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The map label for this gene is rmlA1 [H]

Identifier: 154247483

GI number: 154247483

Start: 3970067

End: 3970951

Strand: Direct

Name: rmlA1 [H]

Synonym: Xaut_3556

Alternate gene names: 154247483

Gene position: 3970067-3970951 (Clockwise)

Preceding gene: 154247482

Following gene: 154247484

Centisome position: 74.78

GC content: 64.41

Gene sequence:

>885_bases
ATGAAGGGGATCATTCTCGCCGGCGGATCGGGCACTCGGCTCTATCCGATCACCAAGGCTGTCTCGAAGCAGCTCATGCC
GGTCTACGACAAGCCGATGATCTACTACCCGCTGACCACGCTGATGCTGGCGGGAATCCGGGAGATCCTCATCATCACCA
CGCCGCATGATGCGGAAGCCTTCGCCCGCCTCCTGGGGGACGGCACGCAGTGGGGCATCCAGATCAGCTACGCGGTGCAG
CCGAGCCCGGACGGGCTGGCGCAGGCCTTCATCATTGGCGCGGACTTCGTTGCCGGCGGGCCGTCGGCGCTGATCCTCGG
CGACAATATCTATTACGGCCACGGCCTGCCGGAATTGCTGCGCGCCGGCAGCGCGCAGGGCAAGGGCGCCCGTGTGTTCG
CCTATCATGTGACCGATCCCGAGCGCTACGGCGTGGTCGAGTTCGACCCCTCGATGCGGGCGATCTCCATCGAGGAAAAG
CCGGCGCAGCCCAAGAGCAACTGGGCGGTGACCGGGCTTTATTTCTACGACGAGCAGGTGGTGGACATCGCCGCCAACCT
GAAGCCGTCCCCCCGGGGCGAGCTGGAGATCACCGATCTCAACCGCGTGTACCTGGAAAAGGGCGAGCTCTCGGTGGAAC
TCATGGGCCGCGGCTATGCCTGGCTCGACACCGGCACGCCGGACAGCCTGCTCGACGCGGCCGACTTCGTCGCGACCCTG
GAGAAGCGCCAGGGTTTCAAGATCGCCTGCCCTGAAGAGGTGGCGTATCGCATGGGGTTCATCGACGTGAACCAGCTTGG
CGAACTGGCTGTTGCCCTGGGCAAGAGCAATTACGGCAAGTATCTCGCGCAGATCGTCAAGCAGAAGGGGAGCGTGGGCG
TCTGA

Upstream 100 bases:

>100_bases
CATCCTATGGAATTGTGCTCGCCGACTGGGACGCGTCCACGCGTGGCGTGGTCGACCGGCTGCTCGCCGCCGGCCCGGCG
ACTTGAAGGAAGGCAGGGGT

Downstream 100 bases:

>100_bases
CGCCCACGCAAGACAGCCTAGCGATTTCGACGCCACAACCCCGGGGGCGGTATGCGTATTCTTGTTGTGTCAGCGATGTT
CCCCCCCAACGTTCTCGGCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKGIILAGGSGTRLYPITKAVSKQLMPVYDKPMIYYPLTTLMLAGIREILIITTPHDAEAFARLLGDGTQWGIQISYAVQ
PSPDGLAQAFIIGADFVAGGPSALILGDNIYYGHGLPELLRAGSAQGKGARVFAYHVTDPERYGVVEFDPSMRAISIEEK
PAQPKSNWAVTGLYFYDEQVVDIAANLKPSPRGELEITDLNRVYLEKGELSVELMGRGYAWLDTGTPDSLLDAADFVATL
EKRQGFKIACPEEVAYRMGFIDVNQLGELAVALGKSNYGKYLAQIVKQKGSVGV

Sequences:

>Translated_294_residues
MKGIILAGGSGTRLYPITKAVSKQLMPVYDKPMIYYPLTTLMLAGIREILIITTPHDAEAFARLLGDGTQWGIQISYAVQ
PSPDGLAQAFIIGADFVAGGPSALILGDNIYYGHGLPELLRAGSAQGKGARVFAYHVTDPERYGVVEFDPSMRAISIEEK
PAQPKSNWAVTGLYFYDEQVVDIAANLKPSPRGELEITDLNRVYLEKGELSVELMGRGYAWLDTGTPDSLLDAADFVATL
EKRQGFKIACPEEVAYRMGFIDVNQLGELAVALGKSNYGKYLAQIVKQKGSVGV
>Mature_294_residues
MKGIILAGGSGTRLYPITKAVSKQLMPVYDKPMIYYPLTTLMLAGIREILIITTPHDAEAFARLLGDGTQWGIQISYAVQ
PSPDGLAQAFIIGADFVAGGPSALILGDNIYYGHGLPELLRAGSAQGKGARVFAYHVTDPERYGVVEFDPSMRAISIEEK
PAQPKSNWAVTGLYFYDEQVVDIAANLKPSPRGELEITDLNRVYLEKGELSVELMGRGYAWLDTGTPDSLLDAADFVATL
EKRQGFKIACPEEVAYRMGFIDVNQLGELAVALGKSNYGKYLAQIVKQKGSVGV

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=257, Percent_Identity=23.7354085603113, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI11761619, Length=257, Percent_Identity=23.7354085603113, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788351, Length=286, Percent_Identity=69.5804195804196, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1790224, Length=289, Percent_Identity=66.0899653979239, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787488, Length=294, Percent_Identity=27.2108843537415, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=28.4584980237154, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=24.3027888446215, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=24.3027888446215, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31897; Mature: 31897

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITKAVSKQLMPVYDKPMIYYPLTTLMLAGIREILIITTPHDAEA
CCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FARLLGDGTQWGIQISYAVQPSPDGLAQAFIIGADFVAGGPSALILGDNIYYGHGLPELL
HHHHHCCCCEEEEEEEEEECCCCCHHHEEEEEECHHHCCCCCEEEEECCEEECCCHHHHH
RAGSAQGKGARVFAYHVTDPERYGVVEFDPSMRAISIEEKPAQPKSNWAVTGLYFYDEQV
HCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCEE
VDIAANLKPSPRGELEITDLNRVYLEKGELSVELMGRGYAWLDTGTPDSLLDAADFVATL
EEHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACPEEVAYRMGFIDVNQLGELAVALGKSNYGKYLAQIVKQKGSVGV
HHHCCCEEECHHHHHHHCCCEEHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITKAVSKQLMPVYDKPMIYYPLTTLMLAGIREILIITTPHDAEA
CCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FARLLGDGTQWGIQISYAVQPSPDGLAQAFIIGADFVAGGPSALILGDNIYYGHGLPELL
HHHHHCCCCEEEEEEEEEECCCCCHHHEEEEEECHHHCCCCCEEEEECCEEECCCHHHHH
RAGSAQGKGARVFAYHVTDPERYGVVEFDPSMRAISIEEKPAQPKSNWAVTGLYFYDEQV
HCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCEE
VDIAANLKPSPRGELEITDLNRVYLEKGELSVELMGRGYAWLDTGTPDSLLDAADFVATL
EEHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACPEEVAYRMGFIDVNQLGELAVALGKSNYGKYLAQIVKQKGSVGV
HHHCCCEEECHHHHHHHCCCEEHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]