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The map label for this gene is fadN [H]

Identifier: 154248364

GI number: 154248364

Start: 4931662

End: 4934031

Strand: Direct

Name: fadN [H]

Synonym: Xaut_4444

Alternate gene names: 154248364

Gene position: 4931662-4934031 (Clockwise)

Preceding gene: 154248363

Following gene: 154248365

Centisome position: 92.89

GC content: 67.59

Gene sequence:

>2370_bases
ATGACCAGCGAAACCGATATCAAGAGCTTCGCCGACATCGGCGGGTTCGACATCAAGAAGGTGGCGGTCATCGGCGCCGG
CGTCATGGGCGCGGGCATCGCCGCCCATGTGGCCAACGCCGGTATTGAGGTATTGCTCCTCGACATCGTCCCGGAGGGCG
CCGCCAACCGCAATGCCATCGCCGAGAAGGCGGTGGAGAAGCTGCTGAAGGCCGACCCCGCCGCCTTCATGTCGAAGCGC
GCGGCCAAGCTCGTGACCGCCGGCAACATCGAGGACAATCTCTCAGATCTTGCCAGCTGCGACTGGATCGTGGAGGCGGT
GATCGAGCGCCTCGACATCAAGCAGGCGCTCTACGCCAAGATCGAGGCCGCCCGCCGGCCGGGCTCGGCGGTGTCGTCCA
ACACCTCCACCATCCCGCTGGGCGACCTCACAGCCGGGCTGCCGGAGAGCTTCAGGCGCGACTTCCTCATCACCCACTTC
TTCAACCCGCCGCGCTACATGCGGCTGCTGGAGATCGTGGCAGGGCCTGAGACCAATCCGGCCACGGTGGCCGCAGTCGC
CCGCTTCGCCGACGTGAAGCTGGGCAAGACGGTGGTGACCTGCAAGGACACCCCCGGCTTCATCGCCAACCGGCTCGGCA
CCTACTGGCTGCAGCTCGCCGTGGGCGAGGCCTTCCGCCTCGGCCTGAAGGTGGAGGAGGCAGACGCTGTCATGGGCCGG
CCGTTCGGCTTCCCCAAGACCGGTGTGTTCGGCCTGATCGACCTCGTGGGCCTCGACCTGATGCCCCATGTGCAGGGCTC
CCTGAAGCGCGCGCTGCCGGCCTCCGACCCGTTCCACGCCACCCTGCGCGACGAGCCGCTGATCTCGAAGATGATCGAGA
CCGGCTATATCGGCCGCAAGGGCAAGGGCGGCTTCTACCGGCTCAACCGGGAGAACGGCGGCAAGGCGAAGGAGGCCATC
GACCTTTCAACCGGCGCCTACCGCCCGCAGGAAAAGGCGAGCGTGCCGGAGCTGGAGGACGGCGGCGGCAAGGACATCTT
CGCCCTCCTTTCCGCGCCGGGAACGGCGGGGCGCTATGCCCGCTCGGTGATGGCGAAGACGCTGGCCTATGCGGCGCGCC
TCGTGCCCGAGGCGGCGGACGACATCGTCGCCATCGATGATGCCATGCGCCTGGGCTACAACTGGAAATTCGGCCCGTTC
GAGCTGATCGACAAGATCGGCGCCGCCCGCCTCGCCGGCCTGCTCGCGGCCGATGGCGAGGAGGTCCCGGCCCTGCTGGC
GCTGGCCGCCGACACCCCCTTCTACCGGGTGGAGAATGGCAAGCGGCAGTATCTCGCCCTCGACGGCAGCTATCGCGACG
TGGTGCGGCCGGACGGCGTGCTGCTGCTCGCGGACATCAAGCTGAAGTCGCAGCCGCTGCTCAAGAATGGCTCCGCCGCC
CTGTGGGATATCGGCGACGGGGTGGTGTGCCTGGAATTCACCTCCAAGAGCAATTCGCTGGACGAGGGCATCATCACGAT
GCTCGCCAAGGCGCTGAAGCTGGTGAAGGACAAGCACAAGGCGCTCGTCATCTATAACGAGGGCTCGAACTTCTCGGTGG
GCGCGAATCTCGGCCTCGCGCTGTTTGCCTGCAACATCGGCGCCTTCGGCGAGGTGGAAAAGCTGGTCGCCACCGGCCAG
AAGACCTACCAGGACATGAAATACGCCCCCTTCCCGGTGGTGGCGGCCCCCTCGGGGCTGGCGCTCGGCGGCGGGTGCGA
GATCCTGCTCCACGCCAGCGCCGTGCAGGCCCATGCGGAGAGCTATATCGGCCTGGTGGAATGCGGCGTGGGCGTGCTGC
CCGCCTGGGGCGGCTGCACCGCCATGCTGGAGCGCTGGGCCACCGATCCGAAATTCCCCAAGGGGCCCATGCCGGCGCCC
TCCAAGGTGTTCGAGACGGTCTCCACCGCCACCGTGGCGAAGTCCGCCGCCGAGGCCAAGGAGCTGAAATTCCTGCGCGA
AAGCGACGGCATCACCATGAACCGCGACCGGCTGCTTGCCGACGCCAAGGCGAAAGCCCTGGCGCTGGTGGAGGGCTATG
CGCCGCCCAAGCCCGTGGAGTTCTTCCTGCCGGGTCCCACCGGCAAGGTGGCCATGGACATGGCAGTGGCGGGCTTCGCC
AAGCGCGGCATGGCGACGAAGCACGACAAGGTGGTCTCCGGCGTGCTGGCGGAAGTGCTCACCGGCGGCAGCGCCGACCA
CATCGAACCGGTGCCCGCCGCCAGGGTGCTGGAACTGGAGCGCGACGGCTTCATGAAGCTCATCCGCACCACCGCCACGC
TGGACCGCATCGAGCACATTCTCGAAACGGGGCGGCCGCTCAGGAACTGA

Upstream 100 bases:

>100_bases
TGCTGAAGCGGGAAGGCGGCAAATATGCCCTCGCCACCCAGTGCATCGGCGGCGGACAGGGCATCGCCACCGTCCTCGAA
CGCGTCTGAGGGGGCGCGTC

Downstream 100 bases:

>100_bases
GGCCCTCGCGGTCTCCCTCTCCCGCTCCGAAGCCGGATGTTTCCGGCTTCGGCCCTCGGAAGTCGAGTTCGGCTGTTACC
GAGTTCGGGCGGGGGAGGGT

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MTSETDIKSFADIGGFDIKKVAVIGAGVMGAGIAAHVANAGIEVLLLDIVPEGAANRNAIAEKAVEKLLKADPAAFMSKR
AAKLVTAGNIEDNLSDLASCDWIVEAVIERLDIKQALYAKIEAARRPGSAVSSNTSTIPLGDLTAGLPESFRRDFLITHF
FNPPRYMRLLEIVAGPETNPATVAAVARFADVKLGKTVVTCKDTPGFIANRLGTYWLQLAVGEAFRLGLKVEEADAVMGR
PFGFPKTGVFGLIDLVGLDLMPHVQGSLKRALPASDPFHATLRDEPLISKMIETGYIGRKGKGGFYRLNRENGGKAKEAI
DLSTGAYRPQEKASVPELEDGGGKDIFALLSAPGTAGRYARSVMAKTLAYAARLVPEAADDIVAIDDAMRLGYNWKFGPF
ELIDKIGAARLAGLLAADGEEVPALLALAADTPFYRVENGKRQYLALDGSYRDVVRPDGVLLLADIKLKSQPLLKNGSAA
LWDIGDGVVCLEFTSKSNSLDEGIITMLAKALKLVKDKHKALVIYNEGSNFSVGANLGLALFACNIGAFGEVEKLVATGQ
KTYQDMKYAPFPVVAAPSGLALGGGCEILLHASAVQAHAESYIGLVECGVGVLPAWGGCTAMLERWATDPKFPKGPMPAP
SKVFETVSTATVAKSAAEAKELKFLRESDGITMNRDRLLADAKAKALALVEGYAPPKPVEFFLPGPTGKVAMDMAVAGFA
KRGMATKHDKVVSGVLAEVLTGGSADHIEPVPAARVLELERDGFMKLIRTTATLDRIEHILETGRPLRN

Sequences:

>Translated_789_residues
MTSETDIKSFADIGGFDIKKVAVIGAGVMGAGIAAHVANAGIEVLLLDIVPEGAANRNAIAEKAVEKLLKADPAAFMSKR
AAKLVTAGNIEDNLSDLASCDWIVEAVIERLDIKQALYAKIEAARRPGSAVSSNTSTIPLGDLTAGLPESFRRDFLITHF
FNPPRYMRLLEIVAGPETNPATVAAVARFADVKLGKTVVTCKDTPGFIANRLGTYWLQLAVGEAFRLGLKVEEADAVMGR
PFGFPKTGVFGLIDLVGLDLMPHVQGSLKRALPASDPFHATLRDEPLISKMIETGYIGRKGKGGFYRLNRENGGKAKEAI
DLSTGAYRPQEKASVPELEDGGGKDIFALLSAPGTAGRYARSVMAKTLAYAARLVPEAADDIVAIDDAMRLGYNWKFGPF
ELIDKIGAARLAGLLAADGEEVPALLALAADTPFYRVENGKRQYLALDGSYRDVVRPDGVLLLADIKLKSQPLLKNGSAA
LWDIGDGVVCLEFTSKSNSLDEGIITMLAKALKLVKDKHKALVIYNEGSNFSVGANLGLALFACNIGAFGEVEKLVATGQ
KTYQDMKYAPFPVVAAPSGLALGGGCEILLHASAVQAHAESYIGLVECGVGVLPAWGGCTAMLERWATDPKFPKGPMPAP
SKVFETVSTATVAKSAAEAKELKFLRESDGITMNRDRLLADAKAKALALVEGYAPPKPVEFFLPGPTGKVAMDMAVAGFA
KRGMATKHDKVVSGVLAEVLTGGSADHIEPVPAARVLELERDGFMKLIRTTATLDRIEHILETGRPLRN
>Mature_788_residues
TSETDIKSFADIGGFDIKKVAVIGAGVMGAGIAAHVANAGIEVLLLDIVPEGAANRNAIAEKAVEKLLKADPAAFMSKRA
AKLVTAGNIEDNLSDLASCDWIVEAVIERLDIKQALYAKIEAARRPGSAVSSNTSTIPLGDLTAGLPESFRRDFLITHFF
NPPRYMRLLEIVAGPETNPATVAAVARFADVKLGKTVVTCKDTPGFIANRLGTYWLQLAVGEAFRLGLKVEEADAVMGRP
FGFPKTGVFGLIDLVGLDLMPHVQGSLKRALPASDPFHATLRDEPLISKMIETGYIGRKGKGGFYRLNRENGGKAKEAID
LSTGAYRPQEKASVPELEDGGGKDIFALLSAPGTAGRYARSVMAKTLAYAARLVPEAADDIVAIDDAMRLGYNWKFGPFE
LIDKIGAARLAGLLAADGEEVPALLALAADTPFYRVENGKRQYLALDGSYRDVVRPDGVLLLADIKLKSQPLLKNGSAAL
WDIGDGVVCLEFTSKSNSLDEGIITMLAKALKLVKDKHKALVIYNEGSNFSVGANLGLALFACNIGAFGEVEKLVATGQK
TYQDMKYAPFPVVAAPSGLALGGGCEILLHASAVQAHAESYIGLVECGVGVLPAWGGCTAMLERWATDPKFPKGPMPAPS
KVFETVSTATVAKSAAEAKELKFLRESDGITMNRDRLLADAKAKALALVEGYAPPKPVEFFLPGPTGKVAMDMAVAGFAK
RGMATKHDKVVSGVLAEVLTGGSADHIEPVPAARVLELERDGFMKLIRTTATLDRIEHILETGRPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=298, Percent_Identity=32.5503355704698, Blast_Score=134, Evalue=5e-31,
Organism=Homo sapiens, GI296179427, Length=314, Percent_Identity=31.2101910828025, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI261878539, Length=316, Percent_Identity=29.1139240506329, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI20127408, Length=296, Percent_Identity=30.4054054054054, Blast_Score=104, Evalue=4e-22,
Organism=Homo sapiens, GI68989263, Length=316, Percent_Identity=29.1139240506329, Blast_Score=104, Evalue=4e-22,
Organism=Homo sapiens, GI115430219, Length=225, Percent_Identity=31.5555555555556, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1787661, Length=460, Percent_Identity=29.1304347826087, Blast_Score=117, Evalue=4e-27,
Organism=Escherichia coli, GI1790281, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788682, Length=392, Percent_Identity=30.6122448979592, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=35.3741496598639, Blast_Score=156, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=301, Percent_Identity=33.2225913621262, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17508951, Length=345, Percent_Identity=33.9130434782609, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17508953, Length=345, Percent_Identity=33.9130434782609, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144276, Length=318, Percent_Identity=33.9622641509434, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17558304, Length=296, Percent_Identity=33.1081081081081, Blast_Score=120, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71985923, Length=338, Percent_Identity=27.2189349112426, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71985930, Length=407, Percent_Identity=25.7985257985258, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=298, Percent_Identity=30.5369127516779, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921000, Length=306, Percent_Identity=31.3725490196078, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24583077, Length=306, Percent_Identity=31.3725490196078, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583079, Length=306, Percent_Identity=31.3725490196078, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45549573, Length=247, Percent_Identity=29.1497975708502, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129993, Length=250, Percent_Identity=29.2, Blast_Score=77, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 83867; Mature: 83736

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSETDIKSFADIGGFDIKKVAVIGAGVMGAGIAAHVANAGIEVLLLDIVPEGAANRNAI
CCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHH
AEKAVEKLLKADPAAFMSKRAAKLVTAGNIEDNLSDLASCDWIVEAVIERLDIKQALYAK
HHHHHHHHHHCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEAARRPGSAVSSNTSTIPLGDLTAGLPESFRRDFLITHFFNPPRYMRLLEIVAGPETNP
HHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHCCCCCCC
ATVAAVARFADVKLGKTVVTCKDTPGFIANRLGTYWLQLAVGEAFRLGLKVEEADAVMGR
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCC
PFGFPKTGVFGLIDLVGLDLMPHVQGSLKRALPASDPFHATLRDEPLISKMIETGYIGRK
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCCC
GKGGFYRLNRENGGKAKEAIDLSTGAYRPQEKASVPELEDGGGKDIFALLSAPGTAGRYA
CCCCEEEEECCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
RSVMAKTLAYAARLVPEAADDIVAIDDAMRLGYNWKFGPFELIDKIGAARLAGLLAADGE
HHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
EVPALLALAADTPFYRVENGKRQYLALDGSYRDVVRPDGVLLLADIKLKSQPLLKNGSAA
CCCEEEEEECCCCEEEECCCCEEEEEECCCCHHCCCCCCEEEEEEEEECCCCCCCCCCEE
LWDIGDGVVCLEFTSKSNSLDEGIITMLAKALKLVKDKHKALVIYNEGSNFSVGANLGLA
EEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCEE
LFACNIGAFGEVEKLVATGQKTYQDMKYAPFPVVAAPSGLALGGGCEILLHASAVQAHAE
EEEECCCCCHHHHHHHHCCHHHHHHCCCCCCCEEECCCCCEECCCCEEEEEHHHHHHHHH
SYIGLVECGVGVLPAWGGCTAMLERWATDPKFPKGPMPAPSKVFETVSTATVAKSAAEAK
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELKFLRESDGITMNRDRLLADAKAKALALVEGYAPPKPVEFFLPGPTGKVAMDMAVAGFA
HHHHHHHCCCCEECHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHH
KRGMATKHDKVVSGVLAEVLTGGSADHIEPVPAARVLELERDGFMKLIRTTATLDRIEHI
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHH
LETGRPLRN
HHCCCCCCC
>Mature Secondary Structure 
TSETDIKSFADIGGFDIKKVAVIGAGVMGAGIAAHVANAGIEVLLLDIVPEGAANRNAI
CCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHH
AEKAVEKLLKADPAAFMSKRAAKLVTAGNIEDNLSDLASCDWIVEAVIERLDIKQALYAK
HHHHHHHHHHCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEAARRPGSAVSSNTSTIPLGDLTAGLPESFRRDFLITHFFNPPRYMRLLEIVAGPETNP
HHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHCCCCCCC
ATVAAVARFADVKLGKTVVTCKDTPGFIANRLGTYWLQLAVGEAFRLGLKVEEADAVMGR
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCC
PFGFPKTGVFGLIDLVGLDLMPHVQGSLKRALPASDPFHATLRDEPLISKMIETGYIGRK
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCCC
GKGGFYRLNRENGGKAKEAIDLSTGAYRPQEKASVPELEDGGGKDIFALLSAPGTAGRYA
CCCCEEEEECCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
RSVMAKTLAYAARLVPEAADDIVAIDDAMRLGYNWKFGPFELIDKIGAARLAGLLAADGE
HHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
EVPALLALAADTPFYRVENGKRQYLALDGSYRDVVRPDGVLLLADIKLKSQPLLKNGSAA
CCCEEEEEECCCCEEEECCCCEEEEEECCCCHHCCCCCCEEEEEEEEECCCCCCCCCCEE
LWDIGDGVVCLEFTSKSNSLDEGIITMLAKALKLVKDKHKALVIYNEGSNFSVGANLGLA
EEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCEE
LFACNIGAFGEVEKLVATGQKTYQDMKYAPFPVVAAPSGLALGGGCEILLHASAVQAHAE
EEEECCCCCHHHHHHHHCCHHHHHHCCCCCCCEEECCCCCEECCCCEEEEEHHHHHHHHH
SYIGLVECGVGVLPAWGGCTAMLERWATDPKFPKGPMPAPSKVFETVSTATVAKSAAEAK
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELKFLRESDGITMNRDRLLADAKAKALALVEGYAPPKPVEFFLPGPTGKVAMDMAVAGFA
HHHHHHHCCCCEECHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHH
KRGMATKHDKVVSGVLAEVLTGGSADHIEPVPAARVLELERDGFMKLIRTTATLDRIEHI
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHH
LETGRPLRN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]