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The map label for this gene is betA [H]

Identifier: 154245558

GI number: 154245558

Start: 1825758

End: 1827359

Strand: Reverse

Name: betA [H]

Synonym: Xaut_1613

Alternate gene names: 154245558

Gene position: 1827359-1825758 (Counterclockwise)

Preceding gene: 154245559

Following gene: 154245557

Centisome position: 34.42

GC content: 67.73

Gene sequence:

>1602_bases
ATGGACAGCTTCGACTATATCGTCGTGGGAGGCGGAACCGCAGGCGCGATCCTCGCGGCCCGCCTCTCGGAAGACCCCCG
CCGCACCGTCCTCCTGCTGGAGGCGGGCGGTACGGACCGGGGCTTCTGGGTGCCCATTCCGGCCGGCTTCTCCAAGCTTC
TGGCCGGCAGCGCCTTCAACTGGCGCTTCCACACCGAGCCGGAAGAAAATACCTACGACCGCCCCATCGTGGTGCCGCGC
GGCAAGGGGCTGGGCGGCTCAACCCTCATCAACGGCATGATTTTCGTGCGCGGCCAGCGCCAGGATTATGACGGCTGGGC
CCAGCTCGGCGCCACCGGCTGGGGCTGGGACGACGTGAAGCCCTACTTCAAGAAGTTCGAGACCTTCGAGGCCTCCGACA
TCGACACCAACGAGCGCGGAACCGACGGCCCCATCAACATCGTCCGCGTGGGCGAACGCCCTGTTCTGTCTGAGGTTTTC
ATCAAGGCGGCGGAGCAGGCCGGCTACCCGCGCAACCCCGACTACAACGGAAAGGTTCAGGACGGGTTCGGCTATTATCA
GGTGAACCAGAAAAACGGGCGCCGCTGGACCGTGGTGGACGGCTATCTGCGCCCCGCTCTCTCCCGTCCCAACCTCAAGG
TGGCGACCCACGCCCAGGCCCTCTGCCTCACCCTCGACGGCCGGCGGGTGACCGGGGTGACCTACCGGCAGGGCGGCCGT
GAAGTGGCGGCCACCGCGCGGGCCGAGGTGCTGCTCGCCGCCGGGGCGGTGCAGTCGCCCCAGTTGCTGGAACTGTCGGG
CATCGGCCATCCGGAGACGCTGAAGGCGGCGGGCATCCCGGTGGTGCATGCCCTTTCCGGCGTCGGCAACAATTATCGCG
ACCACTTCGCCACCCGCATGAACTGGCGCGTCAAGCAGCCGGTGACCCTCAACGAGCAGACCCGCGGCCTCGCCCTCGCC
AAGGCCGTGGCGCAGTATTTCCTGACGCGCAAAGGTATTCTCACCCTGGGAACCGGTCTTGCCCATGGTTTCGTGAAGAC
GCGGCCGGGCTTGGAGGGGCCGGACGTGCAATATTTCTTCATGCACGCCAGCTACGCCAATGCCGCCGACCGTGCGCTGG
ACCGCCAGCCGGGCATGACCATCGGCGTCACCCAGCTGCGCCCGCAATCCATCGGCTCCATCCACGTGACCTCGCCGGAC
CCGTTCAAGGCCCCGGCCATCCGGCCGAACTTCCTTGCGGTTCAGGAGGATCGCGACTGCCTGGTGGAGGGCATGAAGCT
CGCCCGGCGCATCATCGAGCAGCCGGCCATGGACCCCTACCGGGCGTTCGAGATGAACCCCGGCCCGGATGTGCGCAGCG
ACGCCGACTTCCTGGAATTTGCCCGCCGCACCGGCCAGACCATCTACCACCCGGTGGGCACCTGCGCCATGGGCACGGGA
CCCGCGGCGGTGGTGGACCCGCGCCTCAAGGTCATCGGCCTTGAGGGCCTGCGCGTGGTGGATGCCTCGGTGATGCCAAC
CATCGTCTCCGCCAACACGGCGGCGGCGGTGATGATGATCGCCGAGAAGGCCGCCGACATGATCAGGGCCGACGCGCGGT
AG

Upstream 100 bases:

>100_bases
AGACCGCCCTCGACCCGGACGATTTCCTGAACCCCGGAAAGGTCCTGCCAGCCGGGGGCTGATCCCCCGGCCGCACAAAA
AGGTACGCTGGAACAAGGCC

Downstream 100 bases:

>100_bases
GCGCCGCGCCCCTTGAGGCACAAGCCGCTGGAGGAGACCGCCTGCGCAATGGTATAAGAGCGCTTTAGCCCGTTCTCAGC
CATTGCGAACCGCCGTCATG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MDSFDYIVVGGGTAGAILAARLSEDPRRTVLLLEAGGTDRGFWVPIPAGFSKLLAGSAFNWRFHTEPEENTYDRPIVVPR
GKGLGGSTLINGMIFVRGQRQDYDGWAQLGATGWGWDDVKPYFKKFETFEASDIDTNERGTDGPINIVRVGERPVLSEVF
IKAAEQAGYPRNPDYNGKVQDGFGYYQVNQKNGRRWTVVDGYLRPALSRPNLKVATHAQALCLTLDGRRVTGVTYRQGGR
EVAATARAEVLLAAGAVQSPQLLELSGIGHPETLKAAGIPVVHALSGVGNNYRDHFATRMNWRVKQPVTLNEQTRGLALA
KAVAQYFLTRKGILTLGTGLAHGFVKTRPGLEGPDVQYFFMHASYANAADRALDRQPGMTIGVTQLRPQSIGSIHVTSPD
PFKAPAIRPNFLAVQEDRDCLVEGMKLARRIIEQPAMDPYRAFEMNPGPDVRSDADFLEFARRTGQTIYHPVGTCAMGTG
PAAVVDPRLKVIGLEGLRVVDASVMPTIVSANTAAAVMMIAEKAADMIRADAR

Sequences:

>Translated_533_residues
MDSFDYIVVGGGTAGAILAARLSEDPRRTVLLLEAGGTDRGFWVPIPAGFSKLLAGSAFNWRFHTEPEENTYDRPIVVPR
GKGLGGSTLINGMIFVRGQRQDYDGWAQLGATGWGWDDVKPYFKKFETFEASDIDTNERGTDGPINIVRVGERPVLSEVF
IKAAEQAGYPRNPDYNGKVQDGFGYYQVNQKNGRRWTVVDGYLRPALSRPNLKVATHAQALCLTLDGRRVTGVTYRQGGR
EVAATARAEVLLAAGAVQSPQLLELSGIGHPETLKAAGIPVVHALSGVGNNYRDHFATRMNWRVKQPVTLNEQTRGLALA
KAVAQYFLTRKGILTLGTGLAHGFVKTRPGLEGPDVQYFFMHASYANAADRALDRQPGMTIGVTQLRPQSIGSIHVTSPD
PFKAPAIRPNFLAVQEDRDCLVEGMKLARRIIEQPAMDPYRAFEMNPGPDVRSDADFLEFARRTGQTIYHPVGTCAMGTG
PAAVVDPRLKVIGLEGLRVVDASVMPTIVSANTAAAVMMIAEKAADMIRADAR
>Mature_533_residues
MDSFDYIVVGGGTAGAILAARLSEDPRRTVLLLEAGGTDRGFWVPIPAGFSKLLAGSAFNWRFHTEPEENTYDRPIVVPR
GKGLGGSTLINGMIFVRGQRQDYDGWAQLGATGWGWDDVKPYFKKFETFEASDIDTNERGTDGPINIVRVGERPVLSEVF
IKAAEQAGYPRNPDYNGKVQDGFGYYQVNQKNGRRWTVVDGYLRPALSRPNLKVATHAQALCLTLDGRRVTGVTYRQGGR
EVAATARAEVLLAAGAVQSPQLLELSGIGHPETLKAAGIPVVHALSGVGNNYRDHFATRMNWRVKQPVTLNEQTRGLALA
KAVAQYFLTRKGILTLGTGLAHGFVKTRPGLEGPDVQYFFMHASYANAADRALDRQPGMTIGVTQLRPQSIGSIHVTSPD
PFKAPAIRPNFLAVQEDRDCLVEGMKLARRIIEQPAMDPYRAFEMNPGPDVRSDADFLEFARRTGQTIYHPVGTCAMGTG
PAAVVDPRLKVIGLEGLRVVDASVMPTIVSANTAAAVMMIAEKAADMIRADAR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=540, Percent_Identity=39.0740740740741, Blast_Score=384, Evalue=1e-106,
Organism=Escherichia coli, GI1786503, Length=534, Percent_Identity=41.0112359550562, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17532301, Length=544, Percent_Identity=34.1911764705882, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24642055, Length=575, Percent_Identity=37.2173913043478, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24642048, Length=567, Percent_Identity=36.8606701940035, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=37.0826010544815, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI45551458, Length=568, Percent_Identity=36.6197183098592, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24642059, Length=574, Percent_Identity=35.8885017421603, Blast_Score=298, Evalue=9e-81,
Organism=Drosophila melanogaster, GI24642039, Length=572, Percent_Identity=36.013986013986, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI18859995, Length=567, Percent_Identity=36.331569664903, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=34.7826086956522, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24642037, Length=572, Percent_Identity=35.1398601398601, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=35.978835978836, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=35.3046594982079, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24650267, Length=567, Percent_Identity=32.6278659611993, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI18859993, Length=569, Percent_Identity=33.5676625659051, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24642051, Length=566, Percent_Identity=33.3922261484099, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24645930, Length=572, Percent_Identity=29.5454545454545, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642057, Length=599, Percent_Identity=27.8797996661102, Blast_Score=139, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 57993; Mature: 57993

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFDYIVVGGGTAGAILAARLSEDPRRTVLLLEAGGTDRGFWVPIPAGFSKLLAGSAFN
CCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHCCCCCC
WRFHTEPEENTYDRPIVVPRGKGLGGSTLINGMIFVRGQRQDYDGWAQLGATGWGWDDVK
EEEECCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCCCCCCHHHHHCCCCCCCHHHH
PYFKKFETFEASDIDTNERGTDGPINIVRVGERPVLSEVFIKAAEQAGYPRNPDYNGKVQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
DGFGYYQVNQKNGRRWTVVDGYLRPALSRPNLKVATHAQALCLTLDGRRVTGVTYRQGGR
CCCCEEEEECCCCCEEEEECHHHHHCCCCCCEEEEECCEEEEEEECCCEEEEEEECCCCC
EVAATARAEVLLAAGAVQSPQLLELSGIGHPETLKAAGIPVVHALSGVGNNYRDHFATRM
HHHHHHHHEEEEEECCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHC
NWRVKQPVTLNEQTRGLALAKAVAQYFLTRKGILTLGTGLAHGFVKTRPGLEGPDVQYFF
CEEECCCEECCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHCHHCCCCCCCCCCEEEEE
MHASYANAADRALDRQPGMTIGVTQLRPQSIGSIHVTSPDPFKAPAIRPNFLAVQEDRDC
EEECCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHH
LVEGMKLARRIIEQPAMDPYRAFEMNPGPDVRSDADFLEFARRTGQTIYHPVGTCAMGTG
HHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCCEECCCC
PAAVVDPRLKVIGLEGLRVVDASVMPTIVSANTAAAVMMIAEKAADMIRADAR
CCEEECCCEEEEECCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDSFDYIVVGGGTAGAILAARLSEDPRRTVLLLEAGGTDRGFWVPIPAGFSKLLAGSAFN
CCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHCCCCCC
WRFHTEPEENTYDRPIVVPRGKGLGGSTLINGMIFVRGQRQDYDGWAQLGATGWGWDDVK
EEEECCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCCCCCCHHHHHCCCCCCCHHHH
PYFKKFETFEASDIDTNERGTDGPINIVRVGERPVLSEVFIKAAEQAGYPRNPDYNGKVQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
DGFGYYQVNQKNGRRWTVVDGYLRPALSRPNLKVATHAQALCLTLDGRRVTGVTYRQGGR
CCCCEEEEECCCCCEEEEECHHHHHCCCCCCEEEEECCEEEEEEECCCEEEEEEECCCCC
EVAATARAEVLLAAGAVQSPQLLELSGIGHPETLKAAGIPVVHALSGVGNNYRDHFATRM
HHHHHHHHEEEEEECCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHC
NWRVKQPVTLNEQTRGLALAKAVAQYFLTRKGILTLGTGLAHGFVKTRPGLEGPDVQYFF
CEEECCCEECCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHCHHCCCCCCCCCCEEEEE
MHASYANAADRALDRQPGMTIGVTQLRPQSIGSIHVTSPDPFKAPAIRPNFLAVQEDRDC
EEECCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHH
LVEGMKLARRIIEQPAMDPYRAFEMNPGPDVRSDADFLEFARRTGQTIYHPVGTCAMGTG
HHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCCEECCCC
PAAVVDPRLKVIGLEGLRVVDASVMPTIVSANTAAAVMMIAEKAADMIRADAR
CCEEECCCEEEEECCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10708384 [H]