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The map label for this gene is ilvD

Identifier: 154686433

GI number: 154686433

Start: 2106526

End: 2108202

Strand: Reverse

Name: ilvD

Synonym: RBAM_020010

Alternate gene names: 154686433

Gene position: 2108202-2106526 (Counterclockwise)

Preceding gene: 154686434

Following gene: 154686432

Centisome position: 53.8

GC content: 52.3

Gene sequence:

>1677_bases
ATGGCAGAATTACGCAGCAACATGATCACACAGGGAATTGACAGAGCGCCGCACCGCAGCCTTCTTCGCGCTGCCGGCGT
AAAAGAAGAAGACTTCGGCAAGCCGTTTATCGCGGTCTGTAATTCATACATCGATATCGTTCCCGGGCATGTTCACCTGC
AGGAATTTGGAAAAATCGTAAAAGAAGCAATCAGGGAAGCGGGCGGTGTGCCTTTTGAATTTAACACGATCGGAGTAGAT
GACGGAATCGCGATGGGGCATATCGGCATGAGATATTCGCTGCCGAGCCGCGAAATCATTGCCGATTCAGTTGAAACGGT
CGTCTCGGCGCACTGGTTTGACGGAATGGTCTGCATTCCGAACTGCGACAAAATTACGCCGGGAATGCTGATGGCGGCTA
TGCGGATTAATATTCCGACCATTTTTGTCAGCGGGGGGCCGATGGCAGCCGGCCGTACAAGCGACGGCCGCAAAATTTCG
CTTTCTTCAGTATTTGAAGGCGTCGGCGCATATCAAGCCGGGAAAATCGGTGAAAGCGACCTGCAGGAGCTGGAACAGTT
CGGCTGCCCGACGTGCGGATCTTGTTCGGGCATGTTTACGGCAAACTCCATGAACTGTCTGTCTGAAGCGCTCGGTCTGG
CGCTTCCGGGCAACGGAACAATTCTTGCAACTTCACCGGAAAGAAGAGAGTTTGTGAGAAAATCAGCGGCCCAATTGATG
GAGACCATCAAAAAAGACATTAAGCCGCGCGATATCGTCACCGAAAAAGCGATTGACAACGCATTTGCGTTAGACATGGC
TCTCGGCGGCTCAACCAACACAGTGCTACATACGCTTGCGCTTGCCAATGAAGCTGGGGTTGAGTACTCTTTAGAACGCA
TTAACGAAGTGGCTGAACGAGTGCCTCACTTATCGAAATTGGCGCCGGCCTCGGACGTCTTCATTGAAGATCTGCACGAA
GCGGGCGGAGTCTCGGCGGCCCTTAATGAATTAGCGAAAAAAGAAGGGGCGCTTCATCTTGACGCGCTGACTGTAACAGG
CCGCACACTCGGAGAAACAATTGCGGGTCATGAAGTAAAGGATTATGACGTGATTCATCCGCTTGACAATCCGTTTACCG
AAAAAGGCGGTTTGGCCGTCCTGTTTGGGAATCTGGCTCCGGACGGCGCCATTATCAAAACAGGCGGCGTGCAGGACGGG
ATTACAAGACATGAAGGTCCCGCTGTCGTCTTTGATTCCCAGGATGCCGCGCTTGAAGGCATTATAAACCGCAAAGTAAA
AGAAGGAGATGTTGTCATTATCCGTTATGAAGGGCCAAAGGGCGGCCCGGGCATGCCGGAGATGCTCGCTCCGACGTCTC
AGATTGTCGGAATGGGGCTTGGCCCGAAAGTGGCGCTTATTACAGACGGCCGTTTTTCAGGAGCGTCCCGGGGCCTTTCA
ATCGGGCACGTATCGCCTGAAGCGGCTGAAGGCGGCCCGCTCGCATTCGTAGAAAACGGCGACCATGTCATCGTTGACAT
AGAAAAACGGATTTTGGACGTACAAGTGCCTGAAGAAGAATGGGAAAAACGCAAGGCCGAATGGAAAGGCTTCGAGCCGA
AAGTAAAAACAGGATATCTAGCCCGGTATTCCAAACTCGTAACAAGCGCCAATACGGGCGGAATCATGAAAATATAA

Upstream 100 bases:

>100_bases
GAGACAGGGCAAAGACACTGTAAAATTTGCAGAACACGCCCTAGAATAAACTGAAAATTTTAAAAATAGTGCACAGTCTA
AAAACAGTAGGGGGATCACC

Downstream 100 bases:

>100_bases
AACAGAGGCCTGAACAATTGAATTCCGGCCCCCTCTATAGTATCCTTGACTTCATATAAGGATTTTAGAGGGGGCTTTTT
TATGTCAATGGCTTATGAAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVD
DGIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS
LSSVFEGVGAYQAGKIGESDLQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERREFVRKSAAQLM
ETIKKDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAERVPHLSKLAPASDVFIEDLHE
AGGVSAALNELAKKEGALHLDALTVTGRTLGETIAGHEVKDYDVIHPLDNPFTEKGGLAVLFGNLAPDGAIIKTGGVQDG
ITRHEGPAVVFDSQDAALEGIINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLS
IGHVSPEAAEGGPLAFVENGDHVIVDIEKRILDVQVPEEEWEKRKAEWKGFEPKVKTGYLARYSKLVTSANTGGIMKI

Sequences:

>Translated_558_residues
MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVD
DGIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS
LSSVFEGVGAYQAGKIGESDLQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERREFVRKSAAQLM
ETIKKDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAERVPHLSKLAPASDVFIEDLHE
AGGVSAALNELAKKEGALHLDALTVTGRTLGETIAGHEVKDYDVIHPLDNPFTEKGGLAVLFGNLAPDGAIIKTGGVQDG
ITRHEGPAVVFDSQDAALEGIINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLS
IGHVSPEAAEGGPLAFVENGDHVIVDIEKRILDVQVPEEEWEKRKAEWKGFEPKVKTGYLARYSKLVTSANTGGIMKI
>Mature_557_residues
AELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDD
GIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKISL
SSVFEGVGAYQAGKIGESDLQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERREFVRKSAAQLME
TIKKDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAERVPHLSKLAPASDVFIEDLHEA
GGVSAALNELAKKEGALHLDALTVTGRTLGETIAGHEVKDYDVIHPLDNPFTEKGGLAVLFGNLAPDGAIIKTGGVQDGI
TRHEGPAVVFDSQDAALEGIINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLSI
GHVSPEAAEGGPLAFVENGDHVIVDIEKRILDVQVPEEEWEKRKAEWKGFEPKVKTGYLARYSKLVTSANTGGIMKI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=47.7832512315271, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1788157, Length=544, Percent_Identity=32.9044117647059, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI2367371, Length=518, Percent_Identity=33.011583011583, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786464, Length=503, Percent_Identity=32.6043737574553, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=39.6428571428571, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BACA2 (A7Z5T7)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421594.1
- STRING:   A7Z5T7
- EnsemblBacteria:   EBBACT00000007643
- GeneID:   5459548
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020010
- eggNOG:   COG0129
- GeneTree:   EBGT00050000001430
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK00911
- BioCyc:   BAMY326423:RBAM_020010-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59405; Mature: 59274

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIV
CCHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
KEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIP
HHHHHHHCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECC
NCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKISLSSVFEGVGAYQAGKIGESD
CCCCCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCCCHHH
LQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERREFVRKSAAQLM
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHH
ETIKKDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAER
HHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VPHLSKLAPASDVFIEDLHEAGGVSAALNELAKKEGALHLDALTVTGRTLGETIAGHEVK
CCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCCCC
DYDVIHPLDNPFTEKGGLAVLFGNLAPDGAIIKTGGVQDGITRHEGPAVVFDSQDAALEG
CCCEECCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEECCCHHHHHH
IINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLS
HHHCCCCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCE
IGHVSPEAAEGGPLAFVENGDHVIVDIEKRILDVQVPEEEWEKRKAEWKGFEPKVKTGYL
ECCCCCCCCCCCCEEEEECCCEEEEEEECCEEEEECCHHHHHHHHHHCCCCCCCCCHHHH
ARYSKLVTSANTGGIMKI
HHHHHHHHCCCCCCEEEC
>Mature Secondary Structure 
AELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIV
CHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
KEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIP
HHHHHHHCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECC
NCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKISLSSVFEGVGAYQAGKIGESD
CCCCCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCCCHHH
LQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERREFVRKSAAQLM
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHH
ETIKKDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAER
HHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VPHLSKLAPASDVFIEDLHEAGGVSAALNELAKKEGALHLDALTVTGRTLGETIAGHEVK
CCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCCCC
DYDVIHPLDNPFTEKGGLAVLFGNLAPDGAIIKTGGVQDGITRHEGPAVVFDSQDAALEG
CCCEECCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEECCCHHHHHH
IINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLS
HHHCCCCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCE
IGHVSPEAAEGGPLAFVENGDHVIVDIEKRILDVQVPEEEWEKRKAEWKGFEPKVKTGYL
ECCCCCCCCCCCCEEEEECCCEEEEEEECCEEEEECCHHHHHHHHHHCCCCCCCCCHHHH
ARYSKLVTSANTGGIMKI
HHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA