Click here to switch to the map view.

The map label for this gene is pbuX [H]

Identifier: 154686457

GI number: 154686457

Start: 2128092

End: 2129396

Strand: Reverse

Name: pbuX [H]

Synonym: RBAM_020250

Alternate gene names: 154686457

Gene position: 2129396-2128092 (Counterclockwise)

Preceding gene: 154686458

Following gene: 154686456

Centisome position: 54.34

GC content: 49.04

Gene sequence:

>1305_bases
ATGAAAAACGGCTATGCCAAAACACTTTCCCTCGGTATCCAGCACGTGCTTGCCATGTATGCCGGCGCCGTCGTCGTTCC
CTTAATTGTAGGAGCGGCATTGGGACTGAACGCAGAACAGCTGACATATCTCGTATCAATTGACATTTTTATGTGCGGGG
CGGCTACGCTGCTTCAAGTATGGAGGAATAAATGTTTCGGCATCGGCTTGCCCGTTGTGCTCGGCTGTACGTTCACCGCG
GTAGCGCCGATTATTTCCATCGGTAAGGAGTACGGGATTTCAGCCATTTACGGAAGCATTTTGGCATCGGGTCTGCTTGT
CATTCTGCTGTCGTTTTTCTTCGGCAAGCTCGTATCCTTTTTCCCGCCTGTCGTAACCGGATCTGTCGTGACGATTATCG
GGATGACCTTAATGCCGGTCGCGATGAATCATATTGCCGGCGGGGAAGGCAGCAAGGATTTCGGTGATCCGGCTAACCTT
GCCCTCGGATTTACGGTGCTCGTCATCATCGTGCTGCTTTATCGGTTTACAAAAGGATTTTTGAAATCCATTTCGATTTT
AATCGGCATTGTCATCGGGACGGCCATCGCATATTTTATGGGAAAAGTGCAATTTGACAATGTGGCGAATGCTGACGCAA
TTCAAATGATTAAACCGTTTTACTTCGGGACGCCGACATTTCATGCGGCACCGATTATTACGATGTCCATCGTTGCCATT
GTCAGCCTTGTTGAGTCAACCGGCGTCTATTTCGCTCTCGGTGACCTGACAAACCGGCGCCTGTCTGAACGTGATTTAGC
AAAAGGCTACCGCGCGGAAGGCCTGGCGGTATTCATCAGCGGCATTTTTAATGCTTTTCCGTACACGGCTTATTCCCAAA
ACGTCGGCCTCGTGCAGCTGACAGGAATTAAGAAAAACGCGGTTATCGGTGTCACGGGCGCACTTTTAATGCTCTTCGGC
CTTTTTCCGAAAATCGCAGCCTTCACGACCATCATCCCGTCTTCCGTACTGGGAGGCGCGATGGTGGCCATGTTCGGCAT
GGTCATCTCCTACGGCATTAAAATGCTCAGTCAAATTGACTTTAAAAAGCAGGAAAACCTTCTGATTGTCGCGTGTTCGG
TCGGATTGGGACTCGGTGTAACCGTCGTTCCCGATATGTTTAAGCACCTGCCGTCTTACTTAAATCTGCTGACCACAAAC
GGAATCGTCGCCGGAAGCTTTACCGCCGTGCTTTTGAACATTATTTATAATATGATTCCTAAAACGAAAAAAACCCTTGA
TGTAACAAGGGTTCAAGAGGGTTAG

Upstream 100 bases:

>100_bases
GAAGAGATGAGCTGGTGAAAAAAGGATGCCGGGTCGAATCACTGGCGAGAATCCAATCGCTTGAAGACGGAAAAGTGACA
TTTGTACAGGAGGTCCGTTC

Downstream 100 bases:

>100_bases
TTATCCGTTTTCTTTAAAATAACATCTTATTTTATCCAGATCGAGGATGCTTCCGAAAGTTGCTGAACTTTTTGTGAGGC
ATCCTCTTTTTTTATTAGTT

Product: PbuX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKNGYAKTLSLGIQHVLAMYAGAVVVPLIVGAALGLNAEQLTYLVSIDIFMCGAATLLQVWRNKCFGIGLPVVLGCTFTA
VAPIISIGKEYGISAIYGSILASGLLVILLSFFFGKLVSFFPPVVTGSVVTIIGMTLMPVAMNHIAGGEGSKDFGDPANL
ALGFTVLVIIVLLYRFTKGFLKSISILIGIVIGTAIAYFMGKVQFDNVANADAIQMIKPFYFGTPTFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLSERDLAKGYRAEGLAVFISGIFNAFPYTAYSQNVGLVQLTGIKKNAVIGVTGALLMLFG
LFPKIAAFTTIIPSSVLGGAMVAMFGMVISYGIKMLSQIDFKKQENLLIVACSVGLGLGVTVVPDMFKHLPSYLNLLTTN
GIVAGSFTAVLLNIIYNMIPKTKKTLDVTRVQEG

Sequences:

>Translated_434_residues
MKNGYAKTLSLGIQHVLAMYAGAVVVPLIVGAALGLNAEQLTYLVSIDIFMCGAATLLQVWRNKCFGIGLPVVLGCTFTA
VAPIISIGKEYGISAIYGSILASGLLVILLSFFFGKLVSFFPPVVTGSVVTIIGMTLMPVAMNHIAGGEGSKDFGDPANL
ALGFTVLVIIVLLYRFTKGFLKSISILIGIVIGTAIAYFMGKVQFDNVANADAIQMIKPFYFGTPTFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLSERDLAKGYRAEGLAVFISGIFNAFPYTAYSQNVGLVQLTGIKKNAVIGVTGALLMLFG
LFPKIAAFTTIIPSSVLGGAMVAMFGMVISYGIKMLSQIDFKKQENLLIVACSVGLGLGVTVVPDMFKHLPSYLNLLTTN
GIVAGSFTAVLLNIIYNMIPKTKKTLDVTRVQEG
>Mature_434_residues
MKNGYAKTLSLGIQHVLAMYAGAVVVPLIVGAALGLNAEQLTYLVSIDIFMCGAATLLQVWRNKCFGIGLPVVLGCTFTA
VAPIISIGKEYGISAIYGSILASGLLVILLSFFFGKLVSFFPPVVTGSVVTIIGMTLMPVAMNHIAGGEGSKDFGDPANL
ALGFTVLVIIVLLYRFTKGFLKSISILIGIVIGTAIAYFMGKVQFDNVANADAIQMIKPFYFGTPTFHAAPIITMSIVAI
VSLVESTGVYFALGDLTNRRLSERDLAKGYRAEGLAVFISGIFNAFPYTAYSQNVGLVQLTGIKKNAVIGVTGALLMLFG
LFPKIAAFTTIIPSSVLGGAMVAMFGMVISYGIKMLSQIDFKKQENLLIVACSVGLGLGVTVVPDMFKHLPSYLNLLTTN
GIVAGSFTAVLLNIIYNMIPKTKKTLDVTRVQEG

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=506, Percent_Identity=24.901185770751, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI40316845, Length=506, Percent_Identity=24.901185770751, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI44680145, Length=483, Percent_Identity=24.0165631469979, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI44680143, Length=488, Percent_Identity=23.5655737704918, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082181, Length=420, Percent_Identity=41.6666666666667, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1790087, Length=435, Percent_Identity=31.4942528735632, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87082178, Length=428, Percent_Identity=34.1121495327103, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788843, Length=375, Percent_Identity=29.0666666666667, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081818, Length=444, Percent_Identity=27.2522522522523, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17542260, Length=186, Percent_Identity=25.2688172043011, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=186, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=452, Percent_Identity=21.4601769911504, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=426, Percent_Identity=22.3004694835681, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356175, Length=425, Percent_Identity=24.2352941176471, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46051; Mature: 46051

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHCCCCC
>Mature Secondary Structure
MKNGYAKTLSLGIQHVLAMYAGAVVVPLIVGAALGLNAEQLTYLVSIDIFMCGAATLLQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WRNKCFGIGLPVVLGCTFTAVAPIISIGKEYGISAIYGSILASGLLVILLSFFFGKLVSF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPPVVTGSVVTIIGMTLMPVAMNHIAGGEGSKDFGDPANLALGFTVLVIIVLLYRFTKGF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKSISILIGIVIGTAIAYFMGKVQFDNVANADAIQMIKPFYFGTPTFHAAPIITMSIVAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VSLVESTGVYFALGDLTNRRLSERDLAKGYRAEGLAVFISGIFNAFPYTAYSQNVGLVQL
HHHHHHCCCEEEECCHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCEEEE
TGIKKNAVIGVTGALLMLFGLFPKIAAFTTIIPSSVLGGAMVAMFGMVISYGIKMLSQID
ECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FKKQENLLIVACSVGLGLGVTVVPDMFKHLPSYLNLLTTNGIVAGSFTAVLLNIIYNMIP
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCC
KTKKTLDVTRVQEG
CCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]