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The map label for this gene is map [H]

Identifier: 154246982

GI number: 154246982

Start: 3391650

End: 3392477

Strand: Reverse

Name: map [H]

Synonym: Xaut_3053

Alternate gene names: 154246982

Gene position: 3392477-3391650 (Counterclockwise)

Preceding gene: 154246984

Following gene: 154246981

Centisome position: 63.9

GC content: 67.15

Gene sequence:

>828_bases
ATGAATTATGTTGAGGCGGCCAACGCGCCGCTGCGCAAGACCGGCCATATCAAGCTCTATGGGCCGGAAGGCTTCGCGGG
CATGCGCAAGGCCGGGCAGCTCACCGCGCAGGCGCTCGACGCCGTGGCGGACATGGTTGCGCCGGGCGTCACCACCGACG
CCATCGACCGGCTGATCTATGAGTTCGCCATGGATCACGGCGCCTATCCGGCGACCCTGATGTATCGCGGCTACCGCTTC
AGCGTGTGCACCTCGGTGAACCATGTGGTGTGCCACGGCATGCCCAACGCCCGCCCGCTGCGCGAGGGCGACATCGTCAA
CGTGGACGTGACGCTGGTGCTCGATGGCTGGTACGGCGATTCGAGCCGCATGTATCCCGTGGGCGCCATCCCCCGCCGGG
CCGAGCGGCTGCTGGAAGTGACCTACGACGCCATGATGCTCGGCATCGCCGCCATCCGCCCCGGCGGTCATGTGGGCGAC
ATCGGCGCCGCCATCCAGGACTTCGTGGAACCCCAGCACATGAGCGTGGTGCGCGACTTCTGCGGCCATGGCGTGGGCCA
GGTGTTCCACGACGAGCCCAACATCGTGCATGTGGGCCGCCGCGGCGAAGGGCCGAAATTGGTGCCGGGCATGATCTTCA
CGGTGGAGCCCATGATCAACCTGGGCCGCCCCCACGTGAAGGTGCTGTCCGACGGCTGGACCGCCGTCACCCGCGACCGT
TCCCTCTCGGCTCAGTTCGAGCACGCGGTGGGCGTGACCGAGACCGGCGTCGAGATCTTCACTCTGAGCCCCAAGGGCTA
TCACCAGCCGCCCTACATCTCCGCCTGA

Upstream 100 bases:

>100_bases
ACAGAGCGAAGCTTGCTTTGCCGGCCGCTTGGCCTAAATCTGTAGGAAGAGAAATTTCGTGAGCGGCGGCGCGAAAGGCG
CAGCCTTGAAGGCGTGACCC

Downstream 100 bases:

>100_bases
GGAAGAGCCGGACACGCTTATGGCCGAGGCGCCGGAAGACGGCCTGAACGAAGCGCCCCATTTCCATGGGCACCGCGACC
GTCTCCGCGCGCGCTTCCGT

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MNYVEAANAPLRKTGHIKLYGPEGFAGMRKAGQLTAQALDAVADMVAPGVTTDAIDRLIYEFAMDHGAYPATLMYRGYRF
SVCTSVNHVVCHGMPNARPLREGDIVNVDVTLVLDGWYGDSSRMYPVGAIPRRAERLLEVTYDAMMLGIAAIRPGGHVGD
IGAAIQDFVEPQHMSVVRDFCGHGVGQVFHDEPNIVHVGRRGEGPKLVPGMIFTVEPMINLGRPHVKVLSDGWTAVTRDR
SLSAQFEHAVGVTETGVEIFTLSPKGYHQPPYISA

Sequences:

>Translated_275_residues
MNYVEAANAPLRKTGHIKLYGPEGFAGMRKAGQLTAQALDAVADMVAPGVTTDAIDRLIYEFAMDHGAYPATLMYRGYRF
SVCTSVNHVVCHGMPNARPLREGDIVNVDVTLVLDGWYGDSSRMYPVGAIPRRAERLLEVTYDAMMLGIAAIRPGGHVGD
IGAAIQDFVEPQHMSVVRDFCGHGVGQVFHDEPNIVHVGRRGEGPKLVPGMIFTVEPMINLGRPHVKVLSDGWTAVTRDR
SLSAQFEHAVGVTETGVEIFTLSPKGYHQPPYISA
>Mature_275_residues
MNYVEAANAPLRKTGHIKLYGPEGFAGMRKAGQLTAQALDAVADMVAPGVTTDAIDRLIYEFAMDHGAYPATLMYRGYRF
SVCTSVNHVVCHGMPNARPLREGDIVNVDVTLVLDGWYGDSSRMYPVGAIPRRAERLLEVTYDAMMLGIAAIRPGGHVGD
IGAAIQDFVEPQHMSVVRDFCGHGVGQVFHDEPNIVHVGRRGEGPKLVPGMIFTVEPMINLGRPHVKVLSDGWTAVTRDR
SLSAQFEHAVGVTETGVEIFTLSPKGYHQPPYISA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=43.4262948207171, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=39.5161290322581, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=46.3709677419355, Blast_Score=244, Evalue=3e-66,
Organism=Escherichia coli, GI1789275, Length=260, Percent_Identity=25.3846153846154, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=246, Percent_Identity=40.650406504065, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=41.3385826771654, Blast_Score=208, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21355531, Length=257, Percent_Identity=42.8015564202335, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24583427, Length=234, Percent_Identity=41.025641025641, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29912; Mature: 29912

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYVEAANAPLRKTGHIKLYGPEGFAGMRKAGQLTAQALDAVADMVAPGVTTDAIDRLIY
CCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EFAMDHGAYPATLMYRGYRFSVCTSVNHVVCHGMPNARPLREGDIVNVDVTLVLDGWYGD
HHHHHCCCCCCEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYPVGAIPRRAERLLEVTYDAMMLGIAAIRPGGHVGDIGAAIQDFVEPQHMSVVRDF
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
CGHGVGQVFHDEPNIVHVGRRGEGPKLVPGMIFTVEPMINLGRPHVKVLSDGWTAVTRDR
HCCCCCCEECCCCCEEEECCCCCCCCCCCCEEEEECHHHHCCCCCEEEEECCCEEEECCC
SLSAQFEHAVGVTETGVEIFTLSPKGYHQPPYISA
CCCHHHHHHCCCEECCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNYVEAANAPLRKTGHIKLYGPEGFAGMRKAGQLTAQALDAVADMVAPGVTTDAIDRLIY
CCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EFAMDHGAYPATLMYRGYRFSVCTSVNHVVCHGMPNARPLREGDIVNVDVTLVLDGWYGD
HHHHHCCCCCCEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYPVGAIPRRAERLLEVTYDAMMLGIAAIRPGGHVGDIGAAIQDFVEPQHMSVVRDF
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
CGHGVGQVFHDEPNIVHVGRRGEGPKLVPGMIFTVEPMINLGRPHVKVLSDGWTAVTRDR
HCCCCCCEECCCCCEEEECCCCCCCCCCCCEEEEECHHHHCCCCCEEEEECCCEEEECCC
SLSAQFEHAVGVTETGVEIFTLSPKGYHQPPYISA
CCCHHHHHHCCCEECCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]