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The map label for this gene is czcD [H]

Identifier: 154247404

GI number: 154247404

Start: 3869994

End: 3870980

Strand: Direct

Name: czcD [H]

Synonym: Xaut_3476

Alternate gene names: 154247404

Gene position: 3869994-3870980 (Clockwise)

Preceding gene: 154247403

Following gene: 154247411

Centisome position: 72.9

GC content: 69.0

Gene sequence:

>987_bases
ATGGCGACGCCGGAGACCGGGACCCAGCATCACGACCATGATCACGACGACCATGATCACGACCACCACGGTCATGGCGC
GCATGGTCATTCAGACCACGGCCACAGCCATGCGGTGCCGGATTCCCTGCGCGCCTTCGCCATCGGCGCCGGGCTGAATT
TCGGCTTCGTCATCGTCGAGGTGATCTTCGGCCTCTATGCCGGCTCCCTCGCGCTGCTGGCTGACGCCGGGCACAATCTC
TCCGACGTGCTCGGCCTGCTGCTGGCCTGGGGCGCGGCCTGGCTGTCGCGGCGGGCGCCGACGCGGCTGCGTACCTACGG
CTATGGGCGCTCGTCCATCCTCGCGGCGCTGGCCAATGCCATGATCCTGCTGCTGGGCACCGGCGGCATCATCCTTGAGG
CCATCTCGCGCCTGTCGCAGCCTGAGCCGGTCGAGACCGGCATCGTCATGGTGGTGGCCCTGGTGGGCGTCGCGGTGAAC
ATGGGCACGGCGCTGATGTTCATGGCCGGCCGCAAGGGCGATCTCAACGTGCGAGGGGCCTTCATCCACATGGTGGCGGA
TGGCGCCATCTCGCTGGGGGTGGTGGCGGCGGCCGGGGTGATCGCGCTCACCGGCTGGCTGTGGCTCGACCCGCTGGTGT
CGCTGGTGATCGCGGTGGCCATCATCGCTGGCACCTGGGGCCTGCTGCGCGACAGCGTCAACCTCGCCATGGACAAGGTG
CCCACCGGCATCGATCCCGAACGGGTCGAGGCCTTCCTCGCCACCCGTCCCGGGGTGAGCGAGGTGCACGACCTGCACAT
CTGGGGTCTGTCCACGACGTCAGTGGCGCTCTCGGCCCATCTGGTGCGGCCGGGCGCGGCGCTCGACGACGATTTCCTGA
GCGAAACCTGCGCAGAACTCAGGGCGCGCTTCGGCATTGCGCACCCGGTGCTGCAGATCGAGCAGGGGCGCATGGCCTGC
GCCCTCGCCCCGCGGGACATGGTGTGA

Upstream 100 bases:

>100_bases
CGGTGGACGGCTTCCTGAACTGACATCCGGCCGACATCCCGGCCGGTGACATTCGTGCGCGCCTATGGAACATGCGCAGC
GGATGGACCGGGAGGACAGG

Downstream 100 bases:

>100_bases
TCAGGCGGCCTTGGCCGTATCCGTAGGTTTTCTCGCTCACGCGCCGCGTGGGCTGGTCAGGCGGCTTTGGCCGCCTGGAG
GCCTTCCAGCGCTTCCCTGG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MATPETGTQHHDHDHDDHDHDHHGHGAHGHSDHGHSHAVPDSLRAFAIGAGLNFGFVIVEVIFGLYAGSLALLADAGHNL
SDVLGLLLAWGAAWLSRRAPTRLRTYGYGRSSILAALANAMILLLGTGGIILEAISRLSQPEPVETGIVMVVALVGVAVN
MGTALMFMAGRKGDLNVRGAFIHMVADGAISLGVVAAAGVIALTGWLWLDPLVSLVIAVAIIAGTWGLLRDSVNLAMDKV
PTGIDPERVEAFLATRPGVSEVHDLHIWGLSTTSVALSAHLVRPGAALDDDFLSETCAELRARFGIAHPVLQIEQGRMAC
ALAPRDMV

Sequences:

>Translated_328_residues
MATPETGTQHHDHDHDDHDHDHHGHGAHGHSDHGHSHAVPDSLRAFAIGAGLNFGFVIVEVIFGLYAGSLALLADAGHNL
SDVLGLLLAWGAAWLSRRAPTRLRTYGYGRSSILAALANAMILLLGTGGIILEAISRLSQPEPVETGIVMVVALVGVAVN
MGTALMFMAGRKGDLNVRGAFIHMVADGAISLGVVAAAGVIALTGWLWLDPLVSLVIAVAIIAGTWGLLRDSVNLAMDKV
PTGIDPERVEAFLATRPGVSEVHDLHIWGLSTTSVALSAHLVRPGAALDDDFLSETCAELRARFGIAHPVLQIEQGRMAC
ALAPRDMV
>Mature_327_residues
ATPETGTQHHDHDHDDHDHDHHGHGAHGHSDHGHSHAVPDSLRAFAIGAGLNFGFVIVEVIFGLYAGSLALLADAGHNLS
DVLGLLLAWGAAWLSRRAPTRLRTYGYGRSSILAALANAMILLLGTGGIILEAISRLSQPEPVETGIVMVVALVGVAVNM
GTALMFMAGRKGDLNVRGAFIHMVADGAISLGVVAAAGVIALTGWLWLDPLVSLVIAVAIIAGTWGLLRDSVNLAMDKVP
TGIDPERVEAFLATRPGVSEVHDLHIWGLSTTSVALSAHLVRPGAALDDDFLSETCAELRARFGIAHPVLQIEQGRMACA
LAPRDMV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=27.6872964169381, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=30.8724832214765, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI289803013, Length=277, Percent_Identity=29.9638989169675, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI289803009, Length=277, Percent_Identity=29.9638989169675, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI289803007, Length=277, Percent_Identity=29.9638989169675, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI289803003, Length=277, Percent_Identity=29.9638989169675, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI64762489, Length=304, Percent_Identity=28.2894736842105, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI20070323, Length=305, Percent_Identity=26.2295081967213, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI21359890, Length=301, Percent_Identity=25.9136212624585, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=26.8518518518519, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI52351208, Length=120, Percent_Identity=35.8333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786966, Length=277, Percent_Identity=35.3790613718412, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193210990, Length=311, Percent_Identity=32.1543408360129, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17555794, Length=326, Percent_Identity=30.3680981595092, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17555796, Length=328, Percent_Identity=29.8780487804878, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=306, Percent_Identity=27.1241830065359, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323899, Length=114, Percent_Identity=35.0877192982456, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324892, Length=150, Percent_Identity=30.6666666666667, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=32.3353293413174, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583858, Length=328, Percent_Identity=28.3536585365854, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24584409, Length=151, Percent_Identity=31.7880794701987, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28574430, Length=151, Percent_Identity=31.7880794701987, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24585900, Length=155, Percent_Identity=30.3225806451613, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24585898, Length=155, Percent_Identity=30.3225806451613, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24585896, Length=155, Percent_Identity=30.3225806451613, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921672, Length=155, Percent_Identity=30.3225806451613, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24645863, Length=107, Percent_Identity=31.7757009345794, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656728, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24656724, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24656720, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24656715, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21357035, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34507; Mature: 34376

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPETGTQHHDHDHDDHDHDHHGHGAHGHSDHGHSHAVPDSLRAFAIGAGLNFGFVIVE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCHHHHHHH
VIFGLYAGSLALLADAGHNLSDVLGLLLAWGAAWLSRRAPTRLRTYGYGRSSILAALANA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHH
MILLLGTGGIILEAISRLSQPEPVETGIVMVVALVGVAVNMGTALMFMAGRKGDLNVRGA
HEEHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FIHMVADGAISLGVVAAAGVIALTGWLWLDPLVSLVIAVAIIAGTWGLLRDSVNLAMDKV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTGIDPERVEAFLATRPGVSEVHDLHIWGLSTTSVALSAHLVRPGAALDDDFLSETCAEL
CCCCCHHHHHHHHHCCCCHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
RARFGIAHPVLQIEQGRMACALAPRDMV
HHHHCCCCHHHEECCCCEEEECCCCCCC
>Mature Secondary Structure 
ATPETGTQHHDHDHDDHDHDHHGHGAHGHSDHGHSHAVPDSLRAFAIGAGLNFGFVIVE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCHHHHHHH
VIFGLYAGSLALLADAGHNLSDVLGLLLAWGAAWLSRRAPTRLRTYGYGRSSILAALANA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHH
MILLLGTGGIILEAISRLSQPEPVETGIVMVVALVGVAVNMGTALMFMAGRKGDLNVRGA
HEEHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FIHMVADGAISLGVVAAAGVIALTGWLWLDPLVSLVIAVAIIAGTWGLLRDSVNLAMDKV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTGIDPERVEAFLATRPGVSEVHDLHIWGLSTTSVALSAHLVRPGAALDDDFLSETCAEL
CCCCCHHHHHHHHHCCCCHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
RARFGIAHPVLQIEQGRMACALAPRDMV
HHHHCCCCHHHEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]