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The map label for this gene is hisS

Identifier: 154686897

GI number: 154686897

Start: 2587236

End: 2588510

Strand: Reverse

Name: hisS

Synonym: RBAM_024670

Alternate gene names: 154686897

Gene position: 2588510-2587236 (Counterclockwise)

Preceding gene: 154686898

Following gene: 154686896

Centisome position: 66.06

GC content: 48.55

Gene sequence:

>1275_bases
ATGGCATATCACATTCCAAGAGGCACACAGGACATACTGCCGGGTGAATCAGACAGATGGCAGTTCGTCGAACAAATTAT
GAGGGAGACGTGCCGCACTTATCAATATAAAGAAATCCGCACGCCGATTTTCGAGCATACGGAATTGTTCGCAAGAGGCG
TCGGTGAGTCTACAGATATCGTGCAGAAAGAAATGTACACGTTTGAAGACCGTAAAGGGAGAAGCCTGACGCTTCGGCCG
GAAGGAACAGCCGCCGCAGTCCGCGCGTTCAATGAAAATAAATTATTTGCGAACCCGGTGCAGCCGACGAAGCTTTATTA
TGTCGGACCGATGTTCCGTTACGAACGTCCGCAGACAGGGCGTTTCCGCCAATTCTATCAATTCGGAATTGAAGCGATCG
GCTCCAAAGATCCGGCCGTGGATGCAGAAGTCATTGCGCTTGCGATGAGTATTTACCGTAAAGCCGGTTTGAAACATGTC
AAGCTTGTGCTGAACAGCCTTGGTGACCAGGACAGCCGCAAATCCTACCGGGAAGCGCTCGTCAAACATTTTGAACCGCG
CATCGGAGAGTTTTGCTCAGACTGCCAGTCGCGCCTGCACACAAACCCGCTCAGAATTCTTGACTGCAAGAAAGACAGAG
AGCATGAACTGATGAAAACGGCTCCGTCCATTCTTGATTACTTAAATGAAGAATCAGCCGCTTATTTTGAGAAAGTAAAA
CAATACTTAAACGATCTCGGCATCCCGTTCGAAATAGATCCGAACCTTGTCAGAGGGCTTGATTATTATAACCATACCGC
TTTTGAAATTATGAGCAATGCCGAAGGATTCGGAGCGATTACAACCCTTGCCGGCGGGGGCCGCTATGACGGGCTTGTTG
AACAGATCGGCGGACCTGAAGCGCCGGGTATCGGATTTGCGATGAGCATCGAACGTCTGCTGGCAGCCATTGACGCTGAG
AAAACAGAGCTTCCCGTCAATCAGGGGATTGACTGCTACATCGTGACGCTCGGAGAAAAAGCGAAGGATTATTCCGTTTC
CCTCGTGTACAAACTGAGAGAAGCGGGCATCTCAAGTGAAATCGATTATGAAAATAAAAAGATGAAGGGCCAATTTAAAA
CGGCTGACCGCCTCGGCGCACGTTTTATTGCGATTTTAGGGGAAGATGAGCTTGCCCAAAATAAAATCAATGTAAAAGAT
GCGGAAACAGGAGAGCAGCGTGAAGTGGTGTTAGACGAGCTGATACAAGTGTTAAAGGCAGATCAAAAGCAGTGA

Upstream 100 bases:

>100_bases
CTAGGGTGGCACCACGGGTATAACTCTCGTCCCTACTATACATGTATAGTAGGAGCGGGAGTTTTTTTATTTGAAGAAAG
ACATTAAGGAGGCCTGTAAC

Downstream 100 bases:

>100_bases
AGGAGAGGAACGCTATGTTTGGAAGAACATATTATTGTGGCGAGATAACTGAAAAAGCGATTGGCGAAACCGTCAAACTG
AAAGGATGGGTGCAGAAGCG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MAYHIPRGTQDILPGESDRWQFVEQIMRETCRTYQYKEIRTPIFEHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRP
EGTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTGRFRQFYQFGIEAIGSKDPAVDAEVIALAMSIYRKAGLKHV
KLVLNSLGDQDSRKSYREALVKHFEPRIGEFCSDCQSRLHTNPLRILDCKKDREHELMKTAPSILDYLNEESAAYFEKVK
QYLNDLGIPFEIDPNLVRGLDYYNHTAFEIMSNAEGFGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAE
KTELPVNQGIDCYIVTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLGARFIAILGEDELAQNKINVKD
AETGEQREVVLDELIQVLKADQKQ

Sequences:

>Translated_424_residues
MAYHIPRGTQDILPGESDRWQFVEQIMRETCRTYQYKEIRTPIFEHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRP
EGTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTGRFRQFYQFGIEAIGSKDPAVDAEVIALAMSIYRKAGLKHV
KLVLNSLGDQDSRKSYREALVKHFEPRIGEFCSDCQSRLHTNPLRILDCKKDREHELMKTAPSILDYLNEESAAYFEKVK
QYLNDLGIPFEIDPNLVRGLDYYNHTAFEIMSNAEGFGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAE
KTELPVNQGIDCYIVTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLGARFIAILGEDELAQNKINVKD
AETGEQREVVLDELIQVLKADQKQ
>Mature_423_residues
AYHIPRGTQDILPGESDRWQFVEQIMRETCRTYQYKEIRTPIFEHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPE
GTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTGRFRQFYQFGIEAIGSKDPAVDAEVIALAMSIYRKAGLKHVK
LVLNSLGDQDSRKSYREALVKHFEPRIGEFCSDCQSRLHTNPLRILDCKKDREHELMKTAPSILDYLNEESAAYFEKVKQ
YLNDLGIPFEIDPNLVRGLDYYNHTAFEIMSNAEGFGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEK
TELPVNQGIDCYIVTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLGARFIAILGEDELAQNKINVKDA
ETGEQREVVLDELIQVLKADQKQ

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=473, Percent_Identity=25.369978858351, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI15029520, Length=456, Percent_Identity=25.4385964912281, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788861, Length=416, Percent_Identity=44.9519230769231, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71993686, Length=469, Percent_Identity=24.5202558635394, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71993693, Length=469, Percent_Identity=24.5202558635394, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643061, Length=470, Percent_Identity=23.6170212765957, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643059, Length=489, Percent_Identity=22.6993865030675, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_BACA2 (A7Z751)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422058.1
- ProteinModelPortal:   A7Z751
- SMR:   A7Z751
- STRING:   A7Z751
- EnsemblBacteria:   EBBACT00000006634
- GeneID:   5462062
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_024670
- eggNOG:   COG0124
- GeneTree:   EBGT00050000001169
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   BAMY326423:RBAM_024670-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48104; Mature: 47973

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYHIPRGTQDILPGESDRWQFVEQIMRETCRTYQYKEIRTPIFEHTELFARGVGESTDI
CCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
VQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTG
HHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCEEECCCCCCEEEEECCHHCCCCCCCC
RFRQFYQFGIEAIGSKDPAVDAEVIALAMSIYRKAGLKHVKLVLNSLGDQDSRKSYREAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
VKHFEPRIGEFCSDCQSRLHTNPLRILDCKKDREHELMKTAPSILDYLNEESAAYFEKVK
HHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QYLNDLGIPFEIDPNLVRGLDYYNHTAFEIMSNAEGFGAITTLAGGGRYDGLVEQIGGPE
HHHHHCCCCEEECCHHHHHHHHHCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCCC
APGIGFAMSIERLLAAIDAEKTELPVNQGIDCYIVTLGEKAKDYSVSLVYKLREAGISSE
CCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCC
IDYENKKMKGQFKTADRLGARFIAILGEDELAQNKINVKDAETGEQREVVLDELIQVLKA
CCCCCHHHCCCHHHHHHHCCEEEEEECCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
DQKQ
CCCC
>Mature Secondary Structure 
AYHIPRGTQDILPGESDRWQFVEQIMRETCRTYQYKEIRTPIFEHTELFARGVGESTDI
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
VQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTG
HHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCEEECCCCCCEEEEECCHHCCCCCCCC
RFRQFYQFGIEAIGSKDPAVDAEVIALAMSIYRKAGLKHVKLVLNSLGDQDSRKSYREAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
VKHFEPRIGEFCSDCQSRLHTNPLRILDCKKDREHELMKTAPSILDYLNEESAAYFEKVK
HHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QYLNDLGIPFEIDPNLVRGLDYYNHTAFEIMSNAEGFGAITTLAGGGRYDGLVEQIGGPE
HHHHHCCCCEEECCHHHHHHHHHCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCCCC
APGIGFAMSIERLLAAIDAEKTELPVNQGIDCYIVTLGEKAKDYSVSLVYKLREAGISSE
CCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCC
IDYENKKMKGQFKTADRLGARFIAILGEDELAQNKINVKDAETGEQREVVLDELIQVLKA
CCCCCHHHCCCHHHHHHHCCEEEEEECCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
DQKQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA