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The map label for this gene is lysA [H]

Identifier: 154686579

GI number: 154686579

Start: 2239998

End: 2241317

Strand: Reverse

Name: lysA [H]

Synonym: RBAM_021480

Alternate gene names: 154686579

Gene position: 2241317-2239998 (Counterclockwise)

Preceding gene: 154686580

Following gene: 154686577

Centisome position: 57.2

GC content: 49.39

Gene sequence:

>1320_bases
TTGTTCTTACATGGCACAAGCAGACAAAACAAACTAGGTCATTTGGAAATCGGAGGTGTGGACGCGCTGTATTTAGCGGA
GCATTACGGCACGCCTCTTTATGTTTACGATGTGGCTTTAATACGTGAGCGCGCTAAAAGCTTTAAACAGGCATTCATTG
ACGCGGATTTAAAGGCGCAGGTCGCGTACGCGAGCAAGGCGTTTTCTTCCGTTGCGATGATACAGCTCGCTGAGCAGGAG
GGGCTCTCATTGGACGTTGTATCCGGCGGAGAGCTGTTTACGGCGGTTGCGGCCGGTTTTCCGGCTGACAGGATTCACTT
TCACGGCAATAACAAAAGCGAAGAAGAGTTGAAAATGGCGCTCGATCATCAAATCGGCTGCATTGTCGTTGATAATTTTT
ATGAAATATCCTTACTCGCGGAACTGTGCCGCAAATCAGGGCGCACAATGGATGTGCTTCTGCGGATCACTCCAGGGGTA
GAGGCGCATACGCATGATTATATTACAACGGGACAGGAAGATTCCAAATTCGGTTTTGATCTGCATAACGGGCAAATAGA
AAAGGCGATTGAACAAGTATTACAGTCAGACCATATCCGCCTTCTCGGCGTTCACTGCCACATCGGATCGCAAATTTTTG
ATACGGCGGGCTTTGTGCTGGCCGCAGAAAAAATCTTCGCAAAACTGAATGAATGGAGAGAATCATTCGGCTTTGTCTCT
GAAGTGCTGAATTTAGGGGGCGGCTTTGGCATCCGCTACACGGAGGAGGATGAACCCCTTCATCCCGCCGTTTATGTGGA
AAAAATTATCGAAGCGGTAAAAGAAAACGCAGCGCTGCACGCTTTTGACATTCCGGAGATCTGGATTGAACCGGGACGCT
CGCTCGTCGGAGACGCCGGAACGACGCTTTATACCATCGGTTCGCAAAAAGAAGTGCCCGGCACCCGTAAATATGCAGCG
GTTGACGGGGGCATGAGCGATAATATCCGTCCTGCGCTGTATCAGGCGAAATATGAAGCCGTATCGGCAAACAGAATCGG
AGAACACCACGATAAAACGGTATCCATCGCGGGTAAGTGCTGTGAAAGCGGTGATATGCTCATTTGGGATATAGACCTTC
CGGAAGTGAAAGAAGGCGATCTTCTCGCCGTTTTCTGCACGGGAGCATACGGATACAGCATGGCTAACAACTACAACCGC
ATTCCGCGTCCCGCCGTCGTTTTTGTGGAAGACGGCGAAGCGCATCTTGTCATTAGAAGGGAAACTTATGAAGACATTGT
AAAACTGGATCTGCCGTTTAAGACGGGGGTCAAACAATAA

Upstream 100 bases:

>100_bases
ATGATATTGTATGTCTTAACTTATACGGGACTTGTATAAGGACAGCTCAAAAGAAGCTGTCCTTTTCACCCATATGCGGA
TCAGAAAGAGGGAATGAGCA

Downstream 100 bases:

>100_bases
ATAAAAAAGAGACCGGAACAATGGCGTCCGGTCTCTTTTTGCATTCAGCTGTTGTTAGAACTTGATCCGCTGTCTCCTGT
AAATACAGACACGATCGCAT

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFLHGTSRQNKLGHLEIGGVDALYLAEHYGTPLYVYDVALIRERAKSFKQAFIDADLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAVAAGFPADRIHFHGNNKSEEELKMALDHQIGCIVVDNFYEISLLAELCRKSGRTMDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQIEKAIEQVLQSDHIRLLGVHCHIGSQIFDTAGFVLAAEKIFAKLNEWRESFGFVS
EVLNLGGGFGIRYTEEDEPLHPAVYVEKIIEAVKENAALHAFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGTRKYAA
VDGGMSDNIRPALYQAKYEAVSANRIGEHHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAHLVIRRETYEDIVKLDLPFKTGVKQ

Sequences:

>Translated_439_residues
MFLHGTSRQNKLGHLEIGGVDALYLAEHYGTPLYVYDVALIRERAKSFKQAFIDADLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAVAAGFPADRIHFHGNNKSEEELKMALDHQIGCIVVDNFYEISLLAELCRKSGRTMDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQIEKAIEQVLQSDHIRLLGVHCHIGSQIFDTAGFVLAAEKIFAKLNEWRESFGFVS
EVLNLGGGFGIRYTEEDEPLHPAVYVEKIIEAVKENAALHAFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGTRKYAA
VDGGMSDNIRPALYQAKYEAVSANRIGEHHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAHLVIRRETYEDIVKLDLPFKTGVKQ
>Mature_439_residues
MFLHGTSRQNKLGHLEIGGVDALYLAEHYGTPLYVYDVALIRERAKSFKQAFIDADLKAQVAYASKAFSSVAMIQLAEQE
GLSLDVVSGGELFTAVAAGFPADRIHFHGNNKSEEELKMALDHQIGCIVVDNFYEISLLAELCRKSGRTMDVLLRITPGV
EAHTHDYITTGQEDSKFGFDLHNGQIEKAIEQVLQSDHIRLLGVHCHIGSQIFDTAGFVLAAEKIFAKLNEWRESFGFVS
EVLNLGGGFGIRYTEEDEPLHPAVYVEKIIEAVKENAALHAFDIPEIWIEPGRSLVGDAGTTLYTIGSQKEVPGTRKYAA
VDGGMSDNIRPALYQAKYEAVSANRIGEHHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNR
IPRPAVVFVEDGEAHLVIRRETYEDIVKLDLPFKTGVKQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=32.541567695962, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17562780, Length=380, Percent_Identity=23.9473684210526, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48485; Mature: 48485

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLHGTSRQNKLGHLEIGGVDALYLAEHYGTPLYVYDVALIRERAKSFKQAFIDADLKAQ
CCCCCCCCCCCCCEEEECCCCEEEEHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
VAYASKAFSSVAMIQLAEQEGLSLDVVSGGELFTAVAAGFPADRIHFHGNNKSEEELKMA
HHHHHHHHHHHHHEEEHHHCCCEEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
LDHQIGCIVVDNFYEISLLAELCRKSGRTMDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCCE
LHNGQIEKAIEQVLQSDHIRLLGVHCHIGSQIFDTAGFVLAAEKIFAKLNEWRESFGFVS
ECCCHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVLNLGGGFGIRYTEEDEPLHPAVYVEKIIEAVKENAALHAFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCHHCCCCC
TTLYTIGSQKEVPGTRKYAAVDGGMSDNIRPALYQAKYEAVSANRIGEHHDKTVSIAGKC
CEEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHC
CESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNRIPRPAVVFVEDGEAHLVIRR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEE
ETYEDIVKLDLPFKTGVKQ
CCHHHHHEECCCHHCCCCC
>Mature Secondary Structure
MFLHGTSRQNKLGHLEIGGVDALYLAEHYGTPLYVYDVALIRERAKSFKQAFIDADLKAQ
CCCCCCCCCCCCCEEEECCCCEEEEHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
VAYASKAFSSVAMIQLAEQEGLSLDVVSGGELFTAVAAGFPADRIHFHGNNKSEEELKMA
HHHHHHHHHHHHHEEEHHHCCCEEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
LDHQIGCIVVDNFYEISLLAELCRKSGRTMDVLLRITPGVEAHTHDYITTGQEDSKFGFD
HCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCCE
LHNGQIEKAIEQVLQSDHIRLLGVHCHIGSQIFDTAGFVLAAEKIFAKLNEWRESFGFVS
ECCCHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVLNLGGGFGIRYTEEDEPLHPAVYVEKIIEAVKENAALHAFDIPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCHHCCCCC
TTLYTIGSQKEVPGTRKYAAVDGGMSDNIRPALYQAKYEAVSANRIGEHHDKTVSIAGKC
CEEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHC
CESGDMLIWDIDLPEVKEGDLLAVFCTGAYGYSMANNYNRIPRPAVVFVEDGEAHLVIRR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEE
ETYEDIVKLDLPFKTGVKQ
CCHHHHHEECCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]