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The map label for this gene is glcD [H]

Identifier: 154245814

GI number: 154245814

Start: 2107051

End: 2108559

Strand: Reverse

Name: glcD [H]

Synonym: Xaut_1870

Alternate gene names: 154245814

Gene position: 2108559-2107051 (Counterclockwise)

Preceding gene: 154245817

Following gene: 154245813

Centisome position: 39.72

GC content: 67.59

Gene sequence:

>1509_bases
ATGACGGGAACAGCTCCGGGCCTCAGGATGCCGGACGCAGACGCGCGGGTGCTCGCCCGCCGCAATGACATCATCGCCGA
TCTCAAGGCCATCGTCCCCGGCGAGGGCGTCATCGCCCATGAACGGGAGATGCGCCCTTACGAATCGGACGCCCTCACCG
CCTACAAGCAATTGCCCCTCGTGGTGGTGCTGCCCTCCACCACCGCGCAGGTGGCGGCCGTGCTGAAATATTGCCACGAC
AACGAGATCCGCGTGGTGCCCCGTGGCGCCGGCACCTCGCTCTCCGGCGGTGCGCTGCCGCTGGAAGATGCGGTGCTGCT
CGGCCTGGGCAAGTTCAACAAGATCCTGGAGATCGACACCCCCAACCGCTGCGCCGTGGTGCAGCCGGGGGTGACCAATC
TCGGCATCTCCAAGGCGGTGGACCATCTCGGCTTCTATTACGCGCCCGACCCCTCCTCCCAGATCGCCTGCACCATCGGC
GGCAATGTGGCGGAGAATTCCGGCGGCGTGCACTGCCTGAAATACGGCCTCACCACCAACAATGTACTCGGCGCCGAGCT
GGTGCTCATCACCGGCGAGATCGTGCGCCTCGGCGGCAAGCACCTCGACGCCGGCGGACTGGACCTTTTGTCCGTAGTCA
TCGGCTCGGAGGGGCTGCTGGGGGTGGTGACGGAAGTCACCGTGCGCCTGCTGAAGAAGCCGGACACCGCCCGCGCCGTG
CTGGTGGGCTTCCCCACCTCGGAAGACGCCGGCGAATGCGTGGCGCGGATCATCGCGGCCGGCATCATCCCGGCCGGCAT
CGAGATGATGGACAAGGACGCCATCGCCGCCGCCGAGGCCTTCGTGAACGTGGGCTATCCCCTCGACGTGGAAGCCCTGC
TCATCGTCGAGCTGGACGGGCCGGAGGCGGAGTGCGCCCATCTGCTGGAAGAGGTGACCCGCATCGCGCAGGCCTGTAAT
TCGGTCACCCTGCGGGTCTCCACCAGCGAGGCCGAACGGCTCGGCTTCTGGGCCGGGCGCAAGGCCGCCTTCCCGGCGGT
GGGGCGGCTGTCGCCCGACTATCTGTGCATGGACGGCACCATCCCGCGCCGGCAATTGCCCTTCGTGCTCGCCCGCATGC
GGGAGCTCGGGGCGAAATACGGCCTGCGCTGCGCCAACGTGTTCCATGCCGGCGACGGCAACCTGCACCCGCTCATCCTC
TATGACGCGAACGCGCCCGGTGAACTGCACGCGGCCGAGAGCTTCGGCGCCGACATCCTGCGCCTCTGCGTGGAGGTGGG
AGGCGTGCTCACTGGCGAGCATGGCGTGGGGGTGGAGAAGCGCGACCTCATGGACACCATGTTCAACGAGGTCGATCTCG
CCCAGCAGCAGCGCATGAAATGCGCGTTCGACGACAAGAGCCTGCTCAATCCCGGCAAGGTGTTCCCCACCCTCCACCGC
TGCGCCGAATTCGGCCGCATGCATGTGAGCGGCGGCGCCCTGCCCTTCCCGGACCTGCCGCGCTTCTAA

Upstream 100 bases:

>100_bases
CGGACGACTTTATCCGCCACGGAAACAATCTGCGACGTTTTTTCCCGGTGAACCGATTATAGTTCCCCTAAAGAGAACGG
GCTCAACGAGGGACCGCCAC

Downstream 100 bases:

>100_bases
GGCGCGTGCCCAACAGCCTAAGGCCATCCGATGAGCGACATCATCGCAGCGCGCGACGACGGCGAGGTCGCGGACGCGGT
CCGCACCGCGCTTTCCGCCG

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTGTAPGLRMPDADARVLARRNDIIADLKAIVPGEGVIAHEREMRPYESDALTAYKQLPLVVVLPSTTAQVAAVLKYCHD
NEIRVVPRGAGTSLSGGALPLEDAVLLGLGKFNKILEIDTPNRCAVVQPGVTNLGISKAVDHLGFYYAPDPSSQIACTIG
GNVAENSGGVHCLKYGLTTNNVLGAELVLITGEIVRLGGKHLDAGGLDLLSVVIGSEGLLGVVTEVTVRLLKKPDTARAV
LVGFPTSEDAGECVARIIAAGIIPAGIEMMDKDAIAAAEAFVNVGYPLDVEALLIVELDGPEAECAHLLEEVTRIAQACN
SVTLRVSTSEAERLGFWAGRKAAFPAVGRLSPDYLCMDGTIPRRQLPFVLARMRELGAKYGLRCANVFHAGDGNLHPLIL
YDANAPGELHAAESFGADILRLCVEVGGVLTGEHGVGVEKRDLMDTMFNEVDLAQQQRMKCAFDDKSLLNPGKVFPTLHR
CAEFGRMHVSGGALPFPDLPRF

Sequences:

>Translated_502_residues
MTGTAPGLRMPDADARVLARRNDIIADLKAIVPGEGVIAHEREMRPYESDALTAYKQLPLVVVLPSTTAQVAAVLKYCHD
NEIRVVPRGAGTSLSGGALPLEDAVLLGLGKFNKILEIDTPNRCAVVQPGVTNLGISKAVDHLGFYYAPDPSSQIACTIG
GNVAENSGGVHCLKYGLTTNNVLGAELVLITGEIVRLGGKHLDAGGLDLLSVVIGSEGLLGVVTEVTVRLLKKPDTARAV
LVGFPTSEDAGECVARIIAAGIIPAGIEMMDKDAIAAAEAFVNVGYPLDVEALLIVELDGPEAECAHLLEEVTRIAQACN
SVTLRVSTSEAERLGFWAGRKAAFPAVGRLSPDYLCMDGTIPRRQLPFVLARMRELGAKYGLRCANVFHAGDGNLHPLIL
YDANAPGELHAAESFGADILRLCVEVGGVLTGEHGVGVEKRDLMDTMFNEVDLAQQQRMKCAFDDKSLLNPGKVFPTLHR
CAEFGRMHVSGGALPFPDLPRF
>Mature_501_residues
TGTAPGLRMPDADARVLARRNDIIADLKAIVPGEGVIAHEREMRPYESDALTAYKQLPLVVVLPSTTAQVAAVLKYCHDN
EIRVVPRGAGTSLSGGALPLEDAVLLGLGKFNKILEIDTPNRCAVVQPGVTNLGISKAVDHLGFYYAPDPSSQIACTIGG
NVAENSGGVHCLKYGLTTNNVLGAELVLITGEIVRLGGKHLDAGGLDLLSVVIGSEGLLGVVTEVTVRLLKKPDTARAVL
VGFPTSEDAGECVARIIAAGIIPAGIEMMDKDAIAAAEAFVNVGYPLDVEALLIVELDGPEAECAHLLEEVTRIAQACNS
VTLRVSTSEAERLGFWAGRKAAFPAVGRLSPDYLCMDGTIPRRQLPFVLARMRELGAKYGLRCANVFHAGDGNLHPLILY
DANAPGELHAAESFGADILRLCVEVGGVLTGEHGVGVEKRDLMDTMFNEVDLAQQQRMKCAFDDKSLLNPGKVFPTLHRC
AEFGRMHVSGGALPFPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=27.6688453159041, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=26.5560165975104, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI119964728, Length=461, Percent_Identity=27.3318872017354, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4501993, Length=230, Percent_Identity=26.5217391304348, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789351, Length=493, Percent_Identity=56.1866125760649, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1787977, Length=505, Percent_Identity=24.3564356435644, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI48994907, Length=221, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71992373, Length=461, Percent_Identity=27.5488069414317, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71992381, Length=461, Percent_Identity=27.5488069414317, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=27.5766016713092, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17534361, Length=501, Percent_Identity=26.3473053892216, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17556096, Length=229, Percent_Identity=25.764192139738, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=434, Percent_Identity=29.2626728110599, Blast_Score=190, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6320023, Length=496, Percent_Identity=26.2096774193548, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=467, Percent_Identity=24.8394004282655, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI18921117, Length=431, Percent_Identity=29.0023201856148, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24639277, Length=431, Percent_Identity=29.0023201856148, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24639275, Length=431, Percent_Identity=29.0023201856148, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24653753, Length=231, Percent_Identity=24.6753246753247, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53322; Mature: 53191

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTAPGLRMPDADARVLARRNDIIADLKAIVPGEGVIAHEREMRPYESDALTAYKQLPL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCCCHHHHHHHHHCCE
VVVLPSTTAQVAAVLKYCHDNEIRVVPRGAGTSLSGGALPLEDAVLLGLGKFNKILEIDT
EEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHEEECCCCCCEEEECC
PNRCAVVQPGVTNLGISKAVDHLGFYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTTN
CCCEEEECCCCCCCCHHHHHHHCCCEECCCCCCCEEEEECCCEECCCCCEEEEEECCCCC
NVLGAELVLITGEIVRLGGKHLDAGGLDLLSVVIGSEGLLGVVTEVTVRLLKKPDTARAV
CCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEE
LVGFPTSEDAGECVARIIAAGIIPAGIEMMDKDAIAAAEAFVNVGYPLDVEALLIVELDG
EEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC
PEAECAHLLEEVTRIAQACNSVTLRVSTSEAERLGFWAGRKAAFPAVGRLSPDYLCMDGT
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
IPRRQLPFVLARMRELGAKYGLRCANVFHAGDGNLHPLILYDANAPGELHAAESFGADIL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCEECHHHCCHHHH
RLCVEVGGVLTGEHGVGVEKRDLMDTMFNEVDLAQQQRMKCAFDDKSLLNPGKVFPTLHR
HHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHH
CAEFGRMHVSGGALPFPDLPRF
HHHHCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TGTAPGLRMPDADARVLARRNDIIADLKAIVPGEGVIAHEREMRPYESDALTAYKQLPL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCCCHHHHHHHHHCCE
VVVLPSTTAQVAAVLKYCHDNEIRVVPRGAGTSLSGGALPLEDAVLLGLGKFNKILEIDT
EEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHEEECCCCCCEEEECC
PNRCAVVQPGVTNLGISKAVDHLGFYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTTN
CCCEEEECCCCCCCCHHHHHHHCCCEECCCCCCCEEEEECCCEECCCCCEEEEEECCCCC
NVLGAELVLITGEIVRLGGKHLDAGGLDLLSVVIGSEGLLGVVTEVTVRLLKKPDTARAV
CCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEE
LVGFPTSEDAGECVARIIAAGIIPAGIEMMDKDAIAAAEAFVNVGYPLDVEALLIVELDG
EEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC
PEAECAHLLEEVTRIAQACNSVTLRVSTSEAERLGFWAGRKAAFPAVGRLSPDYLCMDGT
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
IPRRQLPFVLARMRELGAKYGLRCANVFHAGDGNLHPLILYDANAPGELHAAESFGADIL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCEECHHHCCHHHH
RLCVEVGGVLTGEHGVGVEKRDLMDTMFNEVDLAQQQRMKCAFDDKSLLNPGKVFPTLHR
HHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHH
CAEFGRMHVSGGALPFPDLPRF
HHHHCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]