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The map label for this gene is rfbD [C]

Identifier: 154247482

GI number: 154247482

Start: 3969159

End: 3970052

Strand: Direct

Name: rfbD [C]

Synonym: Xaut_3555

Alternate gene names: 154247482

Gene position: 3969159-3970052 (Clockwise)

Preceding gene: 154247481

Following gene: 154247483

Centisome position: 74.76

GC content: 69.35

Gene sequence:

>894_bases
ATGCGCCTGATCGTCACCGGCAAGCAGGGTCAGGTCGTCTCTTCGTTGCTGGAGCGCGGCCCTGCCGCCTCCGTCGAGGT
GATCGCGCTCGGCCGGCCGGAACTCGATCTGGCCGACGCGGCCTCCGTGCGCTCCGCCATCGCCGCGGCGGCGCCCGACG
CGATCGTGTCGGCTGCGGCCTACACGGCGGTGGACAAGGCGGAGTGCGAGCCGGACCTCGCCTTCGCCGTCAACGAGACC
GGTGCGGGTGCGGTGGCGGAGGCTGCGGGCGCCCTCGGCGTCCCGGTGATCCATCTCTCAACCGATTATGTCTTCGCCGG
CGACAAGGCCGATCCCTATGTGGAGACCGATCCGACAGGGCCGGTCTCCGTCTATGGTGCCTCGAAGCTTGCCGGTGAAA
AGAAGGTCGCCGCGGCGACGGACAATCACGCCATCCTACGCACCGCCTGGGTCTATTCCCCGTTCGGCGCGAACTTCCTG
AAGACCATGCTGCGCCTTGGCGAAAGCCGCGACGTGCTGCGGGTGGTGGCGGACCAGCGCGGCACGCCGACCAGTGCCCT
CGACATCGCCGACGCGGTGATCGCGGTCGCCCGGCGCCTGAAGGCGGATCCGGATCCGGCCCTGCGCGGCGTGTTCCACC
TGACCGGAGGCGGGGAGGGGACGTGGGCGGACTTCGCCGACGCCATCTTTGGCGGCCTGAAGGAGAAGACCGGGCGCGAG
GTGAAGGTGGAGCGGATCACCACCGCCGACTATCCGACGCCGGCGCGCCGGCCCGCGAATTCGCGGCTTTCGACTAAAAA
ACTGCAATCATCCTATGGAATTGTGCTCGCCGACTGGGACGCGTCCACGCGTGGCGTGGTCGACCGGCTGCTCGCCGCCG
GCCCGGCGACTTGA

Upstream 100 bases:

>100_bases
ATACGGTGAAGTGGTATCTCGACAATGCGTGGTGGTGGCAGCCGCTGCGCGAGAAGGTCTATGTCGGCGAGCGCCTCGGC
ATCATCGAGAAGGCCGAAAA

Downstream 100 bases:

>100_bases
AGGAAGGCAGGGGTATGAAGGGGATCATTCTCGCCGGCGGATCGGGCACTCGGCTCTATCCGATCACCAAGGCTGTCTCG
AAGCAGCTCATGCCGGTCTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRLIVTGKQGQVVSSLLERGPAASVEVIALGRPELDLADAASVRSAIAAAAPDAIVSAAAYTAVDKAECEPDLAFAVNET
GAGAVAEAAGALGVPVIHLSTDYVFAGDKADPYVETDPTGPVSVYGASKLAGEKKVAAATDNHAILRTAWVYSPFGANFL
KTMLRLGESRDVLRVVADQRGTPTSALDIADAVIAVARRLKADPDPALRGVFHLTGGGEGTWADFADAIFGGLKEKTGRE
VKVERITTADYPTPARRPANSRLSTKKLQSSYGIVLADWDASTRGVVDRLLAAGPAT

Sequences:

>Translated_297_residues
MRLIVTGKQGQVVSSLLERGPAASVEVIALGRPELDLADAASVRSAIAAAAPDAIVSAAAYTAVDKAECEPDLAFAVNET
GAGAVAEAAGALGVPVIHLSTDYVFAGDKADPYVETDPTGPVSVYGASKLAGEKKVAAATDNHAILRTAWVYSPFGANFL
KTMLRLGESRDVLRVVADQRGTPTSALDIADAVIAVARRLKADPDPALRGVFHLTGGGEGTWADFADAIFGGLKEKTGRE
VKVERITTADYPTPARRPANSRLSTKKLQSSYGIVLADWDASTRGVVDRLLAAGPAT
>Mature_297_residues
MRLIVTGKQGQVVSSLLERGPAASVEVIALGRPELDLADAASVRSAIAAAAPDAIVSAAAYTAVDKAECEPDLAFAVNET
GAGAVAEAAGALGVPVIHLSTDYVFAGDKADPYVETDPTGPVSVYGASKLAGEKKVAAATDNHAILRTAWVYSPFGANFL
KTMLRLGESRDVLRVVADQRGTPTSALDIADAVIAVARRLKADPDPALRGVFHLTGGGEGTWADFADAIFGGLKEKTGRE
VKVERITTADYPTPARRPANSRLSTKKLQSSYGIVLADWDASTRGVVDRLLAAGPAT

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=283, Percent_Identity=29.6819787985866, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI33519455, Length=283, Percent_Identity=29.6819787985866, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788352, Length=298, Percent_Identity=42.2818791946309, Blast_Score=220, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 30795; Mature: 30795

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIVTGKQGQVVSSLLERGPAASVEVIALGRPELDLADAASVRSAIAAAAPDAIVSAAA
CEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
YTAVDKAECEPDLAFAVNETGAGAVAEAAGALGVPVIHLSTDYVFAGDKADPYVETDPTG
HHHHHHHCCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCEEEECCCCCCCEECCCCC
PVSVYGASKLAGEKKVAAATDNHAILRTAWVYSPFGANFLKTMLRLGESRDVLRVVADQR
CEEECCCHHHCCCCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHCCC
GTPTSALDIADAVIAVARRLKADPDPALRGVFHLTGGGEGTWADFADAIFGGLKEKTGRE
CCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCE
VKVERITTADYPTPARRPANSRLSTKKLQSSYGIVLADWDASTRGVVDRLLAAGPAT
EEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLIVTGKQGQVVSSLLERGPAASVEVIALGRPELDLADAASVRSAIAAAAPDAIVSAAA
CEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
YTAVDKAECEPDLAFAVNETGAGAVAEAAGALGVPVIHLSTDYVFAGDKADPYVETDPTG
HHHHHHHCCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCEEEECCCCCCCEECCCCC
PVSVYGASKLAGEKKVAAATDNHAILRTAWVYSPFGANFLKTMLRLGESRDVLRVVADQR
CEEECCCHHHCCCCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHCCC
GTPTSALDIADAVIAVARRLKADPDPALRGVFHLTGGGEGTWADFADAIFGGLKEKTGRE
CCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCE
VKVERITTADYPTPARRPANSRLSTKKLQSSYGIVLADWDASTRGVVDRLLAAGPAT
EEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]