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The map label for this gene is mutL

Identifier: 154246983

GI number: 154246983

Start: 3392606

End: 3394537

Strand: Direct

Name: mutL

Synonym: Xaut_3054

Alternate gene names: 154246983

Gene position: 3392606-3394537 (Clockwise)

Preceding gene: 154246978

Following gene: 154246989

Centisome position: 63.9

GC content: 73.19

Gene sequence:

>1932_bases
ATGGTGCCGCCGGCTTCGCGCGGCCGCCGCAGGGCCTTAAGATCGCCGATCCCGAATCGTAGCCAAGCCGCCATGCTCAT
CCGCCGCCTGCCTCCCGTGCTCATCGACCGCATCGCCGCCGGCGAAGTGGTGGAGCGGCCGGCTGCCGTGGTGAAGGAGC
TGGTGGAGAACGCGCTGGATGCCGGCGCCCGCGCCATCGAGGTGGTGATCCAGGGCGGCGGCCGGCGCCTGGTGCGGGTC
AGCGACGACGGCAGCGGCATGGGGCCGGACGATCTCGCCTTGTGCGTGGAACGCCACGCCACCTCCAAGCTCGCCGGGGA
AGACCTGCTGTCCATCTCCACCCTCGGCTTCCGGGGGGAGGCGCTGCCCTCCATCGGATCGGTGGCCCATCTTGCCATCG
CCAGCCGGCCGAGGGATGCCGCCCACGCCTTCGAGGTGCGGGTGGATGGCGGGGTCGTTACGCCGCCGCGCCCGGCCGCT
CTGGGCGGCGGGACGCGGGTGGAAGTGCGGGACCTGTTCTATGCGACGCCCGCCCGCCTGAAGTTCCTGAAATCCGACCG
GGCCGAGGGCGCGGCGGCGGCGGACGTGGTGCGCCGGCTGGCGCTGGCGCGGCCGGATGTGGCCTTCACCCTGGTCACCG
ACGAGCGCGCAGCGGTGACATTCCCGGCCCGCGCGGACGATGCGGACGGGCGCGCCGCGCGCCTCGCCGACGTGCTGGGG
GCGGAGGCGGGGCGCAACGTGGTGGCTGTCAACGGCATCCGCGACGACGTGGTGCTGGAGGGCCTCGCCGGCCTCCCCAC
CTTCTCCAAGGCCAATTCGCTCAGCCAATACCTGTTCGTGAACGGCCGCCCGGTGCGCGACAAGCTGCTGATGGGCGCCG
TGCGCGCGGCCTATGCGGACCTGTTGCCGTCGGATCGCTATCCGGTGCTGGCGCTGTTCATCAGCCTCGATCCGCGCGAT
GTGGACGTGAACGTGCACCCGGCGAAGACCGAGGTGCGGTTTCGCGACGGCGGCAATGTGCGGGCCCTCATCGTGCGCAC
CCTGTCCGACGCGCTGGGCGCACGCATCCCCTCCACCGCCGGCACCATGGCCGACCGGCTGGTGGCGCTGGCCCGCACGC
CGGAGCTGGGGCCGCGGGCCGCATTCGCGCCTGCCGCTCCGTTCGCGACCCCCGGCGGCGGGGCCTTCGCCGGCTTCCGG
CCGGCGCCGGCCCTTGATTATGACTGGCGCCAGTCGCCCGCCCGGCCGATGCCATCCGGGCTGGGCGAGGAGGAGCAGGC
GCGCCTCGACATCGCCGAGCCTTCGGCCGACGCGCGCGCCGATGCAGCGCCCGTCTCCGCCGTCGACCTCGACCGGCCGC
TGGGCGCGGCGCGAGCGCAGCTGCACGAGACCTATATCGTCGCCCAGACCCGGGAAGGGCTAGTCCTGGTGGATCAGCAC
GCCGCCCACGAGCGGCTGGTCTATGAGAAGCTGAAGGCGGCGCTGGCCCGCGACGGCGTCGGCCGGCAGGGCCTGCTGAT
CCCGGCGGTGGTGGATCTCGACCCCGCCGATGCCGACCGCCTCACCGAGCGCGCCGGCGATCTCGCGGCGCTGGGGCTGG
TGCTGGAGAGCTTCGGTCCCGGCGCGGTGCTGGTGCGGGAAGTGCCGGCCCTGCTGAAGGATGCCGATGTGACCCGCCTC
GTCACCGACCTCGCCGAGCATGCGGCCGAATGGGACGACGCCTTGCCGCTGGAGCGGCGCCTGCTCCATGTGGCCGCCAC
CATGGCCTGCCACGGCTCGGTGCGGGCGGGACGGCGCCTGAAGGTGGAGGAGATGAACGCCCTGCTGCGCGAGATGGAGG
AGACCCCCAACGCCGGCGAGTGCAACCACGGCCGGCCGACCTTCGTCACCCTGTCGCTGAAGGACGTGGAGAAGCTGTTC
GCCCGGCGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCCGCTCACGAAATTTCTCTTCCTACAGATTTAGGCCAAGCGGCCGGCAAAGCAAGCTTCGCTCTGTTTCTGGCG
GAGAAAGCGCTTTCGGCAGC

Downstream 100 bases:

>100_bases
GGGGGCCATCAAACGACAATGCCCGGCGCGGAGCCGGGCATGACGTGGCAGAACCTCGGGGAGGGTGCGGCTCAGGCGCT
CTTCAGCAGGCGCATGAGAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MVPPASRGRRRALRSPIPNRSQAAMLIRRLPPVLIDRIAAGEVVERPAAVVKELVENALDAGARAIEVVIQGGGRRLVRV
SDDGSGMGPDDLALCVERHATSKLAGEDLLSISTLGFRGEALPSIGSVAHLAIASRPRDAAHAFEVRVDGGVVTPPRPAA
LGGGTRVEVRDLFYATPARLKFLKSDRAEGAAAADVVRRLALARPDVAFTLVTDERAAVTFPARADDADGRAARLADVLG
AEAGRNVVAVNGIRDDVVLEGLAGLPTFSKANSLSQYLFVNGRPVRDKLLMGAVRAAYADLLPSDRYPVLALFISLDPRD
VDVNVHPAKTEVRFRDGGNVRALIVRTLSDALGARIPSTAGTMADRLVALARTPELGPRAAFAPAAPFATPGGGAFAGFR
PAPALDYDWRQSPARPMPSGLGEEEQARLDIAEPSADARADAAPVSAVDLDRPLGAARAQLHETYIVAQTREGLVLVDQH
AAHERLVYEKLKAALARDGVGRQGLLIPAVVDLDPADADRLTERAGDLAALGLVLESFGPGAVLVREVPALLKDADVTRL
VTDLAEHAAEWDDALPLERRLLHVAATMACHGSVRAGRRLKVEEMNALLREMEETPNAGECNHGRPTFVTLSLKDVEKLF
ARR

Sequences:

>Translated_643_residues
MVPPASRGRRRALRSPIPNRSQAAMLIRRLPPVLIDRIAAGEVVERPAAVVKELVENALDAGARAIEVVIQGGGRRLVRV
SDDGSGMGPDDLALCVERHATSKLAGEDLLSISTLGFRGEALPSIGSVAHLAIASRPRDAAHAFEVRVDGGVVTPPRPAA
LGGGTRVEVRDLFYATPARLKFLKSDRAEGAAAADVVRRLALARPDVAFTLVTDERAAVTFPARADDADGRAARLADVLG
AEAGRNVVAVNGIRDDVVLEGLAGLPTFSKANSLSQYLFVNGRPVRDKLLMGAVRAAYADLLPSDRYPVLALFISLDPRD
VDVNVHPAKTEVRFRDGGNVRALIVRTLSDALGARIPSTAGTMADRLVALARTPELGPRAAFAPAAPFATPGGGAFAGFR
PAPALDYDWRQSPARPMPSGLGEEEQARLDIAEPSADARADAAPVSAVDLDRPLGAARAQLHETYIVAQTREGLVLVDQH
AAHERLVYEKLKAALARDGVGRQGLLIPAVVDLDPADADRLTERAGDLAALGLVLESFGPGAVLVREVPALLKDADVTRL
VTDLAEHAAEWDDALPLERRLLHVAATMACHGSVRAGRRLKVEEMNALLREMEETPNAGECNHGRPTFVTLSLKDVEKLF
ARR
>Mature_643_residues
MVPPASRGRRRALRSPIPNRSQAAMLIRRLPPVLIDRIAAGEVVERPAAVVKELVENALDAGARAIEVVIQGGGRRLVRV
SDDGSGMGPDDLALCVERHATSKLAGEDLLSISTLGFRGEALPSIGSVAHLAIASRPRDAAHAFEVRVDGGVVTPPRPAA
LGGGTRVEVRDLFYATPARLKFLKSDRAEGAAAADVVRRLALARPDVAFTLVTDERAAVTFPARADDADGRAARLADVLG
AEAGRNVVAVNGIRDDVVLEGLAGLPTFSKANSLSQYLFVNGRPVRDKLLMGAVRAAYADLLPSDRYPVLALFISLDPRD
VDVNVHPAKTEVRFRDGGNVRALIVRTLSDALGARIPSTAGTMADRLVALARTPELGPRAAFAPAAPFATPGGGAFAGFR
PAPALDYDWRQSPARPMPSGLGEEEQARLDIAEPSADARADAAPVSAVDLDRPLGAARAQLHETYIVAQTREGLVLVDQH
AAHERLVYEKLKAALARDGVGRQGLLIPAVVDLDPADADRLTERAGDLAALGLVLESFGPGAVLVREVPALLKDADVTRL
VTDLAEHAAEWDDALPLERRLLHVAATMACHGSVRAGRRLKVEEMNALLREMEETPNAGECNHGRPTFVTLSLKDVEKLF
ARR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=326, Percent_Identity=38.0368098159509, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI4505911, Length=372, Percent_Identity=28.2258064516129, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI189458898, Length=372, Percent_Identity=28.2258064516129, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI189458896, Length=363, Percent_Identity=26.9972451790634, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=226, Percent_Identity=32.7433628318584, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4505913, Length=337, Percent_Identity=27.299703264095, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128478, Length=337, Percent_Identity=27.299703264095, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI91992162, Length=340, Percent_Identity=24.7058823529412, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI91992160, Length=340, Percent_Identity=24.7058823529412, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790612, Length=567, Percent_Identity=34.2151675485009, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=333, Percent_Identity=37.2372372372372, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=383, Percent_Identity=24.0208877284595, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=33.6283185840708, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=406, Percent_Identity=24.6305418719212, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=720, Percent_Identity=22.3611111111111, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323063, Length=415, Percent_Identity=25.0602409638554, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136968, Length=316, Percent_Identity=37.6582278481013, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17136970, Length=344, Percent_Identity=29.0697674418605, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68369; Mature: 68369

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPPASRGRRRALRSPIPNRSQAAMLIRRLPPVLIDRIAAGEVVERPAAVVKELVENALD
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGARAIEVVIQGGGRRLVRVSDDGSGMGPDDLALCVERHATSKLAGEDLLSISTLGFRGE
CCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCC
ALPSIGSVAHLAIASRPRDAAHAFEVRVDGGVVTPPRPAALGGGTRVEVRDLFYATPARL
CCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHH
KFLKSDRAEGAAAADVVRRLALARPDVAFTLVTDERAAVTFPARADDADGRAARLADVLG
HHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHH
AEAGRNVVAVNGIRDDVVLEGLAGLPTFSKANSLSQYLFVNGRPVRDKLLMGAVRAAYAD
HHCCCCEEEECCCCHHHHHHHHCCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
LLPSDRYPVLALFISLDPRDVDVNVHPAKTEVRFRDGGNVRALIVRTLSDALGARIPSTA
HCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHCCCCCCHH
GTMADRLVALARTPELGPRAAFAPAAPFATPGGGAFAGFRPAPALDYDWRQSPARPMPSG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LGEEEQARLDIAEPSADARADAAPVSAVDLDRPLGAARAQLHETYIVAQTREGLVLVDQH
CCCCHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCEEEEECH
AAHERLVYEKLKAALARDGVGRQGLLIPAVVDLDPADADRLTERAGDLAALGLVLESFGP
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHCCCC
GAVLVREVPALLKDADVTRLVTDLAEHAAEWDDALPLERRLLHVAATMACHGSVRAGRRL
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
KVEEMNALLREMEETPNAGECNHGRPTFVTLSLKDVEKLFARR
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MVPPASRGRRRALRSPIPNRSQAAMLIRRLPPVLIDRIAAGEVVERPAAVVKELVENALD
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGARAIEVVIQGGGRRLVRVSDDGSGMGPDDLALCVERHATSKLAGEDLLSISTLGFRGE
CCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCC
ALPSIGSVAHLAIASRPRDAAHAFEVRVDGGVVTPPRPAALGGGTRVEVRDLFYATPARL
CCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHH
KFLKSDRAEGAAAADVVRRLALARPDVAFTLVTDERAAVTFPARADDADGRAARLADVLG
HHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHH
AEAGRNVVAVNGIRDDVVLEGLAGLPTFSKANSLSQYLFVNGRPVRDKLLMGAVRAAYAD
HHCCCCEEEECCCCHHHHHHHHCCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
LLPSDRYPVLALFISLDPRDVDVNVHPAKTEVRFRDGGNVRALIVRTLSDALGARIPSTA
HCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHCCCCCCHH
GTMADRLVALARTPELGPRAAFAPAAPFATPGGGAFAGFRPAPALDYDWRQSPARPMPSG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LGEEEQARLDIAEPSADARADAAPVSAVDLDRPLGAARAQLHETYIVAQTREGLVLVDQH
CCCCHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCEEEEECH
AAHERLVYEKLKAALARDGVGRQGLLIPAVVDLDPADADRLTERAGDLAALGLVLESFGP
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHCCCC
GAVLVREVPALLKDADVTRLVTDLAEHAAEWDDALPLERRLLHVAATMACHGSVRAGRRL
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
KVEEMNALLREMEETPNAGECNHGRPTFVTLSLKDVEKLFARR
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA