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The map label for this gene is yvaE [H]

Identifier: 154684940

GI number: 154684940

Start: 468004

End: 468369

Strand: Reverse

Name: yvaE [H]

Synonym: RBAM_004710

Alternate gene names: 154684940

Gene position: 468369-468004 (Counterclockwise)

Preceding gene: 154684945

Following gene: 154684939

Centisome position: 11.95

GC content: 36.61

Gene sequence:

>366_bases
ATGCAATGGATTTATTTAAGTTTAGCGATCATTTTTGAAGTATTGGGTACGGTCAGCATGAAATTATCAAATGGATTTAC
AAAACTTGTCCCAAGTATTTTATTATTATTGTTTTATATCGGCAGCCTTTGTTTTCTTACTTTGACTTTGAAATATATAA
GTGTCTCCATCGCGTATGCGGTCTGGTCTGGAATGGGGATCGTGCTGATTTCGGTGATCGGAATTTTTTTCTTTCATGAA
CAGTTCTCTGTCATAAAAGCTGTCTCTGTTCTTCTGATCATCATCGGTGTCGTTTCCTTAAACTTTATTTCTGAAAGTGA
AACGTCATCAAACGGCATCAGCGTTCATACGGACAGAAACAGATGA

Upstream 100 bases:

>100_bases
CCGGACGGATTTTTTATCCGGAAAACATCCCATTGTTTAATTTTCTTCAAATTCTGTATATTGTATAATTTTGAGTAATA
CGATTGAAGGAGAATGTTGA

Downstream 100 bases:

>100_bases
TGAAAGGGTTAAAGGTTCTCTTCCTCATTACAGATATTGGATTTATCGTTTATTGGATTGTTACTTTTTTTGAGTGGATT
CCAAAAAATATGGTGTTTAA

Product: YvaE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MQWIYLSLAIIFEVLGTVSMKLSNGFTKLVPSILLLLFYIGSLCFLTLTLKYISVSIAYAVWSGMGIVLISVIGIFFFHE
QFSVIKAVSVLLIIIGVVSLNFISESETSSNGISVHTDRNR

Sequences:

>Translated_121_residues
MQWIYLSLAIIFEVLGTVSMKLSNGFTKLVPSILLLLFYIGSLCFLTLTLKYISVSIAYAVWSGMGIVLISVIGIFFFHE
QFSVIKAVSVLLIIIGVVSLNFISESETSSNGISVHTDRNR
>Mature_121_residues
MQWIYLSLAIIFEVLGTVSMKLSNGFTKLVPSILLLLFYIGSLCFLTLTLKYISVSIAYAVWSGMGIVLISVIGIFFFHE
QFSVIKAVSVLLIIIGVVSLNFISESETSSNGISVHTDRNR

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=105, Percent_Identity=44.7619047619048, Blast_Score=87, Evalue=4e-19,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=34.3137254901961, Blast_Score=69, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 13369; Mature: 13369

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWIYLSLAIIFEVLGTVSMKLSNGFTKLVPSILLLLFYIGSLCFLTLTLKYISVSIAYA
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVLISVIGIFFFHEQFSVIKAVSVLLIIIGVVSLNFISESETSSNGISVHTDRN
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
R
C
>Mature Secondary Structure
MQWIYLSLAIIFEVLGTVSMKLSNGFTKLVPSILLLLFYIGSLCFLTLTLKYISVSIAYA
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVLISVIGIFFFHEQFSVIKAVSVLLIIIGVVSLNFISESETSSNGISVHTDRN
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]