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The map label for this gene is trxA [H]

Identifier: 154686984

GI number: 154686984

Start: 2676451

End: 2676765

Strand: Reverse

Name: trxA [H]

Synonym: RBAM_025560

Alternate gene names: 154686984

Gene position: 2676765-2676451 (Counterclockwise)

Preceding gene: 154686985

Following gene: 154686983

Centisome position: 68.31

GC content: 44.13

Gene sequence:

>315_bases
ATGGCTATCGTAAAAGCAACTGATCAATCGTTCTCAGCTGAAACAAGTGAAGGTGTCGTATTGGCTGATTTCTGGGCTCC
TTGGTGCGGACCTTGTAAAATGATCGCGCCCGTTCTTGAAGAGCTTGATCAAGAAATGGGAGACAAACTGAAAATCGTCA
AAATCGACGTGGATGAAAACCAAGAAACTGCCGGTAAATACGGCGTCATGAGCATCCCGACACTTCTCGTATTGAAAGAC
GGAGAAGTCGTTGAAACATCTGTCGGTTTCAAACCGAAAGAAGCTCTTGAAGAGCTTGTAAACAAACATCTGTAA

Upstream 100 bases:

>100_bases
CCGGCGGGTTCGGGAGAAAATAATATAAGCATTAAATTAGCATGAACGAATGGGAGATGCTATACTAAAAATCATCATTT
GACAATTGGAGGAATAACAA

Downstream 100 bases:

>100_bases
GCCGAAAACTTCCGTTACGGCAGGGCGATTCCTTTGAAAGGGAATCGCCTTTTTTTGATCTTCCAAAAGCTGAGAATGGA
GAAAAACAAATGTTCGTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKD
GEVVETSVGFKPKEALEELVNKHL

Sequences:

>Translated_104_residues
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKD
GEVVETSVGFKPKEALEELVNKHL
>Mature_103_residues
AIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDG
EVVETSVGFKPKEALEELVNKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=88, Percent_Identity=39.7727272727273, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI42794771, Length=101, Percent_Identity=32.6732673267327, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224493972, Length=101, Percent_Identity=32.6732673267327, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI38505222, Length=104, Percent_Identity=31.7307692307692, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=48.0769230769231, Blast_Score=108, Evalue=1e-25,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=40, Blast_Score=89, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71998175, Length=96, Percent_Identity=36.4583333333333, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=84, Percent_Identity=44.047619047619, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=85, Percent_Identity=44.7058823529412, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=73, Percent_Identity=39.7260273972603, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=73, Percent_Identity=39.7260273972603, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=35.8024691358025, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=30.5882352941176, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=97, Percent_Identity=34.020618556701, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=43.2098765432099, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=43.5897435897436, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=41.7721518987342, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=43.6781609195402, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17648013, Length=91, Percent_Identity=40.6593406593407, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=91, Percent_Identity=40.6593406593407, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=38.6363636363636, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=49.1803278688525, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11394; Mature: 11263

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDEN
CEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALEELVNKHL
CCCCCCCCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDEN
EEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALEELVNKHL
CCCCCCCCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]