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The map label for this gene is dxs [C]

Identifier: 154245657

GI number: 154245657

Start: 1928381

End: 1929379

Strand: Direct

Name: dxs [C]

Synonym: Xaut_1713

Alternate gene names: 154245657

Gene position: 1928381-1929379 (Clockwise)

Preceding gene: 154245656

Following gene: 154245658

Centisome position: 36.32

GC content: 68.07

Gene sequence:

>999_bases
ATGCTTAAGGGCCGCACTCTGGGCATGGGTGAGCTGGAAGCGGTGGAGAACCGCGCCTCAAAGCTCGCCCCCTTCGCCAC
CGGCGCCATCGCCGCACAGGAGGCGCACGGCGACGTGGTGCTGCTCACCGCCGATCTCGGCAAATACACCGACACCTACC
CGTTCCGCGACCGCTTTCCGGATCGCTTCTACAATGTGGGCATGGCGGAGCAGGCTTTGGTGATGGTGGCGGCAGGGCTC
GCCCGCACCGGTCTTTCAGCCTATTGCACCACCTATGGCGCCTTCGCGACGCGGCGCGCCCACGATTTCCTCGCCATCGC
CTGCGCCCATGGCGGGGCGAGCGTGAAGATGTTCGCCGGCAATCCCGGCCTCACCACCGGCTATGGCGGCACCCACCAGG
CCATCGAGGACCTCGCCCTCATGCGGGCGGTGCCCGACATGACGGTGATCGACCCGTGCGATGCCACCGAGATGCAGCAG
ATCGCCGAGCAGGCGCGCGAGATGGAGGGCACGGTCTATTGCCGGCTGCTGCGCGGCAACGTGCCGGTGGTGTTCGATCC
CGCCACCCACCGCTTCGAGCTGGGCAAGGCCAAGCGCATCGGCTCCGGCACGGATATCGGCTTCATCTCCACCGGCTTCA
TGACCGAGCGCTGCCTCGACGCATCAGCCGGCCTCGCGGAGCTGGGCATCAAGGCCTCCGTCCTGCACTGCGCCACCATC
AAGCCGTTCGACACCGAGGCCGTGGCCGCCTTCGCCGCCTCGGTGGACAAGGTGGTGACCGCCGAGAACCATGTGCTCGT
GGGCGGGCTTGCCTCCCTGGTGCTCGATGCCCTCTACGCCAACGGGGTGATGAAGCCCCTGCTCAAGATCGGCATTCCCG
ACCGCTTCATCGAATGCGGGTCCATCCCCTATCTGCAGACCCGCTATGGCCTCACCGCCGCGCGGGTGCGCGAGCAGGTG
GCGCAGTGGCTCGGCGCCGGCGCGCAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
GGCCGGGGCATCGCCCGCCTCGAAGCCCGCGAGCAGGCCCATTTCATCCGGGTCGAAGGCAACGAATGGGACACGCTCGG
GCGTGAACTGGAGCTGGAAA

Downstream 100 bases:

>100_bases
CACCATGCGCGAACTCAAGGTGTTCGGCGCCCCCGGCCTCTATGTGCAGGGCCCCGGCGCGCTGCGCGAACTCGGCCGCC
TCATTGCCCCGGTGGGCTCC

Product: transketolase central region

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MLKGRTLGMGELEAVENRASKLAPFATGAIAAQEAHGDVVLLTADLGKYTDTYPFRDRFPDRFYNVGMAEQALVMVAAGL
ARTGLSAYCTTYGAFATRRAHDFLAIACAHGGASVKMFAGNPGLTTGYGGTHQAIEDLALMRAVPDMTVIDPCDATEMQQ
IAEQAREMEGTVYCRLLRGNVPVVFDPATHRFELGKAKRIGSGTDIGFISTGFMTERCLDASAGLAELGIKASVLHCATI
KPFDTEAVAAFAASVDKVVTAENHVLVGGLASLVLDALYANGVMKPLLKIGIPDRFIECGSIPYLQTRYGLTAARVREQV
AQWLGAGAQAAE

Sequences:

>Translated_332_residues
MLKGRTLGMGELEAVENRASKLAPFATGAIAAQEAHGDVVLLTADLGKYTDTYPFRDRFPDRFYNVGMAEQALVMVAAGL
ARTGLSAYCTTYGAFATRRAHDFLAIACAHGGASVKMFAGNPGLTTGYGGTHQAIEDLALMRAVPDMTVIDPCDATEMQQ
IAEQAREMEGTVYCRLLRGNVPVVFDPATHRFELGKAKRIGSGTDIGFISTGFMTERCLDASAGLAELGIKASVLHCATI
KPFDTEAVAAFAASVDKVVTAENHVLVGGLASLVLDALYANGVMKPLLKIGIPDRFIECGSIPYLQTRYGLTAARVREQV
AQWLGAGAQAAE
>Mature_332_residues
MLKGRTLGMGELEAVENRASKLAPFATGAIAAQEAHGDVVLLTADLGKYTDTYPFRDRFPDRFYNVGMAEQALVMVAAGL
ARTGLSAYCTTYGAFATRRAHDFLAIACAHGGASVKMFAGNPGLTTGYGGTHQAIEDLALMRAVPDMTVIDPCDATEMQQ
IAEQAREMEGTVYCRLLRGNVPVVFDPATHRFELGKAKRIGSGTDIGFISTGFMTERCLDASAGLAELGIKASVLHCATI
KPFDTEAVAAFAASVDKVVTAENHVLVGGLASLVLDALYANGVMKPLLKIGIPDRFIECGSIPYLQTRYGLTAARVREQV
AQWLGAGAQAAE

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637459, Length=296, Percent_Identity=29.3918918918919, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI225637461, Length=296, Percent_Identity=29.3918918918919, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI225637463, Length=296, Percent_Identity=29.3918918918919, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI133778974, Length=267, Percent_Identity=30.7116104868914, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI205277463, Length=245, Percent_Identity=30.2040816326531, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4507521, Length=245, Percent_Identity=30.2040816326531, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786622, Length=271, Percent_Identity=29.8892988929889, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=267, Percent_Identity=32.2097378277154, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=31.2977099236641, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551847, Length=293, Percent_Identity=30.0341296928328, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550715, Length=293, Percent_Identity=30.0341296928328, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645119, Length=293, Percent_Identity=30.0341296928328, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 35216; Mature: 35216

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGRTLGMGELEAVENRASKLAPFATGAIAAQEAHGDVVLLTADLGKYTDTYPFRDRFP
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCC
DRFYNVGMAEQALVMVAAGLARTGLSAYCTTYGAFATRRAHDFLAIACAHGGASVKMFAG
HHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEC
NPGLTTGYGGTHQAIEDLALMRAVPDMTVIDPCDATEMQQIAEQAREMEGTVYCRLLRGN
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECC
VPVVFDPATHRFELGKAKRIGSGTDIGFISTGFMTERCLDASAGLAELGIKASVLHCATI
CCEEECCCCCEEECCCCCCCCCCCCCCEEECCHHHHHHHCCCCCHHHHCCHHEEEEEEEC
KPFDTEAVAAFAASVDKVVTAENHVLVGGLASLVLDALYANGVMKPLLKIGIPDRFIECG
CCCCHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
SIPYLQTRYGLTAARVREQVAQWLGAGAQAAE
CCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKGRTLGMGELEAVENRASKLAPFATGAIAAQEAHGDVVLLTADLGKYTDTYPFRDRFP
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCC
DRFYNVGMAEQALVMVAAGLARTGLSAYCTTYGAFATRRAHDFLAIACAHGGASVKMFAG
HHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEC
NPGLTTGYGGTHQAIEDLALMRAVPDMTVIDPCDATEMQQIAEQAREMEGTVYCRLLRGN
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECC
VPVVFDPATHRFELGKAKRIGSGTDIGFISTGFMTERCLDASAGLAELGIKASVLHCATI
CCEEECCCCCEEECCCCCCCCCCCCCCEEECCHHHHHHHCCCCCHHHHCCHHEEEEEEEC
KPFDTEAVAAFAASVDKVVTAENHVLVGGLASLVLDALYANGVMKPLLKIGIPDRFIECG
CCCCHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
SIPYLQTRYGLTAARVREQVAQWLGAGAQAAE
CCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]