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The map label for this gene is ndk [H]

Identifier: 154686521

GI number: 154686521

Start: 2187817

End: 2188263

Strand: Reverse

Name: ndk [H]

Synonym: RBAM_020890

Alternate gene names: 154686521

Gene position: 2188263-2187817 (Counterclockwise)

Preceding gene: 154686522

Following gene: 154686520

Centisome position: 55.84

GC content: 45.19

Gene sequence:

>447_bases
ATGGAAAAAACTTTTATCATGGTAAAACCGGACGGCGTACAGCGCCAGCTGATCGGAGAGATTTTATCCAGATTTGAGCG
TAAGGGCTTACAATTGGCAGGAGCCAAGCTAATGCAAGTTTCAGAACAGATGGCTGAAACCCATTATGCTGAACATAAAG
GGAAGCCGTTTTTCGGCGAGCTTGTGGAATTCATTACATCAGGACCCGTATTTGCAATGGTATGGGAAGGGGAAAATGTA
GTAGAGATCACAAGACAGCTGATCGGAAAAACGAACCCGAAAGATGCACTGCCGGGCACAATCCGCGGTGACTACGGCAT
GTTTGTCGGCAAAAATATCATTCACGGTTCAGACTCCTTAGAAAGCGCTGAGCGGGAAATTCACATTTTCTTTAAACAGG
AAGAGCTTGTACCGTATCAAAAATTAATGGCCGACTGGGTGTACTAA

Upstream 100 bases:

>100_bases
GTGAACATTCTCCGCCCTGGATTGATTAATTGTCAGAAAGATGTTACGATTTCGGTGTGCAACTTGAAAGCCTATACATA
ATGATGGGGTGGAGAATCTT

Downstream 100 bases:

>100_bases
GCCGTCAGCCTTTCTTTTTCTCGTATTATGAAAAGGTTTACATCATTTATGAAAGACAGAGGCTGCGCTGCCCTGTCTTT
TCGTTTCTCACAAATCAGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFIMVKPDGVQRQLIGEILSRFERKGLQLAGAKLMQVSEQMAETHYAEHKGKPFFGELVEFITSGPVFAMVWEGENV
VEITRQLIGKTNPKDALPGTIRGDYGMFVGKNIIHGSDSLESAEREIHIFFKQEELVPYQKLMADWVY

Sequences:

>Translated_148_residues
MEKTFIMVKPDGVQRQLIGEILSRFERKGLQLAGAKLMQVSEQMAETHYAEHKGKPFFGELVEFITSGPVFAMVWEGENV
VEITRQLIGKTNPKDALPGTIRGDYGMFVGKNIIHGSDSLESAEREIHIFFKQEELVPYQKLMADWVY
>Mature_148_residues
MEKTFIMVKPDGVQRQLIGEILSRFERKGLQLAGAKLMQVSEQMAETHYAEHKGKPFFGELVEFITSGPVFAMVWEGENV
VEITRQLIGKTNPKDALPGTIRGDYGMFVGKNIIHGSDSLESAEREIHIFFKQEELVPYQKLMADWVY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=57.1428571428571, Blast_Score=189, Evalue=8e-49,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=57.4324324324324, Blast_Score=186, Evalue=6e-48,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=57.4324324324324, Blast_Score=186, Evalue=6e-48,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=56.7567567567568, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=56.7567567567568, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=56.7567567567568, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=56.7567567567568, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=56.7567567567568, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=49.2753623188406, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=34.5588235294118, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=30.8823529411765, Blast_Score=76, Evalue=9e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=28.9855072463768, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=48.2269503546099, Blast_Score=149, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=50.6756756756757, Blast_Score=162, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=31.0606060606061, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=55.7823129251701, Blast_Score=187, Evalue=8e-49,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=55.7823129251701, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16850; Mature: 16850

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFIMVKPDGVQRQLIGEILSRFERKGLQLAGAKLMQVSEQMAETHYAEHKGKPFFGE
CCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LVEFITSGPVFAMVWEGENVVEITRQLIGKTNPKDALPGTIRGDYGMFVGKNIIHGSDSL
HHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCEEECCCCHH
ESAEREIHIFFKQEELVPYQKLMADWVY
HHHCCEEEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure
MEKTFIMVKPDGVQRQLIGEILSRFERKGLQLAGAKLMQVSEQMAETHYAEHKGKPFFGE
CCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LVEFITSGPVFAMVWEGENVVEITRQLIGKTNPKDALPGTIRGDYGMFVGKNIIHGSDSL
HHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCEEECCCCHH
ESAEREIHIFFKQEELVPYQKLMADWVY
HHHCCEEEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]