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The map label for this gene is hemE [H]

Identifier: 154245770

GI number: 154245770

Start: 2052795

End: 2053841

Strand: Reverse

Name: hemE [H]

Synonym: Xaut_1826

Alternate gene names: 154245770

Gene position: 2053841-2052795 (Counterclockwise)

Preceding gene: 154245776

Following gene: 154245769

Centisome position: 38.69

GC content: 69.82

Gene sequence:

>1047_bases
ATGACCGCCGCGCTCGAGACACGATCCCCCTTCCTGCGGGTGCTCGACGGCACCCCGCTCGATCCCCCGCCACTCTGGAT
GATGCGGCAGGCCGGGCGCTATCTGCCCGAATATCGCGCGGTGCGGGCGGAAGCGGGCGATTTCCTTACCTTGTGCTACA
CGCCGAAGCTCGCCGCCGAGGTGACGCTCCAGCCCATCCGCCGTTACGGCTTTGATGCGGCCATCATCTTTTCCGACATC
CTGGTGGTGCCCCACGCCCTTGGCGTCGGCCTCACCTTCGAGGCGGGCGAAGGCCCACGGCTGACCCCGGTGACGGATCA
GGCCGGCGTCGCGGCCCTCTCGGATCGGCTGGACCCCGACAAGGTGGACCCTGTCTACGAGGCCATCGCCTCGGTGCGCG
CTACCCTTCCGGCCGAGGTGGCCCTGATCGGCTTCTGCGGCGCGCCCTGGACGGTGGCCACCTACATGGTGGCGGGCCAC
GGCACCGACGACCAGGCCCCCGCCCGCATGCTGGCGCTGCGCGACGAAGCTTTGTTCCAGAGCCTCATCGACCGGCTGGT
GGAAGCCTCCATCGTCCATCTGGCGGGACAGGTAGCGGCCGGCGCCGACGTGGTGCAGATCTTCGATACCTGGGCCGGGG
TGCTCGATCCCTCCTCGTTCGAGCGCTGGTGCGCCGAGCCGCTGCGCCGTATCGTCGCGGGATTGAAGGCGCTGCACCCC
CATGTTCGGGTGATCGCCTTCCCCAAGGGGGCGACGCTGGAGGCGCTGGAGCGGCTGGCCGACACCGGCATCAACGCCAT
TGGCCTCGACTGGTCGGCGGATCGGCAGGCGGCGCGGCGGCGGCTGTCCGGCCGTGTGGCGCTGCAGGGCAATCTGGATC
CGCTGCGGCTCATTGCCGGCGGTGCGGCGCTGGAGGACGAAGTGGCGCGCATTCGCGACGATTTCTCGGGTGCGCGGCAC
ATCTTCAACCTCGGCCACGGCATCCGCCCCGAAACCCCGCTCGACCATGTGGAAAAGCTGGTGGAAGCGGTGCGCCGCGC
GCGCTGA

Upstream 100 bases:

>100_bases
TGTGGATCGGTTGTCGAGGGCGGCGCACATCGTTAATCAACCGTTAAGACTCCAAAGACTCTCTCTCTTTAAAAGATTCT
AGTTAGATTGAAGGACCGGG

Downstream 100 bases:

>100_bases
TCCTCGTCGAGGTCAGGACCCTGATGGCTCACGATTTCTATAGCTGGATCAAGGCTCTGCATGTCATCGCCGTGATCTCC
TGGATGGCGGGGATGCTGTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTAALETRSPFLRVLDGTPLDPPPLWMMRQAGRYLPEYRAVRAEAGDFLTLCYTPKLAAEVTLQPIRRYGFDAAIIFSDI
LVVPHALGVGLTFEAGEGPRLTPVTDQAGVAALSDRLDPDKVDPVYEAIASVRATLPAEVALIGFCGAPWTVATYMVAGH
GTDDQAPARMLALRDEALFQSLIDRLVEASIVHLAGQVAAGADVVQIFDTWAGVLDPSSFERWCAEPLRRIVAGLKALHP
HVRVIAFPKGATLEALERLADTGINAIGLDWSADRQAARRRLSGRVALQGNLDPLRLIAGGAALEDEVARIRDDFSGARH
IFNLGHGIRPETPLDHVEKLVEAVRRAR

Sequences:

>Translated_348_residues
MTAALETRSPFLRVLDGTPLDPPPLWMMRQAGRYLPEYRAVRAEAGDFLTLCYTPKLAAEVTLQPIRRYGFDAAIIFSDI
LVVPHALGVGLTFEAGEGPRLTPVTDQAGVAALSDRLDPDKVDPVYEAIASVRATLPAEVALIGFCGAPWTVATYMVAGH
GTDDQAPARMLALRDEALFQSLIDRLVEASIVHLAGQVAAGADVVQIFDTWAGVLDPSSFERWCAEPLRRIVAGLKALHP
HVRVIAFPKGATLEALERLADTGINAIGLDWSADRQAARRRLSGRVALQGNLDPLRLIAGGAALEDEVARIRDDFSGARH
IFNLGHGIRPETPLDHVEKLVEAVRRAR
>Mature_347_residues
TAALETRSPFLRVLDGTPLDPPPLWMMRQAGRYLPEYRAVRAEAGDFLTLCYTPKLAAEVTLQPIRRYGFDAAIIFSDIL
VVPHALGVGLTFEAGEGPRLTPVTDQAGVAALSDRLDPDKVDPVYEAIASVRATLPAEVALIGFCGAPWTVATYMVAGHG
TDDQAPARMLALRDEALFQSLIDRLVEASIVHLAGQVAAGADVVQIFDTWAGVLDPSSFERWCAEPLRRIVAGLKALHPH
VRVIAFPKGATLEALERLADTGINAIGLDWSADRQAARRRLSGRVALQGNLDPLRLIAGGAALEDEVARIRDDFSGARHI
FNLGHGIRPETPLDHVEKLVEAVRRAR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=345, Percent_Identity=42.8985507246377, Blast_Score=238, Evalue=8e-63,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=48.5294117647059, Blast_Score=301, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6320252, Length=348, Percent_Identity=35.3448275862069, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=40.3458213256484, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=40.3458213256484, Blast_Score=234, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37708; Mature: 37577

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAALETRSPFLRVLDGTPLDPPPLWMMRQAGRYLPEYRAVRAEAGDFLTLCYTPKLAAE
CCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCHHHH
VTLQPIRRYGFDAAIIFSDILVVPHALGVGLTFEAGEGPRLTPVTDQAGVAALSDRLDPD
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCC
KVDPVYEAIASVRATLPAEVALIGFCGAPWTVATYMVAGHGTDDQAPARMLALRDEALFQ
CCCHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
SLIDRLVEASIVHLAGQVAAGADVVQIFDTWAGVLDPSSFERWCAEPLRRIVAGLKALHP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
HVRVIAFPKGATLEALERLADTGINAIGLDWSADRQAARRRLSGRVALQGNLDPLRLIAG
CEEEEEECCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCEEEECCCCHHHHEEC
GAALEDEVARIRDDFSGARHIFNLGHGIRPETPLDHVEKLVEAVRRAR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAALETRSPFLRVLDGTPLDPPPLWMMRQAGRYLPEYRAVRAEAGDFLTLCYTPKLAAE
CCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCHHHH
VTLQPIRRYGFDAAIIFSDILVVPHALGVGLTFEAGEGPRLTPVTDQAGVAALSDRLDPD
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCC
KVDPVYEAIASVRATLPAEVALIGFCGAPWTVATYMVAGHGTDDQAPARMLALRDEALFQ
CCCHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
SLIDRLVEASIVHLAGQVAAGADVVQIFDTWAGVLDPSSFERWCAEPLRRIVAGLKALHP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
HVRVIAFPKGATLEALERLADTGINAIGLDWSADRQAARRRLSGRVALQGNLDPLRLIAG
CEEEEEECCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCEEEECCCCHHHHEEC
GAALEDEVARIRDDFSGARHIFNLGHGIRPETPLDHVEKLVEAVRRAR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA