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The map label for this gene is iscS [H]

Identifier: 154248390

GI number: 154248390

Start: 4961548

End: 4962822

Strand: Reverse

Name: iscS [H]

Synonym: Xaut_4470

Alternate gene names: 154248390

Gene position: 4962822-4961548 (Counterclockwise)

Preceding gene: 154248392

Following gene: 154248389

Centisome position: 93.48

GC content: 73.02

Gene sequence:

>1275_bases
ATGAGCGCGGGCGGCATCCCGGGATCGCAGGATCCCAGGTCGCAGGATCCTCGGTCGCAGGATCGGTCTGAGGCCGGGGC
AGGTGTGCCCGCGGCCAATGCTGCCGCGCGCCGCGCCTATCTCGATCACAATGCCACCAGCCCCCTGAAGCGCGAAGCCC
GTGACGCCATGCTCGCGGCGCTGGAATGCGTGGGCAATGCCTCCTCCGTCCATGCCGATGGCCGCGCCGCCCGAGCGCGC
ATGGAGGCGGCGCGGGCGCATGTGGCCCGCCTCGTGGGCGCCGCGCCGCGTGGGGTGGTCTTCACCTCCGGCGCTACGGA
GGCGGCCGCGCTGGCGCTGCATCCGGCGGTAGAGATGGCCGGCCGGCCCAAGCCCTGCGACGTGCTGCTCATGAGCGCGG
TGGAGCATCCCGCCGTGCTGCGCGGCCATCGCTTTGCCGCCGAGGCAGTGGAGGTGCTGCCCGTGGACGACGCCGGCCGC
TTCCAACTCGATGCGCTGGAAGAATCCCTCGCCCGCCATGCCGCCGCCGGCCGCCGCGCTTTGCTGGCGCTGATGGCGGC
CAACAACGAGACCGGTGTGGTCCAGCCGGTGGCGCAGGCCGCGCGGCTGGTGAAGGCGCGCGATGGCGTGGTGTTCTGCG
ACGCCGTGCAGGCCGCTGGCCGCCTGCCGCTGGACATGGCGGCGCTGGGCGTCGATTTCCTCAGCCTCTCCGCGCACAAG
ATGGGCGGCCCCCAGGGCACCGGAGCGCTGGTGGCGGCGGGGCCTGATGATCGCACACCGGCCCTCATCGCCGGTGGCGG
GCAGGAGCGCGGCCGTCGCGCGGGGACCGAAAACGGCCCGGCCATCGCCGGCTTCGGCGCCGTCGCCGGCGTGGCGTGCG
CCGATCTGGCCGAAGAGGCCGCCCGCCTTGCGACCTTGCGCGATGCGCTGGAACGGGCGGTGCTGGCCGGCGTTCCCGAT
GCAGAGGTCATCGGTTCCGGGGCGGAGCGGCTACCCAATACCAGCATGCTCACTTTCGCCGGACTTCGGGCCGAGACACT
GGTGATCGCGCTCGACCTTGCCCACGTAAGTGTCAGTGCGGGCTCGGCCTGCTCCTCGGGCAAGGTGGGCGCCTCCCATG
TGCTGTCGGCCATGGGCGTTCCCGAGGACCGTGCGGCGGGCGCCATCCGCCTCTCGCTGGGCTGGTCCAGCACCCGGCAG
GATGTGGACGAGGCGGTGGCGGCCTTGCAAAAGGTGGTGCCGCACCTGAGAAGCCGCGCGGTCCGCGCGGCGTAG

Upstream 100 bases:

>100_bases
GCGGGATCGGGTGAAGTTTGAGCTATGACCGAGATTGCCGGCAATTGCAAGTCTGGCGCGGGTCCGGAGCGTGTTTCGCG
CGAGGGGCCAGGAGGCGGAG

Downstream 100 bases:

>100_bases
AAGTAAAGAGCCTGGACCCGCGCAGGCTGCGCGGCTGAGGGGCGGAAATTCAGGACCCGCGCGTCATGCGCGGCATGAGA
CGTAAGACGTGAACTTGACC

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSAGGIPGSQDPRSQDPRSQDRSEAGAGVPAANAAARRAYLDHNATSPLKREARDAMLAALECVGNASSVHADGRAARAR
MEAARAHVARLVGAAPRGVVFTSGATEAAALALHPAVEMAGRPKPCDVLLMSAVEHPAVLRGHRFAAEAVEVLPVDDAGR
FQLDALEESLARHAAAGRRALLALMAANNETGVVQPVAQAARLVKARDGVVFCDAVQAAGRLPLDMAALGVDFLSLSAHK
MGGPQGTGALVAAGPDDRTPALIAGGGQERGRRAGTENGPAIAGFGAVAGVACADLAEEAARLATLRDALERAVLAGVPD
AEVIGSGAERLPNTSMLTFAGLRAETLVIALDLAHVSVSAGSACSSGKVGASHVLSAMGVPEDRAAGAIRLSLGWSSTRQ
DVDEAVAALQKVVPHLRSRAVRAA

Sequences:

>Translated_424_residues
MSAGGIPGSQDPRSQDPRSQDRSEAGAGVPAANAAARRAYLDHNATSPLKREARDAMLAALECVGNASSVHADGRAARAR
MEAARAHVARLVGAAPRGVVFTSGATEAAALALHPAVEMAGRPKPCDVLLMSAVEHPAVLRGHRFAAEAVEVLPVDDAGR
FQLDALEESLARHAAAGRRALLALMAANNETGVVQPVAQAARLVKARDGVVFCDAVQAAGRLPLDMAALGVDFLSLSAHK
MGGPQGTGALVAAGPDDRTPALIAGGGQERGRRAGTENGPAIAGFGAVAGVACADLAEEAARLATLRDALERAVLAGVPD
AEVIGSGAERLPNTSMLTFAGLRAETLVIALDLAHVSVSAGSACSSGKVGASHVLSAMGVPEDRAAGAIRLSLGWSSTRQ
DVDEAVAALQKVVPHLRSRAVRAA
>Mature_423_residues
SAGGIPGSQDPRSQDPRSQDRSEAGAGVPAANAAARRAYLDHNATSPLKREARDAMLAALECVGNASSVHADGRAARARM
EAARAHVARLVGAAPRGVVFTSGATEAAALALHPAVEMAGRPKPCDVLLMSAVEHPAVLRGHRFAAEAVEVLPVDDAGRF
QLDALEESLARHAAAGRRALLALMAANNETGVVQPVAQAARLVKARDGVVFCDAVQAAGRLPLDMAALGVDFLSLSAHKM
GGPQGTGALVAAGPDDRTPALIAGGGQERGRRAGTENGPAIAGFGAVAGVACADLAEEAARLATLRDALERAVLAGVPDA
EVIGSGAERLPNTSMLTFAGLRAETLVIALDLAHVSVSAGSACSSGKVGASHVLSAMGVPEDRAAGAIRLSLGWSSTRQD
VDEAVAALQKVVPHLRSRAVRAA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=413, Percent_Identity=37.046004842615, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI156713448, Length=426, Percent_Identity=34.9765258215962, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI48994898, Length=390, Percent_Identity=36.6666666666667, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789175, Length=408, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787970, Length=377, Percent_Identity=26.2599469496021, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25143064, Length=374, Percent_Identity=35.8288770053476, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17533177, Length=325, Percent_Identity=29.8461538461538, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=388, Percent_Identity=34.5360824742268, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI20129463, Length=415, Percent_Identity=34.4578313253012, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42984; Mature: 42853

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGGIPGSQDPRSQDPRSQDRSEAGAGVPAANAAARRAYLDHNATSPLKREARDAMLAA
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LECVGNASSVHADGRAARARMEAARAHVARLVGAAPRGVVFTSGATEAAALALHPAVEMA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHC
GRPKPCDVLLMSAVEHPAVLRGHRFAAEAVEVLPVDDAGRFQLDALEESLARHAAAGRRA
CCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHH
LLALMAANNETGVVQPVAQAARLVKARDGVVFCDAVQAAGRLPLDMAALGVDFLSLSAHK
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHH
MGGPQGTGALVAAGPDDRTPALIAGGGQERGRRAGTENGPAIAGFGAVAGVACADLAEEA
CCCCCCCCEEEECCCCCCCCEEEECCCHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHH
ARLATLRDALERAVLAGVPDAEVIGSGAERLPNTSMLTFAGLRAETLVIALDLAHVSVSA
HHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCEEEEECCCCCEEEEEEEHHHEEECC
GSACSSGKVGASHVLSAMGVPEDRAAGAIRLSLGWSSTRQDVDEAVAALQKVVPHLRSRA
CCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VRAA
HCCC
>Mature Secondary Structure 
SAGGIPGSQDPRSQDPRSQDRSEAGAGVPAANAAARRAYLDHNATSPLKREARDAMLAA
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LECVGNASSVHADGRAARARMEAARAHVARLVGAAPRGVVFTSGATEAAALALHPAVEMA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHC
GRPKPCDVLLMSAVEHPAVLRGHRFAAEAVEVLPVDDAGRFQLDALEESLARHAAAGRRA
CCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHH
LLALMAANNETGVVQPVAQAARLVKARDGVVFCDAVQAAGRLPLDMAALGVDFLSLSAHK
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHH
MGGPQGTGALVAAGPDDRTPALIAGGGQERGRRAGTENGPAIAGFGAVAGVACADLAEEA
CCCCCCCCEEEECCCCCCCCEEEECCCHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHH
ARLATLRDALERAVLAGVPDAEVIGSGAERLPNTSMLTFAGLRAETLVIALDLAHVSVSA
HHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCEEEEECCCCCEEEEEEEHHHEEECC
GSACSSGKVGASHVLSAMGVPEDRAAGAIRLSLGWSSTRQDVDEAVAALQKVVPHLRSRA
CCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VRAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA