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The map label for this gene is hyuA [H]

Identifier: 154245288

GI number: 154245288

Start: 1540375

End: 1541727

Strand: Direct

Name: hyuA [H]

Synonym: Xaut_1341

Alternate gene names: 154245288

Gene position: 1540375-1541727 (Clockwise)

Preceding gene: 154245287

Following gene: 154245289

Centisome position: 29.01

GC content: 67.78

Gene sequence:

>1353_bases
TTGCAGACCATTCATTCCGGCCCGGTCTCCGGCATTGGCGCCTCCGAGCACCTGGCCATGCTCACCGGGCTCGGCAACGT
GGTGGCCACCGACATGGGCGGCACCAGCTACGACATCGGCATCGTGGTGGACGGCGGCGTGAAGCATTACGACTTCAATC
CGGTGATCGATCGCTGGCTGGTCTCGGTGCCCATGGTGCACCTGGTGACGCTGGGCGCCGGCGGCGGCTCCATCGCCTCC
TACGACCGCATGTACAAGACCGTGAAGTGCGGCCCGGAGAGCGCCGGGTCCGACCCCGGCCCGGCCTGCTACGACCGGGG
CGGCATGCGGCCCACCGTGACCGACGCCGACCTTTTGCTCGGCTATCTCGACCCGGCGAACTATGCGGGCGGCTCCATCC
CGCTCAACCCGCGCCGGGCCAGGGCGGCCATCGAGGACACCCTGTGCGACGAGCTTGACTGCTCGGTGATCGAGGCGGCG
CTGCTGATCCGCGAGAAGGTGGACGACAACATGGCCAACGGCCTGTTCACCGAGCTGCGCGCCCGGGGCTACGACCCCAA
GGACTTCACCATGCTCGCCTACGGCGGCAACGGCCCGCTGCACTGCTGCGGCATCGCCCAGAACCTCAACATCGACCGTA
TTCTGGCGCCGCCGCTCTCCTCGGTGTTCTCCGCGGTGGGCGCCGGTAACATGCACCAGCTCCATATCCATGAGCAGTCG
CTCTACATGGTGCTCTACGACAGCAACACCCGCGCCCTGTTCGACGACTATGACCGCTTCAACGCCATCGTCGCCGACCT
GAAGGAGCGCGGCACCCAGGACCTGCTGCGCCAGGGCGTTCCGCCCGCAGACATCCGCCACAACCTCGAACTGGACATGC
GCTACGGCAACCAGCTGGTGCAGACCACGGCGGTGATCGAGAAGCACGCGGTGGACGGTCCGGCGGACGTGCTCGCCATC
ATCTCCCAGTTCTCGGCGGACTACGGCAAGCGCTTCGGCGAGGGCTCGCAGGCGCCGGAGGCGGGCATCCGCATCAACAC
CATCCGCATCGCCGCCTATGTCCAGCACGAGACCGTGCAGTTCGAGGACATCAAGCCGGTACCCGAGAGCGAGCGCAAGG
CGCCGCCGCCACCCGCGGCGAGCCGTGTGTGCCACTTCGTGGGCCAGGACGGCCCGCTGGAGACGCCGGTGTGGAGCCGC
GCCGATATCGGTCCCGGTGTCCAGATCGAGGGCCCGGCCATCATCGCATCGGAGGTGACCACCTTCCTGGTCAATCCTGG
CTGGAGCTTCGTGGCGGCAAAGCAGGGGGCCTCCTGGTTCCTGCGCGCCAAGATCCCCGCCACCACGCACTGA

Upstream 100 bases:

>100_bases
TCGGCGCTGGAGCAGAACCTGCGCGCCCATCGCTACGACAAGCCCATGCTGGTGATCCACAATTCGGGCGGCATGGCGCA
GCTCAACTCCACCGAACGCG

Downstream 100 bases:

>100_bases
CGCCGTTTCTCTCCCCGCCCCGCGCGGGGAGAGCGCGCCCCATGGCGCTGCGATCACCTGAGATAATCCGGGAGGATAAA
CCCATGAACGACATGAGCAT

Product: hydantoinase/oxoprolinase

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MQTIHSGPVSGIGASEHLAMLTGLGNVVATDMGGTSYDIGIVVDGGVKHYDFNPVIDRWLVSVPMVHLVTLGAGGGSIAS
YDRMYKTVKCGPESAGSDPGPACYDRGGMRPTVTDADLLLGYLDPANYAGGSIPLNPRRARAAIEDTLCDELDCSVIEAA
LLIREKVDDNMANGLFTELRARGYDPKDFTMLAYGGNGPLHCCGIAQNLNIDRILAPPLSSVFSAVGAGNMHQLHIHEQS
LYMVLYDSNTRALFDDYDRFNAIVADLKERGTQDLLRQGVPPADIRHNLELDMRYGNQLVQTTAVIEKHAVDGPADVLAI
ISQFSADYGKRFGEGSQAPEAGIRINTIRIAAYVQHETVQFEDIKPVPESERKAPPPPAASRVCHFVGQDGPLETPVWSR
ADIGPGVQIEGPAIIASEVTTFLVNPGWSFVAAKQGASWFLRAKIPATTH

Sequences:

>Translated_450_residues
MQTIHSGPVSGIGASEHLAMLTGLGNVVATDMGGTSYDIGIVVDGGVKHYDFNPVIDRWLVSVPMVHLVTLGAGGGSIAS
YDRMYKTVKCGPESAGSDPGPACYDRGGMRPTVTDADLLLGYLDPANYAGGSIPLNPRRARAAIEDTLCDELDCSVIEAA
LLIREKVDDNMANGLFTELRARGYDPKDFTMLAYGGNGPLHCCGIAQNLNIDRILAPPLSSVFSAVGAGNMHQLHIHEQS
LYMVLYDSNTRALFDDYDRFNAIVADLKERGTQDLLRQGVPPADIRHNLELDMRYGNQLVQTTAVIEKHAVDGPADVLAI
ISQFSADYGKRFGEGSQAPEAGIRINTIRIAAYVQHETVQFEDIKPVPESERKAPPPPAASRVCHFVGQDGPLETPVWSR
ADIGPGVQIEGPAIIASEVTTFLVNPGWSFVAAKQGASWFLRAKIPATTH
>Mature_450_residues
MQTIHSGPVSGIGASEHLAMLTGLGNVVATDMGGTSYDIGIVVDGGVKHYDFNPVIDRWLVSVPMVHLVTLGAGGGSIAS
YDRMYKTVKCGPESAGSDPGPACYDRGGMRPTVTDADLLLGYLDPANYAGGSIPLNPRRARAAIEDTLCDELDCSVIEAA
LLIREKVDDNMANGLFTELRARGYDPKDFTMLAYGGNGPLHCCGIAQNLNIDRILAPPLSSVFSAVGAGNMHQLHIHEQS
LYMVLYDSNTRALFDDYDRFNAIVADLKERGTQDLLRQGVPPADIRHNLELDMRYGNQLVQTTAVIEKHAVDGPADVLAI
ISQFSADYGKRFGEGSQAPEAGIRINTIRIAAYVQHETVQFEDIKPVPESERKAPPPPAASRVCHFVGQDGPLETPVWSR
ADIGPGVQIEGPAIIASEVTTFLVNPGWSFVAAKQGASWFLRAKIPATTH

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=469, Percent_Identity=29.2110874200426, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322634, Length=445, Percent_Identity=25.8426966292135, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45550492, Length=448, Percent_Identity=26.1160714285714, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 48364; Mature: 48364

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIHSGPVSGIGASEHLAMLTGLGNVVATDMGGTSYDIGIVVDGGVKHYDFNPVIDRWL
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCEEECCCCHHHHHHH
VSVPMVHLVTLGAGGGSIASYDRMYKTVKCGPESAGSDPGPACYDRGGMRPTVTDADLLL
HHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHE
GYLDPANYAGGSIPLNPRRARAAIEDTLCDELDCSVIEAALLIREKVDDNMANGLFTELR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
ARGYDPKDFTMLAYGGNGPLHCCGIAQNLNIDRILAPPLSSVFSAVGAGNMHQLHIHEQS
HCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCE
LYMVLYDSNTRALFDDYDRFNAIVADLKERGTQDLLRQGVPPADIRHNLELDMRYGNQLV
EEEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHCCCCEEEEHHCCHHH
QTTAVIEKHAVDGPADVLAIISQFSADYGKRFGEGSQAPEAGIRINTIRIAAYVQHETVQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECEEE
FEDIKPVPESERKAPPPPAASRVCHFVGQDGPLETPVWSRADIGPGVQIEGPAIIASEVT
ECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEECCEE
TFLVNPGWSFVAAKQGASWFLRAKIPATTH
EEEECCCCCEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure
MQTIHSGPVSGIGASEHLAMLTGLGNVVATDMGGTSYDIGIVVDGGVKHYDFNPVIDRWL
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCEEECCCCHHHHHHH
VSVPMVHLVTLGAGGGSIASYDRMYKTVKCGPESAGSDPGPACYDRGGMRPTVTDADLLL
HHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHE
GYLDPANYAGGSIPLNPRRARAAIEDTLCDELDCSVIEAALLIREKVDDNMANGLFTELR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
ARGYDPKDFTMLAYGGNGPLHCCGIAQNLNIDRILAPPLSSVFSAVGAGNMHQLHIHEQS
HCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCE
LYMVLYDSNTRALFDDYDRFNAIVADLKERGTQDLLRQGVPPADIRHNLELDMRYGNQLV
EEEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHCCCCEEEEHHCCHHH
QTTAVIEKHAVDGPADVLAIISQFSADYGKRFGEGSQAPEAGIRINTIRIAAYVQHETVQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECEEE
FEDIKPVPESERKAPPPPAASRVCHFVGQDGPLETPVWSRADIGPGVQIEGPAIIASEVT
ECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEECCEE
TFLVNPGWSFVAAKQGASWFLRAKIPATTH
EEEECCCCCEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]