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The map label for this gene is cbbA [H]

Identifier: 154245856

GI number: 154245856

Start: 2162085

End: 2163149

Strand: Reverse

Name: cbbA [H]

Synonym: Xaut_1912

Alternate gene names: 154245856

Gene position: 2163149-2162085 (Counterclockwise)

Preceding gene: 154245857

Following gene: 154245855

Centisome position: 40.75

GC content: 67.23

Gene sequence:

>1065_bases
ATGGCCCTCGTTTCCATGCGCCAGCTGCTCGACCATGCGGCGGAGCTTTCCTACGGCCTGCCGGCCTTCAACGTGAACAA
CATGGAGCAGGTGAAGGCGATCATGGACGCGGCCCGCGCCACGCGCTCGCCGGTCATCCTGCAGGGCTCGGCCGGCGCGC
GCAAATATGCCGGCGAGGCGTTCCTGCGCCATCTCATCGCCGCCGCCGTGGAGGCCTACCCCGAGATCCCCGTGGTGATG
CACCAGGACCACGGCGCCTCCCCCGCCGTGTGCATGGGCGCCATCAAGTCCGGTTTCTCCTCGGTGATGATGGACGGCTC
CCTGAAGGAAGACGGCAAGACCCCCGCCGACTATGACTACAACGCCGCCGTCACCGCCAAGGTGGTGGAACTGGCCCATG
CGGTGGGCGTCTCGGTGGAGGGGGAGCTGGGCTGCCTCGGCTCGCTGGAGACCGGCAAGGGCGAGGCCGAGGACGGCCAC
GGCGCCGAAGGGGCCCTCGACCACGACAAGCTGCTCACCGATCCGGAAGAGGCGGCCCAGTTCGTGAAGGCAACCCAGTG
CGACGCGCTGGCCATCGCCATCGGCACCTCCCACGGCGCCTACAAGTTTACCCGCAAGCCCACCGGCGACATCCTCGCCA
TCGACCGGGTGAAAGCCATCCACCAGCGCATTCCCACCACCCATCTGGTGATGCACGGCTCGTCCTCGGTGCCGCAGGAT
CTGCTGGAGGAGATCCGCACCTATGGCGGCGACATCCCGGAGACCTACGGCGTGCCGGTGGAGGAGATCCAGGAGGGCAT
CCGCTACGGCGTGCGCAAGGTGAACATCGACACCGACATCCGCCTCGCCATGACCGCCGGCATGCGCCGCGTGGGGGCGA
AGAACAAATCAGAGTTCGACCCGCGCAAGTTCCTCGCCGCCGCCATGGAAGAGGCCAAGAAGGTGTGCATCAATCGCTTC
GAGGCGTTCGGCGCCGCCGGCAAGGCGGACAAGATCCGTCCCATCGAGCTGGACGACATGGCCAAGCGCTACGCTTCCGG
TGAGCTGGCGCAGGTGGTGCACTAG

Upstream 100 bases:

>100_bases
CGAAGCCGTGCGCCGCGCGGTGGGGTGAGGGTTGGGCCCTCCTCCCGGGAGAGGGGCGGTCCCTGAACGAACGATCTTGC
GAACCCGAAAGGAGAGGACA

Downstream 100 bases:

>100_bases
CCTGCGGAGGCTCGGGGATCGTATAGGAGTTCAAAGAGAAAGCCGTCATGCCCGGGCTTGACCCGGGCATCCATGCAGGG
CCACCCGCGCGACGTTATTC

Product: fructose-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALVSMRQLLDHAAELSYGLPAFNVNNMEQVKAIMDAARATRSPVILQGSAGARKYAGEAFLRHLIAAAVEAYPEIPVVM
HQDHGASPAVCMGAIKSGFSSVMMDGSLKEDGKTPADYDYNAAVTAKVVELAHAVGVSVEGELGCLGSLETGKGEAEDGH
GAEGALDHDKLLTDPEEAAQFVKATQCDALAIAIGTSHGAYKFTRKPTGDILAIDRVKAIHQRIPTTHLVMHGSSSVPQD
LLEEIRTYGGDIPETYGVPVEEIQEGIRYGVRKVNIDTDIRLAMTAGMRRVGAKNKSEFDPRKFLAAAMEEAKKVCINRF
EAFGAAGKADKIRPIELDDMAKRYASGELAQVVH

Sequences:

>Translated_354_residues
MALVSMRQLLDHAAELSYGLPAFNVNNMEQVKAIMDAARATRSPVILQGSAGARKYAGEAFLRHLIAAAVEAYPEIPVVM
HQDHGASPAVCMGAIKSGFSSVMMDGSLKEDGKTPADYDYNAAVTAKVVELAHAVGVSVEGELGCLGSLETGKGEAEDGH
GAEGALDHDKLLTDPEEAAQFVKATQCDALAIAIGTSHGAYKFTRKPTGDILAIDRVKAIHQRIPTTHLVMHGSSSVPQD
LLEEIRTYGGDIPETYGVPVEEIQEGIRYGVRKVNIDTDIRLAMTAGMRRVGAKNKSEFDPRKFLAAAMEEAKKVCINRF
EAFGAAGKADKIRPIELDDMAKRYASGELAQVVH
>Mature_353_residues
ALVSMRQLLDHAAELSYGLPAFNVNNMEQVKAIMDAARATRSPVILQGSAGARKYAGEAFLRHLIAAAVEAYPEIPVVMH
QDHGASPAVCMGAIKSGFSSVMMDGSLKEDGKTPADYDYNAAVTAKVVELAHAVGVSVEGELGCLGSLETGKGEAEDGHG
AEGALDHDKLLTDPEEAAQFVKATQCDALAIAIGTSHGAYKFTRKPTGDILAIDRVKAIHQRIPTTHLVMHGSSSVPQDL
LEEIRTYGGDIPETYGVPVEEIQEGIRYGVRKVNIDTDIRLAMTAGMRRVGAKNKSEFDPRKFLAAAMEEAKKVCINRFE
AFGAAGKADKIRPIELDDMAKRYASGELAQVVH

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=328, Percent_Identity=31.4024390243902, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=29.7872340425532, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788072, Length=333, Percent_Identity=30.03003003003, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789293, Length=356, Percent_Identity=25, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=360, Percent_Identity=28.6111111111111, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37916; Mature: 37784

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSMRQLLDHAAELSYGLPAFNVNNMEQVKAIMDAARATRSPVILQGSAGARKYAGEA
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FLRHLIAAAVEAYPEIPVVMHQDHGASPAVCMGAIKSGFSSVMMDGSLKEDGKTPADYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAVTAKVVELAHAVGVSVEGELGCLGSLETGKGEAEDGHGAEGALDHDKLLTDPEEAAQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKATQCDALAIAIGTSHGAYKFTRKPTGDILAIDRVKAIHQRIPTTHLVMHGSSSVPQD
HHHHHCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCEEEEECCCCCCHHH
LLEEIRTYGGDIPETYGVPVEEIQEGIRYGVRKVNIDTDIRLAMTAGMRRVGAKNKSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCC
PRKFLAAAMEEAKKVCINRFEAFGAAGKADKIRPIELDDMAKRYASGELAQVVH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
ALVSMRQLLDHAAELSYGLPAFNVNNMEQVKAIMDAARATRSPVILQGSAGARKYAGEA
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FLRHLIAAAVEAYPEIPVVMHQDHGASPAVCMGAIKSGFSSVMMDGSLKEDGKTPADYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAVTAKVVELAHAVGVSVEGELGCLGSLETGKGEAEDGHGAEGALDHDKLLTDPEEAAQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKATQCDALAIAIGTSHGAYKFTRKPTGDILAIDRVKAIHQRIPTTHLVMHGSSSVPQD
HHHHHCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCEEEEECCCCCCHHH
LLEEIRTYGGDIPETYGVPVEEIQEGIRYGVRKVNIDTDIRLAMTAGMRRVGAKNKSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCC
PRKFLAAAMEEAKKVCINRFEAFGAAGKADKIRPIELDDMAKRYASGELAQVVH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]