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The map label for this gene is envZ [H]

Identifier: 154247332

GI number: 154247332

Start: 3790225

End: 3791559

Strand: Direct

Name: envZ [H]

Synonym: Xaut_3404

Alternate gene names: 154247332

Gene position: 3790225-3791559 (Clockwise)

Preceding gene: 154247331

Following gene: 154247333

Centisome position: 71.39

GC content: 72.13

Gene sequence:

>1335_bases
GTGATCCGCGCCCTCATCCGCGCATCGGACAGCCTCGCCGTGCGCACCGCCGTGGTGGCGGTGCTGGGCATCGTTGTCGT
GCATCTGCTGAGCCTGTGGACCTACGAGCACGCCATGGAGCGCGAGCGCCACGCCGCCCACGCGATCCGCCTCGCCGACC
AGATCGTCTCGCTGCGCCGGTCGCTCACGGCGGCGGCGTCGGAAAGCCGCGAGGATGTGGCCCATGACCTGTCCGGCGGC
GCCATCGACGCCCACTGGAGCCGGGAAGCCATGGCCGCGCCCGGTTCCCATGTCGTGGAGGGATGGCAGCGCCTCGCCGA
CGACGTGCGCACGTTGGCGCCCGACCTCGGGCCGCAGGATGTGCTGGTCGGCGCGGGCACCGACCCGCACCTCAGCCTGG
TCGCGGTGCGTCTTCCGGACGGCAGCTGGCTGAACGCGCGCCTGTTCGCCTCTGTCCCGCAGGCGGCCGGGGCGCACGGA
TCGGTGCTGTCCACGACCCTCATGGCGTCGGGCGTGCTGCTGCTGTCCCTCGCCATCGCCGCCTGGCTGACGCGGCCGCT
CCGGGCCATGGCGCGGACCGTCGCGACCTTGCCCCCGGATGCGCCGCTGGTGCGGTTGCCGGAGACCGGCCCCAAGGAGG
TGCGGGAGCTGGCCCACGCCTTCAATGGCATGCAGGCCCGCATCGCCGAGCTGATGGAGCGGCGCACCCAGGCCCTTGCC
GCGGTTTCCCACGATCTGCGCACGCCCATGACGCGCCTGCGTTTCCGCATGGAGGACGTGGCCGATCCGGTCCTGCGCGC
GGCCATGGCGGCGGATGTGGCGGAGATGGAGCAGATGGTGGACGCCACCCTGTCCTACCTGCGGGGCGAGGCCAGCAAGG
AGCCGGTGCGCCCGCTCGACCTCGTGGCGCTGGTGGAGACGCTGGTGGACAATGCCCGCGACCGGGGACTTGCCGCCGAT
CTTGCCGCGCCGCCGCGCCTGGTTGTGGCGGGCCGCCTCGTCAGCCTGAAGCGGATGGTGTCGAACCTTCTGGAGAATGC
ACTCCTTTATGGCGGCGCCGCGCATGTCGTGCTTCTGGAAGAGGGCGGCGAGGCGGTGCTGACGGTGCGGGACGAGGGCC
CCGGCATTCCCGATGACCAGCTTGCCGCCGTGCTGGAGCCCTTCGTGCGGCTCGAAGCCTCGCGCAGCCGCTCCACCGGC
GGGGTGGGGCTGGGCCTTCCCATCGCCCGCGCGGTGGCTGAGGCGCATGGCGGCTCGCTGACCCTCGAAAACGGCGCTGG
CGGCGGGTTGGTCGTCACGGTGCGCCTGCCCAAGGTCCAGCCTGAAACAAACTGA

Upstream 100 bases:

>100_bases
TCAGCCGGCTGCGCAAGAAGCTTGAATCCCACGGCGGGCCGGAGATGGTGAAGACCGTGCGCGGCGCCGGTTATTTCTTC
GTCCCGGAGGTGGAACGCTC

Downstream 100 bases:

>100_bases
TACAGAAGCGATACGCGGCGTGACAGCCCGCGCGCTATCTGGCTCCCGTACCACCGGATCAAGGATCGGACGGGTTAAAG
GATGGCGCGTCATTTCGTGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIRALIRASDSLAVRTAVVAVLGIVVVHLLSLWTYEHAMERERHAAHAIRLADQIVSLRRSLTAAASESREDVAHDLSGG
AIDAHWSREAMAAPGSHVVEGWQRLADDVRTLAPDLGPQDVLVGAGTDPHLSLVAVRLPDGSWLNARLFASVPQAAGAHG
SVLSTTLMASGVLLLSLAIAAWLTRPLRAMARTVATLPPDAPLVRLPETGPKEVRELAHAFNGMQARIAELMERRTQALA
AVSHDLRTPMTRLRFRMEDVADPVLRAAMAADVAEMEQMVDATLSYLRGEASKEPVRPLDLVALVETLVDNARDRGLAAD
LAAPPRLVVAGRLVSLKRMVSNLLENALLYGGAAHVVLLEEGGEAVLTVRDEGPGIPDDQLAAVLEPFVRLEASRSRSTG
GVGLGLPIARAVAEAHGGSLTLENGAGGGLVVTVRLPKVQPETN

Sequences:

>Translated_444_residues
MIRALIRASDSLAVRTAVVAVLGIVVVHLLSLWTYEHAMERERHAAHAIRLADQIVSLRRSLTAAASESREDVAHDLSGG
AIDAHWSREAMAAPGSHVVEGWQRLADDVRTLAPDLGPQDVLVGAGTDPHLSLVAVRLPDGSWLNARLFASVPQAAGAHG
SVLSTTLMASGVLLLSLAIAAWLTRPLRAMARTVATLPPDAPLVRLPETGPKEVRELAHAFNGMQARIAELMERRTQALA
AVSHDLRTPMTRLRFRMEDVADPVLRAAMAADVAEMEQMVDATLSYLRGEASKEPVRPLDLVALVETLVDNARDRGLAAD
LAAPPRLVVAGRLVSLKRMVSNLLENALLYGGAAHVVLLEEGGEAVLTVRDEGPGIPDDQLAAVLEPFVRLEASRSRSTG
GVGLGLPIARAVAEAHGGSLTLENGAGGGLVVTVRLPKVQPETN
>Mature_444_residues
MIRALIRASDSLAVRTAVVAVLGIVVVHLLSLWTYEHAMERERHAAHAIRLADQIVSLRRSLTAAASESREDVAHDLSGG
AIDAHWSREAMAAPGSHVVEGWQRLADDVRTLAPDLGPQDVLVGAGTDPHLSLVAVRLPDGSWLNARLFASVPQAAGAHG
SVLSTTLMASGVLLLSLAIAAWLTRPLRAMARTVATLPPDAPLVRLPETGPKEVRELAHAFNGMQARIAELMERRTQALA
AVSHDLRTPMTRLRFRMEDVADPVLRAAMAADVAEMEQMVDATLSYLRGEASKEPVRPLDLVALVETLVDNARDRGLAAD
LAAPPRLVVAGRLVSLKRMVSNLLENALLYGGAAHVVLLEEGGEAVLTVRDEGPGIPDDQLAAVLEPFVRLEASRSRSTG
GVGLGLPIARAVAEAHGGSLTLENGAGGGLVVTVRLPKVQPETN

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=311, Percent_Identity=31.8327974276527, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=33.1896551724138, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790551, Length=307, Percent_Identity=29.3159609120521, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786783, Length=273, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=363, Percent_Identity=29.4765840220386, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=34.1772151898734, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=26.7489711934156, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=25.9515570934256, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=325, Percent_Identity=28, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=23.8738738738739, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=24.8, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47102; Mature: 47102

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRALIRASDSLAVRTAVVAVLGIVVVHLLSLWTYEHAMERERHAAHAIRLADQIVSLRR
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTAAASESREDVAHDLSGGAIDAHWSREAMAAPGSHVVEGWQRLADDVRTLAPDLGPQD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
VLVGAGTDPHLSLVAVRLPDGSWLNARLFASVPQAAGAHGSVLSTTLMASGVLLLSLAIA
EEEECCCCCCEEEEEEECCCCCCCCHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
AWLTRPLRAMARTVATLPPDAPLVRLPETGPKEVRELAHAFNGMQARIAELMERRTQALA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AVSHDLRTPMTRLRFRMEDVADPVLRAAMAADVAEMEQMVDATLSYLRGEASKEPVRPLD
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LVALVETLVDNARDRGLAADLAAPPRLVVAGRLVSLKRMVSNLLENALLYGGAAHVVLLE
HHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
EGGEAVLTVRDEGPGIPDDQLAAVLEPFVRLEASRSRSTGGVGLGLPIARAVAEAHGGSL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEE
TLENGAGGGLVVTVRLPKVQPETN
EEECCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MIRALIRASDSLAVRTAVVAVLGIVVVHLLSLWTYEHAMERERHAAHAIRLADQIVSLRR
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTAAASESREDVAHDLSGGAIDAHWSREAMAAPGSHVVEGWQRLADDVRTLAPDLGPQD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
VLVGAGTDPHLSLVAVRLPDGSWLNARLFASVPQAAGAHGSVLSTTLMASGVLLLSLAIA
EEEECCCCCCEEEEEEECCCCCCCCHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
AWLTRPLRAMARTVATLPPDAPLVRLPETGPKEVRELAHAFNGMQARIAELMERRTQALA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AVSHDLRTPMTRLRFRMEDVADPVLRAAMAADVAEMEQMVDATLSYLRGEASKEPVRPLD
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LVALVETLVDNARDRGLAADLAAPPRLVVAGRLVSLKRMVSNLLENALLYGGAAHVVLLE
HHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
EGGEAVLTVRDEGPGIPDDQLAAVLEPFVRLEASRSRSTGGVGLGLPIARAVAEAHGGSL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEE
TLENGAGGGLVVTVRLPKVQPETN
EEECCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]