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The map label for this gene is hlyU [H]

Identifier: 154246832

GI number: 154246832

Start: 3218491

End: 3218931

Strand: Direct

Name: hlyU [H]

Synonym: Xaut_2896

Alternate gene names: 154246832

Gene position: 3218491-3218931 (Clockwise)

Preceding gene: 154246825

Following gene: 154246833

Centisome position: 60.62

GC content: 58.05

Gene sequence:

>441_bases
ATGAGAGCCGATGCCCTTCATATGTATGAAACTATGAAGATAGAAGAGATGTTCCAAGCGGTAGAGCAAGCGACAGACCT
CTTGAAGGCGCTTGCCAGTCGGAACCGCCTTCTCCTCCTCTGCTACCTTTTGGAGGGCGAGAGGTCGGTCGGCGAACTCG
CTCGCCTCATCCAGGCACGGGAGACAGCTGTCTCGCAACAACTGGCGCTGCTCCGCAAGGATGGCTTGGTTCGCACCCGG
CGTGAGGGCCAGACTGTCTACTACACGCTCGCGAGCACAGAGGCCGCCAAAGTCATAGAGACACTCCATGGAATATATTG
CGCGCCGATCGCGGAAGCAGCCGCTGTCGCGCCCGCGGCGGTTGCTGGCAGCGCTAACGACCAGTCACATGTGAAGAACA
GCCACACCGGACCTGAAAACTCAGATCCTCAGGAGAATTGA

Upstream 100 bases:

>100_bases
ACAACATGCGGGAGGAACGGCTCGTTCATAGAGTCGCTGATCCTCCTGCTGCTGAGGAACTGCGCCACGCCTGCGCCCAG
TCGCCCACCAAGCAACCTTG

Downstream 100 bases:

>100_bases
TCATGAACTACTGCCGTCGCGATGGCCTCGACGGAAGCCGTCCATAATTCGGCCCTGCACGAAGCAACGCATGAGGTTCG
CCAAAAGCGCGCGCGTCATG

Product: regulatory protein ArsR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MRADALHMYETMKIEEMFQAVEQATDLLKALASRNRLLLLCYLLEGERSVGELARLIQARETAVSQQLALLRKDGLVRTR
REGQTVYYTLASTEAAKVIETLHGIYCAPIAEAAAVAPAAVAGSANDQSHVKNSHTGPENSDPQEN

Sequences:

>Translated_146_residues
MRADALHMYETMKIEEMFQAVEQATDLLKALASRNRLLLLCYLLEGERSVGELARLIQARETAVSQQLALLRKDGLVRTR
REGQTVYYTLASTEAAKVIETLHGIYCAPIAEAAAVAPAAVAGSANDQSHVKNSHTGPENSDPQEN
>Mature_146_residues
MRADALHMYETMKIEEMFQAVEQATDLLKALASRNRLLLLCYLLEGERSVGELARLIQARETAVSQQLALLRKDGLVRTR
REGQTVYYTLASTEAAKVIETLHGIYCAPIAEAAAVAPAAVAGSANDQSHVKNSHTGPENSDPQEN

Specific function: Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=90, Percent_Identity=38.8888888888889, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 15966; Mature: 15966

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADALHMYETMKIEEMFQAVEQATDLLKALASRNRLLLLCYLLEGERSVGELARLIQAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
ETAVSQQLALLRKDGLVRTRREGQTVYYTLASTEAAKVIETLHGIYCAPIAEAAAVAPAA
HHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGSANDQSHVKNSHTGPENSDPQEN
HCCCCCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRADALHMYETMKIEEMFQAVEQATDLLKALASRNRLLLLCYLLEGERSVGELARLIQAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
ETAVSQQLALLRKDGLVRTRREGQTVYYTLASTEAAKVIETLHGIYCAPIAEAAAVAPAA
HHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGSANDQSHVKNSHTGPENSDPQEN
HCCCCCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]