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The map label for this gene is bioF [C]

Identifier: 154246853

GI number: 154246853

Start: 3241237

End: 3242400

Strand: Direct

Name: bioF [C]

Synonym: Xaut_2918

Alternate gene names: 154246853

Gene position: 3241237-3242400 (Clockwise)

Preceding gene: 154246849

Following gene: 154246854

Centisome position: 61.05

GC content: 73.37

Gene sequence:

>1164_bases
ATGGAGGCGCATGAGGCGGCGCTCGCGGCGCTCCGCCGCCGGGGCCGGCTGCGGACGCTGGCACCCGCGCAGGGGGCCGA
TTTCGCCTCCAACGACTATCTTGGCCTCGCGCAATCCGAAGAGTTGCGGCAGGCGACGGCCTCCGCCCTCGCCCGTGGCG
TGCCGCTCGGGGCCGGCGGATCGCGCCTGCTGCGCGGCAACCACCCGGAGCACGAGGCCCTTGAAGCCGAGGCGGCGGCC
TTCTTCGGCGCCGAGGCGGCGCTGTTCTTCGCCGGCGGGTTCGCCGCCAACGCCGCGCTGGTCTCCACCCTGCCGCGCCG
GGGCGACCTGGTGGTCTATGACGAGCTCATCCACGCCAGCGTCCATGAGGGGCTCGCCGGGGCGTCATCGGCCGAGCGCG
TCGAGGCGGTGGCGACGCCACATGCCGATGCCCATGCGGTGGACGATGCCATCCGCGCCTGGCGCGCCAAGGGCGGGCGG
GGCCGCGCCTGGATCGCGGCGGAAACCCTCTACAGCATGGACGGCGATTTCGCCCCGATGGACGATCTCATGGCCGTCGC
CGAGCGGCACGACGCCATGCTGCTTCTGGATGAGGCCCACGCCACCGGCGTCTATGGGCCGGCGGGGCGGGGGCTTGCTG
CCCATCTGGAAGGGCGCGCCAACGTGGTGACGCTGCACACCTGCGGCAAGGCGCTGGGCGTGATGGGTGCCCTGGTATGC
CTGCCGCGCGGGCTGAAGGACTATATGGTCAACCGGTCGCGCCCCTTCATCTACGCCACCGCGCCGTCGCCGCTGCTGGC
TGCCACCGTGCGGGCGGCGCTGACTCTGGTCGAGGCGGCGCAGGACCGGCGGGACCGCCTGATGGCGCGCATCGCCCACG
CGCAGCGCGCGCTGGCGGGGATCGGCCTGCCGGCAACCTCTTCGCAGATCCAGAAGGTGATTCTGGGCTCGGACCGGCGC
GCGACCGCCGTCGCCACCGCCTTGCAGGCACAGGGGTTCGACGTGCGCGCGATCCGGCCGCCCACCGTGCCGGAGGGCAC
CGCGCGCTTGCGCGTGGCGCTCACGCTCAACGTGTCCGAAACCGACCTGGATGGTCTGGTGGACGCGCTCGCGCAGGCCC
TTGCGGCGGAGCCGGGTACGAAGGCCGTGAGGTCCGCCCCATGA

Upstream 100 bases:

>100_bases
GCAGACCCGTTTCGCGCAGCGGCCAATTCCGTGCATGAGCGGGATGCTGCCCGCTTCGCGCGGCCAAGCGGGACGGGGAC
GAACACCGGCGGGAGCTCGC

Downstream 100 bases:

>100_bases
CGGGCTACATCGTCACCGGGACGGATACCGGCATCGGCAAGACCATGTTCGCCGCCGCCCTCGCCGGCGCGCTGGATGCC
GCTTATTGGAAGCCGGTGCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEAHEAALAALRRRGRLRTLAPAQGADFASNDYLGLAQSEELRQATASALARGVPLGAGGSRLLRGNHPEHEALEAEAAA
FFGAEAALFFAGGFAANAALVSTLPRRGDLVVYDELIHASVHEGLAGASSAERVEAVATPHADAHAVDDAIRAWRAKGGR
GRAWIAAETLYSMDGDFAPMDDLMAVAERHDAMLLLDEAHATGVYGPAGRGLAAHLEGRANVVTLHTCGKALGVMGALVC
LPRGLKDYMVNRSRPFIYATAPSPLLAATVRAALTLVEAAQDRRDRLMARIAHAQRALAGIGLPATSSQIQKVILGSDRR
ATAVATALQAQGFDVRAIRPPTVPEGTARLRVALTLNVSETDLDGLVDALAQALAAEPGTKAVRSAP

Sequences:

>Translated_387_residues
MEAHEAALAALRRRGRLRTLAPAQGADFASNDYLGLAQSEELRQATASALARGVPLGAGGSRLLRGNHPEHEALEAEAAA
FFGAEAALFFAGGFAANAALVSTLPRRGDLVVYDELIHASVHEGLAGASSAERVEAVATPHADAHAVDDAIRAWRAKGGR
GRAWIAAETLYSMDGDFAPMDDLMAVAERHDAMLLLDEAHATGVYGPAGRGLAAHLEGRANVVTLHTCGKALGVMGALVC
LPRGLKDYMVNRSRPFIYATAPSPLLAATVRAALTLVEAAQDRRDRLMARIAHAQRALAGIGLPATSSQIQKVILGSDRR
ATAVATALQAQGFDVRAIRPPTVPEGTARLRVALTLNVSETDLDGLVDALAQALAAEPGTKAVRSAP
>Mature_387_residues
MEAHEAALAALRRRGRLRTLAPAQGADFASNDYLGLAQSEELRQATASALARGVPLGAGGSRLLRGNHPEHEALEAEAAA
FFGAEAALFFAGGFAANAALVSTLPRRGDLVVYDELIHASVHEGLAGASSAERVEAVATPHADAHAVDDAIRAWRAKGGR
GRAWIAAETLYSMDGDFAPMDDLMAVAERHDAMLLLDEAHATGVYGPAGRGLAAHLEGRANVVTLHTCGKALGVMGALVC
LPRGLKDYMVNRSRPFIYATAPSPLLAATVRAALTLVEAAQDRRDRLMARIAHAQRALAGIGLPATSSQIQKVILGSDRR
ATAVATALQAQGFDVRAIRPPTVPEGTARLRVALTLNVSETDLDGLVDALAQALAAEPGTKAVRSAP

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=32.5779036827195, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI7657118, Length=353, Percent_Identity=32.5779036827195, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI83977440, Length=358, Percent_Identity=28.7709497206704, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI83977442, Length=358, Percent_Identity=28.7709497206704, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI83977444, Length=358, Percent_Identity=28.7709497206704, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI4502025, Length=345, Percent_Identity=29.2753623188406, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI40316939, Length=345, Percent_Identity=29.2753623188406, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4758668, Length=261, Percent_Identity=29.1187739463602, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=24.9315068493151, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI5454084, Length=384, Percent_Identity=23.9583333333333, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=36.3636363636364, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790046, Length=334, Percent_Identity=32.0359281437126, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=370, Percent_Identity=31.8918918918919, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI32566772, Length=382, Percent_Identity=26.9633507853403, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=286, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560914, Length=286, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982625, Length=279, Percent_Identity=24.0143369175627, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982617, Length=279, Percent_Identity=24.0143369175627, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=29.0322580645161, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=25.9562841530055, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=222, Percent_Identity=25.6756756756757, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24662918, Length=366, Percent_Identity=28.1420765027322, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17137420, Length=354, Percent_Identity=28.2485875706215, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136286, Length=376, Percent_Identity=24.468085106383, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24653280, Length=273, Percent_Identity=24.1758241758242, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653276, Length=273, Percent_Identity=24.1758241758242, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653278, Length=273, Percent_Identity=24.1758241758242, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40375; Mature: 40375

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAHEAALAALRRRGRLRTLAPAQGADFASNDYLGLAQSEELRQATASALARGVPLGAGG
CCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
SRLLRGNHPEHEALEAEAAAFFGAEAALFFAGGFAANAALVSTLPRRGDLVVYDELIHAS
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHH
VHEGLAGASSAERVEAVATPHADAHAVDDAIRAWRAKGGRGRAWIAAETLYSMDGDFAPM
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCH
DDLMAVAERHDAMLLLDEAHATGVYGPAGRGLAAHLEGRANVVTLHTCGKALGVMGALVC
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHH
LPRGLKDYMVNRSRPFIYATAPSPLLAATVRAALTLVEAAQDRRDRLMARIAHAQRALAG
HCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLPATSSQIQKVILGSDRRATAVATALQAQGFDVRAIRPPTVPEGTARLRVALTLNVSE
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEEECCC
TDLDGLVDALAQALAAEPGTKAVRSAP
CCHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MEAHEAALAALRRRGRLRTLAPAQGADFASNDYLGLAQSEELRQATASALARGVPLGAGG
CCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
SRLLRGNHPEHEALEAEAAAFFGAEAALFFAGGFAANAALVSTLPRRGDLVVYDELIHAS
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHH
VHEGLAGASSAERVEAVATPHADAHAVDDAIRAWRAKGGRGRAWIAAETLYSMDGDFAPM
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCH
DDLMAVAERHDAMLLLDEAHATGVYGPAGRGLAAHLEGRANVVTLHTCGKALGVMGALVC
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHH
LPRGLKDYMVNRSRPFIYATAPSPLLAATVRAALTLVEAAQDRRDRLMARIAHAQRALAG
HCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLPATSSQIQKVILGSDRRATAVATALQAQGFDVRAIRPPTVPEGTARLRVALTLNVSE
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEEECCC
TDLDGLVDALAQALAAEPGTKAVRSAP
CCHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA