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The map label for this gene is gsaB

Identifier: 154685334

GI number: 154685334

Start: 871990

End: 873279

Strand: Reverse

Name: gsaB

Synonym: RBAM_008800

Alternate gene names: 154685334

Gene position: 873279-871990 (Counterclockwise)

Preceding gene: 154685337

Following gene: 154685333

Centisome position: 22.29

GC content: 50.85

Gene sequence:

>1290_bases
TTGTATACAAAATCAGTTGAACTTCATAAGGAAGCGTTAGAGCATATCGTCGGAGGCGTGAACAGCCCGTCCAGATCCTA
TAAAGCGGTAGGCGGCGGTTCACCCGTTGCGATGGAAAAAGCGAACGGCGCTTATTTCTGGGATGTAGACGGGAATCAGT
ATATCGATTATTTAGCGGCTTACGGCCCGATTATTACCGGACATGCCCATCCGCATATTACTGAAGCGATTAAAACAGCG
GCTGAAAACGGCGTGCTGTACGGGACGCCGACCAAACATGAGGTCACTTTCGCCAAAATGCTGAAGGAGGCCATTCCTTC
ACTTGATAAAGTACGATTCGTAAACTCAGGCACTGAAGCGGTAATGACAACGATCCGGGTTGCACGCGCTTATACAGGCC
GGACAAAAATCATTAAATTCGCCGGCTGCTATCACGGCCATTCTGATCTCGTACTTGTCGCTGCGGGTTCCGGTCCGTCT
ACGCTCGGCACTCCTGATTCCGCCGGCGTGCCGAAAAGCATCGCCAATGAGGTGATTACCGTTCCTTTCAATGATATTGA
AAGCTACAAAGCCGCGCTGGATAAATGGGGTTCAGAAATTGCAGCGGTTCTCGTCGAGCCGATCGTCGGCAACTTCGGCA
TCGTTGAACCTGAAGAAGGATTTTTAGAACAGGTAAATGAATTGACCCATAAAGCGGGCGCGCTCGTCATTTATGATGAA
GTGATCACGGCGTTCCGTTTTATGTACGGAGGCGCGCAGGATCTTCTTCAAGTGAAGCCTGATTTAACGGCGCTCGGTAA
AATTATCGGGGGCGGCTTGCCGATCGGCGCTTACGGAGGCAAAAAAGAGATCATGGAGCAGGTTGCTCCGCTCGGCCCGG
CATATCAAGCCGGCACGATGGCCGGAAACCCGGCATCTATCCTATCAGGCATCGCCTGTCTGGAAGTGCTGAAGGAAGAA
GGCGTTTATGAGCGGCTTGATGAGCTCGGCGCCAGACTTGAGCAAGGCATTCTCGCCCATGCGGAGACACACGGCATTAC
CATCACCGTCAACCGTTTAAAAGGCGCGCTCACGGTTTACTTCACTGATGAAAAGATCGTCAATTACGAGCAGGCGGAAA
ATACGGACGGAGAAGCATTCGCCAAGTTCTTCAAGCTGATGCTTGAGCGCGGCATCAATCTCGCTCCATCGAAGTATGAA
GCTTGGTTTATCACAACCGCACATACTGAAGAGGATATCGACGCCACTTTACAAGCCGTTGAAGATGCGTTCAGACATAT
GAAAAAATAA

Upstream 100 bases:

>100_bases
GTTATCCCCCCGCTCTTTTCTGGAAGCATGAACCGTTGTGCTCGCAATGAAGCATGCTACAATAGAACATGATGTAAGGA
GATATTAGGAGGGTCATTTT

Downstream 100 bases:

>100_bases
CTGCTGAAACAAGCGGGAGCCCAGGGCTTCCGCTTTTTCTTTTTGTCCGATTTGTGAGATAATGGTTTTTTCAAAAAAAG
ACCTTGAATAATTGGTATGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MYTKSVELHKEALEHIVGGVNSPSRSYKAVGGGSPVAMEKANGAYFWDVDGNQYIDYLAAYGPIITGHAHPHITEAIKTA
AENGVLYGTPTKHEVTFAKMLKEAIPSLDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS
TLGTPDSAGVPKSIANEVITVPFNDIESYKAALDKWGSEIAAVLVEPIVGNFGIVEPEEGFLEQVNELTHKAGALVIYDE
VITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEE
GVYERLDELGARLEQGILAHAETHGITITVNRLKGALTVYFTDEKIVNYEQAENTDGEAFAKFFKLMLERGINLAPSKYE
AWFITTAHTEEDIDATLQAVEDAFRHMKK

Sequences:

>Translated_429_residues
MYTKSVELHKEALEHIVGGVNSPSRSYKAVGGGSPVAMEKANGAYFWDVDGNQYIDYLAAYGPIITGHAHPHITEAIKTA
AENGVLYGTPTKHEVTFAKMLKEAIPSLDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS
TLGTPDSAGVPKSIANEVITVPFNDIESYKAALDKWGSEIAAVLVEPIVGNFGIVEPEEGFLEQVNELTHKAGALVIYDE
VITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEE
GVYERLDELGARLEQGILAHAETHGITITVNRLKGALTVYFTDEKIVNYEQAENTDGEAFAKFFKLMLERGINLAPSKYE
AWFITTAHTEEDIDATLQAVEDAFRHMKK
>Mature_429_residues
MYTKSVELHKEALEHIVGGVNSPSRSYKAVGGGSPVAMEKANGAYFWDVDGNQYIDYLAAYGPIITGHAHPHITEAIKTA
AENGVLYGTPTKHEVTFAKMLKEAIPSLDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS
TLGTPDSAGVPKSIANEVITVPFNDIESYKAALDKWGSEIAAVLVEPIVGNFGIVEPEEGFLEQVNELTHKAGALVIYDE
VITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEE
GVYERLDELGARLEQGILAHAETHGITITVNRLKGALTVYFTDEKIVNYEQAENTDGEAFAKFFKLMLERGINLAPSKYE
AWFITTAHTEEDIDATLQAVEDAFRHMKK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=343, Percent_Identity=32.3615160349854, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI13994255, Length=370, Percent_Identity=27.2972972972973, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI24119277, Length=321, Percent_Identity=27.4143302180685, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI284507298, Length=261, Percent_Identity=31.8007662835249, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=49.2957746478873, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1789016, Length=337, Percent_Identity=29.673590504451, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI145693181, Length=375, Percent_Identity=30.6666666666667, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=29.6829971181556, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1789759, Length=303, Percent_Identity=32.013201320132, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788044, Length=321, Percent_Identity=31.7757009345794, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=23.7647058823529, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144271, Length=320, Percent_Identity=29.375, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=329, Percent_Identity=28.2674772036474, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=380, Percent_Identity=25.2631578947368, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=160, Percent_Identity=33.75, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=363, Percent_Identity=29.7520661157025, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=315, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357415, Length=352, Percent_Identity=30.1136363636364, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21356575, Length=326, Percent_Identity=27.3006134969325, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA1_BACA2 (A7Z2N8)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001420495.1
- ProteinModelPortal:   A7Z2N8
- SMR:   A7Z2N8
- STRING:   A7Z2N8
- EnsemblBacteria:   EBBACT00000006571
- GeneID:   5460386
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_008800
- eggNOG:   COG0001
- GeneTree:   EBGT00070000031737
- HOGENOM:   HBG725944
- OMA:   HSEADIL
- ProtClustDB:   PRK12389
- BioCyc:   BAMY326423:RBAM_008800-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46194; Mature: 46194

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTKSVELHKEALEHIVGGVNSPSRSYKAVGGGSPVAMEKANGAYFWDVDGNQYIDYLAA
CCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHH
YGPIITGHAHPHITEAIKTAAENGVLYGTPTKHEVTFAKMLKEAIPSLDKVRFVNSGTEA
HCCEEECCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCHHHEEEECCCHHH
VMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVIT
HHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCEEE
VPFNDIESYKAALDKWGSEIAAVLVEPIVGNFGIVEPEEGFLEQVNELTHKAGALVIYDE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHH
VITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTM
HHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
AGNPASILSGIACLEVLKEEGVYERLDELGARLEQGILAHAETHGITITVNRLKGALTVY
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEE
FTDEKIVNYEQAENTDGEAFAKFFKLMLERGINLAPSKYEAWFITTAHTEEDIDATLQAV
EECCHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
EDAFRHMKK
HHHHHHHCC
>Mature Secondary Structure
MYTKSVELHKEALEHIVGGVNSPSRSYKAVGGGSPVAMEKANGAYFWDVDGNQYIDYLAA
CCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHH
YGPIITGHAHPHITEAIKTAAENGVLYGTPTKHEVTFAKMLKEAIPSLDKVRFVNSGTEA
HCCEEECCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCHHHEEEECCCHHH
VMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVIT
HHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCEEE
VPFNDIESYKAALDKWGSEIAAVLVEPIVGNFGIVEPEEGFLEQVNELTHKAGALVIYDE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHH
VITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTM
HHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
AGNPASILSGIACLEVLKEEGVYERLDELGARLEQGILAHAETHGITITVNRLKGALTVY
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEE
FTDEKIVNYEQAENTDGEAFAKFFKLMLERGINLAPSKYEAWFITTAHTEEDIDATLQAV
EECCHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
EDAFRHMKK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA