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The map label for this gene is tktA [H]

Identifier: 154245857

GI number: 154245857

Start: 2163222

End: 2165309

Strand: Reverse

Name: tktA [H]

Synonym: Xaut_1913

Alternate gene names: 154245857

Gene position: 2165309-2163222 (Counterclockwise)

Preceding gene: 154245858

Following gene: 154245856

Centisome position: 40.79

GC content: 70.74

Gene sequence:

>2088_bases
ATGACTGCTCACGCCAGCACCGCCAAGGCCATGACGGCAGCAAGCGCCACCACCGCCGACGCCGTCCCCACGCTGGACCG
CAGCCCCGGCTCCCTCGCCTGGCCGGTGACGGCGGCCTTGCGCGCGCTCGCCATGGATGGCGTGGAGCAGGCGAAATCCG
GCCATCCCGGCGCGCCGCTGGGCATGGCGGACATCTCCGCCGTGGTGTGGCGTGAGCACCTGCGTCACAATCCCGCCGAT
CCCGCATGGCCCGACCGCGACCGCTTCGTGCTGTCCAACGGGCATGGCTCCATGCTGATCTACGCGCTGCTCCACCTCAC
CGGCTACGACCTGCCGGTGGCGGAGCTGAAGCGCTTCCGGCAGGTGCATTCGCGCACCCCCGGCCATCCCGAATACGGCA
TGACGCCGGGCGTCGAGACCACCACCGGCCCGCTGGGCCAGGGCCTCGCCAATGCGGTGGGCATGGCGCTGGCGGAAAAG
ACGCTGGCCGCCCAGTTCAACCGGCCGGGCCTGGCCATCGTCGATCACCGCACCTTCGTCTTCCTCGGCGACGGCTGCCT
GATGGAAGGCGTGAGCCACGAGGCCTGTTCGCTCGCCGGCCGGCTCGGCCTCGGCAAGCTCGTCGCCTATTATGACGACA
ACGGCATCTCCATCGACGGCAAGGTGGAGGAATGGTTCGCCGACGACACCCCGGCCCGTTTCGAAGCCTATGGCTGGCAC
GTGGTGCGCAACGTGGACGGGCACGATCCCGCCGCCGTGCGCGCCGCCACCGAACAGGCGCTGGCCGAGACCGGCAAGCC
GTCGCTGATCTGCTGCAAGACTGTCATCGGCCGCGGCGCGCCCACCAAGCAGGGCCACCAGGACACCCACGGTGCCCCGC
TCGGTCCGGACGAGATCGCCCGCACCCGCGCCGCCATGGGCTGGGATCACGCCCCCTTCGAGATCCCGGACGACATCTAC
GCCCAGTGGGACGCCCGCAAGGTGGGAGCCGCGCGCCAGCAGGCGTGGGAGGCCCGCATGGTGGCCTATGAGCGCGCCTA
TCCCAAGGAGGCGGCCGAGTTCCGCCGCCGCCTGAAGGGCGACCTCTCCCCGGTCTTCGCCGACACCTATGCAGCGGCGC
TGAAGACCACTTTGGAGAAGGCCGAGACCGTGGCGACCCGCAAGGCGAGCCAGCAGGCCCTAGCGGCCCTAGCCCCGGCG
GTGCCGGAATTTCTCGGCGGCTCGGCGGACCTCGCCCATTCCAACCTCACCACCTTCCCCGGCGCGGTGCCGGTGACGCG
GGATCCGGCGGGCAACCAGATCTATTATGGCGTGCGCGAGTTCGGCATGTCGGCCATCGCCAACGGCATCGCTTTGCACG
GCGGCTTCATCCCGTTCGTGGCCACCTTCCTGGTGTTCTCGGACTATGCCCGCAACGCCATGCGCATGAGCGCGCTCATG
GGCCAAAGGGTGATCTACATTCTCACCCATGATTCCATCGGCCTCGGCGAGGACGGCCCCACCCACCAGCCGGTGGAGCA
TGTGGAAAGCCTGCGCCTCATCCCGAACCTGGACGTGTGGCGGCCCTGCGACACGGTGGAGACGCTGGCCGCCTGGCATG
CGGCGCTGACCCGCACCGACGGTCCCTCCGCCCTCATCCTGTCGCGCCAGAACCTGCCCATGTGGCCGCGCTCGGCGGCG
CAGGTGGAGGCCATCGCCGGCGGCGGCTATGTGCTGCGCGAGAGCGAGGGGGTGGCCCGCGCCATCCTCGTCGCCACCGG
CTCCGAGGTGAAGCTGGCGGTGGCGGCGGCCGAGGCCCTGGACACGGCGGGCATCGCCACCCGCATCGTCTCCATGCCCT
GCCGCGAGCGGTTCGAGGCTTTGACCGAGACCGAGCGCGCCGCGCTGTTCCCGAAGGGCGTGCCGGTGGTGGCGGTGGAA
GCGGGCGTCACCCGCGGCTGGCGCGGCCTCACCGGCACCCGCGAGGAGGGCGTCACCGTCATCGGCATCGACCGCTTCGG
CGAATCCGCCCCCGAGAAGGATCTGTGGCCCCTGTTCGGCTTCACCGTCGAGAAGGTGGCCGAAGCCGTGCGCCGCGCGG
TGGGGTGA

Upstream 100 bases:

>100_bases
CCTGACCGACGACCATGGCACCCCCCTCCCCACCCCTCCCCCGCGCCGGGGAAGGCGGGACGATCGCGAAGGGGCAATGA
AGGTTGAAGGGAGACGAGCC

Downstream 100 bases:

>100_bases
GGGTTGGGCCCTCCTCCCGGGAGAGGGGCGGTCCCTGAACGAACGATCTTGCGAACCCGAAAGGAGAGGACAATGGCCCT
CGTTTCCATGCGCCAGCTGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MTAHASTAKAMTAASATTADAVPTLDRSPGSLAWPVTAALRALAMDGVEQAKSGHPGAPLGMADISAVVWREHLRHNPAD
PAWPDRDRFVLSNGHGSMLIYALLHLTGYDLPVAELKRFRQVHSRTPGHPEYGMTPGVETTTGPLGQGLANAVGMALAEK
TLAAQFNRPGLAIVDHRTFVFLGDGCLMEGVSHEACSLAGRLGLGKLVAYYDDNGISIDGKVEEWFADDTPARFEAYGWH
VVRNVDGHDPAAVRAATEQALAETGKPSLICCKTVIGRGAPTKQGHQDTHGAPLGPDEIARTRAAMGWDHAPFEIPDDIY
AQWDARKVGAARQQAWEARMVAYERAYPKEAAEFRRRLKGDLSPVFADTYAAALKTTLEKAETVATRKASQQALAALAPA
VPEFLGGSADLAHSNLTTFPGAVPVTRDPAGNQIYYGVREFGMSAIANGIALHGGFIPFVATFLVFSDYARNAMRMSALM
GQRVIYILTHDSIGLGEDGPTHQPVEHVESLRLIPNLDVWRPCDTVETLAAWHAALTRTDGPSALILSRQNLPMWPRSAA
QVEAIAGGGYVLRESEGVARAILVATGSEVKLAVAAAEALDTAGIATRIVSMPCRERFEALTETERAALFPKGVPVVAVE
AGVTRGWRGLTGTREEGVTVIGIDRFGESAPEKDLWPLFGFTVEKVAEAVRRAVG

Sequences:

>Translated_695_residues
MTAHASTAKAMTAASATTADAVPTLDRSPGSLAWPVTAALRALAMDGVEQAKSGHPGAPLGMADISAVVWREHLRHNPAD
PAWPDRDRFVLSNGHGSMLIYALLHLTGYDLPVAELKRFRQVHSRTPGHPEYGMTPGVETTTGPLGQGLANAVGMALAEK
TLAAQFNRPGLAIVDHRTFVFLGDGCLMEGVSHEACSLAGRLGLGKLVAYYDDNGISIDGKVEEWFADDTPARFEAYGWH
VVRNVDGHDPAAVRAATEQALAETGKPSLICCKTVIGRGAPTKQGHQDTHGAPLGPDEIARTRAAMGWDHAPFEIPDDIY
AQWDARKVGAARQQAWEARMVAYERAYPKEAAEFRRRLKGDLSPVFADTYAAALKTTLEKAETVATRKASQQALAALAPA
VPEFLGGSADLAHSNLTTFPGAVPVTRDPAGNQIYYGVREFGMSAIANGIALHGGFIPFVATFLVFSDYARNAMRMSALM
GQRVIYILTHDSIGLGEDGPTHQPVEHVESLRLIPNLDVWRPCDTVETLAAWHAALTRTDGPSALILSRQNLPMWPRSAA
QVEAIAGGGYVLRESEGVARAILVATGSEVKLAVAAAEALDTAGIATRIVSMPCRERFEALTETERAALFPKGVPVVAVE
AGVTRGWRGLTGTREEGVTVIGIDRFGESAPEKDLWPLFGFTVEKVAEAVRRAVG
>Mature_694_residues
TAHASTAKAMTAASATTADAVPTLDRSPGSLAWPVTAALRALAMDGVEQAKSGHPGAPLGMADISAVVWREHLRHNPADP
AWPDRDRFVLSNGHGSMLIYALLHLTGYDLPVAELKRFRQVHSRTPGHPEYGMTPGVETTTGPLGQGLANAVGMALAEKT
LAAQFNRPGLAIVDHRTFVFLGDGCLMEGVSHEACSLAGRLGLGKLVAYYDDNGISIDGKVEEWFADDTPARFEAYGWHV
VRNVDGHDPAAVRAATEQALAETGKPSLICCKTVIGRGAPTKQGHQDTHGAPLGPDEIARTRAAMGWDHAPFEIPDDIYA
QWDARKVGAARQQAWEARMVAYERAYPKEAAEFRRRLKGDLSPVFADTYAAALKTTLEKAETVATRKASQQALAALAPAV
PEFLGGSADLAHSNLTTFPGAVPVTRDPAGNQIYYGVREFGMSAIANGIALHGGFIPFVATFLVFSDYARNAMRMSALMG
QRVIYILTHDSIGLGEDGPTHQPVEHVESLRLIPNLDVWRPCDTVETLAAWHAALTRTDGPSALILSRQNLPMWPRSAAQ
VEAIAGGGYVLRESEGVARAILVATGSEVKLAVAAAEALDTAGIATRIVSMPCRERFEALTETERAALFPKGVPVVAVEA
GVTRGWRGLTGTREEGVTVIGIDRFGESAPEKDLWPLFGFTVEKVAEAVRRAVG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=670, Percent_Identity=28.0597014925373, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4507521, Length=670, Percent_Identity=28.0597014925373, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=27.3666092943201, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI225637459, Length=270, Percent_Identity=28.1481481481481, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637461, Length=232, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637463, Length=229, Percent_Identity=29.2576419213974, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI48994911, Length=652, Percent_Identity=61.5030674846626, Blast_Score=844, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=658, Percent_Identity=58.0547112462006, Blast_Score=802, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=583, Percent_Identity=26.4150943396226, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=44.6107784431138, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=43.5820895522388, Blast_Score=532, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666278, Length=585, Percent_Identity=26.8376068376068, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45551847, Length=262, Percent_Identity=33.587786259542, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45550715, Length=262, Percent_Identity=33.587786259542, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24645119, Length=235, Percent_Identity=33.6170212765957, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74285; Mature: 74154

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHASTAKAMTAASATTADAVPTLDRSPGSLAWPVTAALRALAMDGVEQAKSGHPGAPL
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCC
GMADISAVVWREHLRHNPADPAWPDRDRFVLSNGHGSMLIYALLHLTGYDLPVAELKRFR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHH
QVHSRTPGHPEYGMTPGVETTTGPLGQGLANAVGMALAEKTLAAQFNRPGLAIVDHRTFV
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEE
FLGDGCLMEGVSHEACSLAGRLGLGKLVAYYDDNGISIDGKVEEWFADDTPARFEAYGWH
EECCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCHHHHHCCCCCCHHHHCCEE
VVRNVDGHDPAAVRAATEQALAETGKPSLICCKTVIGRGAPTKQGHQDTHGAPLGPDEIA
EEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
RTRAAMGWDHAPFEIPDDIYAQWDARKVGAARQQAWEARMVAYERAYPKEAAEFRRRLKG
HHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DLSPVFADTYAAALKTTLEKAETVATRKASQQALAALAPAVPEFLGGSADLAHSNLTTFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
GAVPVTRDPAGNQIYYGVREFGMSAIANGIALHGGFIPFVATFLVFSDYARNAMRMSALM
CCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQRVIYILTHDSIGLGEDGPTHQPVEHVESLRLIPNLDVWRPCDTVETLAAWHAALTRTD
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
GPSALILSRQNLPMWPRSAAQVEAIAGGGYVLRESEGVARAILVATGSEVKLAVAAAEAL
CCCEEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEECCCCEEEEEHHHHHH
DTAGIATRIVSMPCRERFEALTETERAALFPKGVPVVAVEAGVTRGWRGLTGTREEGVTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
IGIDRFGESAPEKDLWPLFGFTVEKVAEAVRRAVG
EEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAHASTAKAMTAASATTADAVPTLDRSPGSLAWPVTAALRALAMDGVEQAKSGHPGAPL
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCC
GMADISAVVWREHLRHNPADPAWPDRDRFVLSNGHGSMLIYALLHLTGYDLPVAELKRFR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHH
QVHSRTPGHPEYGMTPGVETTTGPLGQGLANAVGMALAEKTLAAQFNRPGLAIVDHRTFV
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEE
FLGDGCLMEGVSHEACSLAGRLGLGKLVAYYDDNGISIDGKVEEWFADDTPARFEAYGWH
EECCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCHHHHHCCCCCCHHHHCCEE
VVRNVDGHDPAAVRAATEQALAETGKPSLICCKTVIGRGAPTKQGHQDTHGAPLGPDEIA
EEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
RTRAAMGWDHAPFEIPDDIYAQWDARKVGAARQQAWEARMVAYERAYPKEAAEFRRRLKG
HHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DLSPVFADTYAAALKTTLEKAETVATRKASQQALAALAPAVPEFLGGSADLAHSNLTTFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
GAVPVTRDPAGNQIYYGVREFGMSAIANGIALHGGFIPFVATFLVFSDYARNAMRMSALM
CCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQRVIYILTHDSIGLGEDGPTHQPVEHVESLRLIPNLDVWRPCDTVETLAAWHAALTRTD
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
GPSALILSRQNLPMWPRSAAQVEAIAGGGYVLRESEGVARAILVATGSEVKLAVAAAEAL
CCCEEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEECCCCEEEEEHHHHHH
DTAGIATRIVSMPCRERFEALTETERAALFPKGVPVVAVEAGVTRGWRGLTGTREEGVTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
IGIDRFGESAPEKDLWPLFGFTVEKVAEAVRRAVG
EEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]