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The map label for this gene is dxs [C]

Identifier: 154245486

GI number: 154245486

Start: 1749268

End: 1750314

Strand: Reverse

Name: dxs [C]

Synonym: Xaut_1539

Alternate gene names: 154245486

Gene position: 1750314-1749268 (Counterclockwise)

Preceding gene: 154245487

Following gene: 154245485

Centisome position: 32.97

GC content: 69.82

Gene sequence:

>1047_bases
ATGAACCACGTAACCCGCAAGGCCGCCCCTGCCGCCCCCCCTGCCGCCGCTGCTGCCGGCAAGCCCCGGCTGACCACCTC
CGCGATGATCGCCTCAATCGCCGCCGAGGGACAGCGCACCAGGCCGGCCCCCTTCGGCCACGCCCTCGTCGCCCTCGCGC
GCGAGAACCCGGCCGTTGTGGGCATGACGGCCGATCTCGGCAAATATACCGACCTGCACATCTTCTCGCAGGCCTTCCCC
GAGCGCTTCTACCAGATGGGCATGGCCGAGCAGCTTCTGTTCGGCGCCGCCTCGGGGCTGGCCGCGGAGGGCTTCATGCC
CTTCGCCACCACCTACGCCGTGTTCGCCTCGCGCCGGGCCTACGACTTCATCCACCAGACGATCGCGGAGGAAAACCGCA
ACGTGAAGATCGTCTGCGCGCTGCCGGGCCTCACCTCCGGCTATGGCCCCTCGCACCAGGCCGCGGAAGACCTCGCCCTG
TTCCGGGCCATGCCCAACATGGTGGTGATCGACCCCTGCGACGCGCACGAGATCGAACAGGCGGTGCCGGTGATGGCGGC
CCATGACGGGCCGGTCTACATGCGCCTGCTGCGCGGCCAGGTGCCGCTGGTGCTGGACGAGTACGGCTACACGTTCGAGC
TCGGCAAGGCCAAGATGCTGCGCGACGGCCCGGATGCCCTGATCGTGTCCTCCGGAATCATGACCATGCGGGCCCTTGAG
GCGGCGGACCTGCTGCGCCAGGACAAGGTCGAGGTCGCGGTGCTTCACGTGCCCACCATCAAGCCTCTCGACGAGGCGAC
CATCGTGGAGGCGGCGCGCAAGAGTGGCCGCCCGGTGATCGTGGCCGAGAACCACACCGTCATCGGTGGCCTCGGCGAGG
CCGTGGCGGGCGCGCTGCTGCGCTCAGGCGTGGCGCCGGCAAGCTTCCACCAGATCGGCCTGCCCGACACCTTCCTCGAT
GCCGGCGCCCTGCCGACCCTCCACGACCGCTACGGCATCTCCGCAGCAGCCGTCGCGGAACAGGTCAAGGGCTGGACCGG
CCGCTAG

Upstream 100 bases:

>100_bases
GCGTGCCGTTCCTTGAGGCGCGCGAGAAGAACCACTTCATCCGCGTCGACGCCCACGAGTGGCAACTGGCGCTGGCCGCA
CTCGACGAGGGGAAGCCGTC

Downstream 100 bases:

>100_bases
CGCGGTTTCTTCAAGCGGACCGATGTCCGCTTCGCCTGGAAATGCCCCAGGCCACCATCGATCCGGGAAGGGGCCCGCCC
CTTCCCGCCCGATCCGCCGG

Product: transketolase central region

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNHVTRKAAPAAPPAAAAAGKPRLTTSAMIASIAAEGQRTRPAPFGHALVALARENPAVVGMTADLGKYTDLHIFSQAFP
ERFYQMGMAEQLLFGAASGLAAEGFMPFATTYAVFASRRAYDFIHQTIAEENRNVKIVCALPGLTSGYGPSHQAAEDLAL
FRAMPNMVVIDPCDAHEIEQAVPVMAAHDGPVYMRLLRGQVPLVLDEYGYTFELGKAKMLRDGPDALIVSSGIMTMRALE
AADLLRQDKVEVAVLHVPTIKPLDEATIVEAARKSGRPVIVAENHTVIGGLGEAVAGALLRSGVAPASFHQIGLPDTFLD
AGALPTLHDRYGISAAAVAEQVKGWTGR

Sequences:

>Translated_348_residues
MNHVTRKAAPAAPPAAAAAGKPRLTTSAMIASIAAEGQRTRPAPFGHALVALARENPAVVGMTADLGKYTDLHIFSQAFP
ERFYQMGMAEQLLFGAASGLAAEGFMPFATTYAVFASRRAYDFIHQTIAEENRNVKIVCALPGLTSGYGPSHQAAEDLAL
FRAMPNMVVIDPCDAHEIEQAVPVMAAHDGPVYMRLLRGQVPLVLDEYGYTFELGKAKMLRDGPDALIVSSGIMTMRALE
AADLLRQDKVEVAVLHVPTIKPLDEATIVEAARKSGRPVIVAENHTVIGGLGEAVAGALLRSGVAPASFHQIGLPDTFLD
AGALPTLHDRYGISAAAVAEQVKGWTGR
>Mature_348_residues
MNHVTRKAAPAAPPAAAAAGKPRLTTSAMIASIAAEGQRTRPAPFGHALVALARENPAVVGMTADLGKYTDLHIFSQAFP
ERFYQMGMAEQLLFGAASGLAAEGFMPFATTYAVFASRRAYDFIHQTIAEENRNVKIVCALPGLTSGYGPSHQAAEDLAL
FRAMPNMVVIDPCDAHEIEQAVPVMAAHDGPVYMRLLRGQVPLVLDEYGYTFELGKAKMLRDGPDALIVSSGIMTMRALE
AADLLRQDKVEVAVLHVPTIKPLDEATIVEAARKSGRPVIVAENHTVIGGLGEAVAGALLRSGVAPASFHQIGLPDTFLD
AGALPTLHDRYGISAAAVAEQVKGWTGR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637463, Length=313, Percent_Identity=35.4632587859425, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI225637461, Length=313, Percent_Identity=35.4632587859425, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI225637459, Length=313, Percent_Identity=35.4632587859425, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI205277463, Length=310, Percent_Identity=31.2903225806452, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4507521, Length=310, Percent_Identity=31.2903225806452, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI133778974, Length=300, Percent_Identity=34, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1786622, Length=346, Percent_Identity=27.4566473988439, Blast_Score=121, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17539652, Length=314, Percent_Identity=33.7579617834395, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551847, Length=302, Percent_Identity=32.7814569536424, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI45550715, Length=302, Percent_Identity=32.7814569536424, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24645119, Length=302, Percent_Identity=32.7814569536424, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24666278, Length=259, Percent_Identity=33.5907335907336, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 36901; Mature: 36901

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHVTRKAAPAAPPAAAAAGKPRLTTSAMIASIAAEGQRTRPAPFGHALVALARENPAVV
CCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEECCCCEEE
GMTADLGKYTDLHIFSQAFPERFYQMGMAEQLLFGAASGLAAEGFMPFATTYAVFASRRA
EEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
YDFIHQTIAEENRNVKIVCALPGLTSGYGPSHQAAEDLALFRAMPNMVVIDPCDAHEIEQ
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHH
AVPVMAAHDGPVYMRLLRGQVPLVLDEYGYTFELGKAKMLRDGPDALIVSSGIMTMRALE
HCCEEEECCCHHHHHHHHCCCCEEEECCCCEEEECCHHHHCCCCCEEEEECCHHHHHHHH
AADLLRQDKVEVAVLHVPTIKPLDEATIVEAARKSGRPVIVAENHTVIGGLGEAVAGALL
HHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHH
RSGVAPASFHQIGLPDTFLDAGALPTLHDRYGISAAAVAEQVKGWTGR
HCCCCCCCHHCCCCCHHHHCCCCCCCHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNHVTRKAAPAAPPAAAAAGKPRLTTSAMIASIAAEGQRTRPAPFGHALVALARENPAVV
CCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEECCCCEEE
GMTADLGKYTDLHIFSQAFPERFYQMGMAEQLLFGAASGLAAEGFMPFATTYAVFASRRA
EEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
YDFIHQTIAEENRNVKIVCALPGLTSGYGPSHQAAEDLALFRAMPNMVVIDPCDAHEIEQ
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHH
AVPVMAAHDGPVYMRLLRGQVPLVLDEYGYTFELGKAKMLRDGPDALIVSSGIMTMRALE
HCCEEEECCCHHHHHHHHCCCCEEEECCCCEEEECCHHHHCCCCCEEEEECCHHHHHHHH
AADLLRQDKVEVAVLHVPTIKPLDEATIVEAARKSGRPVIVAENHTVIGGLGEAVAGALL
HHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHH
RSGVAPASFHQIGLPDTFLDAGALPTLHDRYGISAAAVAEQVKGWTGR
HCCCCCCCHHCCCCCHHHHCCCCCCCHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]