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The map label for this gene is pdhR [H]

Identifier: 154248271

GI number: 154248271

Start: 4821697

End: 4822494

Strand: Direct

Name: pdhR [H]

Synonym: Xaut_4351

Alternate gene names: 154248271

Gene position: 4821697-4822494 (Clockwise)

Preceding gene: 154248269

Following gene: 154248272

Centisome position: 90.82

GC content: 68.42

Gene sequence:

>798_bases
ATGGGCAGGATGACCAAGGACGGCATCAAGGGCGCCAGCGCCGCCGAAAGCACCGCGCGCCACATCGAGGAACTGATCGT
CGAGGGTGCGCTGCGCCCGGGGGAGCCGCTACTTCCGGAACGGGAGATGGCCCTGCGCCTCAACGTCTCGCGCCCGACCT
TGCGTCAGGGCATGAAGATGCTGGAGGACAAGGGCCTGCTGGTCGCCGACACCAATGGCAGCCGGGTTGTGGCCCCGCTC
GGGATCAGCTTCACCGACCCGCTGATCGATCTCCTGTCGTCCGGCGAGGCGGTGACGGACGACTATCTCGAGCTGCGCGC
CACCCTCGAGCGCATGGCGGCCACGCTTGCGGCCACTCGCGCCAACGATGTGGACCGCGCCATCCTGCGGGAAGCCATGG
AGCGCATCGACCGCGCCCATGGCGAGGCCGATGCGGGCGACGAGGCGGAAGCCGACGTGGACCTGCACCTGGCTGTCTAC
GAGGCGAGCCACAATCTGGTCCTGCTCCACATCATGCGCGCCCTGTCGGGCATGCTGCGCAAGGGCATCTTCCACAACCG
CGAAAAGCTCTATGCCCGGCCGGAGGTGCGCGACGTGCTGCGCGACCAGCACCGCGCCATCTACGAAGCCATCATGGCCC
GCGATCCGGAAGCGGCTGGCCGCTGCGCCGAGGCACATATGAGCTATACCCAGCGCGTCATTGCCGAGATCGCGGCCGCC
GATGCGCGCCTCGAAATCTCCCTGCGCCGCATCGAGGGCGGTGGCATCGCCTCACGCGCCGGCAAGGCACGCAGCTGA

Upstream 100 bases:

>100_bases
ACTGGAGAAATCTCTTTCACCGCCACAAAGCGGCGGCTAAAATCAGTTCAAATCGCAAGAAGGCCGCTAAACTCTTGATT
CTCCTCAAGCGGCAGAGCAG

Downstream 100 bases:

>100_bases
GATCGCGCGGCTGAGATTCTGCGGCTGAAGCGGTTCGCGCCCCGATTTTGGCACCGCACGCGCCACGGCGCGATCGGGCG
TGCCCCTGTCGGCCGTCCGT

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MGRMTKDGIKGASAAESTARHIEELIVEGALRPGEPLLPEREMALRLNVSRPTLRQGMKMLEDKGLLVADTNGSRVVAPL
GISFTDPLIDLLSSGEAVTDDYLELRATLERMAATLAATRANDVDRAILREAMERIDRAHGEADAGDEAEADVDLHLAVY
EASHNLVLLHIMRALSGMLRKGIFHNREKLYARPEVRDVLRDQHRAIYEAIMARDPEAAGRCAEAHMSYTQRVIAEIAAA
DARLEISLRRIEGGGIASRAGKARS

Sequences:

>Translated_265_residues
MGRMTKDGIKGASAAESTARHIEELIVEGALRPGEPLLPEREMALRLNVSRPTLRQGMKMLEDKGLLVADTNGSRVVAPL
GISFTDPLIDLLSSGEAVTDDYLELRATLERMAATLAATRANDVDRAILREAMERIDRAHGEADAGDEAEADVDLHLAVY
EASHNLVLLHIMRALSGMLRKGIFHNREKLYARPEVRDVLRDQHRAIYEAIMARDPEAAGRCAEAHMSYTQRVIAEIAAA
DARLEISLRRIEGGGIASRAGKARS
>Mature_264_residues
GRMTKDGIKGASAAESTARHIEELIVEGALRPGEPLLPEREMALRLNVSRPTLRQGMKMLEDKGLLVADTNGSRVVAPLG
ISFTDPLIDLLSSGEAVTDDYLELRATLERMAATLAATRANDVDRAILREAMERIDRAHGEADAGDEAEADVDLHLAVYE
ASHNLVLLHIMRALSGMLRKGIFHNREKLYARPEVRDVLRDQHRAIYEAIMARDPEAAGRCAEAHMSYTQRVIAEIAAAD
ARLEISLRRIEGGGIASRAGKARS

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=232, Percent_Identity=38.7931034482759, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789353, Length=227, Percent_Identity=32.5991189427313, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790032, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790780, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29022; Mature: 28890

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRMTKDGIKGASAAESTARHIEELIVEGALRPGEPLLPEREMALRLNVSRPTLRQGMKM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHH
LEDKGLLVADTNGSRVVAPLGISFTDPLIDLLSSGEAVTDDYLELRATLERMAATLAATR
HHHCCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ANDVDRAILREAMERIDRAHGEADAGDEAEADVDLHLAVYEASHNLVLLHIMRALSGMLR
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHH
KGIFHNREKLYARPEVRDVLRDQHRAIYEAIMARDPEAAGRCAEAHMSYTQRVIAEIAAA
HHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
DARLEISLRRIEGGGIASRAGKARS
CCCEEEEEEEECCCCCHHCCCCCCC
>Mature Secondary Structure 
GRMTKDGIKGASAAESTARHIEELIVEGALRPGEPLLPEREMALRLNVSRPTLRQGMKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHH
LEDKGLLVADTNGSRVVAPLGISFTDPLIDLLSSGEAVTDDYLELRATLERMAATLAATR
HHHCCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ANDVDRAILREAMERIDRAHGEADAGDEAEADVDLHLAVYEASHNLVLLHIMRALSGMLR
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHH
KGIFHNREKLYARPEVRDVLRDQHRAIYEAIMARDPEAAGRCAEAHMSYTQRVIAEIAAA
HHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
DARLEISLRRIEGGGIASRAGKARS
CCCEEEEEEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]