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The map label for this gene is groEL

Identifier: 154248184

GI number: 154248184

Start: 4731779

End: 4733410

Strand: Reverse

Name: groEL

Synonym: Xaut_4264

Alternate gene names: 154248184

Gene position: 4733410-4731779 (Counterclockwise)

Preceding gene: 154248185

Following gene: 154248183

Centisome position: 89.16

GC content: 65.87

Gene sequence:

>1632_bases
ATGGCTGCCAAGGACGTAAAATTCTCCGTTGATGCGCGCGACAAGGTTCTGCGCGGCGTCGACATCCTCGCGAATGCCGT
GAAGGTCACCCTCGGTCCCAAGGGCCGCAACGTGGTGATCGAGAAGAGCTTCGGCGCCCCCCGCATCACCAAGGACGGTG
TGTCGGTGGCCAAGGAAATCGAGCTTGAGGACAAGTTCGAGAACCTCGGTGCCCAGCTGGTGCGCGAAGTCGCCTCCAAG
ACCAATGATCTGGCCGGCGATGGCACCACCACCGCTACCGTGCTGGCCCAGGCCATCGTCCGCGAGGGCGCCAAGGCGGT
TGCCGCCGGCATGAACCCCATGGACCTGAAGCGCGGCATCGACCTCGCCGTGGACGCCATCGTCAAGGATCTGGCCTCCA
ACTCGCGCAAGGTGACCTCCAACGACGAGATCGCCCAGGTCGGCACCATCTCCGCCAACGGCGACGCCGAGGTCGGTAAG
TTTCTCGCCGAGGCCATGAAGAAGGTCGGCAACGAGGGTGTCATCACCGTCGAGGAAGCCAAGACCGCCGAGACCGAGCT
CGACGTGGTCGAGGGCATGCAGTTCGACCGCGGCTACCTCTCGCCCTACTTCGTGACCAACGCCGACAAGATGCGCGTTG
AGTTCGAGGAGCCCTACATCCTCATCAACGAGAAGAAGCTCTCCGGCCTCCAGGAACTGCTGCCCGTGCTCGAGGCGGTG
GTGCAGTCGGCCCGTCCGCTGCTGATCATCGCCGAGGACGTGGAAGGCGAGGCGCTGGCCACCCTCGTGGTGAACAAGCT
GCGCGGCGGCCTGAAGGTCGCGGCCGTGAAGGCCCCCGGCTTCGGCGATCGCCGCAAGGCCATGCTGCAGGACATCGCGA
TCCTGACCGGCGGCACCGTGATCTCCGACGATCTCGGCATCAAGCTCGACAGCGTGAACCTCTCCATGCTCGGCCGCGCC
AAGAAGGTGGTGATCGAGAAGGAGAATACCACCATCGTCGACGGCTCCGGCGAGAAGGCCGAGATCGAGGCCCGCATCGC
CCAGATCCGCGCCCAGATCGAGACCACCACCTCCGACTACGACCGTGAGAAGGCGCAGGAGCGTCTTGCCAAGCTCGCCG
GCGGCGTCGCCGTGGTGCGCGTGGGCGGCTCCACGGAAGTGGAAGTCAAGGAGAAGAAGGATCGCGTGGACGACGCCCTG
CACGCCACCCGCGCTGCGGTGGAAGAAGGCATCGTCCCCGGCGGCGGCGTGGCCCTGCTGCGCTCCATCAAGGCGCTCGA
AGGCCTGAAGGTCGACAATGCCGACCAGAAGACCGGCATCGAGATCGTCCGCCGCGCCATCCAGGCTCCGGCTCGCCAGA
TCGTCCTCAACGCGGGCGACGACGGCTCCGTGGTGGTGGGCAAGATCCTGGAGTCCTCGGACTACAGCTTCGGCTACAAC
GCCCAGACCGGTGAATATGTGGACATGGTGAAGGCCGGCATCATCGACCCCACCAAGGTCGTGCGTACCGCCCTGCAGGA
TGCGGCCTCCGTGTCCGGCCTGCTTATCACCACCGAGGCGCTCATCGCCGAGCTGCCGAAGAAGAACGCCCCCGCGGCCC
CGGCCATGCCGGGCGGCGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
AGACTTCGGCCAACGCCCAGAAGGCCGCCTGAGTCAGCCCGGCTGACCGCGGTTTTCATCCACACCCCCTCTTCCGTCCC
AATCTGAAGGAGCAGGCCAC

Downstream 100 bases:

>100_bases
GGTAGAGCAGGCGTCTGACGCCGCCCGGCGAGTCCTTGCGTAACGCAAACCGGCAACAGCCGGTTTGCTCGGGCGGCGGC
ATGGACTTCTGAGGTAAAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAAKDVKFSVDARDKVLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVDAIVKDLASNSRKVTSNDEIAQVGTISANGDAEVGK
FLAEAMKKVGNEGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVEFEEPYILINEKKLSGLQELLPVLEAV
VQSARPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTVISDDLGIKLDSVNLSMLGRA
KKVVIEKENTTIVDGSGEKAEIEARIAQIRAQIETTTSDYDREKAQERLAKLAGGVAVVRVGGSTEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRSIKALEGLKVDNADQKTGIEIVRRAIQAPARQIVLNAGDDGSVVVGKILESSDYSFGYN
AQTGEYVDMVKAGIIDPTKVVRTALQDAASVSGLLITTEALIAELPKKNAPAAPAMPGGGMDF

Sequences:

>Translated_543_residues
MAAKDVKFSVDARDKVLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVDAIVKDLASNSRKVTSNDEIAQVGTISANGDAEVGK
FLAEAMKKVGNEGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVEFEEPYILINEKKLSGLQELLPVLEAV
VQSARPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTVISDDLGIKLDSVNLSMLGRA
KKVVIEKENTTIVDGSGEKAEIEARIAQIRAQIETTTSDYDREKAQERLAKLAGGVAVVRVGGSTEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRSIKALEGLKVDNADQKTGIEIVRRAIQAPARQIVLNAGDDGSVVVGKILESSDYSFGYN
AQTGEYVDMVKAGIIDPTKVVRTALQDAASVSGLLITTEALIAELPKKNAPAAPAMPGGGMDF
>Mature_542_residues
AAKDVKFSVDARDKVLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASKT
NDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVDAIVKDLASNSRKVTSNDEIAQVGTISANGDAEVGKF
LAEAMKKVGNEGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVEFEEPYILINEKKLSGLQELLPVLEAVV
QSARPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTVISDDLGIKLDSVNLSMLGRAK
KVVIEKENTTIVDGSGEKAEIEARIAQIRAQIETTTSDYDREKAQERLAKLAGGVAVVRVGGSTEVEVKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRSIKALEGLKVDNADQKTGIEIVRRAIQAPARQIVLNAGDDGSVVVGKILESSDYSFGYNA
QTGEYVDMVKAGIIDPTKVVRTALQDAASVSGLLITTEALIAELPKKNAPAAPAMPGGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=55.977229601518, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=55.977229601518, Blast_Score=593, Evalue=1e-169,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=67.9245283018868, Blast_Score=703, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=55.5765595463138, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=57.345971563981, Blast_Score=238, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=58.1749049429658, Blast_Score=620, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.3863636363636, Blast_Score=604, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.3863636363636, Blast_Score=604, Evalue=1e-173,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=55.4285714285714, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=55.4285714285714, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=55.4285714285714, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=47.7941176470588, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=37.196261682243, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=37.196261682243, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57420; Mature: 57289

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSVDARDKVLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCEEECCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHC
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCH
DLAVDAIVKDLASNSRKVTSNDEIAQVGTISANGDAEVGKFLAEAMKKVGNEGVITVEEA
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELDVVEGMQFDRGYLSPYFVTNADKMRVEFEEPYILINEKKLSGLQELLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSARPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISDDLGIKLDSVNLSMLGRAKKVVIEKENTTIVDGSGEKAEIEARIAQIRAQIETTTSDY
EECCCCEEEECCCHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCHH
DREKAQERLAKLAGGVAVVRVGGSTEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSIKALEGLKVDNADQKTGIEIVRRAIQAPARQIVLNAGDDGSVVVGKILESSDYSFGYN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHCCCCCCCCCC
AQTGEYVDMVKAGIIDPTKVVRTALQDAASVSGLLITTEALIAELPKKNAPAAPAMPGGG
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCCC
MDF
CCC
>Mature Secondary Structure 
AAKDVKFSVDARDKVLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCEEECCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHC
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCH
DLAVDAIVKDLASNSRKVTSNDEIAQVGTISANGDAEVGKFLAEAMKKVGNEGVITVEEA
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELDVVEGMQFDRGYLSPYFVTNADKMRVEFEEPYILINEKKLSGLQELLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSARPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISDDLGIKLDSVNLSMLGRAKKVVIEKENTTIVDGSGEKAEIEARIAQIRAQIETTTSDY
EECCCCEEEECCCHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCHH
DREKAQERLAKLAGGVAVVRVGGSTEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSIKALEGLKVDNADQKTGIEIVRRAIQAPARQIVLNAGDDGSVVVGKILESSDYSFGYN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHCCCCCCCCCC
AQTGEYVDMVKAGIIDPTKVVRTALQDAASVSGLLITTEALIAELPKKNAPAAPAMPGGG
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCCC
MDF
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA