCAAACCGGCAATTGAACAAAAACTGTCTGAAATCATCTATAACGGTTTATGGTTCTCGCCGTTA
AAAGACGCGCTGCTTGCATTCCTGAAAGAAACCCAAAAACACGTCACCGGCGTCGTGCGCGTCAAGCTGTTTAAAGGCCA
TGCCATTGTAGAAGGACGTAAGTCGGAATATTCACTCTACGACGAAAAACTTGCGACATATACAAAAGACGATGCTTTTG
ACCATCACGCGGCAATCGGTTTCATTGAGCTTTGGGGGCTGCCGACAAAAGTAAACAGCATTGTGAAAAAGAAGGAGCAG
ATTGAAGCATGA

Upstream 100 bases:

>100_bases
AAAAGGCTTGAAAAAACAGAATTTACTTGTTACAGTGTATACATACAAAATGCATTTTTATTAATTAAAACTAATTTTTA
TACAAAAGGGAGCTTTTAAC

Downstream 100 bases:

>100_bases
AGAAGCTTTGGGGAGGCCGTTTTCAAAAAACACCGGAAAAGTGGGTCGATGAGTTCGGCGCATCCATCACATTCGACCAA
AACTTAGTCAAAGAGGATAT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAEQKKVVLAYSGGLDTSVAIKWLQEQGYDVVACCLDVGEGKDLAFVQQKALEVGAVNSYVIDAKEEFAREYALISMQAH
TMYEGKYPLVSALSRPLIAKKLVEVAEKENAVAVAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA
SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTASLENTPDVPEIIEIAFEAGVPVSIDGVTYPLADL
ILKLNETAGKHGIGRIDHVENRLVGIKSREVYECPGAMTLITAHKELEDLTLVKEVAHFKPAIEQKLSEIIYNGLWFSPL
KDALLAFLKETQKHVTGVVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVNSIVKKKEQ
IEA

Sequences:

>Translated_403_residues
MAEQKKVVLAYSGGLDTSVAIKWLQEQGYDVVACCLDVGEGKDLAFVQQKALEVGAVNSYVIDAKEEFAREYALISMQAH
TMYEGKYPLVSALSRPLIAKKLVEVAEKENAVAVAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA
SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTASLENTPDVPEIIEIAFEAGVPVSIDGVTYPLADL
ILKLNETAGKHGIGRIDHVENRLVGIKSREVYECPGAMTLITAHKELEDLTLVKEVAHFKPAIEQKLSEIIYNGLWFSPL
KDALLAFLKETQKHVTGVVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVNSIVKKKEQ
IEA
>Mature_402_residues
AEQKKVVLAYSGGLDTSVAIKWLQEQGYDVVACCLDVGEGKDLAFVQQKALEVGAVNSYVIDAKEEFAREYALISMQAHT
MYEGKYPLVSALSRPLIAKKLVEVAEKENAVAVAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAAS
RGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTASLENTPDVPEIIEIAFEAGVPVSIDGVTYPLADLI
LKLNETAGKHGIGRIDHVENRLVGIKSREVYECPGAMTLITAHKELEDLTLVKEVAHFKPAIEQKLSEIIYNGLWFSPLK
DALLAFLKETQKHVTGVVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVNSIVKKKEQI
EA

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=400, Percent_Identity=42.25, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI16950633, Length=400, Percent_Identity=42.25, Blast_Score=311, Evalue=7e-85,
Organism=Escherichia coli, GI1789563, Length=413, Percent_Identity=27.1186440677966, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324514, Length=402, Percent_Identity=38.5572139303483, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21358151, Length=396, Percent_Identity=38.6363636363636, Blast_Score=267, Evalue=9e-72,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_BACA2 (A7Z7M0)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422227.1
- ProteinModelPortal:   A7Z7M0
- SMR:   A7Z7M0
- STRING:   A7Z7M0
- EnsemblBacteria:   EBBACT00000006045
- GeneID:   5461722
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_026380
- eggNOG:   COG0137
- GeneTree:   EBGT00050000002857
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- BioCyc:   BAMY326423:RBAM_026380-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44630; Mature: 44499

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 87-87 BINDING 117-117 BINDING 119-119 BINDING 123-123 BINDING 123-123 BINDING 124-124 BINDING 127-127 BINDING 175-175 BINDING 260-260 BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQKKVVLAYSGGLDTSVAIKWLQEQGYDVVACCLDVGEGKDLAFVQQKALEVGAVNSY
CCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCE
VIDAKEEFAREYALISMQAHTMYEGKYPLVSALSRPLIAKKLVEVAEKENAVAVAHGCTG
EECCHHHHHHHHHHEEEEEHEEECCCCHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCCC
KGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAASRGIPIPINLDSPYSIDQNL
CCCCEEEEEEEEECCCCCCEEEECHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHH
WGRANECGILEDPWAAPPEGAYDLTASLENTPDVPEIIEIAFEAGVPVSIDGVTYPLADL
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHH
ILKLNETAGKHGIGRIDHVENRLVGIKSREVYECPGAMTLITAHKELEDLTLVKEVAHFK
HHHHHHCCCCCCCCCHHHHHHHEECCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
PAIEQKLSEIIYNGLWFSPLKDALLAFLKETQKHVTGVVRVKLFKGHAIVEGRKSEYSLY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEECCCCCCHHHH
DEKLATYTKDDAFDHHAAIGFIELWGLPTKVNSIVKKKEQIEA
HHHHHHCCCCCCCCHHHHEEEHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEQKKVVLAYSGGLDTSVAIKWLQEQGYDVVACCLDVGEGKDLAFVQQKALEVGAVNSY
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCE
VIDAKEEFAREYALISMQAHTMYEGKYPLVSALSRPLIAKKLVEVAEKENAVAVAHGCTG
EECCHHHHHHHHHHEEEEEHEEECCCCHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCCC
KGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAASRGIPIPINLDSPYSIDQNL
CCCCEEEEEEEEECCCCCCEEEECHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHH
WGRANECGILEDPWAAPPEGAYDLTASLENTPDVPEIIEIAFEAGVPVSIDGVTYPLADL
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHH
ILKLNETAGKHGIGRIDHVENRLVGIKSREVYECPGAMTLITAHKELEDLTLVKEVAHFK
HHHHHHCCCCCCCCCHHHHHHHEECCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
PAIEQKLSEIIYNGLWFSPLKDALLAFLKETQKHVTGVVRVKLFKGHAIVEGRKSEYSLY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCEEECCCCCCHHHH
DEKLATYTKDDAFDHHAAIGFIELWGLPTKVNSIVKKKEQIEA
HHHHHHCCCCCCCCHHHHEEEHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA