Click here to switch to the map view.

The map label for this gene is nqo2 [H]

Identifier: 154248548

GI number: 154248548

Start: 5116832

End: 5117521

Strand: Reverse

Name: nqo2 [H]

Synonym: Xaut_4629

Alternate gene names: 154248548

Gene position: 5117521-5116832 (Counterclockwise)

Preceding gene: 154248549

Following gene: 154248547

Centisome position: 96.39

GC content: 68.12

Gene sequence:

>690_bases
ATGTCCGTCCGCCGCCTCGCCGCAGAGCAGCCCGAGAGCTTCGACATCACGCCGGAGCTTGAGGCCATCGCCCAGAAGCT
GATCGCGAAATATCCCGAGGGCCGCCAGGCCAGCGCCGTCGTGCCGCTGCTCTGGGAAACCCAGAAGGCCGCCGGCGGCT
GGCTGCCCGAGCCGGCCATACGCGCCGTGGCGGAGCGCCTCGGCATGGCGAACATCCGCGTGCTGGAGATCGCCACCTTC
TACACCATGTTCAACCTGGAACCGGTGGGGAAGTATTTCGTGCAGCTGTGCGGGACGACCCCCTGCATGCTGCGCGGCGC
CGAAGCCATCAAGCATGTGTGCGAGAAGAAGATCGGCCACGAGCGGCACGTTTCCGCCGATGGCACCTTCTCCTGGCTTG
AGGTGGAGTGCCTGGGTGCCTGTACCAACGCCCCCATGGTCCAGATCAACGACGATTACTACGAAGACCTGACGCCCGAG
AATTTCGAGAAGCTGCTCGATGATCTCGCCGCCGGCCGTCCGGTGAAGGTCGGCCCGCAGAATTCGCGCCGTGGCTCCGA
GCCCGAGGGCGGCGCACGGGTGCTGTCCGATCCGGCGCTCTATGCGCACGCCGTCGCGCCCGAGGCGCCTGCGGCTCCCG
CGGCCGAGGCCCCCACATCCGGCGCCTTCGCGCCGACCTCCGGGGAGTGA

Upstream 100 bases:

>100_bases
TTTCCGCCGGGTTTCTCGCCGCCGGGTTTCCTGTCGCCGCGTTTCTTGCCGCCCGATGCCGGCGCACGCTTCGTGCGCCG
CACGTTCCGGGATCTGAGCC

Downstream 100 bases:

>100_bases
CCGCCATGCTCGCCGACAAGGACCGCATCTTCACCAATATCTACGGCCTTCAGGATTTCGGCCTGAAGGGCGCGCGCGCC
CGTGGCAACTGGGACGGCAC

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSVRRLAAEQPESFDITPELEAIAQKLIAKYPEGRQASAVVPLLWETQKAAGGWLPEPAIRAVAERLGMANIRVLEIATF
YTMFNLEPVGKYFVQLCGTTPCMLRGAEAIKHVCEKKIGHERHVSADGTFSWLEVECLGACTNAPMVQINDDYYEDLTPE
NFEKLLDDLAAGRPVKVGPQNSRRGSEPEGGARVLSDPALYAHAVAPEAPAAPAAEAPTSGAFAPTSGE

Sequences:

>Translated_229_residues
MSVRRLAAEQPESFDITPELEAIAQKLIAKYPEGRQASAVVPLLWETQKAAGGWLPEPAIRAVAERLGMANIRVLEIATF
YTMFNLEPVGKYFVQLCGTTPCMLRGAEAIKHVCEKKIGHERHVSADGTFSWLEVECLGACTNAPMVQINDDYYEDLTPE
NFEKLLDDLAAGRPVKVGPQNSRRGSEPEGGARVLSDPALYAHAVAPEAPAAPAAEAPTSGAFAPTSGE
>Mature_228_residues
SVRRLAAEQPESFDITPELEAIAQKLIAKYPEGRQASAVVPLLWETQKAAGGWLPEPAIRAVAERLGMANIRVLEIATFY
TMFNLEPVGKYFVQLCGTTPCMLRGAEAIKHVCEKKIGHERHVSADGTFSWLEVECLGACTNAPMVQINDDYYEDLTPEN
FEKLLDDLAAGRPVKVGPQNSRRGSEPEGGARVLSDPALYAHAVAPEAPAAPAAEAPTSGAFAPTSGE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=186, Percent_Identity=49.4623655913978, Blast_Score=188, Evalue=4e-48,
Organism=Escherichia coli, GI1788621, Length=160, Percent_Identity=33.125, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561328, Length=179, Percent_Identity=52.5139664804469, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI18859877, Length=185, Percent_Identity=47.5675675675676, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355353, Length=185, Percent_Identity=38.3783783783784, Blast_Score=136, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24676; Mature: 24545

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRLAAEQPESFDITPELEAIAQKLIAKYPEGRQASAVVPLLWETQKAAGGWLPEPAI
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHCCCHHHCCCCCCCHHH
RAVAERLGMANIRVLEIATFYTMFNLEPVGKYFVQLCGTTPCMLRGAEAIKHVCEKKIGH
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
ERHVSADGTFSWLEVECLGACTNAPMVQINDDYYEDLTPENFEKLLDDLAAGRPVKVGPQ
CCCCCCCCCEEEEEEEEECCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEECCC
NSRRGSEPEGGARVLSDPALYAHAVAPEAPAAPAAEAPTSGAFAPTSGE
CCCCCCCCCCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVRRLAAEQPESFDITPELEAIAQKLIAKYPEGRQASAVVPLLWETQKAAGGWLPEPAI
CCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHCCCHHHCCCCCCCHHH
RAVAERLGMANIRVLEIATFYTMFNLEPVGKYFVQLCGTTPCMLRGAEAIKHVCEKKIGH
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
ERHVSADGTFSWLEVECLGACTNAPMVQINDDYYEDLTPENFEKLLDDLAAGRPVKVGPQ
CCCCCCCCCEEEEEEEEECCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEECCC
NSRRGSEPEGGARVLSDPALYAHAVAPEAPAAPAAEAPTSGAFAPTSGE
CCCCCCCCCCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]