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The map label for this gene is mtn

Identifier: 154686867

GI number: 154686867

Start: 2557724

End: 2558419

Strand: Reverse

Name: mtn

Synonym: RBAM_024370

Alternate gene names: 154686867

Gene position: 2558419-2557724 (Counterclockwise)

Preceding gene: 154686868

Following gene: 154686866

Centisome position: 65.29

GC content: 46.26

Gene sequence:

>696_bases
ATGAAACTGGCAGTCATCGGAGCAATGGAAGAGGAAGTTACGATTTTAAGAAGCAAACTGAAAGACGCAAAACAAGAGAT
GATCGCTCACTGTGAGTTTACAACTGGCAGCTATGAAGGCGTCGAAGTCATCTTGCTGAAATCAGGTATCGGGAAAGTCA
ACGCGGCGATCAGCACGACGCTTCTGCTTGACCGTTTCAAACCTGATTATGTGATTAACACAGGCTCAGCGGGCGGTTTT
CATCATACATTGAATGTAGGCGACGTCGTCATCTCAACAGATGTCCGCCATCATGACGTGGATGTGACGGCGTTTGACTA
TGAATACGGACAGGTGCCGGGTCTTCCGGCAGCATACAAAGCTGATGAAAAGCTGATCAGTATTACTGAGGAAGCGGTTT
CTGAACTTAACGGCATTCAAGTCGCCAAAGGCACAATCGCAACGGGAGATTCTTTTATGAATGATCCGAAGCGGGTTGAA
GACGTACGCGCCAAATTTGCGGATTTGTACGCGGTTGAAATGGAAGCTGCGGCTGTCGCACAGGTGTGCCACCAGTTCAA
AACGCCTTTTGTTGTCATCAGAGCTTTATCTGATATTGCCGGAAAAGAATCTGACGTTTCATTTGATAAATTTTTAGAAC
AGGCTGCCGTTCATTCAACTGAGCTTGTCCTGAATGTCATCAAACGAATTCACTAA

Upstream 100 bases:

>100_bases
TCTTTTCAGAAGAGGGATTTGCCGCGCGGTTTACGCAGCAAAATGACTTTGTCTGGATAATGGAGGCGATTAAACGGTAA
ATCGAAGGGATTGTGTATAA

Downstream 100 bases:

>100_bases
GCGGGGGATTCTCGTTCTCCTCCGCTTTTCCAGGAGGAGGACATATATTGAACGTGATAACAGATATTACAGAACTGATC
GGAAATACACCGCTGCTCCG

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKLAVIGAMEEEVTILRSKLKDAKQEMIAHCEFTTGSYEGVEVILLKSGIGKVNAAISTTLLLDRFKPDYVINTGSAGGF
HHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYKADEKLISITEEAVSELNGIQVAKGTIATGDSFMNDPKRVE
DVRAKFADLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESDVSFDKFLEQAAVHSTELVLNVIKRIH

Sequences:

>Translated_231_residues
MKLAVIGAMEEEVTILRSKLKDAKQEMIAHCEFTTGSYEGVEVILLKSGIGKVNAAISTTLLLDRFKPDYVINTGSAGGF
HHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYKADEKLISITEEAVSELNGIQVAKGTIATGDSFMNDPKRVE
DVRAKFADLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESDVSFDKFLEQAAVHSTELVLNVIKRIH
>Mature_231_residues
MKLAVIGAMEEEVTILRSKLKDAKQEMIAHCEFTTGSYEGVEVILLKSGIGKVNAAISTTLLLDRFKPDYVINTGSAGGF
HHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYKADEKLISITEEAVSELNGIQVAKGTIATGDSFMNDPKRVE
DVRAKFADLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESDVSFDKFLEQAAVHSTELVLNVIKRIH

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=230, Percent_Identity=52.1739130434783, Blast_Score=224, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_BACA2 (A7Z721)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422028.1
- ProteinModelPortal:   A7Z721
- SMR:   A7Z721
- STRING:   A7Z721
- EnsemblBacteria:   EBBACT00000005184
- GeneID:   5462152
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_024370
- eggNOG:   COG0775
- GeneTree:   EBGT00050000000478
- HOGENOM:   HBG367723
- OMA:   AMEQEVT
- ProtClustDB:   PRK05584
- BioCyc:   BAMY326423:RBAM_024370-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 25169; Mature: 25169

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: ACT_SITE 12-12 BINDING 78-78 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAVIGAMEEEVTILRSKLKDAKQEMIAHCEFTTGSYEGVEVILLKSGIGKVNAAISTT
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHH
LLLDRFKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYK
HHHHCCCCCEEEECCCCCCEEEEECCCCEEEECCCEECCCEEEEEECCCCCCCCCCCHHH
ADEKLISITEEAVSELNGIQVAKGTIATGDSFMNDPKRVEDVRAKFADLYAVEMEAAAVA
CCHHHHHHHHHHHHHCCCEEEECCEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVCHQFKTPFVVIRALSDIAGKESDVSFDKFLEQAAVHSTELVLNVIKRIH
HHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLAVIGAMEEEVTILRSKLKDAKQEMIAHCEFTTGSYEGVEVILLKSGIGKVNAAISTT
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHH
LLLDRFKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYK
HHHHCCCCCEEEECCCCCCEEEEECCCCEEEECCCEECCCEEEEEECCCCCCCCCCCHHH
ADEKLISITEEAVSELNGIQVAKGTIATGDSFMNDPKRVEDVRAKFADLYAVEMEAAAVA
CCHHHHHHHHHHHHHCCCEEEECCEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVCHQFKTPFVVIRALSDIAGKESDVSFDKFLEQAAVHSTELVLNVIKRIH
HHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA