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The map label for this gene is proH [H]

Identifier: 154686297

GI number: 154686297

Start: 1990178

End: 1991059

Strand: Reverse

Name: proH [H]

Synonym: RBAM_018650

Alternate gene names: 154686297

Gene position: 1991059-1990178 (Counterclockwise)

Preceding gene: 154686298

Following gene: 154686296

Centisome position: 50.81

GC content: 47.05

Gene sequence:

>882_bases
GTGAAAAATACGAACAAAATACGAACAAGGGAGATGTTACCGATCTTAGATCAAAAGAAAGTTGCTTTTATCGGAGCAGG
ATCAATGGCTGAAGGAATGATATCAGGCATGGTCCGCGCAAAAAAAATTCCCAACCAAAACATCTGCGTGACAAACCGCC
GCAATACAGAGCGACTCGCTGAATTGGAACATCAATACGGTATTCAGGGCATTGCTTTTGACAGCATGAAAACCGAAGAC
ATTGATGTCTTTATTTTAGCCATGAAACCGAAGGATGCTGAAATCGCTCTGGCTGCGCTGAAACGGCGTATTCAACCTCA
TCAAATCATCCTGTCTGTTCTGGCAGGCATAACAACCTCATTTATACAACAATCATTACATGATAATCAGCCGGTTGTAA
GAGTGATGCCGAACACATCCAGCATGATCGGCGAATCGGCAACAGCTGCGGCTTTCGGAGACCATGTCTCTTACGGTTCA
GCAAAAACCGCGGTATCCCTTTTGGAATGCCTCGGGGAAGTGTACGTGATCAAGGAAGATCAGATGGACATTTTCACCGG
CATCGCAGGCAGCGGACCGGCGTACTTTTATTATTTAATGGAGTTTATTGAAAAAGCAGGTGAAGAAGCCGGCTTAGACA
AACGGCTGTCCCGCAAAATCGGTGCGCAAACGTTATTGGGCGCCGCTAAAATGCTGATGGAAACGGGTGAAAAACCGGAT
GTGCTTCGGGAAAACATCACCTCTCCAAACGGCACGACGGAAGCCGGCCTCGATGCGCTCAGGTCAGAAGGCGGCGGAGA
AGCCATTGCCAAAGCCATTAAACACGCGACCGAACGTTCTATTGAGATCAGCAAAACAATTGAAAAAACGGCAGCACTAT
AA

Upstream 100 bases:

>100_bases
TTCTGTGATTCATTATACATAATAGCAGGCTCGGAACAATACATATCAATAAAACCTTCAAACTTGACATCGACTCTTGA
AGTGGTAACATAAAAAACGT

Downstream 100 bases:

>100_bases
TCGTTAAAAAACAGGAGTGATACAGTGACGTCTCGGACGAAGATCAAAAGAGTCGCCGTGAAAATCGGCAGCAGCTCACT
GACGAGCCTGCACGGGGAAA

Product: ProH

Products: NA

Alternate protein names: P5C reductase 1; P5CR 1 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKNTNKIRTREMLPILDQKKVAFIGAGSMAEGMISGMVRAKKIPNQNICVTNRRNTERLAELEHQYGIQGIAFDSMKTED
IDVFILAMKPKDAEIALAALKRRIQPHQIILSVLAGITTSFIQQSLHDNQPVVRVMPNTSSMIGESATAAAFGDHVSYGS
AKTAVSLLECLGEVYVIKEDQMDIFTGIAGSGPAYFYYLMEFIEKAGEEAGLDKRLSRKIGAQTLLGAAKMLMETGEKPD
VLRENITSPNGTTEAGLDALRSEGGGEAIAKAIKHATERSIEISKTIEKTAAL

Sequences:

>Translated_293_residues
MKNTNKIRTREMLPILDQKKVAFIGAGSMAEGMISGMVRAKKIPNQNICVTNRRNTERLAELEHQYGIQGIAFDSMKTED
IDVFILAMKPKDAEIALAALKRRIQPHQIILSVLAGITTSFIQQSLHDNQPVVRVMPNTSSMIGESATAAAFGDHVSYGS
AKTAVSLLECLGEVYVIKEDQMDIFTGIAGSGPAYFYYLMEFIEKAGEEAGLDKRLSRKIGAQTLLGAAKMLMETGEKPD
VLRENITSPNGTTEAGLDALRSEGGGEAIAKAIKHATERSIEISKTIEKTAAL
>Mature_293_residues
MKNTNKIRTREMLPILDQKKVAFIGAGSMAEGMISGMVRAKKIPNQNICVTNRRNTERLAELEHQYGIQGIAFDSMKTED
IDVFILAMKPKDAEIALAALKRRIQPHQIILSVLAGITTSFIQQSLHDNQPVVRVMPNTSSMIGESATAAAFGDHVSYGS
AKTAVSLLECLGEVYVIKEDQMDIFTGIAGSGPAYFYYLMEFIEKAGEEAGLDKRLSRKIGAQTLLGAAKMLMETGEKPD
VLRENITSPNGTTEAGLDALRSEGGGEAIAKAIKHATERSIEISKTIEKTAAL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=283, Percent_Identity=33.2155477031802, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=31.203007518797, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=31.203007518797, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=30.8270676691729, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=27.1375464684015, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=32.9501915708812, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=26.7605633802817, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=274, Percent_Identity=26.2773722627737, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=28.996282527881, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=30.6049822064057, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=33.1360946745562, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 31818; Mature: 31818

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTNKIRTREMLPILDQKKVAFIGAGSMAEGMISGMVRAKKIPNQNICVTNRRNTERLA
CCCCCCCHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
ELEHQYGIQGIAFDSMKTEDIDVFILAMKPKDAEIALAALKRRIQPHQIILSVLAGITTS
HHHHHHCCCEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FIQQSLHDNQPVVRVMPNTSSMIGESATAAAFGDHVSYGSAKTAVSLLECLGEVYVIKED
HHHHHHCCCCCEEEECCCCHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEECC
QMDIFTGIAGSGPAYFYYLMEFIEKAGEEAGLDKRLSRKIGAQTLLGAAKMLMETGEKPD
CHHHHHCCCCCCHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLRENITSPNGTTEAGLDALRSEGGGEAIAKAIKHATERSIEISKTIEKTAAL
HHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKNTNKIRTREMLPILDQKKVAFIGAGSMAEGMISGMVRAKKIPNQNICVTNRRNTERLA
CCCCCCCHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
ELEHQYGIQGIAFDSMKTEDIDVFILAMKPKDAEIALAALKRRIQPHQIILSVLAGITTS
HHHHHHCCCEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FIQQSLHDNQPVVRVMPNTSSMIGESATAAAFGDHVSYGSAKTAVSLLECLGEVYVIKED
HHHHHHCCCCCEEEECCCCHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEECC
QMDIFTGIAGSGPAYFYYLMEFIEKAGEEAGLDKRLSRKIGAQTLLGAAKMLMETGEKPD
CHHHHHCCCCCCHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLRENITSPNGTTEAGLDALRSEGGGEAIAKAIKHATERSIEISKTIEKTAAL
HHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1849493; 2493444 [H]