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The map label for this gene is clpA [C]

Identifier: 154248456

GI number: 154248456

Start: 5012455

End: 5014926

Strand: Reverse

Name: clpA [C]

Synonym: Xaut_4536

Alternate gene names: 154248456

Gene position: 5014926-5012455 (Counterclockwise)

Preceding gene: 154248457

Following gene: 154248454

Centisome position: 94.46

GC content: 66.55

Gene sequence:

>2472_bases
ATGCCTACATTCTCACGCAGCCTCGAACAGTCGCTCCATCGCGCTCTGGCCCTCGCCAACGAACGCCACCACGAATACGC
GACCCTCGAGCATCTGCTTCTCTCCCTGGTGGACGATCAGGACGCCGCCGCTGTCATGCGGGCCTGCAACGTCGACATGG
AGAAGCTTCGTCGCAATCTCATCGAATACGTGGACACGGAACTGGAAAATCTCGTCCAGTCCGGCTCGGATGATTCCAAG
CCCACTGCCGGCTTCCAGCGCGTCATCCAGCGCGCGGTCATCCACGTGCAGTCCTCCGGCCGGGAAGAGGTGACAGGGGC
CAACGTGCTCGTCGCCATTTTCGCCGAGCGTGAGAGCCATGCCGCCTATTTCCTGCAGGAGCAGGACATGACGCGGTACG
ACGCGGTCAACTACATCTCCCACGGCATCGCCAAGCGCTCGGGCATGTCCGAGAGCCGCCCCGTGCGCGGCGCCGAGGAG
GAGACCGAGACCAAGTCCGGCGACGACACCAAGAAGAAGGCCGACGCGCTCGACGCCTATTGCGTCAACCTCAACAAGAA
GGCGCACGAGGGCAAGATCGATCCCCTCATTGGCCGCGACCAGGAGATCACCCGCACCATCCAGGTGCTGTGCCGCCGGC
AGAAGAACAACCCGCTGTTCGTGGGCGACCCGGGCGTGGGCAAGACCGCCATCGCCGAGGGCCTCGCCAAGCGCATCAAC
GACGGCGACGTGCCGGAGGTGCTCGCCACCGCGACCGTGTTCGCCCTCGACATGGGCGCGCTGCTCGCCGGTACCCGCTA
TCGCGGCGACTTCGAGGAGCGCCTCAAGCAGGTGGTGAAGGAGATCGAGGCCTACCCGAACGCGATCATGTTCATCGACG
AGATCCACACGGTCATCGGTGCCGGTGCGACCTCGGGCGGGGCCATGGACGCCTCCAACCTGCTGAAGCCGGCGCTCGCC
TCGGGCAGCCTGCGCTGCATGGGCTCGACCACCTACAAGGAATACCGTCAGTATTTCGAGAAGGACCGGGCGCTGGTGCG
GCGGTTCCAGAAGATCGACGTGGCGGAGCCGTCTGTCGCCGACGCCATCGAGATCCTCAAGGGCCTCAAGCCTTGCTTCG
AGGACTATCACAAGCTGCGCTACACCAACGACGCCATCAAGGCGGCGGTGGAGCTGTCGGCCCGCTACATCCACGACCGC
AAGCTGCCGGACAAGGCGATCGACGTGATCGACGAGTCGGGTGCGGCGCAGATGCTGCTGCCCGAGGCCAAGCGCAAGAA
GACCATCGGCCTGAAGGAGATCGAGGCCACCATCGCCACCATGGCGCGGATCCCGCCCAAGACCATCTCGAAGGACGATG
CCGAGGTGCTGGCCACCCTGCGCACCACCCTGAAGCGTGTGGTCTACGGGCAGGACAAGGCCATCGATGCGCTGGCCGCC
TCCATCAAGCTGGCCCGCGCTGGGCTGCGGGAACCGGAGAAGCCCATCGGCTCCTACCTGTTCTCCGGCCCCACCGGCGT
CGGCAAGACGGAAGTGGCCAAGCAGCTCGCCTCCGTGCTGGGCGTGCAGCTGCTGCGCTTCGACATGTCGGAGTACATGG
AGCGCCACACGGTCAGCCGCCTCATCGGCGCGCCTCCGGGCTATGTGGGCTTCGACCAGGGCGGCCTGCTCACCGACGGG
GTGGACCAGAACCCGCACTGCGTGCTGCTGCTGGACGAGATCGAGAAGGCCCATCCGGACCTCTTCAACATCCTGCTGCA
GGTGATGGACCACGGGAAGCTGACCGACCACAACGGCAAGCAGATCGACTTCCGCAACGTGATCCTGATCATGACCACCA
ACGCCGGCGCGGCGGACTTGGCGAAGCCCGCCTACGGCTTCACCCGCACCAAGCGCGAGGGCGACGATTCGGAGGCCATC
AACCGGACCTTCGCGCCGGAGTTCCGCAACCGTCTCGACGCGGTGATCCCGTTCGGCCACCTGCCGCCCGAGGTCATCAC
CCAGGTGGTGGAGAAGTTCGTGCTCCAGCTGGAGGCCCAGCTGGCGGACCGCAACGTCACCATCGAGCTGTCCGACGAGG
CCGGCGCGTGGCTGGTGGATCGCGGCTACGACGAGCACATGGGTGCGCGGCCCATGGCCCGCGTGATCCAGGAGCACATC
AAGACCCCGCTCGCCGATCTCGTCCTGTTCGGCGCGCTGAAGAATGGCGGCCATGTCCGCGTGGTGGTGGAGGGCGAGGG
CACCGACTCGAAGCTCGGCTTCGAGTTCCCCGAAGGCCCCGTCACCCCCAAGCCGGACAAGATCGCCCCGGAACCGGCCA
AGCGCCGCAAGCCGGCGGCCAAGGCGAAGGCCTCCCGCCCCGGTTCCAAGGGACCCAAGAGCGGGCCCAAGGGGCCCAAG
TCCGGTGGTCCCGCGGGTGGCTCCGGTCGTTCCGGCAGCCCGGTGCCCAAGCTGCCGCTGGTGAAGGCCTGA

Upstream 100 bases:

>100_bases
GCACTGCGGCATCCGGTACGAAGTTTGTGTGAATGGTGCACGCGCTCCCCAAGCTGGCGGGGTTTCCGAGGGCCGGGAGC
GATGCGCGAAAGAGGTGTCG

Downstream 100 bases:

>100_bases
GCGCCCAACCGGCTGAGACAAAAAGAAAGAGGCGGCTTCGGCCGCCTCTTTTCGTTTCCGGGGGATGGTGCTCGAAATTG
GAAGCGGGCGAAGGCGCCTA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MPTFSRSLEQSLHRALALANERHHEYATLEHLLLSLVDDQDAAAVMRACNVDMEKLRRNLIEYVDTELENLVQSGSDDSK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRSGMSESRPVRGAEE
ETETKSGDDTKKKADALDAYCVNLNKKAHEGKIDPLIGRDQEITRTIQVLCRRQKNNPLFVGDPGVGKTAIAEGLAKRIN
DGDVPEVLATATVFALDMGALLAGTRYRGDFEERLKQVVKEIEAYPNAIMFIDEIHTVIGAGATSGGAMDASNLLKPALA
SGSLRCMGSTTYKEYRQYFEKDRALVRRFQKIDVAEPSVADAIEILKGLKPCFEDYHKLRYTNDAIKAAVELSARYIHDR
KLPDKAIDVIDESGAAQMLLPEAKRKKTIGLKEIEATIATMARIPPKTISKDDAEVLATLRTTLKRVVYGQDKAIDALAA
SIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLASVLGVQLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDG
VDQNPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGAADLAKPAYGFTRTKREGDDSEAI
NRTFAPEFRNRLDAVIPFGHLPPEVITQVVEKFVLQLEAQLADRNVTIELSDEAGAWLVDRGYDEHMGARPMARVIQEHI
KTPLADLVLFGALKNGGHVRVVVEGEGTDSKLGFEFPEGPVTPKPDKIAPEPAKRRKPAAKAKASRPGSKGPKSGPKGPK
SGGPAGGSGRSGSPVPKLPLVKA

Sequences:

>Translated_823_residues
MPTFSRSLEQSLHRALALANERHHEYATLEHLLLSLVDDQDAAAVMRACNVDMEKLRRNLIEYVDTELENLVQSGSDDSK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRSGMSESRPVRGAEE
ETETKSGDDTKKKADALDAYCVNLNKKAHEGKIDPLIGRDQEITRTIQVLCRRQKNNPLFVGDPGVGKTAIAEGLAKRIN
DGDVPEVLATATVFALDMGALLAGTRYRGDFEERLKQVVKEIEAYPNAIMFIDEIHTVIGAGATSGGAMDASNLLKPALA
SGSLRCMGSTTYKEYRQYFEKDRALVRRFQKIDVAEPSVADAIEILKGLKPCFEDYHKLRYTNDAIKAAVELSARYIHDR
KLPDKAIDVIDESGAAQMLLPEAKRKKTIGLKEIEATIATMARIPPKTISKDDAEVLATLRTTLKRVVYGQDKAIDALAA
SIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLASVLGVQLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDG
VDQNPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGAADLAKPAYGFTRTKREGDDSEAI
NRTFAPEFRNRLDAVIPFGHLPPEVITQVVEKFVLQLEAQLADRNVTIELSDEAGAWLVDRGYDEHMGARPMARVIQEHI
KTPLADLVLFGALKNGGHVRVVVEGEGTDSKLGFEFPEGPVTPKPDKIAPEPAKRRKPAAKAKASRPGSKGPKSGPKGPK
SGGPAGGSGRSGSPVPKLPLVKA
>Mature_822_residues
PTFSRSLEQSLHRALALANERHHEYATLEHLLLSLVDDQDAAAVMRACNVDMEKLRRNLIEYVDTELENLVQSGSDDSKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRSGMSESRPVRGAEEE
TETKSGDDTKKKADALDAYCVNLNKKAHEGKIDPLIGRDQEITRTIQVLCRRQKNNPLFVGDPGVGKTAIAEGLAKRIND
GDVPEVLATATVFALDMGALLAGTRYRGDFEERLKQVVKEIEAYPNAIMFIDEIHTVIGAGATSGGAMDASNLLKPALAS
GSLRCMGSTTYKEYRQYFEKDRALVRRFQKIDVAEPSVADAIEILKGLKPCFEDYHKLRYTNDAIKAAVELSARYIHDRK
LPDKAIDVIDESGAAQMLLPEAKRKKTIGLKEIEATIATMARIPPKTISKDDAEVLATLRTTLKRVVYGQDKAIDALAAS
IKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLASVLGVQLLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDGV
DQNPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGAADLAKPAYGFTRTKREGDDSEAIN
RTFAPEFRNRLDAVIPFGHLPPEVITQVVEKFVLQLEAQLADRNVTIELSDEAGAWLVDRGYDEHMGARPMARVIQEHIK
TPLADLVLFGALKNGGHVRVVVEGEGTDSKLGFEFPEGPVTPKPDKIAPEPAKRRKPAAKAKASRPGSKGPKSGPKGPKS
GGPAGGSGRSGSPVPKLPLVKA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=347, Percent_Identity=33.7175792507205, Blast_Score=172, Evalue=2e-42,
Organism=Escherichia coli, GI1787109, Length=753, Percent_Identity=56.8393094289509, Blast_Score=892, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=263, Percent_Identity=57.7946768060836, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=44.3425076452599, Blast_Score=283, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=396, Percent_Identity=39.1414141414141, Blast_Score=256, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 89931; Mature: 89800

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSRSLEQSLHRALALANERHHEYATLEHLLLSLVDDQDAAAVMRACNVDMEKLRRNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
IEYVDTELENLVQSGSDDSKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRSGMSESRPVRGAEEETETKSGDDTKKKADALDAY
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
CVNLNKKAHEGKIDPLIGRDQEITRTIQVLCRRQKNNPLFVGDPGVGKTAIAEGLAKRIN
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
DGDVPEVLATATVFALDMGALLAGTRYRGDFEERLKQVVKEIEAYPNAIMFIDEIHTVIG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
AGATSGGAMDASNLLKPALASGSLRCMGSTTYKEYRQYFEKDRALVRRFQKIDVAEPSVA
CCCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DAIEILKGLKPCFEDYHKLRYTNDAIKAAVELSARYIHDRKLPDKAIDVIDESGAAQMLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHC
PEAKRKKTIGLKEIEATIATMARIPPKTISKDDAEVLATLRTTLKRVVYGQDKAIDALAA
CHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLASVLGVQLLRFDMSEYMERHTVSR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAPPGYVGFDQGGLLTDGVDQNPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGK
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCC
QIDFRNVILIMTTNAGAADLAKPAYGFTRTKREGDDSEAINRTFAPEFRNRLDAVIPFGH
EEEECCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCC
LPPEVITQVVEKFVLQLEAQLADRNVTIELSDEAGAWLVDRGYDEHMGARPMARVIQEHI
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCHHHCCCCHHHHHHHHHH
KTPLADLVLFGALKNGGHVRVVVEGEGTDSKLGFEFPEGPVTPKPDKIAPEPAKRRKPAA
HCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHH
KAKASRPGSKGPKSGPKGPKSGGPAGGSGRSGSPVPKLPLVKA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTFSRSLEQSLHRALALANERHHEYATLEHLLLSLVDDQDAAAVMRACNVDMEKLRRNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
IEYVDTELENLVQSGSDDSKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRSGMSESRPVRGAEEETETKSGDDTKKKADALDAY
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
CVNLNKKAHEGKIDPLIGRDQEITRTIQVLCRRQKNNPLFVGDPGVGKTAIAEGLAKRIN
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
DGDVPEVLATATVFALDMGALLAGTRYRGDFEERLKQVVKEIEAYPNAIMFIDEIHTVIG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
AGATSGGAMDASNLLKPALASGSLRCMGSTTYKEYRQYFEKDRALVRRFQKIDVAEPSVA
CCCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DAIEILKGLKPCFEDYHKLRYTNDAIKAAVELSARYIHDRKLPDKAIDVIDESGAAQMLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHC
PEAKRKKTIGLKEIEATIATMARIPPKTISKDDAEVLATLRTTLKRVVYGQDKAIDALAA
CHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLASVLGVQLLRFDMSEYMERHTVSR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAPPGYVGFDQGGLLTDGVDQNPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGK
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCC
QIDFRNVILIMTTNAGAADLAKPAYGFTRTKREGDDSEAINRTFAPEFRNRLDAVIPFGH
EEEECCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCC
LPPEVITQVVEKFVLQLEAQLADRNVTIELSDEAGAWLVDRGYDEHMGARPMARVIQEHI
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCHHHCCCCHHHHHHHHHH
KTPLADLVLFGALKNGGHVRVVVEGEGTDSKLGFEFPEGPVTPKPDKIAPEPAKRRKPAA
HCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHH
KAKASRPGSKGPKSGPKGPKSGGPAGGSGRSGSPVPKLPLVKA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]