Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 154245369

GI number: 154245369

Start: 1628682

End: 1630094

Strand: Reverse

Name: glcD [H]

Synonym: Xaut_1422

Alternate gene names: 154245369

Gene position: 1630094-1628682 (Counterclockwise)

Preceding gene: 154245371

Following gene: 154245368

Centisome position: 30.7

GC content: 65.25

Gene sequence:

>1413_bases
ATGGTTGTTGCAGCCGCGAAATCCGAGCTCACGCTTCTCGAGAGAAGCTTCGCCGTCATCGAACGGCTGAAGGCCGAACT
GGATCACAAGGTCGTGACCGGCCTCGCTGTCCGGGAACAACACGCTAACGTTACCACCTACCTGCCCAACGAGCCGCCAG
ATGCGGTGGTTTTCGCCGAATGCACACAGGATGTGCAGGCCGTGGTGAGGGCGTGCGCGGACTATGAGGTGCCGGTGATC
GCGTGGGGTGCTGGCACCTCGCTGGAAGGCCACGTGAACGCGCCCTTTGGCGGCATCTGCGTGGACCTGTCGCGCATGAA
CCGCATCCTCGCCGTGAACACGGAAGACCTCGACTGCGTGGTCGAGCCCGGCGTCACCCGCAAGCGGCTCAACGAGGAGC
TGCGCGACCAGGGCCTGTTCTTCCCATTGGATCCCGGCGCCGACGCCTCCATCGGCGGCATGGCGTCCACCCGCTGCTCG
GGCACCAATGCGGTGCGCTACGGCACCATGAAGGACAATGTGCTCTCCCTGAAGGTGGTGACCCCCACCGGCGAGGTCAT
CACCACCGCCACGCGCGCCCGCAAGTCCTCCGCCGGCTACGACCTTACCCGCCTCTATGTGGGCGCCGAGGGCACGCTGG
GCATTATCGTGGAGATCACGCTGAAGCTGTATGGCATTCCAGAGGCGGTCTCCGCCGCGGTCTGCCCGTTCCCCAGCGTG
GAGGCGGCCTGCAACACGGTCATCGCCACCATCCAGAGCGGCATTCCGGTGGCGCGCATCGAGCTACTGGACGAGGTGCA
GGTGAAGGCCTCCAACGCCTACGCCAAGCTCGCCCTCGCCGAGACCCCCACCCTGTTCCTGGAATTCCACGGCACCGAAA
CCAGCGTCCACGAGCAGGCCGACCGCTTCGGCGAACTGGCGGCCGAATTAGGCGGCGGTCCATCGGTGTTCGCGGTGAAG
CCGGAGGAGCGCACCAAGCTGTGGCAGGCCCGGCATGACGCCTATTGGTCCGTGCTGCCCCTGCGGCCGGGCGCCAAGGC
GGTGGCCACCGACGTGTGCGTGCCCATCTCGCGGCTGGCCGAATGCGTCATGGAGACCAAGCGCGACATCGAGGAGATGG
GCCTCGTCGCCCCCATCGTCGGCCATGTGGGCGACGGCAACTTCCACACCACGCTCATGGTGGACGTGGACGACCCCGAG
GATTTCGCCAAGGCCAAGCTCTATATGAAGAGGCTGGTGGAACGCGCCCTCGCCATGGGCGGCACCTCCACCGGCGAGCA
TGGCATCGGCCAGGGCAAGATGAAATACATGCTGCCCGAGCATGGCGAGGAAGCGCTGGAGATCATGCGCTCCATCAAGC
GCGCCATGGATCCTAAAAACATCATGAATCCGGGCAAGATTGTCGCGATCTGA

Upstream 100 bases:

>100_bases
AAGTTCAATGTGGCTCAGAACGAGCCATTTCTGGGGATGACTCCAAGGCCCCTGCCCGGCCCATGGCCGGCGGGCGAGAG
GCAAAGTTAAGGAATCGTAA

Downstream 100 bases:

>100_bases
TCGCATTCCCTGCGCATAGGGAACAGGTTCCCCCCATGAGGGGGACCTTTGGGGGAGACACGCGTGCAGGGGATATTGAT
CAGCCTCGCCACGGCGGTGA

Product: D-lactate dehydrogenase (cytochrome)

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVVAAAKSELTLLERSFAVIERLKAELDHKVVTGLAVREQHANVTTYLPNEPPDAVVFAECTQDVQAVVRACADYEVPVI
AWGAGTSLEGHVNAPFGGICVDLSRMNRILAVNTEDLDCVVEPGVTRKRLNEELRDQGLFFPLDPGADASIGGMASTRCS
GTNAVRYGTMKDNVLSLKVVTPTGEVITTATRARKSSAGYDLTRLYVGAEGTLGIIVEITLKLYGIPEAVSAAVCPFPSV
EAACNTVIATIQSGIPVARIELLDEVQVKASNAYAKLALAETPTLFLEFHGTETSVHEQADRFGELAAELGGGPSVFAVK
PEERTKLWQARHDAYWSVLPLRPGAKAVATDVCVPISRLAECVMETKRDIEEMGLVAPIVGHVGDGNFHTTLMVDVDDPE
DFAKAKLYMKRLVERALAMGGTSTGEHGIGQGKMKYMLPEHGEEALEIMRSIKRAMDPKNIMNPGKIVAI

Sequences:

>Translated_470_residues
MVVAAAKSELTLLERSFAVIERLKAELDHKVVTGLAVREQHANVTTYLPNEPPDAVVFAECTQDVQAVVRACADYEVPVI
AWGAGTSLEGHVNAPFGGICVDLSRMNRILAVNTEDLDCVVEPGVTRKRLNEELRDQGLFFPLDPGADASIGGMASTRCS
GTNAVRYGTMKDNVLSLKVVTPTGEVITTATRARKSSAGYDLTRLYVGAEGTLGIIVEITLKLYGIPEAVSAAVCPFPSV
EAACNTVIATIQSGIPVARIELLDEVQVKASNAYAKLALAETPTLFLEFHGTETSVHEQADRFGELAAELGGGPSVFAVK
PEERTKLWQARHDAYWSVLPLRPGAKAVATDVCVPISRLAECVMETKRDIEEMGLVAPIVGHVGDGNFHTTLMVDVDDPE
DFAKAKLYMKRLVERALAMGGTSTGEHGIGQGKMKYMLPEHGEEALEIMRSIKRAMDPKNIMNPGKIVAI
>Mature_470_residues
MVVAAAKSELTLLERSFAVIERLKAELDHKVVTGLAVREQHANVTTYLPNEPPDAVVFAECTQDVQAVVRACADYEVPVI
AWGAGTSLEGHVNAPFGGICVDLSRMNRILAVNTEDLDCVVEPGVTRKRLNEELRDQGLFFPLDPGADASIGGMASTRCS
GTNAVRYGTMKDNVLSLKVVTPTGEVITTATRARKSSAGYDLTRLYVGAEGTLGIIVEITLKLYGIPEAVSAAVCPFPSV
EAACNTVIATIQSGIPVARIELLDEVQVKASNAYAKLALAETPTLFLEFHGTETSVHEQADRFGELAAELGGGPSVFAVK
PEERTKLWQARHDAYWSVLPLRPGAKAVATDVCVPISRLAECVMETKRDIEEMGLVAPIVGHVGDGNFHTTLMVDVDDPE
DFAKAKLYMKRLVERALAMGGTSTGEHGIGQGKMKYMLPEHGEEALEIMRSIKRAMDPKNIMNPGKIVAI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=467, Percent_Identity=51.6059957173448, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI37595754, Length=490, Percent_Identity=49.1836734693878, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI119964728, Length=418, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4501993, Length=457, Percent_Identity=26.9146608315098, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=29.1866028708134, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787977, Length=497, Percent_Identity=28.169014084507, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI48994907, Length=449, Percent_Identity=24.0534521158129, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994914, Length=148, Percent_Identity=27.7027027027027, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=475, Percent_Identity=44.421052631579, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71992381, Length=475, Percent_Identity=43.578947368421, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=48.6979166666667, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17534361, Length=433, Percent_Identity=26.5588914549654, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556096, Length=465, Percent_Identity=23.6559139784946, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320027, Length=467, Percent_Identity=40.2569593147752, Blast_Score=319, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6320023, Length=441, Percent_Identity=27.437641723356, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320764, Length=438, Percent_Identity=25.5707762557078, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI18921117, Length=422, Percent_Identity=26.5402843601896, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24639277, Length=422, Percent_Identity=26.5402843601896, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24639275, Length=422, Percent_Identity=26.5402843601896, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24653753, Length=465, Percent_Identity=25.8064516129032, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 50569; Mature: 50569

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAAAKSELTLLERSFAVIERLKAELDHKVVTGLAVREQHANVTTYLPNEPPDAVVFAE
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEHH
CTQDVQAVVRACADYEVPVIAWGAGTSLEGHVNAPFGGICVDLSRMNRILAVNTEDLDCV
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEHHHCCEEEEECCCCCEEE
VEPGVTRKRLNEELRDQGLFFPLDPGADASIGGMASTRCSGTNAVRYGTMKDNVLSLKVV
ECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEE
TPTGEVITTATRARKSSAGYDLTRLYVGAEGTLGIIVEITLKLYGIPEAVSAAVCPFPSV
CCCCCEEEHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHCCCCCCH
EAACNTVIATIQSGIPVARIELLDEVQVKASNAYAKLALAETPTLFLEFHGTETSVHEQA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCHHHHHH
DRFGELAAELGGGPSVFAVKPEERTKLWQARHDAYWSVLPLRPGAKAVATDVCVPISRLA
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ECVMETKRDIEEMGLVAPIVGHVGDGNFHTTLMVDVDDPEDFAKAKLYMKRLVERALAMG
HHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GTSTGEHGIGQGKMKYMLPEHGEEALEIMRSIKRAMDPKNIMNPGKIVAI
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEC
>Mature Secondary Structure
MVVAAAKSELTLLERSFAVIERLKAELDHKVVTGLAVREQHANVTTYLPNEPPDAVVFAE
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEHH
CTQDVQAVVRACADYEVPVIAWGAGTSLEGHVNAPFGGICVDLSRMNRILAVNTEDLDCV
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEHHHCCEEEEECCCCCEEE
VEPGVTRKRLNEELRDQGLFFPLDPGADASIGGMASTRCSGTNAVRYGTMKDNVLSLKVV
ECCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEE
TPTGEVITTATRARKSSAGYDLTRLYVGAEGTLGIIVEITLKLYGIPEAVSAAVCPFPSV
CCCCCEEEHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHCCCCCCH
EAACNTVIATIQSGIPVARIELLDEVQVKASNAYAKLALAETPTLFLEFHGTETSVHEQA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCHHHHHH
DRFGELAAELGGGPSVFAVKPEERTKLWQARHDAYWSVLPLRPGAKAVATDVCVPISRLA
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ECVMETKRDIEEMGLVAPIVGHVGDGNFHTTLMVDVDDPEDFAKAKLYMKRLVERALAMG
HHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GTSTGEHGIGQGKMKYMLPEHGEEALEIMRSIKRAMDPKNIMNPGKIVAI
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]