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The map label for this gene is 154247260

Identifier: 154247260

GI number: 154247260

Start: 3706141

End: 3707457

Strand: Reverse

Name: 154247260

Synonym: Xaut_3332

Alternate gene names: NA

Gene position: 3707457-3706141 (Counterclockwise)

Preceding gene: 154247261

Following gene: 154247259

Centisome position: 69.83

GC content: 70.69

Gene sequence:

>1317_bases
ATGATCGACGCGACCCACGATCCCGCCCGCACCAGCTGGGTGGCCTCGGCCAACGGCCATTCCGACTTTCCCATCCAGAA
CCTGCCCTTCGGCATCTTCAGCCCGCCCGGCGGGCAACCGCGCGGGGGCGTCGCCATCGGCGACGACATCCTCGATCTCG
CCGTGGCGCTGGAGCTGGGCCTGTTCGAGGGCATCGCCAAGGCGGCGGCGCAGGCGGCAGCAGGGTCGACCCTCAACGCC
TTCTTCGCCCTCGGGGCGGCGCCGCGCGCCGCGTTGCGCGCGCGGCTCGTCCAGTTGCTGGATGCCCATGGCGTGGAGCG
CTCCAACGTGGAGCCCCACGCCGGCCGGCTGCTGCACCGCGCCGCCGACTGCACCCTGCACCTGCCCGCCGCCATCGGCG
ACTATACGGATTTCTACGCCGGCATCTCCCACGCCACCAATGTGGGCAAGCTGTTCCGGCCGGATAACCCATTGCTGCCC
AACTATAAATACGTGCCCATCGGCTATCACGGGCGGGCCTCCTCCATCCGGCCCTCGGGCTTCGACGTGCGCCGGCCCAA
CGGCCAGCGCAAGCGGGCCGACGAGGCGGAGCCGACCTTCGGCCCCTCCGGCAACCTCGACTACGAGCTGGAGCTGGGCA
TCTTCGTCGGGCCGGGCAACGCCCTCGGCGAGCCAGTTTCCATCCACGCCGCGGGCGAGCACATCGCCGGCTTCTGCCTG
CTCAACGACTGGTCGGCCCGCGACATCCAGGGCTGGGAATACCAGCCGCTCGGCCCGTTCCTCGCCAAGAACTTCATCAC
CACCGTGTCGCCCTGGGTGGTGACGCCGGAAGCGCTGGCCCCCTTCCGCATCCCCCAGCCCGTGCGGCCGCAGGGCGATC
CCGCCCCCCTGCCCTATCTGCTCGATGCCGCCGACCAGGCGCAGGGCGCCCTCGACATCACCCTGGAGGTGCTCATCGAG
ACGCCGGGGCTGAAGGAGAAGGGCCTGCCGCCCCATCGCCTGTCGCGCGGCTCATCAAGCGACCTCTACTGGACCGCCGC
CCAGTTCGTCGCGCACCACACCTGCGGCGGCTGCAACCTGTCGCCCGGCGACCTCATGGGCACCGGCACCATCTCCGGCC
CCACGCCGGATAGCTTCGGCAGCCTTTTGGAACTGTCGCAGGGCGGCAAGGCGCCTCTCACCCTCGCCTCGGGCGAAGAG
CGGCGCTTTCTGGAGGATGGCGACACGGTGATCATCACCGGCCGCGCCGCGCGCGAGGGCTTCGTCTCCATCGGCTTCGG
CGCCTGCAGTGGCACCATCCTGCCGGCGCTCGGGTGA

Upstream 100 bases:

>100_bases
ATGCGTGGTGAGGTGAGGGTCTTCCCCGTCTGACTTTGCCTCCGCGCCGGCGCCGCATCCCGGCGCCGGCCCTTCCTTGC
CCCCTGCCCGGACCGCTCCC

Downstream 100 bases:

>100_bases
GCGCCGTGCGGCTCTATACCTATTGGCGCTCCACCTCGGCCTACCGGGTGCGCATCGCGCTCGCCCTGAAGGGCATCGCG
GTGGAACAGGTGCCGGTGCA

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIDATHDPARTSWVASANGHSDFPIQNLPFGIFSPPGGQPRGGVAIGDDILDLAVALELGLFEGIAKAAAQAAAGSTLNA
FFALGAAPRAALRARLVQLLDAHGVERSNVEPHAGRLLHRAADCTLHLPAAIGDYTDFYAGISHATNVGKLFRPDNPLLP
NYKYVPIGYHGRASSIRPSGFDVRRPNGQRKRADEAEPTFGPSGNLDYELELGIFVGPGNALGEPVSIHAAGEHIAGFCL
LNDWSARDIQGWEYQPLGPFLAKNFITTVSPWVVTPEALAPFRIPQPVRPQGDPAPLPYLLDAADQAQGALDITLEVLIE
TPGLKEKGLPPHRLSRGSSSDLYWTAAQFVAHHTCGGCNLSPGDLMGTGTISGPTPDSFGSLLELSQGGKAPLTLASGEE
RRFLEDGDTVIITGRAAREGFVSIGFGACSGTILPALG

Sequences:

>Translated_438_residues
MIDATHDPARTSWVASANGHSDFPIQNLPFGIFSPPGGQPRGGVAIGDDILDLAVALELGLFEGIAKAAAQAAAGSTLNA
FFALGAAPRAALRARLVQLLDAHGVERSNVEPHAGRLLHRAADCTLHLPAAIGDYTDFYAGISHATNVGKLFRPDNPLLP
NYKYVPIGYHGRASSIRPSGFDVRRPNGQRKRADEAEPTFGPSGNLDYELELGIFVGPGNALGEPVSIHAAGEHIAGFCL
LNDWSARDIQGWEYQPLGPFLAKNFITTVSPWVVTPEALAPFRIPQPVRPQGDPAPLPYLLDAADQAQGALDITLEVLIE
TPGLKEKGLPPHRLSRGSSSDLYWTAAQFVAHHTCGGCNLSPGDLMGTGTISGPTPDSFGSLLELSQGGKAPLTLASGEE
RRFLEDGDTVIITGRAAREGFVSIGFGACSGTILPALG
>Mature_438_residues
MIDATHDPARTSWVASANGHSDFPIQNLPFGIFSPPGGQPRGGVAIGDDILDLAVALELGLFEGIAKAAAQAAAGSTLNA
FFALGAAPRAALRARLVQLLDAHGVERSNVEPHAGRLLHRAADCTLHLPAAIGDYTDFYAGISHATNVGKLFRPDNPLLP
NYKYVPIGYHGRASSIRPSGFDVRRPNGQRKRADEAEPTFGPSGNLDYELELGIFVGPGNALGEPVSIHAAGEHIAGFCL
LNDWSARDIQGWEYQPLGPFLAKNFITTVSPWVVTPEALAPFRIPQPVRPQGDPAPLPYLLDAADQAQGALDITLEVLIE
TPGLKEKGLPPHRLSRGSSSDLYWTAAQFVAHHTCGGCNLSPGDLMGTGTISGPTPDSFGSLLELSQGGKAPLTLASGEE
RRFLEDGDTVIITGRAAREGFVSIGFGACSGTILPALG

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=421, Percent_Identity=49.6437054631829, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17568863, Length=422, Percent_Identity=50.7109004739336, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24657182, Length=420, Percent_Identity=46.4285714285714, Blast_Score=344, Evalue=6e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46105; Mature: 46105

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDATHDPARTSWVASANGHSDFPIQNLPFGIFSPPGGQPRGGVAIGDDILDLAVALELG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
LFEGIAKAAAQAAAGSTLNAFFALGAAPRAALRARLVQLLDAHGVERSNVEPHAGRLLHR
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AADCTLHLPAAIGDYTDFYAGISHATNVGKLFRPDNPLLPNYKYVPIGYHGRASSIRPSG
HCCCEEECCHHHCCHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCC
FDVRRPNGQRKRADEAEPTFGPSGNLDYELELGIFVGPGNALGEPVSIHAAGEHIAGFCL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCEEEEEE
LNDWSARDIQGWEYQPLGPFLAKNFITTVSPWVVTPEALAPFRIPQPVRPQGDPAPLPYL
ECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCCCCCCCHH
LDAADQAQGALDITLEVLIETPGLKEKGLPPHRLSRGSSSDLYWTAAQFVAHHTCGGCNL
CCCHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHCCCCCCCEEEHHHHHHHHHCCCCCCC
SPGDLMGTGTISGPTPDSFGSLLELSQGGKAPLTLASGEERRFLEDGDTVIITGRAAREG
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCEEEEECCCCCCC
FVSIGFGACSGTILPALG
EEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MIDATHDPARTSWVASANGHSDFPIQNLPFGIFSPPGGQPRGGVAIGDDILDLAVALELG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
LFEGIAKAAAQAAAGSTLNAFFALGAAPRAALRARLVQLLDAHGVERSNVEPHAGRLLHR
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AADCTLHLPAAIGDYTDFYAGISHATNVGKLFRPDNPLLPNYKYVPIGYHGRASSIRPSG
HCCCEEECCHHHCCHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCC
FDVRRPNGQRKRADEAEPTFGPSGNLDYELELGIFVGPGNALGEPVSIHAAGEHIAGFCL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCEEEEEE
LNDWSARDIQGWEYQPLGPFLAKNFITTVSPWVVTPEALAPFRIPQPVRPQGDPAPLPYL
ECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCCCCCCCHH
LDAADQAQGALDITLEVLIETPGLKEKGLPPHRLSRGSSSDLYWTAAQFVAHHTCGGCNL
CCCHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHCCCCCCCEEEHHHHHHHHHCCCCCCC
SPGDLMGTGTISGPTPDSFGSLLELSQGGKAPLTLASGEERRFLEDGDTVIITGRAAREG
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCEEEEECCCCCCC
FVSIGFGACSGTILPALG
EEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA