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The map label for this gene is divL [H]

Identifier: 154245748

GI number: 154245748

Start: 2032066

End: 2033679

Strand: Reverse

Name: divL [H]

Synonym: Xaut_1804

Alternate gene names: 154245748

Gene position: 2033679-2032066 (Counterclockwise)

Preceding gene: 154245749

Following gene: 154245747

Centisome position: 38.31

GC content: 72.43

Gene sequence:

>1614_bases
ATGCGATCCATCCGCTTCAAGCTCGCCGCCTTGAGCGGGGCGGCGGCAGCCTTTGCCATCCTGGCCGCCGCAGGGGTGCT
CCTTGCGGCCGGGGCGGCGGATCGCGCCCTGGAGGCGACGGTCTCGGCCCAGCAGCGGCTGGACCTGCTCACCGAAATCT
CCGCCCGCCTGTCCGATTTCGGCCTTGCCGCCGTGGCCGTCGCCGAAAGCCCCGGCGCGGAGATGGGACGTGCGGACTTG
GGACGCATGGAGGAAGCCGGCGCCCGCGTCGCAGCGGTGCTGGAGGCGGCGACCCTGCGGGCGGCGGAAACCGCTCCCGC
CCTTGAGACCGGGGCGCGCCCGCGTGAGCGCATGCTGGCTCACCTGCGGGCCGATTTCACCGTGCTTGACCGCCAGATTT
CCGGCGCCGTGGCCGATGCCGACGCCCGCAGCCGCGGTGATCGCGTGCGCGGCGCGCTCAACGGTTTTGCCGCCTCCGCC
GGTCCCACCCTCTCGCTGCTGGTGGACAGCGAGCGCCGCGCCGTGACGAGCGCGCGGGAGGAGGCGCTGGACCTCTCCTT
CCGCCTGCGGGTGGGCGCTGTGGCGCTCGCAGCTCTCGTGCTGGTCGCGGCAGTGATCCTCTATCGCGCGCTGGCGCGGC
CGCTGCTGACACGGCTCCGGGAGATGGATCGCGCCGCCGCCGCCATCGGCCGCGGCGACCTCGACACCCGCCTCAGCATC
GGCCCGCGCGACGAGTTGGGCGTGCTGACGGCGCGCTTCAATCGCATGGCCGCGCGCCTCGGCCGCCGCGAGCGGCAGGT
GGTCGAGGACCGCGCCGTGCTGGAGAAGACCATTTCAGAGCGCACCGCCGACCTCACGGCTGCCAATGCCCGGCTGGCCG
CTATCGACGCCTCCCGCCGGCGTTTCTTCACCGATGTGAGCCATGAATTGCGCACGCCGCTCACCGTCATCATCGGCGAA
TGCGACGTGACGCAGCGCGCCCCCGCTATTCCCGAGGAATTGAGCCGCACGGTGCTCGCCACGATTCGCAAGCGGGCCGG
GCGCCTGCACCGGCGGATCGAGGATCTGCTGCGCGTCGCCCGCTCGGAAAGCGGGGAGATCGAGCTGGTGTTCCAGGACG
TGCCGCTGCTGCCGCTCCTGGCTGATGCCGTTGCCGGCTTCGAGACCGTGGCGCGCCGGCAGGGGGTGAGCCTTACGCTG
GAGGCCGACCCGCCCGGCCCTCTCGTCCATGCCGATCGCGAGTGGCTGCGGCAGGTGGTGGAGGGCCTCATCGACAATGC
CCTGCGCCATGGCGGCAAGGTGACGCGCATCGCCCTCGCGGTCGCCACCGTGGCCGGTGCCGGCGGAGCGGTTGTGGATG
AGATCACGGTGAGCGACGACGGCCGCGGCATCCCGCCGGAGGCGCGTGCCGCGCTCTTCAAGCGCTTCGAGCGCGGCGAG
CGGTTCGGCGACGGGGCGGGATTCGGCCTGGGTCTCGCGCTGGCGGAATGGGTGGTGACGCGGCACGGTGGACGGATCAC
ACTGGAAGAGGGAGAAGGGGGCGGTACCCGCGTGGTCATCGCGTTGCCCCGTCCGCAGGCCCATCCAGAGGTGGTTGCGA
CGCAGGGCGCCTGA

Upstream 100 bases:

>100_bases
TGAGCGGACCCATCTGGCATCGGTCGAAGATCGAGGCCGATGGTATAAGGGCGGAAAACCAGAACCACCGGGTGTCCCGG
GAGGAAGACCGGCGCGGGCC

Downstream 100 bases:

>100_bases
GCGGACCCGCCCGGCGAGGAGGATACATGAACATTCTGGTGGTCGAGGATGACAGCGACATCGGCGCGATGCTGAGCCGC
GGGCTCTCGGCCGAAGGCTT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MRSIRFKLAALSGAAAAFAILAAAGVLLAAGAADRALEATVSAQQRLDLLTEISARLSDFGLAAVAVAESPGAEMGRADL
GRMEEAGARVAAVLEAATLRAAETAPALETGARPRERMLAHLRADFTVLDRQISGAVADADARSRGDRVRGALNGFAASA
GPTLSLLVDSERRAVTSAREEALDLSFRLRVGAVALAALVLVAAVILYRALARPLLTRLREMDRAAAAIGRGDLDTRLSI
GPRDELGVLTARFNRMAARLGRRERQVVEDRAVLEKTISERTADLTAANARLAAIDASRRRFFTDVSHELRTPLTVIIGE
CDVTQRAPAIPEELSRTVLATIRKRAGRLHRRIEDLLRVARSESGEIELVFQDVPLLPLLADAVAGFETVARRQGVSLTL
EADPPGPLVHADREWLRQVVEGLIDNALRHGGKVTRIALAVATVAGAGGAVVDEITVSDDGRGIPPEARAALFKRFERGE
RFGDGAGFGLGLALAEWVVTRHGGRITLEEGEGGGTRVVIALPRPQAHPEVVATQGA

Sequences:

>Translated_537_residues
MRSIRFKLAALSGAAAAFAILAAAGVLLAAGAADRALEATVSAQQRLDLLTEISARLSDFGLAAVAVAESPGAEMGRADL
GRMEEAGARVAAVLEAATLRAAETAPALETGARPRERMLAHLRADFTVLDRQISGAVADADARSRGDRVRGALNGFAASA
GPTLSLLVDSERRAVTSAREEALDLSFRLRVGAVALAALVLVAAVILYRALARPLLTRLREMDRAAAAIGRGDLDTRLSI
GPRDELGVLTARFNRMAARLGRRERQVVEDRAVLEKTISERTADLTAANARLAAIDASRRRFFTDVSHELRTPLTVIIGE
CDVTQRAPAIPEELSRTVLATIRKRAGRLHRRIEDLLRVARSESGEIELVFQDVPLLPLLADAVAGFETVARRQGVSLTL
EADPPGPLVHADREWLRQVVEGLIDNALRHGGKVTRIALAVATVAGAGGAVVDEITVSDDGRGIPPEARAALFKRFERGE
RFGDGAGFGLGLALAEWVVTRHGGRITLEEGEGGGTRVVIALPRPQAHPEVVATQGA
>Mature_537_residues
MRSIRFKLAALSGAAAAFAILAAAGVLLAAGAADRALEATVSAQQRLDLLTEISARLSDFGLAAVAVAESPGAEMGRADL
GRMEEAGARVAAVLEAATLRAAETAPALETGARPRERMLAHLRADFTVLDRQISGAVADADARSRGDRVRGALNGFAASA
GPTLSLLVDSERRAVTSAREEALDLSFRLRVGAVALAALVLVAAVILYRALARPLLTRLREMDRAAAAIGRGDLDTRLSI
GPRDELGVLTARFNRMAARLGRRERQVVEDRAVLEKTISERTADLTAANARLAAIDASRRRFFTDVSHELRTPLTVIIGE
CDVTQRAPAIPEELSRTVLATIRKRAGRLHRRIEDLLRVARSESGEIELVFQDVPLLPLLADAVAGFETVARRQGVSLTL
EADPPGPLVHADREWLRQVVEGLIDNALRHGGKVTRIALAVATVAGAGGAVVDEITVSDDGRGIPPEARAALFKRFERGE
RFGDGAGFGLGLALAEWVVTRHGGRITLEEGEGGGTRVVIALPRPQAHPEVVATQGA

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=315, Percent_Identity=28.2539682539683, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=34.4827586206897, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=30.7053941908714, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789149, Length=340, Percent_Identity=27.9411764705882, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=29.7872340425532, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=359, Percent_Identity=27.0194986072423, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=30.4721030042918, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=31.3636363636364, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787894, Length=349, Percent_Identity=23.7822349570201, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=28.8079470198675, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=25.9911894273128, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=210, Percent_Identity=25.2380952380952, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=26.3473053892216, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=28.8065843621399, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI87081816, Length=353, Percent_Identity=27.4787535410765, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=243, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=29.1845493562232, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789403, Length=235, Percent_Identity=27.6595744680851, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56946; Mature: 56946

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIRFKLAALSGAAAAFAILAAAGVLLAAGAADRALEATVSAQQRLDLLTEISARLSDF
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLAAVAVAESPGAEMGRADLGRMEEAGARVAAVLEAATLRAAETAPALETGARPRERMLA
CHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHH
HLRADFTVLDRQISGAVADADARSRGDRVRGALNGFAASAGPTLSLLVDSERRAVTSARE
HHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
EALDLSFRLRVGAVALAALVLVAAVILYRALARPLLTRLREMDRAAAAIGRGDLDTRLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GPRDELGVLTARFNRMAARLGRRERQVVEDRAVLEKTISERTADLTAANARLAAIDASRR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
RFFTDVSHELRTPLTVIIGECDVTQRAPAIPEELSRTVLATIRKRAGRLHRRIEDLLRVA
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSESGEIELVFQDVPLLPLLADAVAGFETVARRQGVSLTLEADPPGPLVHADREWLRQVV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEECCHHHHHHHH
EGLIDNALRHGGKVTRIALAVATVAGAGGAVVDEITVSDDGRGIPPEARAALFKRFERGE
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCC
RFGDGAGFGLGLALAEWVVTRHGGRITLEEGEGGGTRVVIALPRPQAHPEVVATQGA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEECCCC
>Mature Secondary Structure
MRSIRFKLAALSGAAAAFAILAAAGVLLAAGAADRALEATVSAQQRLDLLTEISARLSDF
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLAAVAVAESPGAEMGRADLGRMEEAGARVAAVLEAATLRAAETAPALETGARPRERMLA
CHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHH
HLRADFTVLDRQISGAVADADARSRGDRVRGALNGFAASAGPTLSLLVDSERRAVTSARE
HHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
EALDLSFRLRVGAVALAALVLVAAVILYRALARPLLTRLREMDRAAAAIGRGDLDTRLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GPRDELGVLTARFNRMAARLGRRERQVVEDRAVLEKTISERTADLTAANARLAAIDASRR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
RFFTDVSHELRTPLTVIIGECDVTQRAPAIPEELSRTVLATIRKRAGRLHRRIEDLLRVA
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSESGEIELVFQDVPLLPLLADAVAGFETVARRQGVSLTLEADPPGPLVHADREWLRQVV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEECCHHHHHHHH
EGLIDNALRHGGKVTRIALAVATVAGAGGAVVDEITVSDDGRGIPPEARAALFKRFERGE
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCC
RFGDGAGFGLGLALAEWVVTRHGGRITLEEGEGGGTRVVIALPRPQAHPEVVATQGA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]