Click here to switch to the map view.

The map label for this gene is atsA [H]

Identifier: 154248610

GI number: 154248610

Start: 5202002

End: 5203477

Strand: Direct

Name: atsA [H]

Synonym: Xaut_4692

Alternate gene names: 154248610

Gene position: 5202002-5203477 (Clockwise)

Preceding gene: 154248609

Following gene: 154248611

Centisome position: 97.99

GC content: 68.63

Gene sequence:

>1476_bases
ATGACTGACACACCCGCATCTGCCGACGACGACCGCTCGCAGCCGAGCCGTCGCGATGTGCTCGCCGGGGGCGCCGGATT
CCTGGCCGCCGTGGCGGGGCTGTCGCTGCTCTCCTCGGGCGCGAGGGCGGCGGACGCGCCGCGCCCGCACATCGTCTACA
TCCTCGCCGACGATCTTGGCTTTGCCGACGTGGGCTTCCACGGCTCGGACATCAAGACGCCCAATCTCGACCATCTCGCC
GCGCAGGGCGCCCGGCTCGGGCAGTTCTATACCCAGCCCTTCTGCACGCCCACGCGGGCCGCTTTCCTGACCGGCCGCTA
TCCCCTGCATTACGGCCTGCAGGTGGGGGCTATTCCGTCCGGGGCGAAGTACGGCCTTGCCACCGACGAGTTCCTGCTGC
CCCAGGCGCTGAAGGACGTGGGCTACCGCACCGCCCTCGTCGGCAAATGGCACCTCGGCCACGCCGACCAGAAGTTCTGG
CCGCGGCAGCGCGGCTTCGACAGCTTCTATGGCCCGCTGGTGGGCGAGATCGACCATTTCAAGCATGAGGCCCACGGCGT
CACGGACTGGTATCACGACAACACCCAGGTCAAGGAAGAGGGCTACGACACCGAATTGTTCGGCAAGGAGGCGGTGCGGC
TGATCGCGGCGCACGACCCCAAGACCCCGCTCTTCCTCTACCTCGCCTTCACCGCCCCGCACACGCCGTTCCAGGCGCCG
CAATCCTATCTGGACCAGTACGCCCATATTGCCGCCCCTCAACGGCGCGCCTATGCGGCGATGATCACCGCCATGGACGA
CCAGATTGGCCATGTGGTCGCCGCGCTGACATCCCGCGGAATGCGGGAGAACACCTTGATCGTGTTCCACAGCGACAATG
GCGGCACGCGCTCCAAGATGTTCGCGGGCGAAGGTGCCGTCGCAGGGGATCTCCCCGCCAGCAACGCGCCCTATCGCGAC
GGCAAGGGCTCGCTCTACGAGGGCGGCACCCGCGTGGTTGCGCTCGCCAACTGGCCGGGGCGCATCGCCCCTGGAGCGGC
CGAGGGCGTAATGCACGTGGTCGATATGCTGCCGACCCTGGCGAAGCTCGCCGGGGCCAGCCTCGCCAAGTCGAAGCCAT
TGGACGGCGTGGATGTCTGGCCGGCCTTGGCCGCCGGACAGGCCGGACGGGCCGGGATCGTCTACAACGTCGAGCCGACC
CAGGGCGCCGTGCGCGATGGCAGATGGAAGCTGGTGTGGCGGGTGGTGCTGCCGCCGACGGCCGAGCTGTTCGACGTGGA
GGCGGACCCCTCCGAGACGACCGACGTGTCGGCGCAGCATCCGGAGAAAGTGGCGGAGCTGCAGGGGAAGGTCGTCGCGC
TCGCCCGCACCATGGCGCCTCCTCTATTCTACGCCGCCGCGCTCAAGGCCGCGTTGTCCGCGCCGCTGTCCACGCCCGGC
CTTGCTCTCTACGAGATGGGCCTGGACGACGACTGA

Upstream 100 bases:

>100_bases
TATCGCCCCGCCGCGCGCCAGCCCCAGACCATTGACACCGCCTCCGTGCACATCGGCTTCCGATGTGTCCGAAAGGTTGC
GACCCCCTGAGGAGCTCTCG

Downstream 100 bases:

>100_bases
TGCCTGGCTGTCGTCTTCCGAAGGCCCGCGCACTGGTCCCTGCCTGCCGATCGACCTTGACCTGCCTGCACCCGGTGGTT
TCATAAGCGCGATCAGGACG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTDTPASADDDRSQPSRRDVLAGGAGFLAAVAGLSLLSSGARAADAPRPHIVYILADDLGFADVGFHGSDIKTPNLDHLA
AQGARLGQFYTQPFCTPTRAAFLTGRYPLHYGLQVGAIPSGAKYGLATDEFLLPQALKDVGYRTALVGKWHLGHADQKFW
PRQRGFDSFYGPLVGEIDHFKHEAHGVTDWYHDNTQVKEEGYDTELFGKEAVRLIAAHDPKTPLFLYLAFTAPHTPFQAP
QSYLDQYAHIAAPQRRAYAAMITAMDDQIGHVVAALTSRGMRENTLIVFHSDNGGTRSKMFAGEGAVAGDLPASNAPYRD
GKGSLYEGGTRVVALANWPGRIAPGAAEGVMHVVDMLPTLAKLAGASLAKSKPLDGVDVWPALAAGQAGRAGIVYNVEPT
QGAVRDGRWKLVWRVVLPPTAELFDVEADPSETTDVSAQHPEKVAELQGKVVALARTMAPPLFYAAALKAALSAPLSTPG
LALYEMGLDDD

Sequences:

>Translated_491_residues
MTDTPASADDDRSQPSRRDVLAGGAGFLAAVAGLSLLSSGARAADAPRPHIVYILADDLGFADVGFHGSDIKTPNLDHLA
AQGARLGQFYTQPFCTPTRAAFLTGRYPLHYGLQVGAIPSGAKYGLATDEFLLPQALKDVGYRTALVGKWHLGHADQKFW
PRQRGFDSFYGPLVGEIDHFKHEAHGVTDWYHDNTQVKEEGYDTELFGKEAVRLIAAHDPKTPLFLYLAFTAPHTPFQAP
QSYLDQYAHIAAPQRRAYAAMITAMDDQIGHVVAALTSRGMRENTLIVFHSDNGGTRSKMFAGEGAVAGDLPASNAPYRD
GKGSLYEGGTRVVALANWPGRIAPGAAEGVMHVVDMLPTLAKLAGASLAKSKPLDGVDVWPALAAGQAGRAGIVYNVEPT
QGAVRDGRWKLVWRVVLPPTAELFDVEADPSETTDVSAQHPEKVAELQGKVVALARTMAPPLFYAAALKAALSAPLSTPG
LALYEMGLDDD
>Mature_490_residues
TDTPASADDDRSQPSRRDVLAGGAGFLAAVAGLSLLSSGARAADAPRPHIVYILADDLGFADVGFHGSDIKTPNLDHLAA
QGARLGQFYTQPFCTPTRAAFLTGRYPLHYGLQVGAIPSGAKYGLATDEFLLPQALKDVGYRTALVGKWHLGHADQKFWP
RQRGFDSFYGPLVGEIDHFKHEAHGVTDWYHDNTQVKEEGYDTELFGKEAVRLIAAHDPKTPLFLYLAFTAPHTPFQAPQ
SYLDQYAHIAAPQRRAYAAMITAMDDQIGHVVAALTSRGMRENTLIVFHSDNGGTRSKMFAGEGAVAGDLPASNAPYRDG
KGSLYEGGTRVVALANWPGRIAPGAAEGVMHVVDMLPTLAKLAGASLAKSKPLDGVDVWPALAAGQAGRAGIVYNVEPTQ
GAVRDGRWKLVWRVVLPPTAELFDVEADPSETTDVSAQHPEKVAELQGKVVALARTMAPPLFYAAALKAALSAPLSTPGL
ALYEMGLDDD

Specific function: Plays an important role in the mineralization of sulfates [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI59797060, Length=469, Percent_Identity=37.1002132196162, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI109389362, Length=470, Percent_Identity=35.9574468085106, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI38569405, Length=496, Percent_Identity=36.2903225806452, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI38569407, Length=375, Percent_Identity=41.8666666666667, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI4503899, Length=385, Percent_Identity=32.4675324675325, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI146229331, Length=394, Percent_Identity=35.0253807106599, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI146229329, Length=394, Percent_Identity=35.0253807106599, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI6005990, Length=394, Percent_Identity=35.0253807106599, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI146229324, Length=394, Percent_Identity=35.0253807106599, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI45430057, Length=376, Percent_Identity=31.6489361702128, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI146229327, Length=329, Percent_Identity=31.306990881459, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI157266309, Length=151, Percent_Identity=44.3708609271523, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI53831991, Length=143, Percent_Identity=44.7552447552448, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI58743319, Length=137, Percent_Identity=43.7956204379562, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI31742482, Length=161, Percent_Identity=39.7515527950311, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI71852586, Length=142, Percent_Identity=40.1408450704225, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI71852584, Length=142, Percent_Identity=40.1408450704225, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1790233, Length=489, Percent_Identity=29.038854805726, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081924, Length=396, Percent_Identity=26.010101010101, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790112, Length=453, Percent_Identity=25.8278145695364, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI115533416, Length=447, Percent_Identity=33.7807606263982, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI115533418, Length=440, Percent_Identity=33.8636363636364, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17559078, Length=133, Percent_Identity=37.593984962406, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281363223, Length=407, Percent_Identity=37.8378378378378, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24666175, Length=369, Percent_Identity=38.7533875338753, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24666109, Length=359, Percent_Identity=38.7186629526462, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI281366397, Length=413, Percent_Identity=36.0774818401937, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281366395, Length=413, Percent_Identity=36.0774818401937, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24666163, Length=413, Percent_Identity=36.0774818401937, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 52488; Mature: 52357

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTPASADDDRSQPSRRDVLAGGAGFLAAVAGLSLLSSGARAADAPRPHIVYILADDLG
CCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCC
FADVGFHGSDIKTPNLDHLAAQGARLGQFYTQPFCTPTRAAFLTGRYPLHYGLQVGAIPS
CEECCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHHEEECCCCEEECEEECCCCC
GAKYGLATDEFLLPQALKDVGYRTALVGKWHLGHADQKFWPRQRGFDSFYGPLVGEIDHF
CCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHCCCHHHHCHHHHHHHHH
KHEAHGVTDWYHDNTQVKEEGYDTELFGKEAVRLIAAHDPKTPLFLYLAFTAPHTPFQAP
HHHHCCCCCEECCCCEECCCCCCHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCCCCH
QSYLDQYAHIAAPQRRAYAAMITAMDDQIGHVVAALTSRGMRENTLIVFHSDNGGTRSKM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEE
FAGEGAVAGDLPASNAPYRDGKGSLYEGGTRVVALANWPGRIAPGAAEGVMHVVDMLPTL
EECCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AKLAGASLAKSKPLDGVDVWPALAAGQAGRAGIVYNVEPTQGAVRDGRWKLVWRVVLPPT
HHHHCCHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCC
AELFDVEADPSETTDVSAQHPEKVAELQGKVVALARTMAPPLFYAAALKAALSAPLSTPG
HHEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
LALYEMGLDDD
CEEEECCCCCC
>Mature Secondary Structure 
TDTPASADDDRSQPSRRDVLAGGAGFLAAVAGLSLLSSGARAADAPRPHIVYILADDLG
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCC
FADVGFHGSDIKTPNLDHLAAQGARLGQFYTQPFCTPTRAAFLTGRYPLHYGLQVGAIPS
CEECCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHHEEECCCCEEECEEECCCCC
GAKYGLATDEFLLPQALKDVGYRTALVGKWHLGHADQKFWPRQRGFDSFYGPLVGEIDHF
CCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHCCCHHHHCHHHHHHHHH
KHEAHGVTDWYHDNTQVKEEGYDTELFGKEAVRLIAAHDPKTPLFLYLAFTAPHTPFQAP
HHHHCCCCCEECCCCEECCCCCCHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCCCCH
QSYLDQYAHIAAPQRRAYAAMITAMDDQIGHVVAALTSRGMRENTLIVFHSDNGGTRSKM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEE
FAGEGAVAGDLPASNAPYRDGKGSLYEGGTRVVALANWPGRIAPGAAEGVMHVVDMLPTL
EECCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AKLAGASLAKSKPLDGVDVWPALAAGQAGRAGIVYNVEPTQGAVRDGRWKLVWRVVLPPT
HHHHCCHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCC
AELFDVEADPSETTDVSAQHPEKVAELQGKVVALARTMAPPLFYAAALKAALSAPLSTPG
HHEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
LALYEMGLDDD
CEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10336424 [H]