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The map label for this gene is cbh [H]

Identifier: 154248254

GI number: 154248254

Start: 4806708

End: 4807733

Strand: Direct

Name: cbh [H]

Synonym: Xaut_4334

Alternate gene names: 154248254

Gene position: 4806708-4807733 (Clockwise)

Preceding gene: 154248253

Following gene: 154248256

Centisome position: 90.54

GC content: 60.14

Gene sequence:

>1026_bases
ATGTGCACCCGTGTTGTCTATCTCGGGCCCAACGGAAATAACCTGACGGCCAGGTCCATGGACTGGAAAGACGACATCGG
CACCAATCTGTGGATCTTCCCGCGGGGCATGGTGCGCGACGGCAAGGCTGGTCCGAACTCCCTGACCTGGACGTCCAGAT
ACGGCAGCGTCATTGCGTCGGGCTACGACATCGCCACCACCGATGGCCTGAATGAAGCAGGATTGTCGGCCAACCTGCTG
TGGCTGGTGGAATCGGAATATCCAGCCCTCGACAAGGCCAGGCCCGGGCTCTCCATCGCAGCCTGGGCGCAATATGTGCT
CGACAGTTTCGCCACCGTGAAGGAGACCGTCGACGCCCTGAAGGATGAGCCGTTCATCCTTGTAACCGACGGCGTTCCGG
GCGAAAAACGCCTTGCCACCCTGCATCTGTCCATTTCCGACAAGAGCGGCGACAGCGCGATCATCGAATATATCGGCGGC
CGCCAGGTCATTCATCATGATCGCAGCTATCAGGTGATGACCAACTCCCCGGTCTTCGAAAAACAGCTCGCGCTGAACGA
GTATTGGCAGCAGATCAGCGGCACCGTGATGTTGCCCGGAACCAACCGCGCGGCGGATCGCTTTGCCCGTGCTTCGTTCT
ATGTGAATGCCATTCCGAAGGTGGAAGATCCCAAGGTTTCCCTTGCGGGGGTGTTCAGCGTGATCCGCAACGTGTCGGTG
CCATTGGGCATTTCGACACCCAATGAGCCGAATATTTCCTCCACGCGCTGGCGCACCGTGGCCCACCACCACCAGAATCT
CTATTTTTTCGAATCGGCGCTGGCGCCGAACATCTTCTGGATCGATCTCGCTCAGGTAGACTTCTCAGCGGAGACTGGAA
CGGTCCGCAAGCTTGATCTGGGACCCAACCAGGGCAACATTTTTTCGGGCGAGGTGAGCAGCGCTTTCGCGCCAAGCGCG
CCCTTTGCCTTCCTCGGACCCGGCGCCGGGCCGACGCCGCCTCAGCCCGAACCCTCGGGGCCATAG

Upstream 100 bases:

>100_bases
TGAGGCTGCAGGAGCATTTTCGCGATACAGTCCGTCGCGAAAATGCTCCATGCTCCAGTTCGTTGCAGACCACGTCATCC
CGAAAAACAGGAAAGCCTGG

Downstream 100 bases:

>100_bases
ACTTCGCGGGTGAGATCCAGCCACGCGCGGGCGGCGTGGGACAGGTAGCTGCCCTGCCGCCAGACGATGGCCATCTGCCA
TTCGGTGCCCGGCTCATCGA

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MCTRVVYLGPNGNNLTARSMDWKDDIGTNLWIFPRGMVRDGKAGPNSLTWTSRYGSVIASGYDIATTDGLNEAGLSANLL
WLVESEYPALDKARPGLSIAAWAQYVLDSFATVKETVDALKDEPFILVTDGVPGEKRLATLHLSISDKSGDSAIIEYIGG
RQVIHHDRSYQVMTNSPVFEKQLALNEYWQQISGTVMLPGTNRAADRFARASFYVNAIPKVEDPKVSLAGVFSVIRNVSV
PLGISTPNEPNISSTRWRTVAHHHQNLYFFESALAPNIFWIDLAQVDFSAETGTVRKLDLGPNQGNIFSGEVSSAFAPSA
PFAFLGPGAGPTPPQPEPSGP

Sequences:

>Translated_341_residues
MCTRVVYLGPNGNNLTARSMDWKDDIGTNLWIFPRGMVRDGKAGPNSLTWTSRYGSVIASGYDIATTDGLNEAGLSANLL
WLVESEYPALDKARPGLSIAAWAQYVLDSFATVKETVDALKDEPFILVTDGVPGEKRLATLHLSISDKSGDSAIIEYIGG
RQVIHHDRSYQVMTNSPVFEKQLALNEYWQQISGTVMLPGTNRAADRFARASFYVNAIPKVEDPKVSLAGVFSVIRNVSV
PLGISTPNEPNISSTRWRTVAHHHQNLYFFESALAPNIFWIDLAQVDFSAETGTVRKLDLGPNQGNIFSGEVSSAFAPSA
PFAFLGPGAGPTPPQPEPSGP
>Mature_341_residues
MCTRVVYLGPNGNNLTARSMDWKDDIGTNLWIFPRGMVRDGKAGPNSLTWTSRYGSVIASGYDIATTDGLNEAGLSANLL
WLVESEYPALDKARPGLSIAAWAQYVLDSFATVKETVDALKDEPFILVTDGVPGEKRLATLHLSISDKSGDSAIIEYIGG
RQVIHHDRSYQVMTNSPVFEKQLALNEYWQQISGTVMLPGTNRAADRFARASFYVNAIPKVEDPKVSLAGVFSVIRNVSV
PLGISTPNEPNISSTRWRTVAHHHQNLYFFESALAPNIFWIDLAQVDFSAETGTVRKLDLGPNQGNIFSGEVSSAFAPSA
PFAFLGPGAGPTPPQPEPSGP

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37028; Mature: 37028

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTRVVYLGPNGNNLTARSMDWKDDIGTNLWIFPRGMVRDGKAGPNSLTWTSRYGSVIAS
CCEEEEEECCCCCCEEEECCCCCHHCCCEEEEECCCCCCCCCCCCCCEEEEHHCCHHHCC
GYDIATTDGLNEAGLSANLLWLVESEYPALDKARPGLSIAAWAQYVLDSFATVKETVDAL
CCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KDEPFILVTDGVPGEKRLATLHLSISDKSGDSAIIEYIGGRQVIHHDRSYQVMTNSPVFE
CCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCEEEEECCCCHH
KQLALNEYWQQISGTVMLPGTNRAADRFARASFYVNAIPKVEDPKVSLAGVFSVIRNVSV
HHHHHHHHHHHHCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCC
PLGISTPNEPNISSTRWRTVAHHHQNLYFFESALAPNIFWIDLAQVDFSAETGTVRKLDL
CEECCCCCCCCCCCHHHHHHHHHCCCEEEEHHHCCCCEEEEEEEEEEECCCCCCEEEEEC
GPNQGNIFSGEVSSAFAPSAPFAFLGPGAGPTPPQPEPSGP
CCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MCTRVVYLGPNGNNLTARSMDWKDDIGTNLWIFPRGMVRDGKAGPNSLTWTSRYGSVIAS
CCEEEEEECCCCCCEEEECCCCCHHCCCEEEEECCCCCCCCCCCCCCEEEEHHCCHHHCC
GYDIATTDGLNEAGLSANLLWLVESEYPALDKARPGLSIAAWAQYVLDSFATVKETVDAL
CCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KDEPFILVTDGVPGEKRLATLHLSISDKSGDSAIIEYIGGRQVIHHDRSYQVMTNSPVFE
CCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCEEEEECCCCHH
KQLALNEYWQQISGTVMLPGTNRAADRFARASFYVNAIPKVEDPKVSLAGVFSVIRNVSV
HHHHHHHHHHHHCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCC
PLGISTPNEPNISSTRWRTVAHHHQNLYFFESALAPNIFWIDLAQVDFSAETGTVRKLDL
CEECCCCCCCCCCCHHHHHHHHHCCCEEEEHHHCCCCEEEEEEEEEEECCCCCCEEEEEC
GPNQGNIFSGEVSSAFAPSAPFAFLGPGAGPTPPQPEPSGP
CCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]