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The map label for this gene is adhA [H]

Identifier: 154685036

GI number: 154685036

Start: 551123

End: 552172

Strand: Reverse

Name: adhA [H]

Synonym: RBAM_005740

Alternate gene names: 154685036

Gene position: 552172-551123 (Counterclockwise)

Preceding gene: 154685039

Following gene: 154685025

Centisome position: 14.09

GC content: 50.86

Gene sequence:

>1050_bases
ATGTGCAATAATCATCCGACTCGTGTATTAAGCGCTCCGCATGCAAAAGCTAAATTTGAGCGGACGACGATTGAGAGAAG
AGCATTACGGCCGCACGATATCCTGATTGATATTAAGTACAGCGGGATTTGTCACTCAGACATCCACAGTGCATTCGATG
AATGGGGCGGCGGAATCTTTCCGATGGTTCCCGGACACGAAATTGCCGGAGTTGTGGAAGCCGTGGGTGAAGAAGTCACC
ACATTTGCCGTCGGAGACCGTGTGGGTGTCGGCTGTTTTGTAGACTCCTGCGGGGAATGTGAATACTGCCTTAACGGAGA
CGAACAATATTGCACAAAAGGCGTTGTTCAGACTTATAATAACCTGGACTACGACGGAAACCCTACGTACGGCGGCTACA
GCCAGAAAATAGTTGTCACTGACAGATTCGTTGTCCGGATTCCGGATCAGCTGGATTTGGATGCTGCCAGCCCGCTATTG
TGCGCGGGCATTACCACCTATTCTCCGCTGAAACACTGGAATGCCGGCCCCGGCAAAAAAGTGGCGATTGTCGGAATGGG
CGGACTCGGACATTTAGCCGTTCAATTCGCGCACGCTTTAGGCGCAGAGGTCACCGTCCTCAGCCGCTCAATGAACAAAA
AAGACGAAGCGCTTGAATTTGGAGCCGATCATTACTTTGCCACAAGCGATCCGGATACATTTACTGAGCTGGCCGGACGA
TTTGATCTTATTTTAAATACAGTATCCGCGAACCTTGACGTAGATGCCTACTTATCCCTGCTTCGCATTGACGGTACATT
GGTAAATGTGGGAGCGCCCGCTAAGCCGGACTCATACAGTGTGTTCTCCTTAATCACGGGCCGCCGCAGCATTGCTGGTT
CACTCGTCGGCGGTATTCCGCAGACTCAGGAGATGCTTGATTTCGCCGCCGAGCACGGCATTGCTCCTAAAATTGAAGTG
ATACCGGCCAATCAAGTCGACGAAGCGTACGAACGGGTTCTCCGAAGCGATGTCCGCTACCGTTTCGTCATTGATATTTC
AACTTTATAA

Upstream 100 bases:

>100_bases
TAAAAAAATAAACCAAACTCCTTGACTTAAAGTCCGCTTTAACATTTAAAGTAAAATCGAACAGAGGATTCATCACTTTA
TCTTGGAAAGGAAGATAACC

Downstream 100 bases:

>100_bases
TCGACATAAAAAAACATACCAATATTTGTTGGTATGTTTTTTTCAGTTCAAATTATTTTTTATTTCAGCAGCCATCCGGG
CACCGCTTTTATATAAACCA

Product: AdhA

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MCNNHPTRVLSAPHAKAKFERTTIERRALRPHDILIDIKYSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVEAVGEEVT
TFAVGDRVGVGCFVDSCGECEYCLNGDEQYCTKGVVQTYNNLDYDGNPTYGGYSQKIVVTDRFVVRIPDQLDLDAASPLL
CAGITTYSPLKHWNAGPGKKVAIVGMGGLGHLAVQFAHALGAEVTVLSRSMNKKDEALEFGADHYFATSDPDTFTELAGR
FDLILNTVSANLDVDAYLSLLRIDGTLVNVGAPAKPDSYSVFSLITGRRSIAGSLVGGIPQTQEMLDFAAEHGIAPKIEV
IPANQVDEAYERVLRSDVRYRFVIDISTL

Sequences:

>Translated_349_residues
MCNNHPTRVLSAPHAKAKFERTTIERRALRPHDILIDIKYSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVEAVGEEVT
TFAVGDRVGVGCFVDSCGECEYCLNGDEQYCTKGVVQTYNNLDYDGNPTYGGYSQKIVVTDRFVVRIPDQLDLDAASPLL
CAGITTYSPLKHWNAGPGKKVAIVGMGGLGHLAVQFAHALGAEVTVLSRSMNKKDEALEFGADHYFATSDPDTFTELAGR
FDLILNTVSANLDVDAYLSLLRIDGTLVNVGAPAKPDSYSVFSLITGRRSIAGSLVGGIPQTQEMLDFAAEHGIAPKIEV
IPANQVDEAYERVLRSDVRYRFVIDISTL
>Mature_349_residues
MCNNHPTRVLSAPHAKAKFERTTIERRALRPHDILIDIKYSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVEAVGEEVT
TFAVGDRVGVGCFVDSCGECEYCLNGDEQYCTKGVVQTYNNLDYDGNPTYGGYSQKIVVTDRFVVRIPDQLDLDAASPLL
CAGITTYSPLKHWNAGPGKKVAIVGMGGLGHLAVQFAHALGAEVTVLSRSMNKKDEALEFGADHYFATSDPDTFTELAGR
FDLILNTVSANLDVDAYLSLLRIDGTLVNVGAPAKPDSYSVFSLITGRRSIAGSLVGGIPQTQEMLDFAAEHGIAPKIEV
IPANQVDEAYERVLRSDVRYRFVIDISTL

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=28.8770053475936, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=28.6096256684492, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=25.6983240223464, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=27.8820375335121, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=26.0989010989011, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=26.0989010989011, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI156523966, Length=347, Percent_Identity=25.6484149855908, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71565152, Length=342, Percent_Identity=24.5614035087719, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4501939, Length=347, Percent_Identity=25.6484149855908, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786518, Length=345, Percent_Identity=53.3333333333333, Blast_Score=333, Evalue=8e-93,
Organism=Escherichia coli, GI87082401, Length=336, Percent_Identity=36.9047619047619, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=32.1981424148607, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788075, Length=285, Percent_Identity=29.1228070175439, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=201, Percent_Identity=32.3383084577114, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=350, Percent_Identity=26, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790045, Length=205, Percent_Identity=29.2682926829268, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=278, Percent_Identity=28.0575539568345, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787863, Length=277, Percent_Identity=28.158844765343, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082125, Length=282, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=249, Percent_Identity=26.9076305220884, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=323, Percent_Identity=31.2693498452012, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=30.6060606060606, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=323, Percent_Identity=30.6501547987616, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25146526, Length=223, Percent_Identity=31.8385650224215, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=225, Percent_Identity=31.5555555555556, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=200, Percent_Identity=33, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=202, Percent_Identity=27.7227722772277, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=39.2749244712991, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319949, Length=319, Percent_Identity=35.423197492163, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=33.6257309941521, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=33.4319526627219, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=33.0383480825959, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=31.3782991202346, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=28.3783783783784, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=293, Percent_Identity=28.3276450511945, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=298, Percent_Identity=22.1476510067114, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=293, Percent_Identity=28.3276450511945, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=260, Percent_Identity=28.0769230769231, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=310, Percent_Identity=23.8709677419355, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=26.2162162162162, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137530, Length=211, Percent_Identity=31.7535545023697, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17737897, Length=204, Percent_Identity=31.8627450980392, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37829; Mature: 37829

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNNHPTRVLSAPHAKAKFERTTIERRALRPHDILIDIKYSGICHSDIHSAFDEWGGGIF
CCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
PMVPGHEIAGVVEAVGEEVTTFAVGDRVGVGCFVDSCGECEYCLNGDEQYCTKGVVQTYN
CCCCCHHHHHHHHHHCCHHEEEEECCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHC
NLDYDGNPTYGGYSQKIVVTDRFVVRIPDQLDLDAASPLLCAGITTYSPLKHWNAGPGKK
CCCCCCCCCCCCCCCEEEEECEEEEECCCCCCCCCCCCEEEECCCCCCCHHHCCCCCCCE
VAIVGMGGLGHLAVQFAHALGAEVTVLSRSMNKKDEALEFGADHYFATSDPDTFTELAGR
EEEEECCCHHHHHHHHHHHHCCEEEEEHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHH
FDLILNTVSANLDVDAYLSLLRIDGTLVNVGAPAKPDSYSVFSLITGRRSIAGSLVGGIP
HHHHHHHHHCCCCHHHHHHHHEECCEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHCCCC
QTQEMLDFAAEHGIAPKIEVIPANQVDEAYERVLRSDVRYRFVIDISTL
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MCNNHPTRVLSAPHAKAKFERTTIERRALRPHDILIDIKYSGICHSDIHSAFDEWGGGIF
CCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
PMVPGHEIAGVVEAVGEEVTTFAVGDRVGVGCFVDSCGECEYCLNGDEQYCTKGVVQTYN
CCCCCHHHHHHHHHHCCHHEEEEECCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHC
NLDYDGNPTYGGYSQKIVVTDRFVVRIPDQLDLDAASPLLCAGITTYSPLKHWNAGPGKK
CCCCCCCCCCCCCCCEEEEECEEEEECCCCCCCCCCCCEEEECCCCCCCHHHCCCCCCCE
VAIVGMGGLGHLAVQFAHALGAEVTVLSRSMNKKDEALEFGADHYFATSDPDTFTELAGR
EEEEECCCHHHHHHHHHHHHCCEEEEEHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHH
FDLILNTVSANLDVDAYLSLLRIDGTLVNVGAPAKPDSYSVFSLITGRRSIAGSLVGGIP
HHHHHHHHHCCCCHHHHHHHHEECCEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHCCCC
QTQEMLDFAAEHGIAPKIEVIPANQVDEAYERVLRSDVRYRFVIDISTL
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]