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The map label for this gene is yngE [H]

Identifier: 154686266

GI number: 154686266

Start: 1921412

End: 1922941

Strand: Reverse

Name: yngE [H]

Synonym: RBAM_018330

Alternate gene names: 154686266

Gene position: 1922941-1921412 (Counterclockwise)

Preceding gene: 154686267

Following gene: 154686262

Centisome position: 49.07

GC content: 50.2

Gene sequence:

>1530_bases
ATGGATTACGAAAAAGAACGGCAGACACGCAGCAAAACGATTGAAAAGGGAGGAGCCGCGAAATATCACGCAAGCAACGA
AAAGAAGGGAAAACTTTTTGTAAGAGACAGGCTGAAGCTTTTATTCGATGACGGCATATCCGTTGAAGACGCTTTTTTCG
CCGAGTGCATGTCAGACGGACTTCCGGCTGACGGGGTCGTTACCGGAATCGGAACCATCGGCGGCAGAACCGTTTGTGTG
ATGGCAAACGACTCAACCGTAAAGGCGGGCTCGTGGGGCGCGAAAACGGTGGAAAAAATCATCCGCATTCAGGAGACGGC
GGAAAAGCTTCAGTGTCCGCTCTTGTACTTAGTCGATTCCGCAGGTGCGAGAATTACGGATCAGGTCGACATGTTCCCGG
GCAGAAGGGGAGCCGGCCGCATCTTTTATAATCAAGTAAAGCTATCGGGCCGCATTCCGCAAATCTGTTTATTGTTCGGC
CCTTCCGCTGCGGGCGGCGCTTACATTCCGGCCTTTTGCGACATTGTCATTATGGTCGAAGGCAACGCATCCATGTACTT
AGGTTCCCCGCGTATGGCAGAAATGGTGATTGGCGAGAAAGTATCGCTTGAAGAAATGGGCGGCGCCCGTATGCATTGTT
CCGTATCAGGCTGCGGTGATCTCCTCGCCCCGACGGAACAGGAGGCAATCATGATGGCGCAGACATACCTCAGCTATTTT
CCGTCAAATTATACTGAAAAAGCGCCCGTCAACAAATCTAAGAACCCGAAAGCTTTTGAAAAACCGCTCTCAGATGTCAT
CCCGGCACATCAAAACGCACCGTTCAACATGATGGATTTAATTGAACGTGTCATTGATGAAGACTCATTTTTTGAGATTA
AACCGTTATTTGCGCAGGAATTAATAACGGGGCTTGCGCGGATTCACGGACAGCCGGTCGGCATTATCGCCAATCAGCCG
CGTGTCAAAGGCGGGGTTTTATTTCTCGATTCGGCGGATAAAGCCGCAAAATTTATCGCTTTGTGCGACGCATTCCATAT
TCCGCTTCTGTTTTTAGCAGACATTCCCGGATTCATGATCGGAACGAAGGTTGAGCAGGCGGGCATCATCAGGCATGGCG
CAAAAATGATCTCCGCAATGGCGGAAGCGACTGTTCCGAAGCTTTCCGTTATCGTCAGAAAAGCCTACGGTGCCGGATTA
TACGCGATGGCGGGGCCTGCTTTTGAACCGGACTGCTGTTTAGCGCTTCCGACTGCGCAAATTGCCGTAATGGGTCCTGA
AGCAGCGGTGAATGCGGTCTACGCAAACAAAATCAGCGAGCTAGCCCCTGAAGAAAGGCCGGCTTTTATTCAAGAAAAGC
GTGATGAATATAAGGAAGACATTAACCTTTACCGGCTTGCCTCTGAAATGGTGATTGACGGCATTGTTCCTGCTGATTCC
TTGCGGGAAGAACTCAATAAACGCCTCACTGCTTACATGTCCAAACAACTGACATTCACACACCGGAAACACCCCGTATA
CCCGGTATAA

Upstream 100 bases:

>100_bases
AACAAGTCATTCCCACACTTGACAGAGAAGAGGGCCTGCGCGCTTTTAAAGAAAAAAGACCCCCTGAATACAAAGGAAAA
TAAAACATGGAGGGACTCGG

Downstream 100 bases:

>100_bases
ATAAAAAAAAGACTGCATAGATCCGGCTCGCAGCCGTTCTTATGCAGTCTTTTTTCACAGTCTTGATCTCATTTTCTTCA
CAACGAAATAAACAACAATA

Product: YngE

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDYEKERQTRSKTIEKGGAAKYHASNEKKGKLFVRDRLKLLFDDGISVEDAFFAECMSDGLPADGVVTGIGTIGGRTVCV
MANDSTVKAGSWGAKTVEKIIRIQETAEKLQCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYNQVKLSGRIPQICLLFG
PSAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDLLAPTEQEAIMMAQTYLSYF
PSNYTEKAPVNKSKNPKAFEKPLSDVIPAHQNAPFNMMDLIERVIDEDSFFEIKPLFAQELITGLARIHGQPVGIIANQP
RVKGGVLFLDSADKAAKFIALCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMAEATVPKLSVIVRKAYGAGL
YAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYANKISELAPEERPAFIQEKRDEYKEDINLYRLASEMVIDGIVPADS
LREELNKRLTAYMSKQLTFTHRKHPVYPV

Sequences:

>Translated_509_residues
MDYEKERQTRSKTIEKGGAAKYHASNEKKGKLFVRDRLKLLFDDGISVEDAFFAECMSDGLPADGVVTGIGTIGGRTVCV
MANDSTVKAGSWGAKTVEKIIRIQETAEKLQCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYNQVKLSGRIPQICLLFG
PSAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDLLAPTEQEAIMMAQTYLSYF
PSNYTEKAPVNKSKNPKAFEKPLSDVIPAHQNAPFNMMDLIERVIDEDSFFEIKPLFAQELITGLARIHGQPVGIIANQP
RVKGGVLFLDSADKAAKFIALCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMAEATVPKLSVIVRKAYGAGL
YAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYANKISELAPEERPAFIQEKRDEYKEDINLYRLASEMVIDGIVPADS
LREELNKRLTAYMSKQLTFTHRKHPVYPV
>Mature_509_residues
MDYEKERQTRSKTIEKGGAAKYHASNEKKGKLFVRDRLKLLFDDGISVEDAFFAECMSDGLPADGVVTGIGTIGGRTVCV
MANDSTVKAGSWGAKTVEKIIRIQETAEKLQCPLLYLVDSAGARITDQVDMFPGRRGAGRIFYNQVKLSGRIPQICLLFG
PSAAGGAYIPAFCDIVIMVEGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDLLAPTEQEAIMMAQTYLSYF
PSNYTEKAPVNKSKNPKAFEKPLSDVIPAHQNAPFNMMDLIERVIDEDSFFEIKPLFAQELITGLARIHGQPVGIIANQP
RVKGGVLFLDSADKAAKFIALCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMAEATVPKLSVIVRKAYGAGL
YAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYANKISELAPEERPAFIQEKRDEYKEDINLYRLASEMVIDGIVPADS
LREELNKRLTAYMSKQLTFTHRKHPVYPV

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=513, Percent_Identity=36.8421052631579, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI295821216, Length=533, Percent_Identity=35.6472795497186, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI11545863, Length=488, Percent_Identity=36.8852459016393, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI134142062, Length=342, Percent_Identity=24.8538011695906, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=515, Percent_Identity=36.3106796116505, Blast_Score=321, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=36.399217221135, Blast_Score=320, Evalue=8e-88,
Organism=Caenorhabditis elegans, GI17552936, Length=432, Percent_Identity=37.7314814814815, Blast_Score=301, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI133931226, Length=311, Percent_Identity=24.1157556270096, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586065, Length=522, Percent_Identity=34.6743295019157, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 55522; Mature: 55522

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEKERQTRSKTIEKGGAAKYHASNEKKGKLFVRDRLKLLFDDGISVEDAFFAECMSDG
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHCC
LPADGVVTGIGTIGGRTVCVMANDSTVKAGSWGAKTVEKIIRIQETAEKLQCPLLYLVDS
CCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVDMFPGRRGAGRIFYNQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVIMVE
CCCCCCCHHHCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEE
GNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDLLAPTEQEAIMMAQTYLSYF
CCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PSNYTEKAPVNKSKNPKAFEKPLSDVIPAHQNAPFNMMDLIERVIDEDSFFEIKPLFAQE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECHHHHHH
LITGLARIHGQPVGIIANQPRVKGGVLFLDSADKAAKFIALCDAFHIPLLFLADIPGFMI
HHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHC
GTKVEQAGIIRHGAKMISAMAEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCLALPTAQ
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCE
IAVMGPEAAVNAVYANKISELAPEERPAFIQEKRDEYKEDINLYRLASEMVIDGIVPADS
EEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LREELNKRLTAYMSKQLTFTHRKHPVYPV
HHHHHHHHHHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure
MDYEKERQTRSKTIEKGGAAKYHASNEKKGKLFVRDRLKLLFDDGISVEDAFFAECMSDG
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHCC
LPADGVVTGIGTIGGRTVCVMANDSTVKAGSWGAKTVEKIIRIQETAEKLQCPLLYLVDS
CCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVDMFPGRRGAGRIFYNQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVIMVE
CCCCCCCHHHCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEE
GNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSVSGCGDLLAPTEQEAIMMAQTYLSYF
CCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PSNYTEKAPVNKSKNPKAFEKPLSDVIPAHQNAPFNMMDLIERVIDEDSFFEIKPLFAQE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECHHHHHH
LITGLARIHGQPVGIIANQPRVKGGVLFLDSADKAAKFIALCDAFHIPLLFLADIPGFMI
HHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHC
GTKVEQAGIIRHGAKMISAMAEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCLALPTAQ
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCE
IAVMGPEAAVNAVYANKISELAPEERPAFIQEKRDEYKEDINLYRLASEMVIDGIVPADS
EEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LREELNKRLTAYMSKQLTFTHRKHPVYPV
HHHHHHHHHHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]