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The map label for this gene is mprA [H]

Identifier: 154245747

GI number: 154245747

Start: 2031341

End: 2032039

Strand: Reverse

Name: mprA [H]

Synonym: Xaut_1803

Alternate gene names: 154245747

Gene position: 2032039-2031341 (Counterclockwise)

Preceding gene: 154245748

Following gene: 154245746

Centisome position: 38.28

GC content: 70.53

Gene sequence:

>699_bases
ATGAACATTCTGGTGGTCGAGGATGACAGCGACATCGGCGCGATGCTGAGCCGCGGGCTCTCGGCCGAAGGCTTTGACGT
GACCGTGGTGGGCCGCGCGGACGAGGCGCTGGAGGCAGCGCGCCAGTACAATCCCTGCGCGGTGGTGCTCGACATCATGC
TGCCCGATGGCTCGGGGATCGAGGTGTGCCGCGCGCTGCGCGAGGCCGGGCACTCGGGCCCCATCCTGTTCCTGTCCGCC
AAGGACGAGGTGCGCGACCGGGCCGAGGGCCTTGGCGCCGGGGCCGACGACTACATCGTGAAGCCGTTCGAGTTCGCCGA
GCTGGTGGCGCGGTTGCGCGCCCATTTGCTGCACCGCCTCGGCGACAACCATGCGGGCCGGATTGTCGCAGGGCGCCTGG
TGCTGGACCAGTCCACCCGCACCGTGCTGTTCGGCGAGATCCACGCCCGCCTGACGGAACGGGAGGCGGAGCTTCTGGCG
CTGCTGATGGCGACCCCCAACCGGCCGGTGCCGCGCGGCGAAATCTTTGACCGGCTCTGGGCCAACCAGGGCGGTGCCTC
GCTGAACGTGGTGGATGTCTATGTGGGCTACCTGCGCACCAAGCTGGCGCCGGTGAGCCGCGCCGGCGGGCCGCAGGTGT
CCACGGTGCGCGGCCGTGGCTTCATGCTGGACCTCTCGGCGCCCGCCGCCGCCCAATGA

Upstream 100 bases:

>100_bases
GCGGTACCCGCGTGGTCATCGCGTTGCCCCGTCCGCAGGCCCATCCAGAGGTGGTTGCGACGCAGGGCGCCTGAGCGGAC
CCGCCCGGCGAGGAGGATAC

Downstream 100 bases:

>100_bases
TCTGTTGCGGCGCAGCATCACATTTTGCTTGCGGGAACCAAATTGAACGCCAATATTTGATCTCAATGCGATGAACTTCA
TCATTGCAGCGTGTTCTTAT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNILVVEDDSDIGAMLSRGLSAEGFDVTVVGRADEALEAARQYNPCAVVLDIMLPDGSGIEVCRALREAGHSGPILFLSA
KDEVRDRAEGLGAGADDYIVKPFEFAELVARLRAHLLHRLGDNHAGRIVAGRLVLDQSTRTVLFGEIHARLTEREAELLA
LLMATPNRPVPRGEIFDRLWANQGGASLNVVDVYVGYLRTKLAPVSRAGGPQVSTVRGRGFMLDLSAPAAAQ

Sequences:

>Translated_232_residues
MNILVVEDDSDIGAMLSRGLSAEGFDVTVVGRADEALEAARQYNPCAVVLDIMLPDGSGIEVCRALREAGHSGPILFLSA
KDEVRDRAEGLGAGADDYIVKPFEFAELVARLRAHLLHRLGDNHAGRIVAGRLVLDQSTRTVLFGEIHARLTEREAELLA
LLMATPNRPVPRGEIFDRLWANQGGASLNVVDVYVGYLRTKLAPVSRAGGPQVSTVRGRGFMLDLSAPAAAQ
>Mature_232_residues
MNILVVEDDSDIGAMLSRGLSAEGFDVTVVGRADEALEAARQYNPCAVVLDIMLPDGSGIEVCRALREAGHSGPILFLSA
KDEVRDRAEGLGAGADDYIVKPFEFAELVARLRAHLLHRLGDNHAGRIVAGRLVLDQSTRTVLFGEIHARLTEREAELLA
LLMATPNRPVPRGEIFDRLWANQGGASLNVVDVYVGYLRTKLAPVSRAGGPQVSTVRGRGFMLDLSAPAAAQ

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=35.8407079646018, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=34.5132743362832, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.8744394618834, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=34.8214285714286, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.375, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786911, Length=202, Percent_Identity=33.1683168316832, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=30.2631578947368, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=32.7510917030568, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=29.9559471365639, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=256, Percent_Identity=32.8125, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787229, Length=212, Percent_Identity=32.5471698113208, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=28.3261802575107, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=30.5084745762712, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24922; Mature: 24922

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVVEDDSDIGAMLSRGLSAEGFDVTVVGRADEALEAARQYNPCAVVLDIMLPDGSGI
CEEEEEECCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEEECCCCCH
EVCRALREAGHSGPILFLSAKDEVRDRAEGLGAGADDYIVKPFEFAELVARLRAHLLHRL
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHH
GDNHAGRIVAGRLVLDQSTRTVLFGEIHARLTEREAELLALLMATPNRPVPRGEIFDRLW
CCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ANQGGASLNVVDVYVGYLRTKLAPVSRAGGPQVSTVRGRGFMLDLSAPAAAQ
CCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCCC
>Mature Secondary Structure
MNILVVEDDSDIGAMLSRGLSAEGFDVTVVGRADEALEAARQYNPCAVVLDIMLPDGSGI
CEEEEEECCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEEECCCCCH
EVCRALREAGHSGPILFLSAKDEVRDRAEGLGAGADDYIVKPFEFAELVARLRAHLLHRL
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHH
GDNHAGRIVAGRLVLDQSTRTVLFGEIHARLTEREAELLALLMATPNRPVPRGEIFDRLW
CCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ANQGGASLNVVDVYVGYLRTKLAPVSRAGGPQVSTVRGRGFMLDLSAPAAAQ
CCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA