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The map label for this gene is mmgB [H]

Identifier: 154686675

GI number: 154686675

Start: 2382357

End: 2383208

Strand: Reverse

Name: mmgB [H]

Synonym: RBAM_022440

Alternate gene names: 154686675

Gene position: 2383208-2382357 (Counterclockwise)

Preceding gene: 154686676

Following gene: 154686674

Centisome position: 60.82

GC content: 49.18

Gene sequence:

>852_bases
ATGAAGATGAAAACAATCATGGTCGCAGGTGCGGGTCAGATGGGAGCAGGCATCGCGCAGACGGCTGCAGAAGCCGGGTT
TGCCGTCAAGTTATACGATTGGGAGCCGGAAACGGTAACAAAAGGTCTTCACCGCATAAAGACAAACCTGGAGAAAGAGC
AGGCAAAAGGACGGAAGTCACGGCAGGAGACAGATGCCGTTTTCAGCCGTATTTCCCCGGCAGAACTCACAGAAGCGGAA
GATGCTGATTTTATAATTGAAGCCATTGCAGAAAACAAAAAAGCAAAAGCAGAATTGTTTGACACACTAGATAAAATCTG
TCCCCCTCATGCCGTATTGGCAAGCAATACGTCTTCTCTTCCCATTACGGAGCTTGCCGCGGCCACAAAAAGGCCTGAAA
AAGTAATCGGCATGCATTTTATGAATCCGGTTCCTGTCATGGAGCTTGTCGAAGTCATCAGAGGACTCGCCACATCGGAA
GAAACGGCGGAAACAGTAAAGAAGCTTGCCGTCCGGATGAATAAAACCCCTGTCGAAGTCAATGACTTCCCGGGCTTTAT
ATCTAATCGCATATTAATGCCGATGATTAACGAAGCCGTTTATTGCCTTTATGAAGGAGCAGCTTCAAAGGAAGCGATTG
ATGAGGTGATGAAGCTCGGCATGCGGCATCCGATGGGTCCTTTAACATTAGCTGACTTCATCGGGCTGGATACGTGCCTT
TCCATTATGGAGGTTCTCTATGCGGGGCTCGGAGATCCGAAATACCGCCCATGCCCTCTGCTCAGAAAATATGTCAGCGC
CGGCTGGCTCGGCAAAAAAAGCGGGCGCGGTTTTTATGAGTACGGCAGATGA

Upstream 100 bases:

>100_bases
CGTCGCGGAGGGGGTTTAGGCGTAGCGGCTATATGCAGCGGAGCGGCTCAAGGAGATGCCGTCCTGCTTGAGGTGTACTG
ATCAAAGGAGGGAGCGCCGG

Downstream 100 bases:

>100_bases
CGTAAAGATCATGAGGGGAGACGGCAGCCATGCATTTTACAGAAGAGCACATCATGATGAGAAAAATGGTGCGTGATTTT
GCCCGCAAGGAAATCGCGCC

Product: MmgB

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVTKGLHRIKTNLEKEQAKGRKSRQETDAVFSRISPAELTEAE
DADFIIEAIAENKKAKAELFDTLDKICPPHAVLASNTSSLPITELAAATKRPEKVIGMHFMNPVPVMELVEVIRGLATSE
ETAETVKKLAVRMNKTPVEVNDFPGFISNRILMPMINEAVYCLYEGAASKEAIDEVMKLGMRHPMGPLTLADFIGLDTCL
SIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKKSGRGFYEYGR

Sequences:

>Translated_283_residues
MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVTKGLHRIKTNLEKEQAKGRKSRQETDAVFSRISPAELTEAE
DADFIIEAIAENKKAKAELFDTLDKICPPHAVLASNTSSLPITELAAATKRPEKVIGMHFMNPVPVMELVEVIRGLATSE
ETAETVKKLAVRMNKTPVEVNDFPGFISNRILMPMINEAVYCLYEGAASKEAIDEVMKLGMRHPMGPLTLADFIGLDTCL
SIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKKSGRGFYEYGR
>Mature_283_residues
MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVTKGLHRIKTNLEKEQAKGRKSRQETDAVFSRISPAELTEAE
DADFIIEAIAENKKAKAELFDTLDKICPPHAVLASNTSSLPITELAAATKRPEKVIGMHFMNPVPVMELVEVIRGLATSE
ETAETVKKLAVRMNKTPVEVNDFPGFISNRILMPMINEAVYCLYEGAASKEAIDEVMKLGMRHPMGPLTLADFIGLDTCL
SIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKKSGRGFYEYGR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=42.1602787456446, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=40.655737704918, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=36.2989323843416, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=32.6530612244898, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=32.6530612244898, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI115430219, Length=231, Percent_Identity=31.1688311688312, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=39.2226148409894, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI1788682, Length=264, Percent_Identity=37.8787878787879, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=36.7424242424242, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.6306620209059, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=39.9305555555556, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=37.5, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25144276, Length=280, Percent_Identity=37.1428571428571, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17508953, Length=280, Percent_Identity=37.1428571428571, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=37.1428571428571, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=280, Percent_Identity=36.0714285714286, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=32.0422535211268, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=28.5211267605634, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193203623, Length=195, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=195, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=36.1702127659575, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=36.1702127659575, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=36.1702127659575, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=30.1255230125523, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129993, Length=235, Percent_Identity=26.3829787234043, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31060; Mature: 31060

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVTKGLHRIKTNLEKEQAKGRKS
CCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQETDAVFSRISPAELTEAEDADFIIEAIAENKKAKAELFDTLDKICPPHAVLASNTSSL
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
PITELAAATKRPEKVIGMHFMNPVPVMELVEVIRGLATSEETAETVKKLAVRMNKTPVEV
CHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
NDFPGFISNRILMPMINEAVYCLYEGAASKEAIDEVMKLGMRHPMGPLTLADFIGLDTCL
CCCCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKKSGRGFYEYGR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVTKGLHRIKTNLEKEQAKGRKS
CCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQETDAVFSRISPAELTEAEDADFIIEAIAENKKAKAELFDTLDKICPPHAVLASNTSSL
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
PITELAAATKRPEKVIGMHFMNPVPVMELVEVIRGLATSEETAETVKKLAVRMNKTPVEV
CHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
NDFPGFISNRILMPMINEAVYCLYEGAASKEAIDEVMKLGMRHPMGPLTLADFIGLDTCL
CCCCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKKSGRGFYEYGR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]