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The map label for this gene is mmuM [H]

Identifier: 154684747

GI number: 154684747

Start: 251228

End: 252175

Strand: Reverse

Name: mmuM [H]

Synonym: RBAM_002780

Alternate gene names: 154684747

Gene position: 252175-251228 (Counterclockwise)

Preceding gene: 154684748

Following gene: 154684746

Centisome position: 6.44

GC content: 53.27

Gene sequence:

>948_bases
ATGAATCCCATTACACAAATATTAAATGAATACCCGGTTATGATCATAGACGGCGCGATGGCAACCGAGCTTGAGCGGAT
GGGCTGTGATTTACATGACGATCTGTGGTCGGCCAAAATTCTTTTGGAGAGGCCAGAACTGATCAAACAGGTGCATGCAG
AATATTTTGCCGCCGGCGCTGATTGCGCGATCACCGCCAGTTATCAATCGACAATTGAAGGATTTGCAGCGCGCGGCATC
CCGGAAACCGATGCGATACGTCTCATTCAGACATCTGTTGAACTTGCCGCACAAGCACGCGATGAATTTTGGGCGCATGA
AGAAAACCGTTTACACCGGCCCAAACCTTTGGTCGCCGCTTCTATCGGGCCTTACGGCGCGAGCCTCGCTGACGGCTCAG
AATATCGCGGGCATTACGGACTGACGGAGGATGAGCTGATCAGCTTTCACCGCCCCCGGATGAAAGCCCTTATAGAATCC
GGCGCCGATCTTTTGGCCTGTGAGACCATTCCGTGTCTGTCAGAAGCAAAAGCGATCACAAGGCTGCTGGAGGAATTCCC
CGGCACTTATGCATGGATCAGCTTCAGCGCCAAAGACGGACGGCATATCAGCGAAGGCACGCCAATTTCCGAATGCGCGG
CCCTGCTTGACTCCTGCAGCCAAATCGCAGCGATCGGCATCAACTGCACACCGATTGAACATATTCCGCCGCTGATAGAA
GAAATCAAACGGGCAGCATCCAAACCGATTATCGCCTATCCGAACTCCGGCGAACAATATGACCCAGTGACAAAAACCTG
GAAAGGCGCAGCGTGCGAAAACAATTTCGGAAAAAGCGCGCAAGGCTGGTACGAAAACGGCGTGAGCCTGATCGGCGGCT
GCTGCCGGACGAAACCCGCGGACATTCAGGCCATTGCCGATTGGGCCAAGACCTTAAAAACAACTTGA

Upstream 100 bases:

>100_bases
GCAGCGTCCTGAACACCTTTTTTCTGCCGGTTCATTGACAAAGAGAATAGCATCCATTACCCTTTTTATATATTTTCAGT
AAAGTCAGAAAGGAAGGCCT

Downstream 100 bases:

>100_bases
CTAATCGGAATAGTTTGTATATTCTATTCAAAAAGCCGGTTCGCCGGAATCTCGTGCCGTTCGCCGGCATGAGATTTTTT
ATTAGGACGGCCCTCGCAGA

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MNPITQILNEYPVMIIDGAMATELERMGCDLHDDLWSAKILLERPELIKQVHAEYFAAGADCAITASYQSTIEGFAARGI
PETDAIRLIQTSVELAAQARDEFWAHEENRLHRPKPLVAASIGPYGASLADGSEYRGHYGLTEDELISFHRPRMKALIES
GADLLACETIPCLSEAKAITRLLEEFPGTYAWISFSAKDGRHISEGTPISECAALLDSCSQIAAIGINCTPIEHIPPLIE
EIKRAASKPIIAYPNSGEQYDPVTKTWKGAACENNFGKSAQGWYENGVSLIGGCCRTKPADIQAIADWAKTLKTT

Sequences:

>Translated_315_residues
MNPITQILNEYPVMIIDGAMATELERMGCDLHDDLWSAKILLERPELIKQVHAEYFAAGADCAITASYQSTIEGFAARGI
PETDAIRLIQTSVELAAQARDEFWAHEENRLHRPKPLVAASIGPYGASLADGSEYRGHYGLTEDELISFHRPRMKALIES
GADLLACETIPCLSEAKAITRLLEEFPGTYAWISFSAKDGRHISEGTPISECAALLDSCSQIAAIGINCTPIEHIPPLIE
EIKRAASKPIIAYPNSGEQYDPVTKTWKGAACENNFGKSAQGWYENGVSLIGGCCRTKPADIQAIADWAKTLKTT
>Mature_315_residues
MNPITQILNEYPVMIIDGAMATELERMGCDLHDDLWSAKILLERPELIKQVHAEYFAAGADCAITASYQSTIEGFAARGI
PETDAIRLIQTSVELAAQARDEFWAHEENRLHRPKPLVAASIGPYGASLADGSEYRGHYGLTEDELISFHRPRMKALIES
GADLLACETIPCLSEAKAITRLLEEFPGTYAWISFSAKDGRHISEGTPISECAALLDSCSQIAAIGINCTPIEHIPPLIE
EIKRAASKPIIAYPNSGEQYDPVTKTWKGAACENNFGKSAQGWYENGVSLIGGCCRTKPADIQAIADWAKTLKTT

Specific function: Catalyzes Methyl Transfer From S-Methylmethionine Or S- Adenosylmethionine (Less Efficient) To Homocysteine, Selenohomocysteine And Less Efficiently Selenocysteine. [C]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=338, Percent_Identity=28.1065088757396, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786456, Length=309, Percent_Identity=49.8381877022654, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1790450, Length=335, Percent_Identity=28.6567164179104, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569783, Length=265, Percent_Identity=24.9056603773585, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322966, Length=327, Percent_Identity=27.217125382263, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324982, Length=327, Percent_Identity=28.1345565749235, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323983, Length=88, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585077, Length=318, Percent_Identity=33.9622641509434, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20129603, Length=327, Percent_Identity=33.0275229357798, Blast_Score=174, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 34381; Mature: 34381

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50970 HCY ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPITQILNEYPVMIIDGAMATELERMGCDLHDDLWSAKILLERPELIKQVHAEYFAAGA
CCHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
DCAITASYQSTIEGFAARGIPETDAIRLIQTSVELAAQARDEFWAHEENRLHRPKPLVAA
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SIGPYGASLADGSEYRGHYGLTEDELISFHRPRMKALIESGADLLACETIPCLSEAKAIT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCEEEECCCCHHHHHHHHH
RLLEEFPGTYAWISFSAKDGRHISEGTPISECAALLDSCSQIAAIGINCTPIEHIPPLIE
HHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EIKRAASKPIIAYPNSGEQYDPVTKTWKGAACENNFGKSAQGWYENGVSLIGGCCRTKPA
HHHHHHCCCEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCC
DIQAIADWAKTLKTT
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPITQILNEYPVMIIDGAMATELERMGCDLHDDLWSAKILLERPELIKQVHAEYFAAGA
CCHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
DCAITASYQSTIEGFAARGIPETDAIRLIQTSVELAAQARDEFWAHEENRLHRPKPLVAA
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SIGPYGASLADGSEYRGHYGLTEDELISFHRPRMKALIESGADLLACETIPCLSEAKAIT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCEEEECCCCHHHHHHHHH
RLLEEFPGTYAWISFSAKDGRHISEGTPISECAALLDSCSQIAAIGINCTPIEHIPPLIE
HHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EIKRAASKPIIAYPNSGEQYDPVTKTWKGAACENNFGKSAQGWYENGVSLIGGCCRTKPA
HHHHHHCCCEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCC
DIQAIADWAKTLKTT
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]