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The map label for this gene is recQ [H]

Identifier: 154248226

GI number: 154248226

Start: 4773118

End: 4774941

Strand: Direct

Name: recQ [H]

Synonym: Xaut_4306

Alternate gene names: 154248226

Gene position: 4773118-4774941 (Clockwise)

Preceding gene: 154248223

Following gene: 154248228

Centisome position: 89.91

GC content: 68.64

Gene sequence:

>1824_bases
ATGCCCGCCTTTGAAGCCGCCCCTGATTCCGATCCGCTCCGCGTCCTGCGCCATGTCTTCGGCTACGAGGCCTTTCGCGG
GCATCAGAAGGAGATCGTGGAGCACGTGGCGGCGGGGGGCGATGCCCTGGTGCTGATGCCCACGGGCGGCGGCAAGTCCC
TGTGCTATCAGGTGCCGGCGCTGGTGCGGCCGGGCACCGCCATCGTCGTCTCGCCCCTCATCGCCCTGATGCACGACCAG
GTGCAGGCCCTGCGCCAGCTGGGTGTTAAGGCGGCCATGCTCAATTCGTCGCTCGCCCCCGGCGAGGCGCGGCAGGTGGA
ACGGGCCCTCGCCATGGGCGACCTCGACCTGCTCTATGTGGCGCCCGAGCGGCTCCTGACCGACAGCTTCCTCACCCTGC
TCGACGGTGCGCGCATTTCGCTCTTCGCCATCGACGAGGCGCACTGCGTGTCCCAGTGGGGGCACGATTTCCGGCCCGAA
TACCGCCAGCTCACCATCCTGCACGAGCGCTTCCCCGGCGTGCCGCGGCTCGCCCTCACCGCCACGGCGGACGGGCCCAC
CCGCCGCGAGATCATGGAGCGGCTGGCGCTGGAGGAGGGCAGGGTTTTCCTTTCCTCCTTCGACCGGCCCAACATCCGCT
ACCGCATCGAGCCGAAGGCCAATCCCCGGGCCCAGCTGCGGGCCTTCCTCGACGCCCACGCGGACGAGGCGGGCATCGTC
TATTGCATGAGCCGGGCGAAGGTGGAGGCCACCGCCGAGATCCTCTCCACCGAGGGCCGCACCGCGCTGCCCTACCATGC
CGGCCTCGACGCCGACACCCGCGCCCGCCACCAGGACCGCTTCCTGAAGGAGGAGGGGGTGGTAATGGTGGCCACCGTCG
CCTTCGGCATGGGCATCGACAAGCCGGACGTGCGTTTCGTGGTCCATCTCGACCTGCCGAAAAGCATCGAGGCCTATTAC
CAGGAGACCGGCCGCGCCGGTCGTGACGGCCTGCCCTCCGAAGCGCTGCTGCTCTACGGCGTGGAGGATGTGGCGAAGCT
GATCCAGTTCGTGGAATCCTCCGACTCGCCCGAGGCGAGGAAGCGTGTGGAGCGCGGCAAGCTCGATGCCCTGCTCGGCC
TGTGCGAGACCGCGAGCTGCCGCCGCCAGGTGCTGCTGAAATATTTCGAGGAGGACCTCCCCGAGCCCTGCGGCAATTGC
GACACCTGCCTCTCGCCTCCGCGCACCTTCGATGGGACCGAGGCGGCACAGAAGCTCTTATCCTGTGTCTACCGCACCGG
CGAGCGCTTCGGCGCCGGCCACGTCATCGACGTGCTCAAGGGCGAGGCCAACGACAAGGTGCTGAAGTTCGGCCACGAGA
AGCTCTCCACCTTCGCCATCGGCAAGGATTTCTCGCGGGACGAGTGGCGCGCCATCGTCCGCCAGCTGGTGGCCATGGGC
CATTTGTGGGTGGACGTGGAGGGTCACGGCAGCCTCGGTCTCACTGAGAAATGCCGCGCCGTGTTGCGTGGCGCCGAGAA
GGTGGAGCTGAAGGCGGAGGCGCGCACCCGCCCGGCCCGGGTCACCGGTGGCGCACGGGGGGCGGGGCCGGTGCTGTCGG
ACCCGGCGGACGAGGCCCTGTTCCGCAAGCTCAAGGCTCTGCGGCTGGACATCGCCCGCGCCCAGGGGGTGCCGCCCTAT
GTGATCTTCCACGACACCACGCTGATGGCCCTGGCCGAGCTGAAGCCCGATTCCATGAAGGCGCTGGGCATGATTTCCGG
CATCGGCGAAGCCAAGCTCACGCGCTACGGCAGCCAATTCCTCGCCGTGATCGCGGAAGGGTAG

Upstream 100 bases:

>100_bases
TTGACACTTCGACGACACAGCTCCGTGTCATTGCGAAGTGTCAGCAGCGGCGCGGCTTCAGCCCGCATTGCCCGGCCGGC
CGACGGGTCTATAAGGCGCC

Downstream 100 bases:

>100_bases
GGCGCACTTAAAACGCGTTCCGCGTCAGGACGCCGCGCGGGCCAGCAGGTCGAGGGCTTCCAGCACGGAGAGCTGGCGAA
TCTCGCCGCGCCCGATTTCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MPAFEAAPDSDPLRVLRHVFGYEAFRGHQKEIVEHVAAGGDALVLMPTGGGKSLCYQVPALVRPGTAIVVSPLIALMHDQ
VQALRQLGVKAAMLNSSLAPGEARQVERALAMGDLDLLYVAPERLLTDSFLTLLDGARISLFAIDEAHCVSQWGHDFRPE
YRQLTILHERFPGVPRLALTATADGPTRREIMERLALEEGRVFLSSFDRPNIRYRIEPKANPRAQLRAFLDAHADEAGIV
YCMSRAKVEATAEILSTEGRTALPYHAGLDADTRARHQDRFLKEEGVVMVATVAFGMGIDKPDVRFVVHLDLPKSIEAYY
QETGRAGRDGLPSEALLLYGVEDVAKLIQFVESSDSPEARKRVERGKLDALLGLCETASCRRQVLLKYFEEDLPEPCGNC
DTCLSPPRTFDGTEAAQKLLSCVYRTGERFGAGHVIDVLKGEANDKVLKFGHEKLSTFAIGKDFSRDEWRAIVRQLVAMG
HLWVDVEGHGSLGLTEKCRAVLRGAEKVELKAEARTRPARVTGGARGAGPVLSDPADEALFRKLKALRLDIARAQGVPPY
VIFHDTTLMALAELKPDSMKALGMISGIGEAKLTRYGSQFLAVIAEG

Sequences:

>Translated_607_residues
MPAFEAAPDSDPLRVLRHVFGYEAFRGHQKEIVEHVAAGGDALVLMPTGGGKSLCYQVPALVRPGTAIVVSPLIALMHDQ
VQALRQLGVKAAMLNSSLAPGEARQVERALAMGDLDLLYVAPERLLTDSFLTLLDGARISLFAIDEAHCVSQWGHDFRPE
YRQLTILHERFPGVPRLALTATADGPTRREIMERLALEEGRVFLSSFDRPNIRYRIEPKANPRAQLRAFLDAHADEAGIV
YCMSRAKVEATAEILSTEGRTALPYHAGLDADTRARHQDRFLKEEGVVMVATVAFGMGIDKPDVRFVVHLDLPKSIEAYY
QETGRAGRDGLPSEALLLYGVEDVAKLIQFVESSDSPEARKRVERGKLDALLGLCETASCRRQVLLKYFEEDLPEPCGNC
DTCLSPPRTFDGTEAAQKLLSCVYRTGERFGAGHVIDVLKGEANDKVLKFGHEKLSTFAIGKDFSRDEWRAIVRQLVAMG
HLWVDVEGHGSLGLTEKCRAVLRGAEKVELKAEARTRPARVTGGARGAGPVLSDPADEALFRKLKALRLDIARAQGVPPY
VIFHDTTLMALAELKPDSMKALGMISGIGEAKLTRYGSQFLAVIAEG
>Mature_606_residues
PAFEAAPDSDPLRVLRHVFGYEAFRGHQKEIVEHVAAGGDALVLMPTGGGKSLCYQVPALVRPGTAIVVSPLIALMHDQV
QALRQLGVKAAMLNSSLAPGEARQVERALAMGDLDLLYVAPERLLTDSFLTLLDGARISLFAIDEAHCVSQWGHDFRPEY
RQLTILHERFPGVPRLALTATADGPTRREIMERLALEEGRVFLSSFDRPNIRYRIEPKANPRAQLRAFLDAHADEAGIVY
CMSRAKVEATAEILSTEGRTALPYHAGLDADTRARHQDRFLKEEGVVMVATVAFGMGIDKPDVRFVVHLDLPKSIEAYYQ
ETGRAGRDGLPSEALLLYGVEDVAKLIQFVESSDSPEARKRVERGKLDALLGLCETASCRRQVLLKYFEEDLPEPCGNCD
TCLSPPRTFDGTEAAQKLLSCVYRTGERFGAGHVIDVLKGEANDKVLKFGHEKLSTFAIGKDFSRDEWRAIVRQLVAMGH
LWVDVEGHGSLGLTEKCRAVLRGAEKVELKAEARTRPARVTGGARGAGPVLSDPADEALFRKLKALRLDIARAQGVPPYV
IFHDTTLMALAELKPDSMKALGMISGIGEAKLTRYGSQFLAVIAEG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=640, Percent_Identity=33.4375, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI14591902, Length=404, Percent_Identity=38.8613861386139, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI14591904, Length=404, Percent_Identity=38.8613861386139, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI110735439, Length=685, Percent_Identity=30.0729927007299, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI169218196, Length=685, Percent_Identity=30.0729927007299, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI148612816, Length=432, Percent_Identity=39.3518518518519, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI51242947, Length=405, Percent_Identity=38.7654320987654, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI51242943, Length=402, Percent_Identity=39.3034825870647, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI284005309, Length=374, Percent_Identity=36.8983957219251, Blast_Score=184, Evalue=3e-46,
Organism=Escherichia coli, GI48994977, Length=597, Percent_Identity=46.9011725293132, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI87082221, Length=331, Percent_Identity=24.773413897281, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25145561, Length=647, Percent_Identity=33.693972179289, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI32564293, Length=674, Percent_Identity=31.4540059347181, Blast_Score=304, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI71987997, Length=437, Percent_Identity=39.1304347826087, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71987993, Length=437, Percent_Identity=39.1304347826087, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17552866, Length=454, Percent_Identity=35.4625550660793, Blast_Score=258, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI71995718, Length=343, Percent_Identity=24.198250728863, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17555296, Length=337, Percent_Identity=23.7388724035608, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=487, Percent_Identity=37.782340862423, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6320041, Length=338, Percent_Identity=23.6686390532544, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323947, Length=377, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324217, Length=360, Percent_Identity=22.5, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=636, Percent_Identity=35.6918238993711, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24664226, Length=443, Percent_Identity=37.4717832957111, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI62472181, Length=439, Percent_Identity=37.3576309794989, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24664230, Length=439, Percent_Identity=37.3576309794989, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI21358123, Length=354, Percent_Identity=36.4406779661017, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66538; Mature: 66407

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFEAAPDSDPLRVLRHVFGYEAFRGHQKEIVEHVAAGGDALVLMPTGGGKSLCYQVPA
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCH
LVRPGTAIVVSPLIALMHDQVQALRQLGVKAAMLNSSLAPGEARQVERALAMGDLDLLYV
HHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEE
APERLLTDSFLTLLDGARISLFAIDEAHCVSQWGHDFRPEYRQLTILHERFPGVPRLALT
CHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEE
ATADGPTRREIMERLALEEGRVFLSSFDRPNIRYRIEPKANPRAQLRAFLDAHADEAGIV
ECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEE
YCMSRAKVEATAEILSTEGRTALPYHAGLDADTRARHQDRFLKEEGVVMVATVAFGMGID
EEEHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCC
KPDVRFVVHLDLPKSIEAYYQETGRAGRDGLPSEALLLYGVEDVAKLIQFVESSDSPEAR
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHH
KRVERGKLDALLGLCETASCRRQVLLKYFEEDLPEPCGNCDTCLSPPRTFDGTEAAQKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SCVYRTGERFGAGHVIDVLKGEANDKVLKFGHEKLSTFAIGKDFSRDEWRAIVRQLVAMG
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
HLWVDVEGHGSLGLTEKCRAVLRGAEKVELKAEARTRPARVTGGARGAGPVLSDPADEAL
CEEEEEECCCCCCHHHHHHHHHCCCHHEEEEHHHCCCCCEECCCCCCCCCCCCCCHHHHH
FRKLKALRLDIARAQGVPPYVIFHDTTLMALAELKPDSMKALGMISGIGEAKLTRYGSQF
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCE
LAVIAEG
EEEEECC
>Mature Secondary Structure 
PAFEAAPDSDPLRVLRHVFGYEAFRGHQKEIVEHVAAGGDALVLMPTGGGKSLCYQVPA
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCH
LVRPGTAIVVSPLIALMHDQVQALRQLGVKAAMLNSSLAPGEARQVERALAMGDLDLLYV
HHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEE
APERLLTDSFLTLLDGARISLFAIDEAHCVSQWGHDFRPEYRQLTILHERFPGVPRLALT
CHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEE
ATADGPTRREIMERLALEEGRVFLSSFDRPNIRYRIEPKANPRAQLRAFLDAHADEAGIV
ECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEE
YCMSRAKVEATAEILSTEGRTALPYHAGLDADTRARHQDRFLKEEGVVMVATVAFGMGID
EEEHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCC
KPDVRFVVHLDLPKSIEAYYQETGRAGRDGLPSEALLLYGVEDVAKLIQFVESSDSPEAR
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHHH
KRVERGKLDALLGLCETASCRRQVLLKYFEEDLPEPCGNCDTCLSPPRTFDGTEAAQKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SCVYRTGERFGAGHVIDVLKGEANDKVLKFGHEKLSTFAIGKDFSRDEWRAIVRQLVAMG
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
HLWVDVEGHGSLGLTEKCRAVLRGAEKVELKAEARTRPARVTGGARGAGPVLSDPADEAL
CEEEEEECCCCCCHHHHHHHHHCCCHHEEEEHHHCCCCCEECCCCCCCCCCCCCCHHHHH
FRKLKALRLDIARAQGVPPYVIFHDTTLMALAELKPDSMKALGMISGIGEAKLTRYGSQF
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCE
LAVIAEG
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]