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The map label for this gene is mutM

Identifier: 154247235

GI number: 154247235

Start: 3676359

End: 3677240

Strand: Direct

Name: mutM

Synonym: Xaut_3307

Alternate gene names: 154247235

Gene position: 3676359-3677240 (Clockwise)

Preceding gene: 154247234

Following gene: 154247236

Centisome position: 69.25

GC content: 69.39

Gene sequence:

>882_bases
ATGCCCGAATTGCCCGAGGTGGAGACCGTCCGCCGCGGTCTCATTCCTGTCCTGCAAGGTGCCGTGATCGAAAGCGCGGA
GGCCCGCAGGCCGGACCTGCGCTGGCCCTTGCCCGACAATTTCGCCGAGCGCCTTGCCGGCCGCCGGGTCGAGGCCATCG
GCCGTCGCGCCAAATATCTCCTTGCCGATCTGGACGGCGGCGAGGTGATGATCCTGCATCTCGGCATGTCCGGCTCCATC
CGCATCGAAGGTGGCGCGGTGAAGGGCCGCCCCGGCCGCTTCCATCATCCGCGCGGGGCGGGTGGACCGCACGACCACGT
GGTGCTGCACCTCGCCGGCGGGGCGACGGTGACCTTCAACGATCCCCGGCGCTTCGGCGCCATCCTGATCGTGCCCTACG
ACCAGATCATGTCCCATCCGCTGCTGGCGGGCCTCGGGCCGGAGCCGCTGGGCAACGGCTTCAATGCCGAATATCTCGCT
CGCGCCTGCGCCCGCCGCCACACCTCGCTGAAGGCGGCGCTGCTGGACCAGAAGCTGGTGGCCGGGCTTGGCAACATCTA
TGTGTGCGAGGCGCTGTTTCGCGCCGGCCTGTCGCCGCGCCGCCTCGCCCACACCATCGCCACCGCCGAGGGCGCGCCCA
CCCGGAGGGCCGAGCGGCTGGTGATCGCCATCCGCGACGTGCTGCGCGAGGCGATCCATGCCGGCGGCTCCTCCCTGCGC
GACCACCGGCAGGTGAACGGTGAGCTGGGCTATTTCCAGCACACCTTCAAGGTCTACGACCGCGAGGGGCAGCCCTGCCA
GACACTGCACTGCAAGGACACCATCCGGCGCATCGTGCAGAATGGGCGTTCGACCTTCTACTGCCCCACCTGCCAGAGGT
AG

Upstream 100 bases:

>100_bases
GACGCGCTCTCTTGCGCGGGGGGCCGGTCGGTCCGATCCTATGACGCGATGAAGATTCGCGTGCCGGTTGCGGCGCGTCC
CATTCAGTTTTGAGAACAAC

Downstream 100 bases:

>100_bases
CTTGCCGGAGGTCGTCCCCCGAAGGGCATCCGCCAAAGGTCGGGCAGGCCTGCACGACGACTGTGCGGCAATGCCTCTTC
GCCTCGCCCCCCTGACGCGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPELPEVETVRRGLIPVLQGAVIESAEARRPDLRWPLPDNFAERLAGRRVEAIGRRAKYLLADLDGGEVMILHLGMSGSI
RIEGGAVKGRPGRFHHPRGAGGPHDHVVLHLAGGATVTFNDPRRFGAILIVPYDQIMSHPLLAGLGPEPLGNGFNAEYLA
RACARRHTSLKAALLDQKLVAGLGNIYVCEALFRAGLSPRRLAHTIATAEGAPTRRAERLVIAIRDVLREAIHAGGSSLR
DHRQVNGELGYFQHTFKVYDREGQPCQTLHCKDTIRRIVQNGRSTFYCPTCQR

Sequences:

>Translated_293_residues
MPELPEVETVRRGLIPVLQGAVIESAEARRPDLRWPLPDNFAERLAGRRVEAIGRRAKYLLADLDGGEVMILHLGMSGSI
RIEGGAVKGRPGRFHHPRGAGGPHDHVVLHLAGGATVTFNDPRRFGAILIVPYDQIMSHPLLAGLGPEPLGNGFNAEYLA
RACARRHTSLKAALLDQKLVAGLGNIYVCEALFRAGLSPRRLAHTIATAEGAPTRRAERLVIAIRDVLREAIHAGGSSLR
DHRQVNGELGYFQHTFKVYDREGQPCQTLHCKDTIRRIVQNGRSTFYCPTCQR
>Mature_292_residues
PELPEVETVRRGLIPVLQGAVIESAEARRPDLRWPLPDNFAERLAGRRVEAIGRRAKYLLADLDGGEVMILHLGMSGSIR
IEGGAVKGRPGRFHHPRGAGGPHDHVVLHLAGGATVTFNDPRRFGAILIVPYDQIMSHPLLAGLGPEPLGNGFNAEYLAR
ACARRHTSLKAALLDQKLVAGLGNIYVCEALFRAGLSPRRLAHTIATAEGAPTRRAERLVIAIRDVLREAIHAGGSSLRD
HRQVNGELGYFQHTFKVYDREGQPCQTLHCKDTIRRIVQNGRSTFYCPTCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=293, Percent_Identity=43.6860068259386, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1786932, Length=295, Percent_Identity=23.3898305084746, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_XANP2 (A7IKJ3)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001418193.1
- STRING:   A7IKJ3
- GeneID:   5422613
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_3307
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   XAUT78245:XAUT_3307-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32196; Mature: 32064

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 283-283 BINDING 104-104 BINDING 123-123 BINDING 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLIPVLQGAVIESAEARRPDLRWPLPDNFAERLAGRRVEAIGRRAKYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHEE
LADLDGGEVMILHLGMSGSIRIEGGAVKGRPGRFHHPRGAGGPHDHVVLHLAGGATVTFN
EEECCCCEEEEEEECCCCEEEEECCEECCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEC
DPRRFGAILIVPYDQIMSHPLLAGLGPEPLGNGFNAEYLARACARRHTSLKAALLDQKLV
CCCCCCEEEEEEHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGLGNIYVCEALFRAGLSPRRLAHTIATAEGAPTRRAERLVIAIRDVLREAIHAGGSSLR
HHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
DHRQVNGELGYFQHTFKVYDREGQPCQTLHCKDTIRRIVQNGRSTFYCPTCQR
HHHHCCCCCCHHHHEEHEECCCCCCCCEECHHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLIPVLQGAVIESAEARRPDLRWPLPDNFAERLAGRRVEAIGRRAKYL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHEE
LADLDGGEVMILHLGMSGSIRIEGGAVKGRPGRFHHPRGAGGPHDHVVLHLAGGATVTFN
EEECCCCEEEEEEECCCCEEEEECCEECCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEC
DPRRFGAILIVPYDQIMSHPLLAGLGPEPLGNGFNAEYLARACARRHTSLKAALLDQKLV
CCCCCCEEEEEEHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGLGNIYVCEALFRAGLSPRRLAHTIATAEGAPTRRAERLVIAIRDVLREAIHAGGSSLR
HHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
DHRQVNGELGYFQHTFKVYDREGQPCQTLHCKDTIRRIVQNGRSTFYCPTCQR
HHHHCCCCCCHHHHEEHEECCCCCCCCEECHHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA