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The map label for this gene is ghrA [H]

Identifier: 154246512

GI number: 154246512

Start: 2862395

End: 2863354

Strand: Direct

Name: ghrA [H]

Synonym: Xaut_2571

Alternate gene names: 154246512

Gene position: 2862395-2863354 (Clockwise)

Preceding gene: 154246511

Following gene: 154246515

Centisome position: 53.92

GC content: 69.9

Gene sequence:

>960_bases
GTGAACGAGCAGGCGAGCGGGGCGCTGGTGTTCTACAGCGCCGTGGACATCGGCCAGGACTGGAAGAGCGCCCTTCAGGC
CGCCCATCCCGGCCTCGACGTGCGGATCGCGCGGGCGGGGGACGGCCATGTGGAGGGCGATCCGGAGGAGGTGCGCTATG
CGCTGGTTTGGAAGCCGCCCCACGGCTTCTTCGCGCGCTTCCCCAACCTGAAGCTCGTCATCAATCTCGGCGCCGGGGTG
GATGCCCTGGTGGCGCGGGATGACCTGCCGGACGTACCGGTCACCCGTCTCAGCGACCCCAACATGTCGCAGATGATGGC
GTCGTTCGTCCTGTTCTGCGTGCTGCGCCACGCCCGCGACATCCCCACCTTCGAGCGGGCGCAGCGCGAGGGGCGCTGGC
ACTATGTGCATCCGCGCACGGCGGCCGAGATCCGCGTGGGCGTGCTGGGCCTCGGGGACCTGGGCGCGGCGGCTGCGCTG
GAACTGGCCCGGCACGGCTTCGACGTGCGGGGATGGTCGCGCACTCCCAAGGCGCTGGAGGGCGTTTCGTGCTTCCACGG
CCTTGAAGCACTGCCCGGCTTTCTCGCAGGCAGCGAAATCGTGGTGGTGATGCTGCCGCTGACGCCTGAGACGCGCGGGC
TCATGAACGCCGAGCGCCTCGCGCATCTGCCCAGGGGCGCCAAGTTCATCAATGTGGCCAGGGGGCCGGTGGTGGACGAG
GCGGCGCTGATCGCGGCGCTGCGCTCAGGCCACATCGCTGAGGCCACCCTCGACGTGTTCGAGGTGGAGCCGCTGCCTGT
CGGAAGCCCGCTCTGGGCCATGGACAACGTGCTGGTGACGCCGCACCTCGCCTCCATCGCCATCCCGCGCACCGCCGCGC
CCCAGATCGTGGAGAATATCCGCCGCATCGAGGCGGGCGAGCCCGTCCTGAACCAGGTGGACCCCAGACGCGGGTATTGA

Upstream 100 bases:

>100_bases
CCAAGGCGGCGACGGGGATCGTGGCGGGGCTCGGCGCGCTGGGCTACGAACTCGCCATCAGCGCGGCGGCGAAGCTGGCG
CAGGCGGAAGGGGCGCAGCT

Downstream 100 bases:

>100_bases
AGGCGCGAGGGGAGGCGTCCCCTCGCGCTGCCGGCGGTCCACTCAGCGCTTGGCGATGATCTCGCAGGCGCGCTCGTGGG
GCGCCACCGCTTCGGGCGTC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNEQASGALVFYSAVDIGQDWKSALQAAHPGLDVRIARAGDGHVEGDPEEVRYALVWKPPHGFFARFPNLKLVINLGAGV
DALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARDIPTFERAQREGRWHYVHPRTAAEIRVGVLGLGDLGAAAAL
ELARHGFDVRGWSRTPKALEGVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDE
AALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAIPRTAAPQIVENIRRIEAGEPVLNQVDPRRGY

Sequences:

>Translated_319_residues
MNEQASGALVFYSAVDIGQDWKSALQAAHPGLDVRIARAGDGHVEGDPEEVRYALVWKPPHGFFARFPNLKLVINLGAGV
DALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARDIPTFERAQREGRWHYVHPRTAAEIRVGVLGLGDLGAAAAL
ELARHGFDVRGWSRTPKALEGVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDE
AALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAIPRTAAPQIVENIRRIEAGEPVLNQVDPRRGY
>Mature_319_residues
MNEQASGALVFYSAVDIGQDWKSALQAAHPGLDVRIARAGDGHVEGDPEEVRYALVWKPPHGFFARFPNLKLVINLGAGV
DALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARDIPTFERAQREGRWHYVHPRTAAEIRVGVLGLGDLGAAAAL
ELARHGFDVRGWSRTPKALEGVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDE
AALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAIPRTAAPQIVENIRRIEAGEPVLNQVDPRRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=224, Percent_Identity=31.25, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI23308577, Length=224, Percent_Identity=32.1428571428571, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI61743967, Length=239, Percent_Identity=28.8702928870293, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4557497, Length=239, Percent_Identity=28.8702928870293, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI145580578, Length=239, Percent_Identity=27.1966527196653, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4557499, Length=239, Percent_Identity=27.1966527196653, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI145580575, Length=239, Percent_Identity=27.1966527196653, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87081824, Length=317, Percent_Identity=38.801261829653, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI87082289, Length=262, Percent_Identity=35.1145038167939, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789279, Length=176, Percent_Identity=30.6818181818182, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=250, Percent_Identity=30.8, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=214, Percent_Identity=32.7102803738318, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=178, Percent_Identity=27.5280898876405, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=233, Percent_Identity=24.4635193133047, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=31.1538461538462, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=29.7709923664122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=29.7709923664122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=29.7709923664122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=29.7709923664122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=29.7709923664122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921140, Length=232, Percent_Identity=32.7586206896552, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28571528, Length=175, Percent_Identity=35.4285714285714, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585516, Length=176, Percent_Identity=32.9545454545455, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34581; Mature: 34581

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQASGALVFYSAVDIGQDWKSALQAAHPGLDVRIARAGDGHVEGDPEEVRYALVWKPP
CCCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEEEEEEEECC
HGFFARFPNLKLVINLGAGVDALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARD
CCHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IPTFERAQREGRWHYVHPRTAAEIRVGVLGLGDLGAAAALELARHGFDVRGWSRTPKALE
CCHHHHHHHCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
GVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDE
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHCHHCHHHHHHCCCCCEEEEECCCCCHHH
AALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAIPRTAAPQIVENI
HHHHHHHHCCCHHEEEEEEEEECCCCCCCCHHHHCCEEECCCHHHEECCCCCCHHHHHHH
RRIEAGEPVLNQVDPRRGY
HHHCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MNEQASGALVFYSAVDIGQDWKSALQAAHPGLDVRIARAGDGHVEGDPEEVRYALVWKPP
CCCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEEEEEEEECC
HGFFARFPNLKLVINLGAGVDALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARD
CCHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IPTFERAQREGRWHYVHPRTAAEIRVGVLGLGDLGAAAALELARHGFDVRGWSRTPKALE
CCHHHHHHHCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
GVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDE
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHCHHCHHHHHHCCCCCEEEEECCCCCHHH
AALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAIPRTAAPQIVENI
HHHHHHHHCCCHHEEEEEEEEECCCCCCCCHHHHCCEEECCCHHHEECCCCCCHHHHHHH
RRIEAGEPVLNQVDPRRGY
HHHCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA