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The map label for this gene is mdtA [H]

Identifier: 154248476

GI number: 154248476

Start: 5036306

End: 5037457

Strand: Reverse

Name: mdtA [H]

Synonym: Xaut_4556

Alternate gene names: 154248476

Gene position: 5037457-5036306 (Counterclockwise)

Preceding gene: 154248477

Following gene: 154248475

Centisome position: 94.89

GC content: 70.57

Gene sequence:

>1152_bases
ATGTCCGCCGAGACGGGAACGCGTAGACGACGGATTTTCTTGGCTGTCCTGTGTCTTGCCGCGCTCGGCGCGGGCGCCTG
GGCGTGGGACAGGAAGCCGTGGGCCAGCGCCGCGGCGCCAAAGCCGCAGGGCGCGCCGAGCCGGGTCGTCGCCGTGCTGG
CCGCCAAGGCCGAGCGCACGGCCCTTCCGGTCCGGGTGGAGGCGCTGGGCACCGTGGAATCCATGGTCACCGTGCCCATC
CGCTCGCGCGTGGCGGCGGCGGTGGAAAAGGTCGGCTTTGCCGACGGCGCCTTCGTGAAGGAGGGCGACCTGCTCTTCGC
CCTCGATTCCCGCGTCATTGACGCCGAGATCCGCCAGTCCGAGGCGACGCTGGCCCGTGACAAGGTGCAACTGGAGAAGA
CCCGGCGCGACGTGGAGCGCTACACCGGCCTTGCCGCGCGCAACGCGGTCTCCCAGGTGCAAGTGGACGACGCCAAGACC
ACTGCCGACGTGCAGAAAGCCACCGTGGCGCAGGACGAGGCCAACCTGCAGTCGCTCAAGGTCCAGCGCGGCTATTACGA
CATCCGCTCCCCGGCTTCCGGTCGCATCGGCGTTGCGGCGGCCCGGCCCGGCGCGGTGATCCGCGTGGACGACATCCTCG
CCACGGTGCGCCAGCTGAAGCCCATCTATGTCGCCTTCGGCCTGCCGGAACGCTACATCGCCGACCTGCGCGCGGCCCAG
GACGCCAACGTCTCCATCACCCTCCAGGGTTCGGGCGAGACCATCTCCGACGGCAGGGTGGCGGTGATCGACAATACGGT
GGACCCGCAGACCGGGACCCTCACCGCCCGCGCCATCTTTGCCAATGCGGACGAGCGGCTGTGGCCGGGCACGCTCGGCG
CCGTCACCGTGACGCTGCGGATGGAGTCCGACATCGTCGCCGTGCCCAGCGAGGCGGTGCAGAACGGGCAGGATGGCACC
TTCGTGTTCGTGGTGGAGGACGGCATCGCCAGGGTGAGGCCGGTCACCACCACGCGCACGGTGGAGGGACGCTCCGTCAT
CACCAGGGGGCTCTCCGGCGGCGAGACGGTGGTCACCGATGGCCAGCTCTCCCTGCGCAACGGCAGCCGGGTGAACGTGC
GCAACCCCGCGCAGCCTGCCGCCGGGAGCTGA

Upstream 100 bases:

>100_bases
GAGCGGAAAGACGGTTTCAGGAAGGCGGGAGGCGGGGTGCCGATCGGGTCGAGCGATCCTGATGGCCTCCGGCTTCGGCG
TTGGGTCGATCGAGGTTTGC

Downstream 100 bases:

>100_bases
TCCGCCATGTTCGCCGAACTGTGCATCCGCCGCCCCGTCATGACGACGCTGATGATGCTGTCGCTGATCGTGGCGGGCCT
GTTCGCCTATCGCCAGCTGC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSAETGTRRRRIFLAVLCLAALGAGAWAWDRKPWASAAAPKPQGAPSRVVAVLAAKAERTALPVRVEALGTVESMVTVPI
RSRVAAAVEKVGFADGAFVKEGDLLFALDSRVIDAEIRQSEATLARDKVQLEKTRRDVERYTGLAARNAVSQVQVDDAKT
TADVQKATVAQDEANLQSLKVQRGYYDIRSPASGRIGVAAARPGAVIRVDDILATVRQLKPIYVAFGLPERYIADLRAAQ
DANVSITLQGSGETISDGRVAVIDNTVDPQTGTLTARAIFANADERLWPGTLGAVTVTLRMESDIVAVPSEAVQNGQDGT
FVFVVEDGIARVRPVTTTRTVEGRSVITRGLSGGETVVTDGQLSLRNGSRVNVRNPAQPAAGS

Sequences:

>Translated_383_residues
MSAETGTRRRRIFLAVLCLAALGAGAWAWDRKPWASAAAPKPQGAPSRVVAVLAAKAERTALPVRVEALGTVESMVTVPI
RSRVAAAVEKVGFADGAFVKEGDLLFALDSRVIDAEIRQSEATLARDKVQLEKTRRDVERYTGLAARNAVSQVQVDDAKT
TADVQKATVAQDEANLQSLKVQRGYYDIRSPASGRIGVAAARPGAVIRVDDILATVRQLKPIYVAFGLPERYIADLRAAQ
DANVSITLQGSGETISDGRVAVIDNTVDPQTGTLTARAIFANADERLWPGTLGAVTVTLRMESDIVAVPSEAVQNGQDGT
FVFVVEDGIARVRPVTTTRTVEGRSVITRGLSGGETVVTDGQLSLRNGSRVNVRNPAQPAAGS
>Mature_382_residues
SAETGTRRRRIFLAVLCLAALGAGAWAWDRKPWASAAAPKPQGAPSRVVAVLAAKAERTALPVRVEALGTVESMVTVPIR
SRVAAAVEKVGFADGAFVKEGDLLFALDSRVIDAEIRQSEATLARDKVQLEKTRRDVERYTGLAARNAVSQVQVDDAKTT
ADVQKATVAQDEANLQSLKVQRGYYDIRSPASGRIGVAAARPGAVIRVDDILATVRQLKPIYVAFGLPERYIADLRAAQD
ANVSITLQGSGETISDGRVAVIDNTVDPQTGTLTARAIFANADERLWPGTLGAVTVTLRMESDIVAVPSEAVQNGQDGTF
VFVVEDGIARVRPVTTTRTVEGRSVITRGLSGGETVVTDGQLSLRNGSRVNVRNPAQPAAGS

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=367, Percent_Identity=30.7901907356948, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789665, Length=383, Percent_Identity=27.154046997389, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789929, Length=382, Percent_Identity=27.4869109947644, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786668, Length=357, Percent_Identity=27.7310924369748, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40650; Mature: 40518

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAETGTRRRRIFLAVLCLAALGAGAWAWDRKPWASAAAPKPQGAPSRVVAVLAAKAERT
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ALPVRVEALGTVESMVTVPIRSRVAAAVEKVGFADGAFVKEGDLLFALDSRVIDAEIRQS
CCCEEEEHHHCHHHHEEHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCEEEEHHHHHH
EATLARDKVQLEKTRRDVERYTGLAARNAVSQVQVDDAKTTADVQKATVAQDEANLQSLK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCHHHEE
VQRGYYDIRSPASGRIGVAAARPGAVIRVDDILATVRQLKPIYVAFGLPERYIADLRAAQ
EECCEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCC
DANVSITLQGSGETISDGRVAVIDNTVDPQTGTLTARAIFANADERLWPGTLGAVTVTLR
CCCEEEEEECCCCEECCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEE
MESDIVAVPSEAVQNGQDGTFVFVVEDGIARVRPVTTTRTVEGRSVITRGLSGGETVVTD
ECCCEEECCHHHHHCCCCCEEEEEEECCCCCEECCEEEEEECCHHHHHCCCCCCCEEEEC
GQLSLRNGSRVNVRNPAQPAAGS
CEEEECCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
SAETGTRRRRIFLAVLCLAALGAGAWAWDRKPWASAAAPKPQGAPSRVVAVLAAKAERT
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ALPVRVEALGTVESMVTVPIRSRVAAAVEKVGFADGAFVKEGDLLFALDSRVIDAEIRQS
CCCEEEEHHHCHHHHEEHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCEEEEHHHHHH
EATLARDKVQLEKTRRDVERYTGLAARNAVSQVQVDDAKTTADVQKATVAQDEANLQSLK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCHHHEE
VQRGYYDIRSPASGRIGVAAARPGAVIRVDDILATVRQLKPIYVAFGLPERYIADLRAAQ
EECCEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCC
DANVSITLQGSGETISDGRVAVIDNTVDPQTGTLTARAIFANADERLWPGTLGAVTVTLR
CCCEEEEEECCCCEECCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEE
MESDIVAVPSEAVQNGQDGTFVFVVEDGIARVRPVTTTRTVEGRSVITRGLSGGETVVTD
ECCCEEECCHHHHHCCCCCEEEEEEECCCCCEECCEEEEEECCHHHHHCCCCCCCEEEEC
GQLSLRNGSRVNVRNPAQPAAGS
CEEEECCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA