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The map label for this gene is nuoF1 [H]

Identifier: 154248547

GI number: 154248547

Start: 5115525

End: 5116826

Strand: Reverse

Name: nuoF1 [H]

Synonym: Xaut_4628

Alternate gene names: 154248547

Gene position: 5116826-5115525 (Counterclockwise)

Preceding gene: 154248548

Following gene: 154248546

Centisome position: 96.38

GC content: 66.21

Gene sequence:

>1302_bases
ATGCTCGCCGACAAGGACCGCATCTTCACCAATATCTACGGCCTTCAGGATTTCGGCCTGAAGGGCGCGCGCGCCCGTGG
CAACTGGGACGGCACCAAGGCCATCCTGGAGAAGGGCCGCGATTGGATCATCAACGAGATGAAGACCTCCGGCCTGCGTG
GTCGCGGCGGGGCCGGCTTCTCCACCGGCATGAAGTGGTCCTTCATGCCCAAGCAGTCCGACGGGCGCCCCCACTATCTG
GTGGTGAACGCCGACGAATCCGAGCCCGGCACCTGCAAGGACCGGGAGATCATGCGCAACGATCCGCATACGCTGATCGA
GGGCTGCCTGATCGCCTCCTTCGCCATGGGTGCGCATGCCGCCTACATCTATGTGCGCGGGGAATACATCTTCGAGCGCA
AGCGACTGCAGGCGGCCATCGACGAGGCCTATGACGCCGGCCTCATCGGCAAGAGCAACATCCACGACTACCCCTTCGAC
CTCTACGTGCACCACGGCGCCGGCGCCTATATCTGCGGCGAAGAGACCGCACTGCTGGAGAGCCTCGAGGGCAAGAAGGG
CATGCCACGCCTGAAGCCCCCGTTCCCCGCGAACATGGGCCTGTACGGCTGCCCGACCACGGTGAACAACGTGGAGAGCA
TCGCGGTCGCCCCCACCATCCTGCGGCGCGGGGCGGCGTGGTTCTCCTCCATCGGCCGGCCGAACAACGTGGGCACCAAG
CTGTTCAGCCTGGCCGGTCACGTGAACACGCCCTGCGTGGTGGAAGAAGCCATGAGCATCCCGTTCCGGGAGCTGGTCGA
CAAGCATGGCGGCGGCGTGCGCGGCGGCTGGGACAACCTGCTCGGCATCATCCCCGGCGGCGCATCCTGCCCGGTGATCC
CGGCGGAACAGTGCGCCGACCTGATCATGGATTTCGACGGCACCCGCGCGGTGAAGTCGTCCCTCGGCACCGCGGGCGTG
CTGGTGATGGACAAGTCCACGGACATCATTAAGGCGATCGCCCGCATCTCCGCCTTCTTCAAGCACGAGAGCTGCGGCCA
GTGCACGCCCTGCCGCGAAGGCACCGGCTGGATGTGGCGCGTGGTCAACCGCATGGCCGAGGGCCGCGCCCAGAAGCGCG
AGATCGACATGCTGCTGGAAGTGACGACCCAGATTGAGGGCCACACCATCTGCGCGCTCGGCGATGCCGCCGCGTGGCCG
GTCCAGGGCCTCATCCGCCACTATCGTCACGTGATCGAAGAGCGGATCGACCAATATGCCGCCAACCCGCATCCGGACCC
GGTTCCGGTGGCGGCGGAGTGA

Upstream 100 bases:

>100_bases
CGCTCTATGCGCACGCCGTCGCGCCCGAGGCGCCTGCGGCTCCCGCGGCCGAGGCCCCCACATCCGGCGCCTTCGCGCCG
ACCTCCGGGGAGTGACCGCC

Downstream 100 bases:

>100_bases
GAACGTCCCGCGTGGCGCGCGCGTCGCGACAGGCGGGAAGGGGACTGACACGGGAGGCTGGGCGCGCTGCGCTGGGTTTC
CCGCCGCGCATGGCGCGGCA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLADKDRIFTNIYGLQDFGLKGARARGNWDGTKAILEKGRDWIINEMKTSGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYIFERKRLQAAIDEAYDAGLIGKSNIHDYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFSLAGHVNTPCVVEEAMSIPFRELVDKHGGGVRGGWDNLLGIIPGGASCPVIPAEQCADLIMDFDGTRAVKSSLGTAGV
LVMDKSTDIIKAIARISAFFKHESCGQCTPCREGTGWMWRVVNRMAEGRAQKREIDMLLEVTTQIEGHTICALGDAAAWP
VQGLIRHYRHVIEERIDQYAANPHPDPVPVAAE

Sequences:

>Translated_433_residues
MLADKDRIFTNIYGLQDFGLKGARARGNWDGTKAILEKGRDWIINEMKTSGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYIFERKRLQAAIDEAYDAGLIGKSNIHDYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFSLAGHVNTPCVVEEAMSIPFRELVDKHGGGVRGGWDNLLGIIPGGASCPVIPAEQCADLIMDFDGTRAVKSSLGTAGV
LVMDKSTDIIKAIARISAFFKHESCGQCTPCREGTGWMWRVVNRMAEGRAQKREIDMLLEVTTQIEGHTICALGDAAAWP
VQGLIRHYRHVIEERIDQYAANPHPDPVPVAAE
>Mature_433_residues
MLADKDRIFTNIYGLQDFGLKGARARGNWDGTKAILEKGRDWIINEMKTSGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYIFERKRLQAAIDEAYDAGLIGKSNIHDYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFSLAGHVNTPCVVEEAMSIPFRELVDKHGGGVRGGWDNLLGIIPGGASCPVIPAEQCADLIMDFDGTRAVKSSLGTAGV
LVMDKSTDIIKAIARISAFFKHESCGQCTPCREGTGWMWRVVNRMAEGRAQKREIDMLLEVTTQIEGHTICALGDAAAWP
VQGLIRHYRHVIEERIDQYAANPHPDPVPVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=65.6324582338902, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=65.6324582338902, Blast_Score=588, Evalue=1e-168,
Organism=Escherichia coli, GI1788620, Length=412, Percent_Identity=41.747572815534, Blast_Score=321, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17531727, Length=419, Percent_Identity=65.8711217183771, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI19920794, Length=420, Percent_Identity=69.0476190476191, Blast_Score=618, Evalue=1e-177,
Organism=Drosophila melanogaster, GI45550452, Length=421, Percent_Identity=65.3206650831354, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=44.0758293838863, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24653817, Length=422, Percent_Identity=40.9952606635071, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47318; Mature: 47318

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADKDRIFTNIYGLQDFGLKGARARGNWDGTKAILEKGRDWIINEMKTSGLRGRGGAGF
CCCCHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYIFERKRLQAAIDEAYDAGLIGKSNIHDYPFDLYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LFSLAGHVNTPCVVEEAMSIPFRELVDKHGGGVRGGWDNLLGIIPGGASCPVIPAEQCAD
HHHHHCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHH
LIMDFDGTRAVKSSLGTAGVLVMDKSTDIIKAIARISAFFKHESCGQCTPCREGTGWMWR
HHHCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VVNRMAEGRAQKREIDMLLEVTTQIEGHTICALGDAAAWPVQGLIRHYRHVIEERIDQYA
HHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
ANPHPDPVPVAAE
CCCCCCCCCCCCC
>Mature Secondary Structure
MLADKDRIFTNIYGLQDFGLKGARARGNWDGTKAILEKGRDWIINEMKTSGLRGRGGAGF
CCCCHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYIFERKRLQAAIDEAYDAGLIGKSNIHDYPFDLYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LFSLAGHVNTPCVVEEAMSIPFRELVDKHGGGVRGGWDNLLGIIPGGASCPVIPAEQCAD
HHHHHCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHH
LIMDFDGTRAVKSSLGTAGVLVMDKSTDIIKAIARISAFFKHESCGQCTPCREGTGWMWR
HHHCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VVNRMAEGRAQKREIDMLLEVTTQIEGHTICALGDAAAWPVQGLIRHYRHVIEERIDQYA
HHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
ANPHPDPVPVAAE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]